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Protein

Phosphoinositide-3-kinase-interacting protein 1

Gene

Pik3ip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
  • negative regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide-3-kinase-interacting protein 1
Alternative name(s):
Calcineurin-regulated kringle domain-containing protein
Kringle domain-containing protein HGFL
Gene namesi
Name:Pik3ip1
Synonyms:Crkd, Hgfl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917016. Pik3ip1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 170149ExtracellularSequence analysisAdd
BLAST
Transmembranei171 – 19121HelicalSequence analysisAdd
BLAST
Topological domaini192 – 26473CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121By similarityAdd
BLAST
Chaini22 – 264243Phosphoinositide-3-kinase-interacting protein 1PRO_0000280348Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi25 ↔ 101PROSITE-ProRule annotation
Disulfide bondi46 ↔ 82PROSITE-ProRule annotation
Disulfide bondi70 ↔ 96PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiQ7TMJ8.
PaxDbiQ7TMJ8.
PeptideAtlasiQ7TMJ8.
PRIDEiQ7TMJ8.

PTM databases

iPTMnetiQ7TMJ8.
PhosphoSiteiQ7TMJ8.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034614.
CleanExiMM_PIK3IP1.
ExpressionAtlasiQ7TMJ8. baseline and differential.
GenevisibleiQ7TMJ8. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036921.

Structurei

3D structure databases

ProteinModelPortaliQ7TMJ8.
SMRiQ7TMJ8. Positions 25-116.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini24 – 10178KringlePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 kringle domain.PROSITE-ProRule annotation

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIHU. Eukaryota.
ENOG4112B5B. LUCA.
GeneTreeiENSGT00390000017774.
HOVERGENiHBG080617.
InParanoidiQ7TMJ8.
OMAiKEQHDQK.
OrthoDBiEOG091G0GAF.
PhylomeDBiQ7TMJ8.
TreeFamiTF331319.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TMJ8-1) [UniParc]FASTAAdd to basket
Also known as: HGFL(L)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLAWVHTFL LSNMLLAEAY GSGGCFWDNG HLYREDQPSP APGLRCLNWL
60 70 80 90 100
AAQGSRESLT EPSPGNHNYC RNPDQDPRGP WCYISSETGV PEKRPCEDVS
110 120 130 140 150
CPETTSQAPP PSSAMELEEK SGAPGDKEAQ VFPPANALPA RSEAAEVQPV
160 170 180 190 200
IGISQLVRMN SKEKKDLGTL GYVLGITMMV IILAIGAGII VGYTYKRGKD
210 220 230 240 250
LKEQHEKKAC EREMQRITLP LSAFTNPTCE TVDENTIIVH SNQTPADVQE
260
GSTLLTGQAG TPGA
Length:264
Mass (Da):28,567
Last modified:October 1, 2003 - v1
Checksum:i833EA578FEB763A4
GO
Isoform 2 (identifier: Q7TMJ8-2) [UniParc]FASTAAdd to basket
Also known as: HGFL(S)

The sequence of this isoform differs from the canonical sequence as follows:
     198-213: GKDLKEQHEKKACERE → WVLSPPGSLGIGLRKT
     214-264: Missing.

Show »
Length:213
Mass (Da):23,011
Checksum:i4A5E3481025EAE97
GO

Sequence cautioni

The sequence CAI35211 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI35213 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI35214 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti243 – 2431Q → R in AAO33764 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei198 – 21316GKDLK…ACERE → WVLSPPGSLGIGLRKT in isoform 2. 1 PublicationVSP_023641Add
BLAST
Alternative sequencei214 – 26451Missing in isoform 2. 1 PublicationVSP_023642Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528078 mRNA. Translation: AAO33761.1.
AF528081 mRNA. Translation: AAO33764.1.
AY522649 mRNA. Translation: AAS13454.1.
AK154842 mRNA. Translation: BAE32868.1.
AK161428 mRNA. Translation: BAE36390.1.
AL671968 Genomic DNA. Translation: CAI35210.1.
AL671968 Genomic DNA. Translation: CAI35211.1. Sequence problems.
AL671968 Genomic DNA. Translation: CAI35212.1.
AL671968 Genomic DNA. Translation: CAI35213.1. Sequence problems.
AL671968 Genomic DNA. Translation: CAI35214.1. Sequence problems.
BC055920 mRNA. Translation: AAH55920.1.
BC079641 mRNA. Translation: AAH79641.1.
CCDSiCCDS24357.1. [Q7TMJ8-1]
RefSeqiNP_835362.2. NM_178149.4. [Q7TMJ8-1]
UniGeneiMm.390323.

Genome annotation databases

EnsembliENSMUST00000045153; ENSMUSP00000036921; ENSMUSG00000034614. [Q7TMJ8-1]
ENSMUST00000093399; ENSMUSP00000091100; ENSMUSG00000034614. [Q7TMJ8-2]
GeneIDi216505.
KEGGimmu:216505.
UCSCiuc007hsp.1. mouse. [Q7TMJ8-2]
uc007hsq.1. mouse. [Q7TMJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528078 mRNA. Translation: AAO33761.1.
AF528081 mRNA. Translation: AAO33764.1.
AY522649 mRNA. Translation: AAS13454.1.
AK154842 mRNA. Translation: BAE32868.1.
AK161428 mRNA. Translation: BAE36390.1.
AL671968 Genomic DNA. Translation: CAI35210.1.
AL671968 Genomic DNA. Translation: CAI35211.1. Sequence problems.
AL671968 Genomic DNA. Translation: CAI35212.1.
AL671968 Genomic DNA. Translation: CAI35213.1. Sequence problems.
AL671968 Genomic DNA. Translation: CAI35214.1. Sequence problems.
BC055920 mRNA. Translation: AAH55920.1.
BC079641 mRNA. Translation: AAH79641.1.
CCDSiCCDS24357.1. [Q7TMJ8-1]
RefSeqiNP_835362.2. NM_178149.4. [Q7TMJ8-1]
UniGeneiMm.390323.

3D structure databases

ProteinModelPortaliQ7TMJ8.
SMRiQ7TMJ8. Positions 25-116.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036921.

PTM databases

iPTMnetiQ7TMJ8.
PhosphoSiteiQ7TMJ8.

Proteomic databases

MaxQBiQ7TMJ8.
PaxDbiQ7TMJ8.
PeptideAtlasiQ7TMJ8.
PRIDEiQ7TMJ8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000045153; ENSMUSP00000036921; ENSMUSG00000034614. [Q7TMJ8-1]
ENSMUST00000093399; ENSMUSP00000091100; ENSMUSG00000034614. [Q7TMJ8-2]
GeneIDi216505.
KEGGimmu:216505.
UCSCiuc007hsp.1. mouse. [Q7TMJ8-2]
uc007hsq.1. mouse. [Q7TMJ8-1]

Organism-specific databases

CTDi113791.
MGIiMGI:1917016. Pik3ip1.

Phylogenomic databases

eggNOGiENOG410IIHU. Eukaryota.
ENOG4112B5B. LUCA.
GeneTreeiENSGT00390000017774.
HOVERGENiHBG080617.
InParanoidiQ7TMJ8.
OMAiKEQHDQK.
OrthoDBiEOG091G0GAF.
PhylomeDBiQ7TMJ8.
TreeFamiTF331319.

Miscellaneous databases

PROiQ7TMJ8.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034614.
CleanExiMM_PIK3IP1.
ExpressionAtlasiQ7TMJ8. baseline and differential.
GenevisibleiQ7TMJ8. MM.

Family and domain databases

InterProiIPR000001. Kringle.
IPR013806. Kringle-like.
IPR018056. Kringle_CS.
[Graphical view]
PfamiPF00051. Kringle. 1 hit.
[Graphical view]
SMARTiSM00130. KR. 1 hit.
[Graphical view]
SUPFAMiSSF57440. SSF57440. 1 hit.
PROSITEiPS00021. KRINGLE_1. 1 hit.
PS50070. KRINGLE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP3IP1_MOUSE
AccessioniPrimary (citable) accession number: Q7TMJ8
Secondary accession number(s): Q3TTD5
, Q5NBY3, Q5NBY4, Q5NBY6, Q811Z2, Q811Z3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.