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Protein

Mediator of RNA polymerase II transcription subunit 26

Gene

Med26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional pre-initiation complex with RNA polymerase II and the general transcription factors (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-212436 Generic Transcription Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Mediator of RNA polymerase II transcription subunit 26
Alternative name(s):
Cofactor required for Sp1 transcriptional activation subunit 7
Short name:
CRSP complex subunit 7
Mediator complex subunit 26
Gene namesi
Name:Med26
Synonyms:Crsp7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1917875 Med26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003049591 – 588Mediator of RNA polymerase II transcription subunit 26Add BLAST588

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei435PhosphoserineCombined sources1
Modified residuei458PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ7TN02
MaxQBiQ7TN02
PaxDbiQ7TN02
PeptideAtlasiQ7TN02
PRIDEiQ7TN02

PTM databases

iPTMnetiQ7TN02
PhosphoSitePlusiQ7TN02

Expressioni

Gene expression databases

BgeeiENSMUSG00000045248
CleanExiMM_MED26
GenevisibleiQ7TN02 MM

Interactioni

Subunit structurei

Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP (By similarity). Interacts with CEBPB (when not methylated)(PubMed:20111005).By similarity1 Publication

Protein-protein interaction databases

BioGridi214175, 1 interactor
IntActiQ7TN02, 7 interactors
MINTiQ7TN02
STRINGi10090.ENSMUSP00000058697

Structurei

3D structure databases

ProteinModelPortaliQ7TN02
SMRiQ7TN02
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 87TFIIS N-terminalPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi159 – 342Pro-richAdd BLAST184

Sequence similaritiesi

Belongs to the Mediator complex subunit 26 family.Curated

Phylogenomic databases

eggNOGiKOG1105 Eukaryota
COG1594 LUCA
GeneTreeiENSGT00390000000259
HOGENOMiHOG000113539
HOVERGENiHBG051124
InParanoidiQ7TN02
KOiK15169
OMAiHFMSEYL
OrthoDBiEOG091G0H00
PhylomeDBiQ7TN02
TreeFamiTF328436

Family and domain databases

Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR031416 Med26_C
IPR031417 Med26_Mid
IPR003617 TFIIS/CRSP70_N_sub
IPR035441 TFIIS/LEDGF_dom_sf
IPR017923 TFIIS_N
PfamiView protein in Pfam
PF08711 Med26, 1 hit
PF15693 Med26_C, 1 hit
PF15694 Med26_M, 1 hit
SMARTiView protein in SMART
SM00509 TFS2N, 1 hit
SUPFAMiSSF47676 SSF47676, 1 hit
PROSITEiView protein in PROSITE
PS51319 TFIIS_N, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TN02-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTAAPASPQQ MRDRLLQAID SQSNIRNMVA VLEVISSLER YPITKEALEE
60 70 80 90 100
TRLGKLINDV RKKTKNEELA KRAKRLLRSW QKLIEPVHQN EVALRALAGA
110 120 130 140 150
AGSANGGAHN CRPEMGVAGA PKSIHDLKNR NDIQRLPGQR LDRLGSRKRR
160 170 180 190 200
GDQRDLGHPG PPHKVSKGSP DPLVPNASPL PTNGISGSPE SLPSPLDGSG
210 220 230 240 250
HLGPDGSRLE PSDNEKHSTK IPVNAVRPRP SSPGLGKPPV PCLQTKAAQL
260 270 280 290 300
QQLDRADESP GPPYPRGSSR CSFSPRNSRH EGSFSRHRSS YIPKGQVSSP
310 320 330 340 350
SPWPQPPDNT QVPSPLPLAQ PPTPPVRRQE LLPNAESPVH WPEQSEGHPR
360 370 380 390 400
LTGPACRAGF SPDSSKADSD ATSSGGSDSK KKKRYRPRDY TVNLDGQVAE
410 420 430 440 450
AGVKPVRLKE RKLTFDPMTR QIRPLTQKEP VRADSPVPTE QLPRTELEQQ
460 470 480 490 500
EVKASLQSPF EQTNWKELSR NEIIQSYLSR QSSLLSSSGA QTPGAHHFMA
510 520 530 540 550
EYLKQEESSR QGARQPHVLL PLPTPTDLPG LTREVTQDDL DRIQAQQWPG
560 570 580
VNGCEDTQGN WYDWTQCISL DPHGDDGRLN ILPYVCLD
Length:588
Mass (Da):64,680
Last modified:October 1, 2003 - v1
Checksum:i0CAFE5930234B293
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64T → N in BAC38738 (PubMed:16141072).Curated1
Sequence conflicti212 – 214SDN → VII in BAB30898 (PubMed:16141072).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK017726 mRNA Translation: BAB30898.1
AK083035 mRNA Translation: BAC38738.1
BC024555 mRNA Translation: AAH24555.1
BC054737 mRNA Translation: AAH54737.1
CCDSiCCDS22416.1
RefSeqiNP_081761.2, NM_027485.4
UniGeneiMm.235885
Mm.440960

Genome annotation databases

EnsembliENSMUST00000058534; ENSMUSP00000058697; ENSMUSG00000045248
GeneIDi70625
KEGGimmu:70625
UCSCiuc009mgg.2 mouse

Similar proteinsi

Entry informationi

Entry nameiMED26_MOUSE
AccessioniPrimary (citable) accession number: Q7TN02
Secondary accession number(s): Q8BUP9, Q8R1G7, Q9CS67
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health