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Q7TMM8 (PAR16_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Poly [ADP-ribose] polymerase 16
Short name=PARP-16
EC=2.4.2.30
Gene names
Name:Parp16
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor.

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Contains 1 PARP catalytic domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainTransmembrane
Transmembrane helix
   LigandNAD
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionNAD+ ADP-ribosyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Poly [ADP-ribose] polymerase 16
PRO_0000252438

Regions

Transmembrane285 – 30521Helical; Potential
Domain77 – 280204PARP catalytic
Compositional bias297 – 3037Poly-Leu

Experimental info

Sequence conflict251S → N in BAC28475. Ref.1
Sequence conflict1681H → Q in BAC28475. Ref.1
Sequence conflict3121V → A in AAH55447. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q7TMM8 [UniParc].

Last modified October 17, 2006. Version 2.
Checksum: CA90D8E628AD1874

FASTA32236,764
        10         20         30         40         50         60 
MQLSNRAAAR EAASRDVLAA DLRCSLFASA LQSYKRDSVL RPFPASYARH DCKDFEALLA 

        70         80         90        100        110        120 
DTGRLPNLKE LLQSSRDTDK QAWDLVSWIL SSKILTIHSA KKAEFEKIQQ LTGAPHTPVP 

       130        140        150        160        170        180 
TPDFLFEIEY FDPANSRFYE TKGERDLIYA FHGSRLENFH SIIHNGLHCH LNKTSLFGEG 

       190        200        210        220        230        240 
TYLTSDLSLA LIYSPHGHGW QHSLLGPILS CVAVCEVIDH PDVKCQIKKK DSKEIDRSRA 

       250        260        270        280        290        300 
RIKHSEGGEI PPKYFVVTNN QLLRVKYLLV YSQKQPKRAS SQLSWLSSHW FVIMMSLYLL 

       310        320 
LLLIVSVTNS SVFHHFWNRV KR

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Epididymis, Ovary and Uterus.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK033791 mRNA. Translation: BAC28475.1.
AK133475 mRNA. Translation: BAE21674.1.
BC055447 mRNA. Translation: AAH55447.1.
IPIIPI00652326.
RefSeqNP_803411.3. NM_177460.4.
UniGeneMm.31129.

3D structure databases

ProteinModelPortalQ7TMM8.
ModBaseSearch...

PTM databases

PhosphoSiteQ7TMM8.

Proteomic databases

PRIDEQ7TMM8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000069000; ENSMUSP00000070098; ENSMUSG00000032392.
GeneID214424.
KEGGmmu:214424.
UCSCuc009qcx.2. mouse.

Organism-specific databases

CTD54956.
MGIMGI:2446133. Parp16.

Phylogenomic databases

eggNOGroNOG13009.
HOVERGENHBG058859.
InParanoidQ7TMM8.
OMAAVCEIID.

Gene expression databases

ArrayExpressQ7TMM8.
BgeeQ7TMM8.
CleanExMM_PARP16.
GenevestigatorQ7TMM8.
GermOnlineENSMUSG00000032392. Mus musculus.

Family and domain databases

InterProIPR012317. Poly(ADP-ribose)pol_cat_dom.
[Graphical view]
KOK00774.
PfamPF00644. PARP. 1 hit.
[Graphical view]
PROSITEPS51059. PARP_CATALYTIC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio374304.
SOURCESearch...

Entry information

Entry namePAR16_MOUSE
AccessionPrimary (citable) accession number: Q7TMM8
Secondary accession number(s): Q3V031, Q8CC71
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: November 16, 2011
This is version 55 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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