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Protein

AP-1 complex subunit sigma-3

Gene

Ap1s3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Involved in TLR3 trafficking (By similarity).By similarity

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295 MHC class II antigen presentation
R-MMU-432720 Lysosome Vesicle Biogenesis
R-MMU-432722 Golgi Associated Vesicle Biogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit sigma-3
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1C
Adaptor-related protein complex 1 subunit sigma-1C
Clathrin assembly protein complex 1 sigma-1C small chain
Golgi adaptor HA1/AP1 adaptin sigma-1C subunit
Sigma 1C subunit of AP-1 clathrin
Sigma-adaptin 1C
Sigma1C-adaptin
Gene namesi
Name:Ap1s3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi

Organism-specific databases

MGIiMGI:1891304 Ap1s3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001938021 – 154AP-1 complex subunit sigma-3Add BLAST154

Proteomic databases

EPDiQ7TN05
MaxQBiQ7TN05
PaxDbiQ7TN05
PRIDEiQ7TN05

PTM databases

PhosphoSitePlusiQ7TN05

Expressioni

Gene expression databases

BgeeiENSMUSG00000054702
CleanExiMM_AP1S3
ExpressionAtlasiQ7TN05 baseline and differential
GenevisibleiQ7TN05 MM

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125268

Structurei

3D structure databases

ProteinModelPortaliQ7TN05
SMRiQ7TN05
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0934 Eukaryota
COG5030 LUCA
GeneTreeiENSGT00530000062839
HOGENOMiHOG000185227
HOVERGENiHBG050517
InParanoidiQ7TN05
KOiK12395
OMAiFCCAVEN
OrthoDBiEOG091G0QZV
PhylomeDBiQ7TN05
TreeFamiTF312921

Family and domain databases

InterProiView protein in InterPro
IPR016635 AP_complex_ssu
IPR022775 AP_mu_sigma_su
IPR000804 Clathrin_sm-chain_CS
IPR011012 Longin-like_dom_sf
PANTHERiPTHR11753 PTHR11753, 1 hit
PfamiView protein in Pfam
PF01217 Clat_adaptor_s, 1 hit
PIRSFiPIRSF015588 AP_complex_sigma, 1 hit
SUPFAMiSSF64356 SSF64356, 1 hit
PROSITEiView protein in PROSITE
PS00989 CLAT_ADAPTOR_S, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TN05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHFILLFSR QGKLRLQKWY TTLPDKERKK ITRDIIQTVL SRGHRTSSFI
60 70 80 90 100
DWKELKLVYK RYASLYFCCA IENQDNELLT LEIVHRYVEL LDKYFGNVCE
110 120 130 140 150
LDIIFNFEKA YFILDEFIIG GEIQETSKKT AVKAIEDSDM LQETMEEYMN

KPTF
Length:154
Mass (Da):18,440
Last modified:October 1, 2003 - v1
Checksum:i231E454DDECBB302
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054111 mRNA Translation: AAH54111.1
BC098237 mRNA Translation: AAH98237.1
CCDSiCCDS35628.1
RefSeqiNP_898848.1, NM_183027.2
UniGeneiMm.32409

Genome annotation databases

EnsembliENSMUST00000162342; ENSMUSP00000125268; ENSMUSG00000054702
GeneIDi252903
KEGGimmu:252903
UCSCiuc011wnw.1 mouse

Similar proteinsi

Entry informationi

Entry nameiAP1S3_MOUSE
AccessioniPrimary (citable) accession number: Q7TN05
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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