Q7TMR8 (Q7TMR8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Tyrosine-protein kinase receptor PIRNR PIRNR000615
EC=2.7.10.1 PIRNR PIRNR000615

Gene names

Name:

Pdgfrb MGI 97531

Organism

Mus musculus (Mouse) EMBL AAH55311.1

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	1099 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000615 RuleBase RU000311 SAAS SAAS008266
Subcellular location	Membrane; Single-pass type I membrane protein By similarity RuleBase RU000311.
Sequence similarities	Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. PIRNR PIRNR000615 RuleBase RU000311 Contains 1 protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
Cellular component	Membrane
Domain	Immunoglobulin domain SAAS SAAS008266 RuleBase RU000311 Transmembrane Transmembrane helix SAAS SAAS008266
Ligand	ATP-binding PIRNR PIRNR000615 SAAS SAAS008266 Nucleotide-binding
Molecular function	Kinase Receptor PIRNR PIRNR000615 RuleBase RU000311 SAAS SAAS008266 EMBL AAH55311.1 Transferase Tyrosine-protein kinase PIRNR PIRNR000615 SAAS SAAS008266
PTM	Disulfide bond SAAS SAAS013151 Phosphoprotein RuleBase RU003595 SAAS SAAS008266
Gene Ontology (GO)
Biological_process	adrenal gland development Inferred from genetic interaction PubMed 19056881. Source: MGI in utero embryonic development Inferred from mutant phenotype PubMed 17143286. Source: MGI kidney development Inferred from mutant phenotype PubMed 17143286. Source: MGI nitrogen compound metabolic process Inferred from mutant phenotype PubMed 17143286. Source: MGI platelet-derived growth factor receptor-beta signaling pathway Inferred from electronic annotation. Source: GOC regulation of peptidyl-tyrosine phosphorylation Inferred from mutant phenotype PubMed 11940581. Source: MGI skeletal system morphogenesis Inferred from mutant phenotype PubMed 17143286. Source: MGI smooth muscle tissue development Inferred from mutant phenotype PubMed 17143286. Source: MGI tissue homeostasis Inferred from mutant phenotype PubMed 17143286. Source: MGI vascular endothelial growth factor receptor signaling pathway Inferred from electronic annotation. Source: InterPro vascular endothelial growth factor signaling pathway Inferred from electronic annotation. Source: GOC
Cellular_component	cytoplasm Inferred from direct assay PubMed 22027834. Source: MGI integral to plasma membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from mutant phenotype PubMed 12808090. Source: MGI platelet-derived growth factor beta-receptor activity Inferred from electronic annotation. Source: InterPro signal transducer activity Inferred from direct assay PubMed 11940581. Source: MGI vascular endothelial growth factor-activated receptor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7TMR8 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: BCE126ACC116F740	FASTA	1,099	122,935
	10 20 30 40 50 60 MGLPGVIPAL VLRGQLLLSV LWLLGPQTSR GLVITPPGPE FVLNISSTFV LTCSGSAPVM 70 80 90 100 110 120 WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP 130 140 150 160 170 180 DPTMDFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFTG 190 200 210 220 230 240 TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND 250 260 270 280 290 300 VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG 310 320 330 340 350 360 DEKAINISVI ENGYVRLLET LGDVEIAELH RSRTLRVVFE AYPMPSVLWL KDNRTLGDSG 370 380 390 400 410 420 AGELVLSTRN MSETRYVSEL ILVRVKVSEA GYYTMRAFHE DDEVQLSFKL QVNVPVRVLE 430 440 450 460 470 480 LSESHPANGE QTIRCRGRGM PQPNVTWSTC RDLKSRCPRK LSPTPLGNSS KEESQLETNV 490 500 510 520 530 540 TFWEEDQEYE VVSTLRLRHV DQPLSVRCML QNSMGGDSQE VTVVPHSLPF KVVVISAILA 550 560 570 580 590 600 LVVLTVISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPVQLPYD STWELPRDQL 610 620 630 640 650 660 VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 670 680 690 700 710 720 HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQRHSNKHCP PSAELYSNAL 730 740 750 760 770 780 PVGFSLPSHL NLTGESDGGY MDMSKDESID YVPMLDMKGD IKYADIESPS YMAPYDNYVP 790 800 810 820 830 840 SAPERTYRAT LINDSPVLSY TDLVGFSYQV ANGMDFLASK NCVHRDLAAR NVLICEGKLV 850 860 870 880 890 900 KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 910 920 930 940 950 960 GTPYPELPMN DQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFETRPP FSQLVLLLER 970 980 990 1000 1010 1020 LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RFPGIHSLRS PLDTSSVLYT AVQPNESDND 1030 1040 1050 1060 1070 1080 YIIPLPDPKP DVADEGLPEG SPSLASSTLN EVNTSSTISC DSPLELQEEP QQAEPEAQLE 1090 QPQDSGCPGP LAEAEDSFL

References

[1]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J. Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C3H/He EMBL AAH55311.1. Tissue: Mesenchymal Stem Cell EMBL AAH55311.1.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC055311 mRNA. Translation: AAH55311.1.
IPI	IPI00121827.
UniGene	Mm.4146.
3D structure databases
HSSP	HSSP built from PDB template 1FGI based on UniProtKB P11362.
ProteinModelPortal	Q7TMR8.
SMR	Q7TMR8. Positions 559-707, 795-960.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc008fbl.2. mouse.
Organism-specific databases
MGI	MGI:97531. Pdgfrb.
Phylogenomic databases
HOGENOM	HOG000112009.
HOVERGEN	HBG004335.
InParanoid	Q7TMR8.
Gene expression databases
Genevestigator	Q7TMR8.
Family and domain databases
Gene3D	2.60.40.10. 5 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013151. Immunoglobulin. IPR011009. Kinase-like_dom. IPR027288. PGFRB. IPR000719. Prot_kinase_cat_dom. IPR017441. Protein_kinase_ATP_BS. IPR001245. Ser-Thr/Tyr_kinase_cat_dom. IPR008266. Tyr_kinase_AS. IPR020635. Tyr_kinase_cat_dom. IPR016243. Tyr_kinase_CSF1/PDGF_rcpt. IPR001824. Tyr_kinase_rcpt_3_CS. IPR009134. Tyr_kinase_VEGFR_rcpt_N. [Graphical view]
Pfam	PF00047. ig. 1 hit. PF07714. Pkinase_Tyr. 1 hit. [Graphical view]
PIRSF	PIRSF500948. Beta-PDGF_receptor. 1 hit. PIRSF000615. TyrPK_CSF1-R. 1 hit.
PRINTS	PR01832. VEGFRECEPTOR.
SMART	SM00409. IG. 1 hit. SM00408. IGc2. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view]
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS50835. IG_LIKE. 3 hits. PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00109. PROTEIN_KINASE_TYR. 1 hit. PS00240. RECEPTOR_TYR_KIN_III. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

Q7TMR8_MOUSE

Accession

Primary (citable) accession number: Q7TMR8

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 89 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)