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Protein

AP-1 complex subunit sigma-3

Gene

Ap1s3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules (By similarity). Involved in TLR3 trafficking (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-432722. Golgi Associated Vesicle Biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
AP-1 complex subunit sigma-3
Alternative name(s):
Adaptor protein complex AP-1 subunit sigma-1C
Adaptor-related protein complex 1 subunit sigma-1C
Clathrin assembly protein complex 1 sigma-1C small chain
Golgi adaptor HA1/AP1 adaptin sigma-1C subunit
Sigma 1C subunit of AP-1 clathrin
Sigma-adaptin 1C
Sigma1C-adaptin
Gene namesi
Name:Ap1s3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:1891304. Ap1s3.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Coated pit, Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 154154AP-1 complex subunit sigma-3PRO_0000193802Add
BLAST

Proteomic databases

EPDiQ7TN05.
MaxQBiQ7TN05.
PaxDbiQ7TN05.
PRIDEiQ7TN05.

PTM databases

PhosphoSiteiQ7TN05.

Expressioni

Gene expression databases

BgeeiENSMUSG00000054702.
CleanExiMM_AP1S3.
ExpressionAtlasiQ7TN05. baseline and differential.
GenevisibleiQ7TN05. MM.

Interactioni

Subunit structurei

Adaptor protein complex 1 (AP-1) is a heterotetramer composed of two large adaptins (gamma-type subunit AP1G1 and beta-type subunit AP1B1), a medium adaptin (mu-type subunit AP1M1 or AP1M2) and a small adaptin (sigma-type subunit AP1S1 or AP1S2 or AP1S3).By similarity

Protein-protein interaction databases

MINTiMINT-4997535.
STRINGi10090.ENSMUSP00000125268.

Structurei

3D structure databases

ProteinModelPortaliQ7TN05.
SMRiQ7TN05. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0934. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00530000062839.
HOGENOMiHOG000185227.
HOVERGENiHBG050517.
InParanoidiQ7TN05.
KOiK12395.
OMAiESDMLQE.
OrthoDBiEOG091G0QZV.
PhylomeDBiQ7TN05.
TreeFamiTF312921.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TN05-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIHFILLFSR QGKLRLQKWY TTLPDKERKK ITRDIIQTVL SRGHRTSSFI
60 70 80 90 100
DWKELKLVYK RYASLYFCCA IENQDNELLT LEIVHRYVEL LDKYFGNVCE
110 120 130 140 150
LDIIFNFEKA YFILDEFIIG GEIQETSKKT AVKAIEDSDM LQETMEEYMN

KPTF
Length:154
Mass (Da):18,440
Last modified:October 1, 2003 - v1
Checksum:i231E454DDECBB302
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054111 mRNA. Translation: AAH54111.1.
BC098237 mRNA. Translation: AAH98237.1.
CCDSiCCDS35628.1.
RefSeqiNP_898848.1. NM_183027.2.
UniGeneiMm.32409.

Genome annotation databases

EnsembliENSMUST00000162342; ENSMUSP00000125268; ENSMUSG00000054702.
GeneIDi252903.
KEGGimmu:252903.
UCSCiuc011wnw.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054111 mRNA. Translation: AAH54111.1.
BC098237 mRNA. Translation: AAH98237.1.
CCDSiCCDS35628.1.
RefSeqiNP_898848.1. NM_183027.2.
UniGeneiMm.32409.

3D structure databases

ProteinModelPortaliQ7TN05.
SMRiQ7TN05. Positions 1-143.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4997535.
STRINGi10090.ENSMUSP00000125268.

PTM databases

PhosphoSiteiQ7TN05.

Proteomic databases

EPDiQ7TN05.
MaxQBiQ7TN05.
PaxDbiQ7TN05.
PRIDEiQ7TN05.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000162342; ENSMUSP00000125268; ENSMUSG00000054702.
GeneIDi252903.
KEGGimmu:252903.
UCSCiuc011wnw.1. mouse.

Organism-specific databases

CTDi130340.
MGIiMGI:1891304. Ap1s3.

Phylogenomic databases

eggNOGiKOG0934. Eukaryota.
COG5030. LUCA.
GeneTreeiENSGT00530000062839.
HOGENOMiHOG000185227.
HOVERGENiHBG050517.
InParanoidiQ7TN05.
KOiK12395.
OMAiESDMLQE.
OrthoDBiEOG091G0QZV.
PhylomeDBiQ7TN05.
TreeFamiTF312921.

Enzyme and pathway databases

ReactomeiR-MMU-2132295. MHC class II antigen presentation.
R-MMU-432720. Lysosome Vesicle Biogenesis.
R-MMU-432722. Golgi Associated Vesicle Biogenesis.

Miscellaneous databases

PROiQ7TN05.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000054702.
CleanExiMM_AP1S3.
ExpressionAtlasiQ7TN05. baseline and differential.
GenevisibleiQ7TN05. MM.

Family and domain databases

InterProiIPR016635. AP_complex_ssu.
IPR022775. AP_mu_sigma_su.
IPR000804. Clathrin_sm-chain_CS.
IPR011012. Longin-like_dom.
[Graphical view]
PANTHERiPTHR11753. PTHR11753. 1 hit.
PfamiPF01217. Clat_adaptor_s. 1 hit.
[Graphical view]
PIRSFiPIRSF015588. AP_complex_sigma. 1 hit.
SUPFAMiSSF64356. SSF64356. 1 hit.
PROSITEiPS00989. CLAT_ADAPTOR_S. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiAP1S3_MOUSE
AccessioniPrimary (citable) accession number: Q7TN05
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.