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Protein

Phosphoinositide-3-kinase-interacting protein 1

Gene

Pik3ip1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Negative regulator of hepatic phosphatidylinositol 3-kinase (PI3K) activity.1 Publication

GO - Molecular functioni

GO - Biological processi

  • negative regulation of phosphatidylinositol 3-kinase activity Source: UniProtKB
  • negative regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoinositide-3-kinase-interacting protein 1
Alternative name(s):
Calcineurin-regulated kringle domain-containing protein
Kringle domain-containing protein HGFL
Gene namesi
Name:Pik3ip1
Synonyms:Crkd, Hgfl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1917016 Pik3ip1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 170ExtracellularSequence analysisAdd BLAST149
Transmembranei171 – 191HelicalSequence analysisAdd BLAST21
Topological domaini192 – 264CytoplasmicSequence analysisAdd BLAST73

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000028034822 – 264Phosphoinositide-3-kinase-interacting protein 1Add BLAST243

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi25 ↔ 101PROSITE-ProRule annotation
Disulfide bondi46 ↔ 82PROSITE-ProRule annotation
Disulfide bondi70 ↔ 96PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7TMJ8
PeptideAtlasiQ7TMJ8
PRIDEiQ7TMJ8

PTM databases

iPTMnetiQ7TMJ8
PhosphoSitePlusiQ7TMJ8

Expressioni

Gene expression databases

BgeeiENSMUSG00000034614
CleanExiMM_PIK3IP1
ExpressionAtlasiQ7TMJ8 baseline and differential
GenevisibleiQ7TMJ8 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000036921

Structurei

3D structure databases

ProteinModelPortaliQ7TMJ8
SMRiQ7TMJ8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 101KringlePROSITE-ProRule annotationAdd BLAST78

Keywords - Domaini

Kringle, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIHU Eukaryota
ENOG4112B5B LUCA
GeneTreeiENSGT00390000017774
HOVERGENiHBG080617
InParanoidiQ7TMJ8
OMAiAFTNPTC
OrthoDBiEOG091G0GAF
PhylomeDBiQ7TMJ8
TreeFamiTF331319

Family and domain databases

Gene3Di2.40.20.10, 1 hit
InterProiView protein in InterPro
IPR000001 Kringle
IPR013806 Kringle-like
IPR018056 Kringle_CS
IPR038178 Kringle_sf
PfamiView protein in Pfam
PF00051 Kringle, 1 hit
SMARTiView protein in SMART
SM00130 KR, 1 hit
SUPFAMiSSF57440 SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00021 KRINGLE_1, 1 hit
PS50070 KRINGLE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TMJ8-1) [UniParc]FASTAAdd to basket
Also known as: HGFL(L)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLLAWVHTFL LSNMLLAEAY GSGGCFWDNG HLYREDQPSP APGLRCLNWL
60 70 80 90 100
AAQGSRESLT EPSPGNHNYC RNPDQDPRGP WCYISSETGV PEKRPCEDVS
110 120 130 140 150
CPETTSQAPP PSSAMELEEK SGAPGDKEAQ VFPPANALPA RSEAAEVQPV
160 170 180 190 200
IGISQLVRMN SKEKKDLGTL GYVLGITMMV IILAIGAGII VGYTYKRGKD
210 220 230 240 250
LKEQHEKKAC EREMQRITLP LSAFTNPTCE TVDENTIIVH SNQTPADVQE
260
GSTLLTGQAG TPGA
Length:264
Mass (Da):28,567
Last modified:October 1, 2003 - v1
Checksum:i833EA578FEB763A4
GO
Isoform 2 (identifier: Q7TMJ8-2) [UniParc]FASTAAdd to basket
Also known as: HGFL(S)

The sequence of this isoform differs from the canonical sequence as follows:
     198-213: GKDLKEQHEKKACERE → WVLSPPGSLGIGLRKT
     214-264: Missing.

Show »
Length:213
Mass (Da):23,011
Checksum:i4A5E3481025EAE97
GO

Sequence cautioni

The sequence CAI35211 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI35213 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAI35214 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti243Q → R in AAO33764 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_023641198 – 213GKDLK…ACERE → WVLSPPGSLGIGLRKT in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_023642214 – 264Missing in isoform 2. 1 PublicationAdd BLAST51

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF528078 mRNA Translation: AAO33761.1
AF528081 mRNA Translation: AAO33764.1
AY522649 mRNA Translation: AAS13454.1
AK154842 mRNA Translation: BAE32868.1
AK161428 mRNA Translation: BAE36390.1
AL671968 Genomic DNA Translation: CAI35210.1
AL671968 Genomic DNA Translation: CAI35211.1 Sequence problems.
AL671968 Genomic DNA Translation: CAI35212.1
AL671968 Genomic DNA Translation: CAI35213.1 Sequence problems.
AL671968 Genomic DNA Translation: CAI35214.1 Sequence problems.
BC055920 mRNA Translation: AAH55920.1
BC079641 mRNA Translation: AAH79641.1
CCDSiCCDS24357.1 [Q7TMJ8-1]
RefSeqiNP_835362.2, NM_178149.4 [Q7TMJ8-1]
UniGeneiMm.390323

Genome annotation databases

EnsembliENSMUST00000045153; ENSMUSP00000036921; ENSMUSG00000034614 [Q7TMJ8-1]
ENSMUST00000093399; ENSMUSP00000091100; ENSMUSG00000034614 [Q7TMJ8-2]
GeneIDi216505
KEGGimmu:216505
UCSCiuc007hsp.1 mouse [Q7TMJ8-2]
uc007hsq.1 mouse [Q7TMJ8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiP3IP1_MOUSE
AccessioniPrimary (citable) accession number: Q7TMJ8
Secondary accession number(s): Q3TTD5
, Q5NBY3, Q5NBY4, Q5NBY6, Q811Z2, Q811Z3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 20, 2007
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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