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Q7TMR8 (Q7TMR8_MOUSE) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Tyrosine-protein kinase receptor PIRNR PIRNR000615

EC=2.7.10.1 PIRNR PIRNR000615
Gene names
Name:Pdgfrb EMBL AAH55311.1 MGI 97531
OrganismMus musculus (Mouse) EMBL AAH55311.1
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length1099 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. PIRNR PIRNR000615 RuleBase RU000311 SAAS SAAS020635

Subcellular location

Membrane; Single-pass type I membrane protein By similarity RuleBase RU000311.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. PIRNR PIRNR000615 RuleBase RU000311

Contains 1 protein kinase domain.

Contains protein kinase domain. SAAS SAAS008266

Ontologies

Keywords
   Cellular componentMembrane
   DomainImmunoglobulin domain RuleBase RU003326 SAAS SAAS013151
Transmembrane
Transmembrane helix SAAS SAAS020635
   LigandATP-binding PIRNR PIRNR000615 SAAS SAAS020635
Nucleotide-binding
   Molecular functionKinase
Receptor PIRNR PIRNR000615 RuleBase RU000311 SAAS SAAS020635 EMBL AAH55311.1
Transferase
Tyrosine-protein kinase PIRNR PIRNR000615 SAAS SAAS020635
   PTMDisulfide bond SAAS SAAS013151
Phosphoprotein RuleBase RU003595 SAAS SAAS020635
Gene Ontology (GO)
   Biological_processadrenal gland development

Inferred from genetic interaction PubMed 19056881. Source: MGI

in utero embryonic development

Inferred from mutant phenotype PubMed 17143286. Source: MGI

kidney development

Inferred from mutant phenotype PubMed 17143286. Source: MGI

nitrogen compound metabolic process

Inferred from mutant phenotype PubMed 17143286. Source: MGI

platelet-derived growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 17143286. Source: MGI

regulation of peptidyl-tyrosine phosphorylation

Inferred from mutant phenotype PubMed 11940581. Source: MGI

signal transduction

Inferred from direct assay PubMed 11940581. Source: MGI

skeletal system morphogenesis

Inferred from mutant phenotype PubMed 17143286. Source: MGI

smooth muscle tissue development

Inferred from mutant phenotype PubMed 17143286. Source: MGI

tissue homeostasis

Inferred from mutant phenotype PubMed 17143286. Source: MGI

   Cellular_componentcell surface

Inferred from direct assay PubMed 24029230. Source: MGI

cytoplasm

Inferred from direct assay PubMed 22027834PubMed 24029230. Source: MGI

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

kinase activity

Inferred from mutant phenotype PubMed 12808090. Source: MGI

platelet-derived growth factor beta-receptor activity

Inferred from electronic annotation. Source: InterPro

signal transducer activity

Inferred from direct assay PubMed 11940581. Source: MGI

Complete GO annotation...

Sequences

Sequence LengthMass (Da)Tools
Q7TMR8 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: BCE126ACC116F740

FASTA1,099122,935
        10         20         30         40         50         60 
MGLPGVIPAL VLRGQLLLSV LWLLGPQTSR GLVITPPGPE FVLNISSTFV LTCSGSAPVM 

        70         80         90        100        110        120 
WEQMSQVPWQ EAAMNQDGTF SSVLTLTNVT GGDTGEYFCV YNNSLGPELS ERKRIYIFVP 

       130        140        150        160        170        180 
DPTMDFLPMD SEDLFIFVTD VTETTIPCRV TDPQLEVTLH EKKVDIPLHV PYDHQRGFTG 

       190        200        210        220        230        240 
TFEDKTYICK TTIGDREVDS DTYYVYSLQV SSINVSVNAV QTVVRQGESI TIRCIVMGND 

       250        260        270        280        290        300 
VVNFQWTYPR MKSGRLVEPV TDYLFGVPSR IGSILHIPTA ELSDSGTYTC NVSVSVNDHG 

       310        320        330        340        350        360 
DEKAINISVI ENGYVRLLET LGDVEIAELH RSRTLRVVFE AYPMPSVLWL KDNRTLGDSG 

       370        380        390        400        410        420 
AGELVLSTRN MSETRYVSEL ILVRVKVSEA GYYTMRAFHE DDEVQLSFKL QVNVPVRVLE 

       430        440        450        460        470        480 
LSESHPANGE QTIRCRGRGM PQPNVTWSTC RDLKSRCPRK LSPTPLGNSS KEESQLETNV 

       490        500        510        520        530        540 
TFWEEDQEYE VVSTLRLRHV DQPLSVRCML QNSMGGDSQE VTVVPHSLPF KVVVISAILA 

       550        560        570        580        590        600 
LVVLTVISLI ILIMLWQKKP RYEIRWKVIE SVSSDGHEYI YVDPVQLPYD STWELPRDQL 

       610        620        630        640        650        660 
VLGRTLGSGA FGQVVEATAH GLSHSQATMK VAVKMLKSTA RSSEKQALMS ELKIMSHLGP 

       670        680        690        700        710        720 
HLNVVNLLGA CTKGGPIYII TEYCRYGDLV DYLHRNKHTF LQRHSNKHCP PSAELYSNAL 

       730        740        750        760        770        780 
PVGFSLPSHL NLTGESDGGY MDMSKDESID YVPMLDMKGD IKYADIESPS YMAPYDNYVP 

       790        800        810        820        830        840 
SAPERTYRAT LINDSPVLSY TDLVGFSYQV ANGMDFLASK NCVHRDLAAR NVLICEGKLV 

       850        860        870        880        890        900 
KICDFGLARD IMRDSNYISK GSTFLPLKWM APESIFNSLY TTLSDVWSFG ILLWEIFTLG 

       910        920        930        940        950        960 
GTPYPELPMN DQFYNAIKRG YRMAQPAHAS DEIYEIMQKC WEEKFETRPP FSQLVLLLER 

       970        980        990       1000       1010       1020 
LLGEGYKKKY QQVDEEFLRS DHPAILRSQA RFPGIHSLRS PLDTSSVLYT AVQPNESDND 

      1030       1040       1050       1060       1070       1080 
YIIPLPDPKP DVADEGLPEG SPSLASSTLN EVNTSSTISC DSPLELQEEP QQAEPEAQLE 

      1090 
QPQDSGCPGP LAEAEDSFL 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Gerhard D.S., Wagner L., Feingold E.A., Shenmen C.M., Grouse L.H., Schuler G., Klein S.L., Old S., Rasooly R., Good P., Guyer M., Peck A.M., Derge J.G., Lipman D., Collins F.S., Jang W., Sherry S., Feolo M. expand/collapse author list , Misquitta L., Lee E., Rotmistrovsky K., Greenhut S.F., Schaefer C.F., Buetow K., Bonner T.I., Haussler D., Kent J., Kiekhaus M., Furey T., Brent M., Prange C., Schreiber K., Shapiro N., Bhat N.K., Hopkins R.F., Hsie F., Driscoll T., Soares M.B., Casavant T.L., Scheetz T.E., Brown-stein M.J., Usdin T.B., Toshiyuki S., Carninci P., Piao Y., Dudekula D.B., Ko M.S., Kawakami K., Suzuki Y., Sugano S., Gruber C.E., Smith M.R., Simmons B., Moore T., Waterman R., Johnson S.L., Ruan Y., Wei C.L., Mathavan S., Gunaratne P.H., Wu J., Garcia A.M., Hulyk S.W., Fuh E., Yuan Y., Sneed A., Kowis C., Hodgson A., Muzny D.M., McPherson J., Gibbs R.A., Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A., Whiting M., Madari A., Young A.C., Wetherby K.D., Granite S.J., Kwong P.N., Brinkley C.P., Pearson R.L., Bouffard G.G., Blakesly R.W., Green E.D., Dickson M.C., Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S., Griffith M., Griffith O.L., Krzywinski M.I., Liao N., Morin R., Morrin R., Palmquist D., Petrescu A.S., Skalska U., Smailus D.E., Stott J.M., Schnerch A., Schein J.E., Jones S.J., Holt R.A., Baross A., Marra M.A., Clifton S., Makowski K.A., Bosak S., Malek J.
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C3H/He EMBL AAH55311.1.
Tissue: Mesenchymal Stem Cell EMBL AAH55311.1.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC055311 mRNA. Translation: AAH55311.1.
UniGeneMm.4146.

3D structure databases

ProteinModelPortalQ7TMR8.
SMRQ7TMR8. Positions 559-707, 795-960.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:97531. Pdgfrb.

Phylogenomic databases

HOGENOMHOG000112009.
HOVERGENHBG004335.
InParanoidQ7TMR8.

Gene expression databases

GenevestigatorQ7TMR8.

Family and domain databases

Gene3D2.60.40.10. 5 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR011009. Kinase-like_dom.
IPR027288. PGFRB.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016243. Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824. Tyr_kinase_rcpt_3_CS.
[Graphical view]
PANTHERPTHR24416:SF53. PTHR24416:SF53. 1 hit.
PfamPF00047. ig. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
[Graphical view]
PIRSFPIRSF500948. Beta-PDGF_receptor. 1 hit.
PIRSF000615. TyrPK_CSF1-R. 1 hit.
SMARTSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF56112. SSF56112. 2 hits.
PROSITEPS50835. IG_LIKE. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00240. RECEPTOR_TYR_KIN_III. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameQ7TMR8_MOUSE
AccessionPrimary (citable) accession number: Q7TMR8
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 11, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)