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Protein
Submitted name:

Ccl2 protein

Gene

Ccl2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  1. chemokine activity Source: MGI
  2. G-protein coupled receptor binding Source: MGI
  3. heparin binding Source: Ensembl

GO - Biological processi

  1. aging Source: Ensembl
  2. astrocyte cell migration Source: Ensembl
  3. cellular calcium ion homeostasis Source: Ensembl
  4. cellular response to ATP Source: Ensembl
  5. cellular response to dexamethasone stimulus Source: Ensembl
  6. cellular response to drug Source: Ensembl
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to high density lipoprotein particle stimulus Source: Ensembl
  9. cellular response to insulin stimulus Source: Ensembl
  10. cellular response to interferon-gamma Source: Ensembl
  11. cellular response to interleukin-1 Source: Ensembl
  12. cellular response to interleukin-6 Source: Ensembl
  13. cellular response to macrophage colony-stimulating factor stimulus Source: Ensembl
  14. cellular response to platelet-derived growth factor stimulus Source: Ensembl
  15. cellular response to retinoic acid Source: Ensembl
  16. cellular response to tumor necrosis factor Source: Ensembl
  17. chemokine-mediated signaling pathway Source: Ensembl
  18. cytoskeleton organization Source: MGI
  19. eosinophil chemotaxis Source: MGI
  20. leukocyte migration involved in inflammatory response Source: Ensembl
  21. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  22. lymphocyte chemotaxis Source: Ensembl
  23. macrophage chemotaxis Source: Ensembl
  24. MAPK cascade Source: Ensembl
  25. maternal process involved in female pregnancy Source: Ensembl
  26. maternal process involved in parturition Source: Ensembl
  27. monocyte chemotaxis Source: Ensembl
  28. negative regulation of glial cell apoptotic process Source: Ensembl
  29. negative regulation of natural killer cell chemotaxis Source: Ensembl
  30. negative regulation of neuron apoptotic process Source: Ensembl
  31. neutrophil chemotaxis Source: Ensembl
  32. organ regeneration Source: Ensembl
  33. positive regulation of calcium ion import Source: Ensembl
  34. positive regulation of cell-cell adhesion Source: Ensembl
  35. positive regulation of cellular extravasation Source: Ensembl
  36. positive regulation of collagen biosynthetic process Source: Ensembl
  37. positive regulation of endothelial cell proliferation Source: Ensembl
  38. positive regulation of leukocyte mediated cytotoxicity Source: Ensembl
  39. positive regulation of macrophage chemotaxis Source: Ensembl
  40. positive regulation of monocyte chemotaxis Source: Ensembl
  41. positive regulation of synaptic transmission Source: Ensembl
  42. positive regulation of tumor necrosis factor production Source: Ensembl
  43. protein kinase B signaling Source: Ensembl
  44. regulation of cell shape Source: MGI
  45. response to activity Source: Ensembl
  46. response to amino acid Source: Ensembl
  47. response to antibiotic Source: Ensembl
  48. response to ethanol Source: Ensembl
  49. response to gamma radiation Source: Ensembl
  50. response to heat Source: Ensembl
  51. response to hypoxia Source: Ensembl
  52. response to mechanical stimulus Source: Ensembl
  53. response to progesterone Source: Ensembl
  54. response to vitamin B3 Source: Ensembl
  55. response to wounding Source: MGI
  56. transforming growth factor beta receptor signaling pathway Source: Ensembl
  57. vascular endothelial growth factor receptor signaling pathway Source: Ensembl
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Ccl2 proteinImported
Gene namesi
Name:Ccl2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:98259. Ccl2.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: Ensembl
  2. C-fiber Source: Ensembl
  3. dendrite Source: Ensembl
  4. endocytic vesicle Source: Ensembl
  5. extracellular space Source: MGI
  6. perikaryon Source: Ensembl
  7. perinuclear region of cytoplasm Source: Ensembl
  8. rough endoplasmic reticulum Source: Ensembl
  9. synapse Source: Ensembl
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiQ7TMS1.
ExpressionAtlasiQ7TMS1. baseline and differential.
GenevestigatoriQ7TMS1.

Structurei

3D structure databases

ProteinModelPortaliQ7TMS1.
SMRiQ7TMS1. Positions 24-65.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

HOVERGENiHBG017871.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TMS1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVPVMLLGL LFTVAGWSIH VLAQPDAVNA PLTCCYSFTS KMIPMSRLES
60
YKRITSSRCP KEAVV
Length:65
Mass (Da):7,188
Last modified:October 1, 2003 - v1
Checksum:i9FB7F1460A424B80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055070 mRNA. Translation: AAH55070.1.
UniGeneiMm.290320.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055070 mRNA. Translation: AAH55070.1.
UniGeneiMm.290320.

3D structure databases

ProteinModelPortaliQ7TMS1.
SMRiQ7TMS1. Positions 24-65.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:98259. Ccl2.

Phylogenomic databases

HOVERGENiHBG017871.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiQ7TMS1.
ExpressionAtlasiQ7TMS1. baseline and differential.
GenevestigatoriQ7TMS1.

Family and domain databases

InterProiIPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeImported.
    Tissue: Mesenchymal Stem CellImported.

Entry informationi

Entry nameiQ7TMS1_MOUSE
AccessioniPrimary (citable) accession number: Q7TMS1
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: February 4, 2015
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.