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Protein

Platelet-derived growth factor receptor beta

Gene

Pdgfrb

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.UniRule annotation

Catalytic activityi

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei826 – 8261Proton acceptorUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. kinase activity Source: MGI
  3. platelet-derived growth factor beta-receptor activity Source: MGI
  4. platelet-derived growth factor binding Source: MGI
  5. platelet-derived growth factor receptor binding Source: MGI
  6. protein kinase binding Source: MGI
  7. protein tyrosine kinase activity Source: MGI
  8. receptor binding Source: MGI
  9. signal transducer activity Source: MGI
  10. vascular endothelial growth factor binding Source: MGI

GO - Biological processi

  1. adrenal gland development Source: MGI
  2. cell chemotaxis Source: MGI
  3. cell migration Source: MGI
  4. in utero embryonic development Source: MGI
  5. kidney development Source: MGI
  6. nitrogen compound metabolic process Source: MGI
  7. peptidyl-tyrosine phosphorylation Source: MGI
  8. phosphatidylinositol-mediated signaling Source: MGI
  9. phosphatidylinositol metabolic process Source: MGI
  10. platelet-derived growth factor receptor-beta signaling pathway Source: MGI
  11. platelet-derived growth factor receptor signaling pathway Source: MGI
  12. positive regulation of cell migration Source: MGI
  13. positive regulation of cell proliferation Source: MGI
  14. positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway Source: MGI
  15. positive regulation of ERK1 and ERK2 cascade Source: MGI
  16. positive regulation of phosphatidylinositol 3-kinase activity Source: MGI
  17. positive regulation of phospholipase C activity Source: MGI
  18. positive regulation of phosphoprotein phosphatase activity Source: MGI
  19. positive regulation of smooth muscle cell migration Source: MGI
  20. positive regulation of smooth muscle cell proliferation Source: MGI
  21. protein autophosphorylation Source: MGI
  22. regulation of peptidyl-tyrosine phosphorylation Source: MGI
  23. signal transduction Source: MGI
  24. skeletal system morphogenesis Source: MGI
  25. smooth muscle tissue development Source: MGI
  26. tissue homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Developmental proteinUniRule annotation, Kinase, ReceptorUniRule annotationSAAS annotation, Transferase, Tyrosine-protein kinaseUniRule annotationSAAS annotation

Keywords - Biological processi

ChemotaxisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Platelet-derived growth factor receptor betaUniRule annotation (EC:2.7.10.1UniRule annotation)
Short name:
PDGF-R-betaUniRule annotation
Short name:
PDGFR-betaUniRule annotation
Alternative name(s):
Beta platelet-derived growth factor receptorUniRule annotation
Beta-type platelet-derived growth factor receptorUniRule annotation
Gene namesi
Name:PdgfrbImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:97531. Pdgfrb.

Subcellular locationi

Cell membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation. Cytoplasmic vesicle UniRule annotation. Lysosome lumen UniRule annotation
Membrane UniRule annotation; Single-pass type I membrane protein UniRule annotation

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular vesicular exosome Source: MGI
  4. focal adhesion Source: MGI
  5. integral component of membrane Source: UniProtKB-KW
  6. intrinsic component of plasma membrane Source: MGI
  7. membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membraneUniRule annotation, Cytoplasmic vesicleUniRule annotation, LysosomeUniRule annotation, Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation, PhosphoproteinUniRule annotationSAAS annotation

Expressioni

Gene expression databases

GenevestigatoriQ7TMR8.

Interactioni

Subunit structurei

Interacts with homodimeric PDGFB and PDGFD, and with heterodimers formed by PDGFA and PDGFB.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliQ7TMR8.
SMRiQ7TMR8. Positions 559-707, 795-960.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.UniRule annotation
Contains protein kinase domain.SAAS annotation

Keywords - Domaini

Immunoglobulin domainUniRule annotationSAAS annotation, Transmembrane, Transmembrane helixSAAS annotation

Phylogenomic databases

HOGENOMiHOG000112009.
HOVERGENiHBG004335.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR027288. PGFRB.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF53. PTHR24416:SF53. 1 hit.
PfamiPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500948. Beta-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TMR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPGVIPAL VLRGQLLLSV LWLLGPQTSR GLVITPPGPE FVLNISSTFV
60 70 80 90 100
LTCSGSAPVM WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV
110 120 130 140 150
YNNSLGPELS ERKRIYIFVP DPTMDFLPMD SEDLFIFVTD VTETTIPCRV
160 170 180 190 200
TDPQLEVTLH EKKVDIPLHV PYDHQRGFTG TFEDKTYICK TTIGDREVDS
210 220 230 240 250
DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND VVNFQWTYPR
260 270 280 290 300
MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG
310 320 330 340 350
DEKAINISVI ENGYVRLLET LGDVEIAELH RSRTLRVVFE AYPMPSVLWL
360 370 380 390 400
KDNRTLGDSG AGELVLSTRN MSETRYVSEL ILVRVKVSEA GYYTMRAFHE
410 420 430 440 450
DDEVQLSFKL QVNVPVRVLE LSESHPANGE QTIRCRGRGM PQPNVTWSTC
460 470 480 490 500
RDLKSRCPRK LSPTPLGNSS KEESQLETNV TFWEEDQEYE VVSTLRLRHV
510 520 530 540 550
DQPLSVRCML QNSMGGDSQE VTVVPHSLPF KVVVISAILA LVVLTVISLI
560 570 580 590 600
ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPVQLPYD STWELPRDQL
610 620 630 640 650
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS
660 670 680 690 700
ELKIMSHLGP HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF
710 720 730 740 750
LQRHSNKHCP PSAELYSNAL PVGFSLPSHL NLTGESDGGY MDMSKDESID
760 770 780 790 800
YVPMLDMKGD IKYADIESPS YMAPYDNYVP SAPERTYRAT LINDSPVLSY
810 820 830 840 850
TDLVGFSYQV ANGMDFLASK NCVHRDLAAR NVLICEGKLV KICDFGLARD
860 870 880 890 900
IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG
910 920 930 940 950
GTPYPELPMN DQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFETRPP
960 970 980 990 1000
FSQLVLLLER LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RFPGIHSLRS
1010 1020 1030 1040 1050
PLDTSSVLYT AVQPNESDND YIIPLPDPKP DVADEGLPEG SPSLASSTLN
1060 1070 1080 1090
EVNTSSTISC DSPLELQEEP QQAEPEAQLE QPQDSGCPGP LAEAEDSFL
Length:1,099
Mass (Da):122,935
Last modified:October 1, 2003 - v1
Checksum:iBCE126ACC116F740
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055311 mRNA. Translation: AAH55311.1.
UniGeneiMm.4146.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC055311 mRNA. Translation: AAH55311.1.
UniGeneiMm.4146.

3D structure databases

ProteinModelPortaliQ7TMR8.
SMRiQ7TMR8. Positions 559-707, 795-960.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:97531. Pdgfrb.

Phylogenomic databases

HOGENOMiHOG000112009.
HOVERGENiHBG004335.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

GenevestigatoriQ7TMR8.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR027288. PGFRB.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERiPTHR24416:SF53. PTHR24416:SF53. 1 hit.
PfamiPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFiPIRSF500948. Beta-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M.
    , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C3H/HeImported.
    Tissue: Mesenchymal Stem CellImported.

Entry informationi

Entry nameiQ7TMR8_MOUSE
AccessioniPrimary (citable) accession number: Q7TMR8
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: April 1, 2015
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.