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Q7TMF5 (SPA12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 62. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Serpin A12
Alternative name(s):
Visceral adipose tissue-derived serine protease inhibitor
Short name=Vaspin
Visceral adipose-specific serpin
Gene names
Name:Serpina12
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length413 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May modulates insulin action conceivably only in the presence of its yet undefined target proteases in white adipose tissues. Ref.1

Subcellular location

Secreted Potential.

Tissue specificity

Expressed in visceral adipose tissues. Ref.1

Sequence similarities

Belongs to the serpin family.

Ontologies

Keywords
   Cellular componentSecreted
   DomainSignal
   Molecular functionProtease inhibitor
Serine protease inhibitor
   PTMGlycoprotein
   Technical termComplete proteome
Direct protein sequencing
Reference proteome
Gene Ontology (GO)
   Biological processregulation of proteolysis

Inferred from Biological aspect of Ancestor. Source: RefGenome

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionserine-type endopeptidase inhibitor activity

Inferred from Biological aspect of Ancestor. Source: RefGenome

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020
Chain21 – 413393Serpin A12
PRO_0000041977

Amino acid modifications

Glycosylation921N-linked (GlcNAc...) Potential
Glycosylation2671N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict691Q → R in AAP88383. Ref.1
Sequence conflict1101W → R in AAP88383. Ref.1
Sequence conflict1831Q → R in AAP88383. Ref.1
Sequence conflict4031V → I in AAP88383. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7TMF5 [UniParc].

Last modified September 27, 2005. Version 2.
Checksum: D0AE8E1EE24FD60A

FASTA41347,634
        10         20         30         40         50         60 
MTRMLDLGLF LAGLLTVKGL LQDRDAPDMY DSPVRVQEWR GKKDARQLAR HNMEFGFKLL 

        70         80         90        100        110        120 
QRLASNSPQG NIFLSPLSIS TAFSMLSLGA QNSTLEEIRE GFNFKEMSNW DVHAAFHYLL 

       130        140        150        160        170        180 
HKLNQETEDT KMNLGNALFM DQKLRPQQRF LNLAKNVYDA DMVLTNFQDL ENTQKDINRY 

       190        200        210        220        230        240 
ISQKTHSRIK NMVKSIDPGT VMILTNYIYF RGRWQYEFDP KQTKEEEFFI EKGKTVKVPM 

       250        260        270        280        290        300 
MFQRGLYDMA YDSQLSCTIL EIPYRGNITA TFVLPDNGKL KLLEQGLQAD IFAKWKSLLS 

       310        320        330        340        350        360 
KRVVDVWVPK LRISSTYNMK KVLSRLGISK IFEENGDLTR ISSHRSLKVG EAVHKAELKM 

       370        380        390        400        410 
DEKGMEGAAG SGAQTLPMET PRHMKLDRPF LMMIYENFMP SMVFLARIYD PSG

« Hide

References

« Hide 'large scale' references
[1]"Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity."
Hida K., Wada J., Eguchi J., Zhang H., Baba M., Seida A., Hashimoto I., Okada T., Yasuhara A., Nakatsuka A., Shikata K., Hourai S., Futami J., Watanabe E., Matsuki Y., Hiramatsu R., Akagi S., Makino H., Kanwar Y.S.
Proc. Natl. Acad. Sci. U.S.A. 102:10610-10615(2005) [PubMed: 16030142] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, PROTEIN SEQUENCE OF N-TERMINUS, TISSUE SPECIFICITY.
Strain: Swiss Webster.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed: 16141072] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Head and Skin.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY326419 mRNA. Translation: AAP88383.1.
AK014346 mRNA. Translation: BAB29287.1.
AK014589 mRNA. Translation: BAB29447.1.
IPIIPI00131951.
RefSeqNP_080811.1. NM_026535.2.
UniGeneMm.20286.

3D structure databases

ProteinModelPortalQ7TMF5.
SMRQ7TMF5. Positions 44-412.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7TMF5.

Protein family/group databases

MEROPSI04.965.

PTM databases

PhosphoSiteQ7TMF5.

Proteomic databases

PRIDEQ7TMF5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000043915; ENSMUSP00000045572; ENSMUSG00000041567.
GeneID68054.
KEGGmmu:68054.
UCSCuc007owp.1. mouse.

Organism-specific databases

CTD145264.
MGIMGI:1915304. Serpina12.

Phylogenomic databases

GeneTreeENSGT00560000076583.
HOGENOMHBG714743.
HOVERGENHBG005957.
InParanoidQ7TMF5.
OMAPMMYRGG.
OrthoDBEOG4CG088.
PhylomeDBQ7TMF5.

Gene expression databases

ArrayExpressQ7TMF5.
BgeeQ7TMF5.
GenevestigatorQ7TMF5.
GermOnlineENSMUSG00000041567. Mus musculus.

Family and domain databases

InterProIPR000295. Prot_inh_Lserp2.
IPR000215. Protease_inhib_I4_serpin.
IPR023795. Protease_inhib_I4_serpin_CS.
IPR023796. Sepin_dom.
[Graphical view]
PANTHERPTHR11461. Prot_inh_serpin. 1 hit.
PfamPF00079. Serpin. 1 hit.
[Graphical view]
PRINTSPR00780. LEUSERPINII.
SMARTSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMSSF56574. Prot_inh_serpin. 1 hit.
PROSITEPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326328.
SOURCESearch...

Entry information

Entry nameSPA12_MOUSE
AccessionPrimary (citable) accession number: Q7TMF5
Secondary accession number(s): Q9CQ32
Entry history
Integrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: September 27, 2005
Last modified: November 16, 2011
This is version 62 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents