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Submitted name:

Ccl2 protein



Mus musculus (Mouse)
Unreviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli


GO - Molecular functioni

  1. G-protein coupled receptor binding Source: MGI
  2. heparin binding Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. astrocyte cell migration Source: Ensembl
  3. cellular calcium ion homeostasis Source: Ensembl
  4. cellular response to ATP Source: Ensembl
  5. cellular response to dexamethasone stimulus Source: Ensembl
  6. cellular response to drug Source: Ensembl
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to high density lipoprotein particle stimulus Source: Ensembl
  9. cellular response to insulin stimulus Source: Ensembl
  10. cellular response to interferon-gamma Source: Ensembl
  11. cellular response to interleukin-1 Source: Ensembl
  12. cellular response to interleukin-6 Source: Ensembl
  13. cellular response to macrophage colony-stimulating factor stimulus Source: Ensembl
  14. cellular response to platelet-derived growth factor stimulus Source: Ensembl
  15. cellular response to retinoic acid Source: Ensembl
  16. cellular response to tumor necrosis factor Source: Ensembl
  17. chemokine-mediated signaling pathway Source: Ensembl
  18. cytoskeleton organization Source: Ensembl
  19. leukocyte migration involved in inflammatory response Source: Ensembl
  20. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  21. lymphocyte chemotaxis Source: Ensembl
  22. macrophage chemotaxis Source: Ensembl
  23. MAPK cascade Source: Ensembl
  24. maternal process involved in female pregnancy Source: Ensembl
  25. maternal process involved in parturition Source: Ensembl
  26. monocyte chemotaxis Source: Ensembl
  27. negative regulation of glial cell apoptotic process Source: Ensembl
  28. negative regulation of natural killer cell chemotaxis Source: Ensembl
  29. negative regulation of neuron apoptotic process Source: Ensembl
  30. neutrophil chemotaxis Source: Ensembl
  31. organ regeneration Source: Ensembl
  32. positive regulation of calcium ion import Source: Ensembl
  33. positive regulation of cell-cell adhesion Source: Ensembl
  34. positive regulation of cellular extravasation Source: Ensembl
  35. positive regulation of collagen biosynthetic process Source: Ensembl
  36. positive regulation of endothelial cell proliferation Source: Ensembl
  37. positive regulation of leukocyte mediated cytotoxicity Source: Ensembl
  38. positive regulation of macrophage chemotaxis Source: Ensembl
  39. positive regulation of monocyte chemotaxis Source: Ensembl
  40. positive regulation of synaptic transmission Source: Ensembl
  41. positive regulation of tumor necrosis factor production Source: Ensembl
  42. protein kinase B signaling Source: Ensembl
  43. regulation of cell shape Source: Ensembl
  44. response to activity Source: Ensembl
  45. response to amino acid Source: Ensembl
  46. response to antibiotic Source: Ensembl
  47. response to ethanol Source: Ensembl
  48. response to gamma radiation Source: Ensembl
  49. response to heat Source: Ensembl
  50. response to hypoxia Source: Ensembl
  51. response to mechanical stimulus Source: Ensembl
  52. response to progesterone Source: Ensembl
  53. response to vitamin B3 Source: Ensembl
  54. response to wounding Source: MGI
  55. transforming growth factor beta receptor signaling pathway Source: Ensembl
  56. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ccl2 proteinImported
Gene namesi
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98259. Ccl2.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. C-fiber Source: Ensembl
  3. dendrite Source: Ensembl
  4. endocytic vesicle Source: Ensembl
  5. extracellular space Source: MGI
  6. perikaryon Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. rough endoplasmic reticulum Source: Ensembl
  9. synapse Source: Ensembl
Complete GO annotation...


Gene expression databases

ExpressionAtlasiQ7TMS1. baseline and differential.


3D structure databases

SMRiQ7TMS1. Positions 24-65.

Family & Domainsi

Phylogenomic databases


Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.


Sequence statusi: Complete.

Q7TMS1-1 [UniParc]FASTAAdd to Basket

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Mass (Da):7,188
Last modified:October 1, 2003 - v1

Sequence databases

Select the link destinations:
Links Updated
BC055070 mRNA. Translation: AAH55070.1.


Sequence databases

Select the link destinations:
Links Updated
BC055070 mRNA. Translation: AAH55070.1 .
UniGenei Mm.290320.

3D structure databases

ProteinModelPortali Q7TMS1.
SMRi Q7TMS1. Positions 24-65.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Organism-specific databases

MGIi MGI:98259. Ccl2.

Phylogenomic databases


Miscellaneous databases

SOURCEi Search...

Gene expression databases

Bgeei Q7TMS1.
ExpressionAtlasi Q7TMS1. baseline and differential.
Genevestigatori Q7TMS1.

Family and domain databases

InterProi IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
ProtoNeti Search...


  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Strain: C3H/HeImported.
    Tissue: Mesenchymal Stem CellImported.

Entry informationi

Entry nameiQ7TMS1_MOUSE
AccessioniPrimary (citable) accession number: Q7TMS1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 26, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.