E3 ubiquitin-protein ligase HUWE1 - Mus musculus (Mouse)

Preferred order of sections

Names and origin

Protein names

Recommended name:
E3 ubiquitin-protein ligase HUWE1
EC=6.3.2.-

Alternative name(s):
E3Histone
HECT, UBA and WWE domain-containing protein 1
Upstream regulatory element-binding protein 1
Short name=URE-B1
Short name=URE-binding protein 1

Gene names

Name:	Huwe1
Synonyms:	Kiaa0312, Ureb1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	4377 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	E3 ubiquitin-protein ligase which mediates ubiquitination and subsequent proteasomal degradation of target proteins. Regulates apoptosis by catalyzing the polyubiquitination and degradation of MCL1. Mediates monoubiquitination of DNA polymerase beta (POLB) at 'Lys-41', 'Lys-61' and 'Lys-81', thereby playing a role in base-excision repair. Also ubiquitinates the p53/TP53 tumor suppressor and core histones including H1, H2A, H2B, H3 and H4. Binds to an upstream initiator-like sequence in the preprodynorphin gene By similarity. Regulates neural differentiation and proliferation by catalyzing the polyubiquitination and degradation of MYCN. May regulate abundance of CDC6 after DNA damage by polyubiquitinating and targeting CDC6 to degradation By similarity. Ref.3 Ref.15
Pathway	Protein modification; protein ubiquitination.
Subunit structure	Interacts with isoform p19ARF of CDKN2A which strongly inhibits HUWE1 ubiquitin ligase activity By similarity. Interacts with MYCN, POLB and CDC6 By similarity.
Subcellular location	Cytoplasm. Nucleus. Note: Mainly expressed in the cytoplasm of most tissues, except in the nucleus of spermatogonia, primary spermatocytes and neuronal cells. Ref.14
Tissue specificity	Widely expressed. Ref.14
Developmental stage	Expression increases during neuronal differentiation such that the cortical plate contains the highest level. Ref.15
Domain	The HECT domain mediates inhibition of the transcriptional activity of p53 By similarity.
Post-translational modification	Phosphorylated on tyrosine; phosphorylation is probably required for its ability to inhibit TP53 transactivation By similarity.
Sequence similarities	Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain. Contains 1 UBA domain. Contains 1 UIM (ubiquitin-interacting motif) repeat. Contains 1 WWE domain.

Ontologies

Keywords
Biological process	DNA damage DNA repair Differentiation Ubl conjugation pathway
Cellular component	Cytoplasm Nucleus
Coding sequence diversity	Alternative splicing
Ligand	DNA-binding
Molecular function	Ligase
PTM	Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	base-excision repair Inferred from sequence or structural similarity. Source: UniProtKB cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW histone ubiquitination Inferred from sequence or structural similarity. Source: UniProtKB protein monoubiquitination Inferred from sequence or structural similarity. Source: UniProtKB protein polyubiquitination Inferred from sequence or structural similarity. Source: UniProtKB protein ubiquitination involved in ubiquitin-dependent protein catabolic process Inferred from Biological aspect of Ancestor. Source: RefGenome
Cellular_component	cytoplasm Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	DNA binding Inferred from sequence or structural similarity. Source: UniProtKB ubiquitin-protein ligase activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q7TMY8-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q7TMY8-2) The sequence of this isoform differs from the canonical sequence as follows: 3347-3364: FPSHFTQQRTKETNCESD → RSLKESLTPGFFGHQHLG 3365-4377: Missing.
Note: No experimental confirmation available.

Isoform 3 (identifier: Q7TMY8-3) The sequence of this isoform differs from the canonical sequence as follows: 3780-3794: Missing.
Note: No experimental confirmation available.

Isoform 4 (identifier: Q7TMY8-4) The sequence of this isoform differs from the canonical sequence as follows: 3795-3832: SESSNQSETS...DTQSIVISDG → VSMMPVAPHS...LVCFCITFAK 3833-4377: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 4377

4377

E3 ubiquitin-protein ligase HUWE1

PRO_0000120341

Regions

Domain

1316 – 1355

40

UBA

Repeat

1370 – 1389

20

UIM

Domain

1603 – 1680

78

WWE

Domain

4041 – 4377

337

HECT

Compositional bias

2295 – 2469

175

Glu-rich

Compositional bias

2427 – 2490

64

Asp-rich

Compositional bias

3484 – 3552

69

Thr-rich

Sites

Active site

4344

1

Glycyl thioester intermediate By similarity

Amino acid modifications

Modified residue

1084

1

Phosphoserine By similarity

Modified residue

1368

1

Phosphoserine By similarity

Modified residue

1370

1

Phosphoserine By similarity

Modified residue

1395

1

Phosphoserine By similarity

Modified residue

1907

1

Phosphoserine Ref.12 Ref.16

Modified residue

2362

1

Phosphoserine By similarity

Modified residue

2365

1

Phosphoserine By similarity

Modified residue

2391

1

Phosphoserine By similarity

Modified residue

2595

1

Phosphoserine By similarity

Modified residue

2619

1

Phosphoserine By similarity

Modified residue

2751

1

Phosphothreonine By similarity

Modified residue

2887

1

Phosphoserine By similarity

Modified residue

2918

1

Phosphoserine By similarity

Modified residue

3116

1

Phosphoserine By similarity

Modified residue

3127

1

Phosphoserine By similarity

Modified residue

3663

1

Phosphoserine By similarity

Modified residue

3753

1

Phosphoserine By similarity

Modified residue

3758

1

Phosphoserine Ref.11 Ref.13

Modified residue

3761

1

Phosphoserine By similarity

Modified residue

3810

1

Phosphoserine Ref.13

Modified residue

3818

1

Phosphoserine By similarity

Modified residue

3922

1

Phosphoserine By similarity

Modified residue

3927

1

Phosphothreonine By similarity

Modified residue

3930

1

Phosphothreonine By similarity

Natural variations

Alternative sequence

3347 – 3364

18

FPSHF…NCESD → RSLKESLTPGFFGHQHLG in isoform 2.

VSP_011147

Alternative sequence

3365 – 4377

1013

Missing in isoform 2.

VSP_011148

Alternative sequence

3780 – 3794

15

Missing in isoform 3.

VSP_011149

Alternative sequence

3795 – 3832

38

SESSN…VISDG → VSMMPVAPHSFLYPPSCTMS SVGVHCPYLVCFCITFAK in isoform 4.

VSP_011150

Alternative sequence

3833 – 4377

545

Missing in isoform 4.

VSP_011151

Experimental info

Sequence conflict

253

1

K → R in AAX24124. Ref.3

Sequence conflict

253

1

K → R in AAV90839. Ref.1

Sequence conflict

1728

1

S → I in AAV90839. Ref.1

Sequence conflict

1728

1

S → I in BAC41411. Ref.5

Sequence conflict

2032

1

E → EG in AAV90839. Ref.1

Sequence conflict

2032

1

E → EG in BAC41411. Ref.5

Sequence conflict

2032

1

E → EG in AAH70444. Ref.8

Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified July 27, 2011. Version 5. Checksum: 22700C859CD9AF83 Show »	FASTA	4,377	482,635
10 20 30 40 50 60 MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 70 80 90 100 110 120 FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 130 140 150 160 170 180 TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA 190 200 210 220 230 240 ECCRDLQMLK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM 250 260 270 280 290 300 ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 310 320 330 340 350 360 LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP 370 380 390 400 410 420 VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG 430 440 450 460 470 480 DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ 490 500 510 520 530 540 RPSTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL 550 560 570 580 590 600 KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV 610 620 630 640 650 660 LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG 670 680 690 700 710 720 SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH 730 740 750 760 770 780 AAEEASSEDE EEEEVQAMQS FNSAQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI 790 800 810 820 830 840 LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV 850 860 870 880 890 900 LQEGLLQLDL ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH 910 920 930 940 950 960 AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL 970 980 990 1000 1010 1020 PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS MDASAQGLLE GIELDGDTLA 1030 1040 1050 1060 1070 1080 PMETDEPSSS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR 1090 1100 1110 1120 1130 1140 QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP 1150 1160 1170 1180 1190 1200 MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD 1210 1220 1230 1240 1250 1260 AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF TCIKNLWNRK 1270 1280 1290 1300 1310 1320 PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEEAGQEEGG SRREPQVNQQ 1330 1340 1350 1360 1370 1380 QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPII GGVVRDLSMS EEDQMMRAIA 1390 1400 1410 1420 1430 1440 MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT 1450 1460 1470 1480 1490 1500 DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL 1510 1520 1530 1540 1550 1560 PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL 1570 1580 1590 1600 1610 1620 LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF 1630 1640 1650 1660 1670 1680 DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML 1690 1700 1710 1720 1730 1740 TLLRVPRLSK NSKSSNGQEL EKTLEESKET DIKHKENKGN DIPLALESTN TEKEASLDET 1750 1760 1770 1780 1790 1800 KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS 1810 1820 1830 1840 1850 1860 TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG 1870 1880 1890 1900 1910 1920 SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN 1930 1940 1950 1960 1970 1980 AVQLVKTTPL KPSSLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG GTTQEVGQLL 1990 2000 2010 2020 2030 2040 QDMGDDVYQQ YRSLTRQSSD FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEASTPEETR 2050 2060 2070 2080 2090 2100 EGKKDKEGDR TSEEGKQKSK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE 2110 2120 2130 2140 2150 2160 LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL 2170 2180 2190 2200 2210 2220 GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG 2230 2240 2250 2260 2270 2280 LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ 2290 2300 2310 2320 2330 2340 GASQDSSSHQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ 2350 2360 2370 2380 2390 2400 EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR 2410 2420 2430 2440 2450 2460 EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD 2470 2480 2490 2500 2510 2520 DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV 2530 2540 2550 2560 2570 2580 RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL 2590 2600 2610 2620 2630 2640 LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT 2650 2660 2670 2680 2690 2700 LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVPIVNHLEF LRDEELEERR EKRRKQLAEE 2710 2720 2730 2740 2750 2760 ETKIIDKGKE DKENRDQSAQ CTVTKTNDST EQNVSDGTPM PDSYPTTPSS TDAPTSESKE 2770 2780 2790 2800 2810 2820 TLGTLQPSQQ QPALPPPPSL GEIPQELQSP AEEVANSTQL LMPIELEELG PTRPSGEAET 2830 2840 2850 2860 2870 2880 TQMELSPAPT ITSLSPERAE DSDALTAVSS QLEGSPMDTS SLASCTLEEA VGDTPAAGSS 2890 2900 2910 2920 2930 2940 EQPTAGSSTP GDAPSVVAEV QGRPDVSRES NQPPEDSSPP ASSESSSTRD SAVAISGADS 2950 2960 2970 2980 2990 3000 RGILEEPLPS TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRSAPS 3010 3020 3030 3040 3050 3060 SNSSAPAVVG NPGVTEVSPE FLAALPPAIQ EEVLAQQRAE QQRRELAQNA SSDTPMDPVT 3070 3080 3090 3100 3110 3120 FIQTLPSDLR RSVLEDMEDS VLAVMPPDIA AEAQALRREQ EARQRQLMHE RLFGHSSTSA 3130 3140 3150 3160 3170 3180 LSAILRSPAF TSRLSGNRGV QYTRLAVQRG GTFQMGGSSS HNRPSGSNVD TLLRLRGRLL 3190 3200 3210 3220 3230 3240 LDHEALSCLL VLLFVDEPKL NTSRLHRVLR NLCYHAQTRH WVIRSLLSIL QRSSESELCI 3250 3260 3270 3280 3290 3300 ETPKLSTSEE RGKKSSKSCA SSSHENRPLD LLHKMESKSS NQLSWLSVSM DAALGCRTNI 3310 3320 3330 3340 3350 3360 FQIQRSGGRK HTEKHASSGS TVHIHPQAAP VVCRHVLDTL IQLAKVFPSH FTQQRTKETN 3370 3380 3390 3400 3410 3420 CESDRERGSK QACSPCSSQS SSSGICTDFW DLLVKLDNMN VSRKGKNSVK SVPVSSGGEG 3430 3440 3450 3460 3470 3480 ETSPHSLEAS PLGQLMNMLS HPVIRRSSLL TEKLLRLLSL ISIALPENKV SEVQTNSSNS 3490 3500 3510 3520 3530 3540 GSSTAATSNT STTTTTTTTA TAPTPTPPAA TTPVTSAPAL VAATAISTIT VAASTTVTTP 3550 3560 3570 3580 3590 3600 TTATTTVSTS TTKGSKSPAK VGEGGSGIDF KMVSSGLTEN QLQLSVEVLT SHSCSEEGLE 3610 3620 3630 3640 3650 3660 DAANVLLQLS RGDSGTRDTV LKLLLNGARH LGYTLCKQIG TLLAELREYN LEQQRRAQCE 3670 3680 3690 3700 3710 3720 TLSPDGLPEE QPQTTKLKGK MQSRFDMAEN VVIVASQKRP LGGRELQLPS MSMLTSKTST 3730 3740 3750 3760 3770 3780 QKFFLRVLQV IIQLRDDTRR ANKKAKQTGR LGSSGLGSAS SIQAAVRQLE AEADAIIQMV 3790 3800 3810 3820 3830 3840 REGQRARRQQ QAATSESSNQ SETSVRREES PMDVDQPSPS AQDTQSIVIS DGTPQGEKEK 3850 3860 3870 3880 3890 3900 EEKPPELPLL SEQLSLDELW DMLGECLKEL EESHDQHAVL VLQPAVEAFF LVHATERESK 3910 3920 3930 3940 3950 3960 PPVRDTRESQ LAHIKDEPPP LSPAPLTPAT PSSLDPFFSR EPSSMHISSS LPPDTQKFLR 3970 3980 3990 4000 4010 4020 FAETHRTVLN QILRQSTTHL ADGPFAVLVD YIRVLDFDVK RKYFRQELER LDEGLRKEDM 4030 4040 4050 4060 4070 4080 AVHVRRDHVF EDSYRELHRK SPEEMKNRLY IVFEGEEGQD AGGLLREWYM IISREMFNPM 4090 4100 4110 4120 4130 4140 YALFRTSPGD RVTYTINPSS HCNPNHLSYF KFVGRIVAKA VYDNRLLECY FTRSFYKHIL 4150 4160 4170 4180 4190 4200 GKSVRYTDME SEDYHFYQGL VYLLENDVST LGYDLTFSTE VQEFGVCEVR DLKPNGANIL 4210 4220 4230 4240 4250 4260 VTEENKKEYV HLVCQMRMTG AIRKQLAAFL EGFYEIIPKR LISIFTEQEL ELLISGLPTI 4270 4280 4290 4300 4310 4320 DIDDLKSNTE YHKYQSNSIQ IQWFWRALRS FDQADRAKFL QFVTGTSKVP LQGFAALEGM 4330 4340 4350 4360 4370 NGIQKFQIHR DDRSTDRLPS AHTCFNQLDL PAYESFEKLR HMLLLAIQEC SEGFGLA « Hide
Isoform 2 [UniParc]. Checksum: BD5116429BF0E509 Show »	FASTA	3,364	369,701
10 20 30 40 50 60 MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 70 80 90 100 110 120 FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 130 140 150 160 170 180 TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA 190 200 210 220 230 240 ECCRDLQMLK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM 250 260 270 280 290 300 ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 310 320 330 340 350 360 LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP 370 380 390 400 410 420 VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG 430 440 450 460 470 480 DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ 490 500 510 520 530 540 RPSTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL 550 560 570 580 590 600 KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV 610 620 630 640 650 660 LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG 670 680 690 700 710 720 SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH 730 740 750 760 770 780 AAEEASSEDE EEEEVQAMQS FNSAQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI 790 800 810 820 830 840 LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV 850 860 870 880 890 900 LQEGLLQLDL ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH 910 920 930 940 950 960 AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL 970 980 990 1000 1010 1020 PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS MDASAQGLLE GIELDGDTLA 1030 1040 1050 1060 1070 1080 PMETDEPSSS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR 1090 1100 1110 1120 1130 1140 QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP 1150 1160 1170 1180 1190 1200 MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD 1210 1220 1230 1240 1250 1260 AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF TCIKNLWNRK 1270 1280 1290 1300 1310 1320 PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEEAGQEEGG SRREPQVNQQ 1330 1340 1350 1360 1370 1380 QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPII GGVVRDLSMS EEDQMMRAIA 1390 1400 1410 1420 1430 1440 MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT 1450 1460 1470 1480 1490 1500 DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL 1510 1520 1530 1540 1550 1560 PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL 1570 1580 1590 1600 1610 1620 LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF 1630 1640 1650 1660 1670 1680 DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML 1690 1700 1710 1720 1730 1740 TLLRVPRLSK NSKSSNGQEL EKTLEESKET DIKHKENKGN DIPLALESTN TEKEASLDET 1750 1760 1770 1780 1790 1800 KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS 1810 1820 1830 1840 1850 1860 TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG 1870 1880 1890 1900 1910 1920 SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN 1930 1940 1950 1960 1970 1980 AVQLVKTTPL KPSSLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG GTTQEVGQLL 1990 2000 2010 2020 2030 2040 QDMGDDVYQQ YRSLTRQSSD FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEASTPEETR 2050 2060 2070 2080 2090 2100 EGKKDKEGDR TSEEGKQKSK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE 2110 2120 2130 2140 2150 2160 LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL 2170 2180 2190 2200 2210 2220 GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG 2230 2240 2250 2260 2270 2280 LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ 2290 2300 2310 2320 2330 2340 GASQDSSSHQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ 2350 2360 2370 2380 2390 2400 EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR 2410 2420 2430 2440 2450 2460 EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD 2470 2480 2490 2500 2510 2520 DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV 2530 2540 2550 2560 2570 2580 RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL 2590 2600 2610 2620 2630 2640 LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT 2650 2660 2670 2680 2690 2700 LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVPIVNHLEF LRDEELEERR EKRRKQLAEE 2710 2720 2730 2740 2750 2760 ETKIIDKGKE DKENRDQSAQ CTVTKTNDST EQNVSDGTPM PDSYPTTPSS TDAPTSESKE 2770 2780 2790 2800 2810 2820 TLGTLQPSQQ QPALPPPPSL GEIPQELQSP AEEVANSTQL LMPIELEELG PTRPSGEAET 2830 2840 2850 2860 2870 2880 TQMELSPAPT ITSLSPERAE DSDALTAVSS QLEGSPMDTS SLASCTLEEA VGDTPAAGSS 2890 2900 2910 2920 2930 2940 EQPTAGSSTP GDAPSVVAEV QGRPDVSRES NQPPEDSSPP ASSESSSTRD SAVAISGADS 2950 2960 2970 2980 2990 3000 RGILEEPLPS TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRSAPS 3010 3020 3030 3040 3050 3060 SNSSAPAVVG NPGVTEVSPE FLAALPPAIQ EEVLAQQRAE QQRRELAQNA SSDTPMDPVT 3070 3080 3090 3100 3110 3120 FIQTLPSDLR RSVLEDMEDS VLAVMPPDIA AEAQALRREQ EARQRQLMHE RLFGHSSTSA 3130 3140 3150 3160 3170 3180 LSAILRSPAF TSRLSGNRGV QYTRLAVQRG GTFQMGGSSS HNRPSGSNVD TLLRLRGRLL 3190 3200 3210 3220 3230 3240 LDHEALSCLL VLLFVDEPKL NTSRLHRVLR NLCYHAQTRH WVIRSLLSIL QRSSESELCI 3250 3260 3270 3280 3290 3300 ETPKLSTSEE RGKKSSKSCA SSSHENRPLD LLHKMESKSS NQLSWLSVSM DAALGCRTNI 3310 3320 3330 3340 3350 3360 FQIQRSGGRK HTEKHASSGS TVHIHPQAAP VVCRHVLDTL IQLAKVRSLK ESLTPGFFGH QHLG « Hide
Isoform 3 [UniParc]. Checksum: 0D640BFE13725964 Show »	FASTA	4,362	480,898
10 20 30 40 50 60 MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 70 80 90 100 110 120 FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 130 140 150 160 170 180 TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA 190 200 210 220 230 240 ECCRDLQMLK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM 250 260 270 280 290 300 ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 310 320 330 340 350 360 LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP 370 380 390 400 410 420 VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG 430 440 450 460 470 480 DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ 490 500 510 520 530 540 RPSTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL 550 560 570 580 590 600 KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV 610 620 630 640 650 660 LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG 670 680 690 700 710 720 SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH 730 740 750 760 770 780 AAEEASSEDE EEEEVQAMQS FNSAQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI 790 800 810 820 830 840 LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV 850 860 870 880 890 900 LQEGLLQLDL ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH 910 920 930 940 950 960 AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL 970 980 990 1000 1010 1020 PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS MDASAQGLLE GIELDGDTLA 1030 1040 1050 1060 1070 1080 PMETDEPSSS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR 1090 1100 1110 1120 1130 1140 QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP 1150 1160 1170 1180 1190 1200 MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD 1210 1220 1230 1240 1250 1260 AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF TCIKNLWNRK 1270 1280 1290 1300 1310 1320 PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEEAGQEEGG SRREPQVNQQ 1330 1340 1350 1360 1370 1380 QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPII GGVVRDLSMS EEDQMMRAIA 1390 1400 1410 1420 1430 1440 MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT 1450 1460 1470 1480 1490 1500 DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL 1510 1520 1530 1540 1550 1560 PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL 1570 1580 1590 1600 1610 1620 LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF 1630 1640 1650 1660 1670 1680 DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML 1690 1700 1710 1720 1730 1740 TLLRVPRLSK NSKSSNGQEL EKTLEESKET DIKHKENKGN DIPLALESTN TEKEASLDET 1750 1760 1770 1780 1790 1800 KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS 1810 1820 1830 1840 1850 1860 TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG 1870 1880 1890 1900 1910 1920 SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN 1930 1940 1950 1960 1970 1980 AVQLVKTTPL KPSSLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG GTTQEVGQLL 1990 2000 2010 2020 2030 2040 QDMGDDVYQQ YRSLTRQSSD FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEASTPEETR 2050 2060 2070 2080 2090 2100 EGKKDKEGDR TSEEGKQKSK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE 2110 2120 2130 2140 2150 2160 LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL 2170 2180 2190 2200 2210 2220 GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG 2230 2240 2250 2260 2270 2280 LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ 2290 2300 2310 2320 2330 2340 GASQDSSSHQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ 2350 2360 2370 2380 2390 2400 EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR 2410 2420 2430 2440 2450 2460 EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD 2470 2480 2490 2500 2510 2520 DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV 2530 2540 2550 2560 2570 2580 RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL 2590 2600 2610 2620 2630 2640 LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT 2650 2660 2670 2680 2690 2700 LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVPIVNHLEF LRDEELEERR EKRRKQLAEE 2710 2720 2730 2740 2750 2760 ETKIIDKGKE DKENRDQSAQ CTVTKTNDST EQNVSDGTPM PDSYPTTPSS TDAPTSESKE 2770 2780 2790 2800 2810 2820 TLGTLQPSQQ QPALPPPPSL GEIPQELQSP AEEVANSTQL LMPIELEELG PTRPSGEAET 2830 2840 2850 2860 2870 2880 TQMELSPAPT ITSLSPERAE DSDALTAVSS QLEGSPMDTS SLASCTLEEA VGDTPAAGSS 2890 2900 2910 2920 2930 2940 EQPTAGSSTP GDAPSVVAEV QGRPDVSRES NQPPEDSSPP ASSESSSTRD SAVAISGADS 2950 2960 2970 2980 2990 3000 RGILEEPLPS TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRSAPS 3010 3020 3030 3040 3050 3060 SNSSAPAVVG NPGVTEVSPE FLAALPPAIQ EEVLAQQRAE QQRRELAQNA SSDTPMDPVT 3070 3080 3090 3100 3110 3120 FIQTLPSDLR RSVLEDMEDS VLAVMPPDIA AEAQALRREQ EARQRQLMHE RLFGHSSTSA 3130 3140 3150 3160 3170 3180 LSAILRSPAF TSRLSGNRGV QYTRLAVQRG GTFQMGGSSS HNRPSGSNVD TLLRLRGRLL 3190 3200 3210 3220 3230 3240 LDHEALSCLL VLLFVDEPKL NTSRLHRVLR NLCYHAQTRH WVIRSLLSIL QRSSESELCI 3250 3260 3270 3280 3290 3300 ETPKLSTSEE RGKKSSKSCA SSSHENRPLD LLHKMESKSS NQLSWLSVSM DAALGCRTNI 3310 3320 3330 3340 3350 3360 FQIQRSGGRK HTEKHASSGS TVHIHPQAAP VVCRHVLDTL IQLAKVFPSH FTQQRTKETN 3370 3380 3390 3400 3410 3420 CESDRERGSK QACSPCSSQS SSSGICTDFW DLLVKLDNMN VSRKGKNSVK SVPVSSGGEG 3430 3440 3450 3460 3470 3480 ETSPHSLEAS PLGQLMNMLS HPVIRRSSLL TEKLLRLLSL ISIALPENKV SEVQTNSSNS 3490 3500 3510 3520 3530 3540 GSSTAATSNT STTTTTTTTA TAPTPTPPAA TTPVTSAPAL VAATAISTIT VAASTTVTTP 3550 3560 3570 3580 3590 3600 TTATTTVSTS TTKGSKSPAK VGEGGSGIDF KMVSSGLTEN QLQLSVEVLT SHSCSEEGLE 3610 3620 3630 3640 3650 3660 DAANVLLQLS RGDSGTRDTV LKLLLNGARH LGYTLCKQIG TLLAELREYN LEQQRRAQCE 3670 3680 3690 3700 3710 3720 TLSPDGLPEE QPQTTKLKGK MQSRFDMAEN VVIVASQKRP LGGRELQLPS MSMLTSKTST 3730 3740 3750 3760 3770 3780 QKFFLRVLQV IIQLRDDTRR ANKKAKQTGR LGSSGLGSAS SIQAAVRQLE AEADAIIQMS 3790 3800 3810 3820 3830 3840 ESSNQSETSV RREESPMDVD QPSPSAQDTQ SIVISDGTPQ GEKEKEEKPP ELPLLSEQLS 3850 3860 3870 3880 3890 3900 LDELWDMLGE CLKELEESHD QHAVLVLQPA VEAFFLVHAT ERESKPPVRD TRESQLAHIK 3910 3920 3930 3940 3950 3960 DEPPPLSPAP LTPATPSSLD PFFSREPSSM HISSSLPPDT QKFLRFAETH RTVLNQILRQ 3970 3980 3990 4000 4010 4020 STTHLADGPF AVLVDYIRVL DFDVKRKYFR QELERLDEGL RKEDMAVHVR RDHVFEDSYR 4030 4040 4050 4060 4070 4080 ELHRKSPEEM KNRLYIVFEG EEGQDAGGLL REWYMIISRE MFNPMYALFR TSPGDRVTYT 4090 4100 4110 4120 4130 4140 INPSSHCNPN HLSYFKFVGR IVAKAVYDNR LLECYFTRSF YKHILGKSVR YTDMESEDYH 4150 4160 4170 4180 4190 4200 FYQGLVYLLE NDVSTLGYDL TFSTEVQEFG VCEVRDLKPN GANILVTEEN KKEYVHLVCQ 4210 4220 4230 4240 4250 4260 MRMTGAIRKQ LAAFLEGFYE IIPKRLISIF TEQELELLIS GLPTIDIDDL KSNTEYHKYQ 4270 4280 4290 4300 4310 4320 SNSIQIQWFW RALRSFDQAD RAKFLQFVTG TSKVPLQGFA ALEGMNGIQK FQIHRDDRST 4330 4340 4350 4360 DRLPSAHTCF NQLDLPAYES FEKLRHMLLL AIQECSEGFG LA « Hide
Isoform 4 [UniParc]. Checksum: C8B75208FD6CB0EC Show »	FASTA	3,832	419,496
10 20 30 40 50 60 MKVDRTKLKK TPTEAPADCR ALIDKLKVCN DEQLLLELQQ IKTWNIGKCE LYHWVDLLDR 70 80 90 100 110 120 FDGILADAGQ TVENMSWMLV CDRPEKEQLK MLLLAVLNFT ALLIEYSFSR HLYSSIEHLT 130 140 150 160 170 180 TLLASSDMQV VLAVLNLLYV FSKRSNYITR LGSDKRTPLL TRLQHLAESW GGKENGFGLA 190 200 210 220 230 240 ECCRDLQMLK YPPSATTLHF EFYADPGAEV KIEKRTTSNT LHYIHIEQLD KISESPSEIM 250 260 270 280 290 300 ESLTKMYSIP KDKQMLLFTH IRLAHGFSNH RKRLQAVQAR LHAISILVYS NALQESANSI 310 320 330 340 350 360 LYNGLIEELV DVLQITDKQL MEIKAASLRT LTSIVHLERT PKLSSIIDCT GTASYHGFLP 370 380 390 400 410 420 VLVRNCIQAM IDPSMDPYPH QFATALFSFL YHLASYDAGG EALVSCGMME ALLKVIKFLG 430 440 450 460 470 480 DEQDQITFVT RAVRVVDLIT NLDMAAFQSH SGLSIFIYRL EHEVDLCRKE CPFVIKPKIQ 490 500 510 520 530 540 RPSTTQEGEE METDMDGVQC IPQRAALLKS MLNFLKKAIQ DPAFSDGIRH VMDGSLPTSL 550 560 570 580 590 600 KHIISNAEYY GPSLFLLATE VVTVFVFQEP SLLSSLQDNG LTDVMLHALL IKDVPATREV 610 620 630 640 650 660 LGSLPNVFSA LCLNARGLQS FVQCQPFERL FKVLLSPDYL PAMRRRRSSD PLGDTASNLG 670 680 690 700 710 720 SAVDELMRHQ PTLKTDATTA IIKLLEEICN LGRDPKYICQ KPSIQKADGT ATAPPPRSNH 730 740 750 760 770 780 AAEEASSEDE EEEEVQAMQS FNSAQQNETE PNQQVVGTEE RIPIPLMDYI LNVMKFVESI 790 800 810 820 830 840 LSNNTTDDHC QEFVNQKGLL PLVTILGLPN LPIDFPTSAA CQAVAGVCKS ILTLSHEPKV 850 860 870 880 890 900 LQEGLLQLDL ILSSLEPLHR PIESPGGSVL LRELACAGNV ADATLSAQAT PLLHALTAAH 910 920 930 940 950 960 AYIMMFVHTC RVGQSEIRSI SVNQWGSQLG LSVLSKLSQL YCSLVWESTV LLSLCTPNSL 970 980 990 1000 1010 1020 PSGCEFGQAD MQKLVPKDEK AGTTQGGKRS DGEQDGTAGS MDASAQGLLE GIELDGDTLA 1030 1040 1050 1060 1070 1080 PMETDEPSSS DSKGKSKITP AMAARIKQIK PLLSASSRLG RALAELFGLL VKLCVGSPVR 1090 1100 1110 1120 1130 1140 QRRSHHAAST TTAPTPAARS TASALTKLLT KGLSWQPPPY TPTPRFRLTF FICSVGFTSP 1150 1160 1170 1180 1190 1200 MLFDERKYPY HLMLQKFLCS GGHNALFETF NWALSMGGKV PVSEGLEHSD LPDGTGEFLD 1210 1220 1230 1240 1250 1260 AWLMLVEKMV NPTTVLESPH SLPAKLPGGV QSFPQFSALR FLVVTQKAAF TCIKNLWNRK 1270 1280 1290 1300 1310 1320 PLKVYGGRMA ESMLAILCHI LRGEPVIRER LSKEKEGSRG EEEAGQEEGG SRREPQVNQQ 1330 1340 1350 1360 1370 1380 QLQQLMDMGF TREHAMEALL NTSTMEQATE YLLTHPPPII GGVVRDLSMS EEDQMMRAIA 1390 1400 1410 1420 1430 1440 MSLGQDIPMD QRAESPEEVA CRKEEEERKA REKQEEEEAK CLEKFQDADP LEQDELHTFT 1450 1460 1470 1480 1490 1500 DTMLPGCFHL LDELPDTVYR VCDLIMTAIK RNGADYRDMI LKQVVNQVWE AADVLIKAAL 1510 1520 1530 1540 1550 1560 PLTTSDTKTV SEWISQMATL PQASNLATRI LLLTLLFEEL KLPCAWVVES SGILNVLIKL 1570 1580 1590 1600 1610 1620 LEVVQPCLQA AKEQKEVQTP KWITPVLLLI DFYEKTAISS KRRAQMTKYL QSNSNNWRWF 1630 1640 1650 1660 1670 1680 DDRSGRWCSY SASNNSTIDS AWKSGETSVR FTAGRRRYTV QFTTMVQVNE ETGNRRPVML 1690 1700 1710 1720 1730 1740 TLLRVPRLSK NSKSSNGQEL EKTLEESKET DIKHKENKGN DIPLALESTN TEKEASLDET 1750 1760 1770 1780 1790 1800 KIGEILIQGL TEDMVTVLIR ACVSMLGVPV DPDTLHATLR LCLRLTRDHK YAMMFAELKS 1810 1820 1830 1840 1850 1860 TRMILNLTQS SGFNGFTPLV TLLLRHIIED PCTLRHTMEK VVRSAATSGA GSTTSGVVSG 1870 1880 1890 1900 1910 1920 SLGSREINYI LRVLGPAACR NPDIFTEVAN CCIRIALPAP RGSGTASDDE FENLRIKGPN 1930 1940 1950 1960 1970 1980 AVQLVKTTPL KPSSLPVIPD TIKEVIYDML NALAAYHAPE EADKSDPKPG GTTQEVGQLL 1990 2000 2010 2020 2030 2040 QDMGDDVYQQ YRSLTRQSSD FDTQSGFSLN SQVFAADGAP AETSTTGTSQ GEASTPEETR 2050 2060 2070 2080 2090 2100 EGKKDKEGDR TSEEGKQKSK GSKPLMPTST ILRLLAELVR SYVGIATLIA NYSYTVGQSE 2110 2120 2130 2140 2150 2160 LIKEDCSVLA FVLDHLLPHT QNAEDKDTPA LARLFLASLA AAGSGTDAQV ALVNEVKAAL 2170 2180 2190 2200 2210 2220 GRALAMAEST EKHARLQAVM CIISTIMESC PSTSSFYSSA TAKTQHNGMN NIIRLFLKKG 2230 2240 2250 2260 2270 2280 LVNDLARVPH SLDLSSPNMA NTVNAALKPL ETLSRIVNQP SSLFGSKSAS SKNKSEQDAQ 2290 2300 2310 2320 2330 2340 GASQDSSSHQ QDPGEPGEAE VQEEDHDVTQ TEVADGDIMD GEAETDSVVI AGQPEVLSSQ 2350 2360 2370 2380 2390 2400 EMQVENELED LIDELLERDG GSGNSTIIVS RSGEDESQED VLMDEAPSNL SQASTLQANR 2410 2420 2430 2440 2450 2460 EDSMNILDPE DEEEHTQEED SSGSNEDEDD SQDEEEEEEE DEEDDQEDDE GEEGDEDDDD 2470 2480 2490 2500 2510 2520 DGSEMELDED YPDMNASPLV RFERFDREDD LIIEFDNMFS SATDIPPSPG NIPTTHPLMV 2530 2540 2550 2560 2570 2580 RHADHSSLTL GSGSSTTRLT QGIGRSQRTL RQLTANTGHT IHVHYPGNRQ PNPPLILQRL 2590 2600 2610 2620 2630 2640 LGPSAAADIL QLSSSLPLQS RGRARLLVGN DDVHIIARSD DELLDDFFHD QSTATSQAGT 2650 2660 2670 2680 2690 2700 LSSIPTALTR WTEECKVLDA ESMHDCVSVV KVPIVNHLEF LRDEELEERR EKRRKQLAEE 2710 2720 2730 2740 2750 2760 ETKIIDKGKE DKENRDQSAQ CTVTKTNDST EQNVSDGTPM PDSYPTTPSS TDAPTSESKE 2770 2780 2790 2800 2810 2820 TLGTLQPSQQ QPALPPPPSL GEIPQELQSP AEEVANSTQL LMPIELEELG PTRPSGEAET 2830 2840 2850 2860 2870 2880 TQMELSPAPT ITSLSPERAE DSDALTAVSS QLEGSPMDTS SLASCTLEEA VGDTPAAGSS 2890 2900 2910 2920 2930 2940 EQPTAGSSTP GDAPSVVAEV QGRPDVSRES NQPPEDSSPP ASSESSSTRD SAVAISGADS 2950 2960 2970 2980 2990 3000 RGILEEPLPS TSSEEEDPLA GISLPEGVDP SFLAALPDDI RREVLQNQLG IRPPTRSAPS 3010 3020 3030 3040 3050 3060 SNSSAPAVVG NPGVTEVSPE FLAALPPAIQ EEVLAQQRAE QQRRELAQNA SSDTPMDPVT 3070 3080 3090 3100 3110 3120 FIQTLPSDLR RSVLEDMEDS VLAVMPPDIA AEAQALRREQ EARQRQLMHE RLFGHSSTSA 3130 3140 3150 3160 3170 3180 LSAILRSPAF TSRLSGNRGV QYTRLAVQRG GTFQMGGSSS HNRPSGSNVD TLLRLRGRLL 3190 3200 3210 3220 3230 3240 LDHEALSCLL VLLFVDEPKL NTSRLHRVLR NLCYHAQTRH WVIRSLLSIL QRSSESELCI 3250 3260 3270 3280 3290 3300 ETPKLSTSEE RGKKSSKSCA SSSHENRPLD LLHKMESKSS NQLSWLSVSM DAALGCRTNI 3310 3320 3330 3340 3350 3360 FQIQRSGGRK HTEKHASSGS TVHIHPQAAP VVCRHVLDTL IQLAKVFPSH FTQQRTKETN 3370 3380 3390 3400 3410 3420 CESDRERGSK QACSPCSSQS SSSGICTDFW DLLVKLDNMN VSRKGKNSVK SVPVSSGGEG 3430 3440 3450 3460 3470 3480 ETSPHSLEAS PLGQLMNMLS HPVIRRSSLL TEKLLRLLSL ISIALPENKV SEVQTNSSNS 3490 3500 3510 3520 3530 3540 GSSTAATSNT STTTTTTTTA TAPTPTPPAA TTPVTSAPAL VAATAISTIT VAASTTVTTP 3550 3560 3570 3580 3590 3600 TTATTTVSTS TTKGSKSPAK VGEGGSGIDF KMVSSGLTEN QLQLSVEVLT SHSCSEEGLE 3610 3620 3630 3640 3650 3660 DAANVLLQLS RGDSGTRDTV LKLLLNGARH LGYTLCKQIG TLLAELREYN LEQQRRAQCE 3670 3680 3690 3700 3710 3720 TLSPDGLPEE QPQTTKLKGK MQSRFDMAEN VVIVASQKRP LGGRELQLPS MSMLTSKTST 3730 3740 3750 3760 3770 3780 QKFFLRVLQV IIQLRDDTRR ANKKAKQTGR LGSSGLGSAS SIQAAVRQLE AEADAIIQMV 3790 3800 3810 3820 3830 REGQRARRQQ QAATVSMMPV APHSFLYPPS CTMSSVGVHC PYLVCFCITF AK « Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor." Chen D., Kon N., Li M., Zhang W., Qin J., Gu W. Cell 121:1071-1083(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Strain: C57BL/6J.
[2]	Chen D., Kon N., Li M., Zhang W., Qin J., Gu W. Submitted (APR-2006) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 253; 1728; 2009-2010; 2032 AND 3034-3035.
[3]	"Characterization of E3Histone, a novel testis ubiquitin protein ligase which ubiquitinates histones." Liu Z., Oughtred R., Wing S.S. Mol. Cell. Biol. 25:2819-2831(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION. Strain: C57BL/6J.
[4]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[5]	"Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries." Okazaki N., Kikuno R., Ohara R., Inamoto S., Hara Y., Nagase T., Ohara O., Koga H. DNA Res. 9:179-188(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1445-4377 (ISOFORM 1). Tissue: Embryonic intestine.
[6]	Okazaki N., Kikuno R., Nagase T., Ohara O., Koga H. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION. Tissue: Brain.
[7]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 1627-1655; 3127-3133 AND 3245-3253, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1630-4377 (ISOFORM 2), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3283-4377 (ISOFORM 3). Strain: C57BL/6 and FVB/N-3. Tissue: Brain, Eye and Mammary gland.
[9]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3421-4377 (ISOFORM 4). Strain: C57BL/6J.
[10]	"Mouse homolog to KIAA0312." Seki N., Hattori A., Hayashi A., Kozuma S., Muramatsu M., Saito T. Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4005-4377 (ISOFORMS 1/3).
[11]	"Phosphoproteomic analysis of the developing mouse brain." Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P. Mol. Cell. Proteomics 3:1093-1101(2004) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3758, MASS SPECTROMETRY. Tissue: Embryonic brain.
[12]	"Protein phosphorylation and expression profiling by Yin-yang multidimensional liquid chromatography (Yin-yang MDLC) mass spectrometry." Dai J., Jin W.-H., Sheng Q.-H., Shieh C.-H., Wu J.-R., Zeng R. J. Proteome Res. 6:250-262(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907, MASS SPECTROMETRY. Tissue: Liver.
[13]	"Large-scale phosphorylation analysis of mouse liver." Villen J., Beausoleil S.A., Gerber S.A., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-3758 AND SER-3810, MASS SPECTROMETRY. Tissue: Liver.
[14]	"Regulated expression of the ubiquitin protein ligase, E3(Histone)/LASU1/Mule/ARF-BP1/HUWE1, during spermatogenesis." Liu Z., Miao D., Xia Q., Hermo L., Wing S.S. Dev. Dyn. 236:2889-2898(2007) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[15]	"The HECT-domain ubiquitin ligase Huwe1 controls neural differentiation and proliferation by destabilizing the N-Myc oncoprotein." Zhao X., Heng J.I.-T., Guardavaccaro D., Jiang R., Pagano M., Guillemot F., Iavarone A., Lasorella A. Nat. Cell Biol. 10:643-653(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, DEVELOPMENTAL STAGE.
[16]	"Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry." Sweet S.M., Bailey C.M., Cunningham D.L., Heath J.K., Cooper H.J. Mol. Cell. Proteomics 8:904-912(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1907, MASS SPECTROMETRY. Tissue: Embryonic fibroblast.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY772010 mRNA. Translation: AAV90839.3. AY929611 mRNA. Translation: AAX24124.1. BX571795, AL672180, AL954855 Genomic DNA. Translation: CAM13774.1. AL954855, AL672180, BX571795 Genomic DNA. Translation: CAM17616.1. AL672180, AL954855, BX571795 Genomic DNA. Translation: CAM23826.1. AB093227 mRNA. Translation: BAC41411.2. BC011391 mRNA. Translation: AAH11391.1. BC017642 mRNA. Translation: AAH17642.2. BC054372 mRNA. Translation: AAH54372.1. BC070444 mRNA. Translation: AAH70444.1. AK083499 mRNA. Translation: BAC38936.1. AB025966 mRNA. Translation: BAA84697.1.
IPI	IPI00453613. IPI00453615. IPI00463909. IPI00655012.
RefSeq	NP_067498.4. NM_021523.4.
UniGene	Mm.27372. Mm.488413.
3D structure databases
ProteinModelPortal	Q7TMY8.
SMR	Q7TMY8. Positions 1310-1356, 4003-4369.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q7TMY8. 1 interaction.
STRING	10090.ENSMUSP00000026292.
PTM databases
PhosphoSite	Q7TMY8.
Proteomic databases
PaxDb	Q7TMY8.
PRIDE	Q7TMY8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000112622; ENSMUSP00000108241; ENSMUSG00000025261.
GeneID	59026.
KEGG	mmu:59026.
UCSC	uc009upr.1. mouse.
Organism-specific databases
CTD	10075.
MGI	MGI:1926884. Huwe1.
Rouge	Search...
Phylogenomic databases
eggNOG	COG5021.
GeneTree	ENSGT00640000091448.
HOVERGEN	HBG080254.
KO	K10592.
Enzyme and pathway databases
UniPathway	UPA00143.
Gene expression databases
ArrayExpress	Q7TMY8.
Bgee	Q7TMY8.
CleanEx	MM_HUWE1.
Genevestigator	Q7TMY8.
Family and domain databases
InterPro	IPR016024. ARM-type_fold. IPR025527. DUF4414. IPR010309. E3_Ub_ligase_DUF908. IPR010314. E3_Ub_ligase_DUF913. IPR000569. HECT. IPR009060. UBA-like. IPR000449. UBA/transl_elong_EF1B_N. IPR015940. UBA/transl_elong_EF1B_N_euk. IPR004170. WWE-dom. [Graphical view]
Pfam	PF14377. DUF4414. 1 hit. PF06012. DUF908. 1 hit. PF06025. DUF913. 1 hit. PF00632. HECT. 1 hit. PF00627. UBA. 1 hit. PF02825. WWE. 1 hit. [Graphical view]
SMART	SM00119. HECTc. 1 hit. SM00165. UBA. 1 hit. [Graphical view]
SUPFAM	SSF48371. ARM-type_fold. 1 hit. SSF56204. HECT. 1 hit. SSF46934. UBA_like. 1 hit.
PROSITE	PS50237. HECT. 1 hit. PS50030. UBA. 1 hit. PS50330. UIM. False negative. PS50918. WWE. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HUWE1. mouse.
NextBio	314602.
SOURCE	Search...

Entry information

Entry name

HUWE1_MOUSE

Accession

Primary (citable) accession number: Q7TMY8
Secondary accession number(s): A2AFQ1

Q9R0P2

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	July 27, 2011
Last modified:	May 1, 2013
This is version 90 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Alternative products

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Natural variations

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents