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Protein

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

Gene

Ndufa12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Names & Taxonomyi

Protein namesi
Recommended name:
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
Alternative name(s):
Complex I-B17.2
Short name:
CI-B17.2
Short name:
CIB17.2
NADH-ubiquinone oxidoreductase subunit B17.2
Gene namesi
Name:Ndufa12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1913664. Ndufa12.

Subcellular locationi

GO - Cellular componenti

  • mitochondrial respiratory chain complex I Source: MGI
  • mitochondrion Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 145145NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12PRO_0000118846Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ7TMF3.
MaxQBiQ7TMF3.
PaxDbiQ7TMF3.
PRIDEiQ7TMF3.

PTM databases

iPTMnetiQ7TMF3.
PhosphoSiteiQ7TMF3.

Expressioni

Gene expression databases

BgeeiQ7TMF3.
ExpressionAtlasiQ7TMF3. baseline and differential.
GenevisibleiQ7TMF3. MM.

Interactioni

Subunit structurei

Complex I is composed of 45 different subunits.By similarity

Protein-protein interaction databases

BioGridi211458. 1 interaction.
IntActiQ7TMF3. 1 interaction.
STRINGi10090.ENSMUSP00000136313.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I NDUFA12 subunit family.Curated

Phylogenomic databases

eggNOGiKOG3382. Eukaryota.
ENOG4111XVR. LUCA.
GeneTreeiENSGT00390000005848.
HOVERGENiHBG024390.
InParanoidiQ7TMF3.
KOiK11352.
OrthoDBiEOG7M0NT4.
TreeFamiTF106106.

Family and domain databases

InterProiIPR007763. NDUFA12.
[Graphical view]
PANTHERiPTHR12910. PTHR12910. 1 hit.
PfamiPF05071. NDUFA12. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TMF3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELVEVLKRG VQQVTGHGGL RGLLRVFFRA NDIRIGTLVG EDKYGNKYYE
60 70 80 90 100
DNKQFFGRHR WVIYTTEMNG KNTFWDVDGS MVPPEWHRWL HCMTDDPPTT
110 120 130 140
NPPTARKFIW TNHKFNVSAT PEQYVPYSTT RKKIHEWVPP STPYK
Length:145
Mass (Da):17,086
Last modified:May 10, 2004 - v2
Checksum:iB53B37CD0DCDE8CA
GO

Sequence cautioni

The sequence BAB26955.2 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010460 mRNA. Translation: BAB26955.2. Different initiation.
AK167943 mRNA. Translation: BAE39946.1.
RefSeqiNP_079827.2. NM_025551.3.
UniGeneiMm.27886.
Mm.461501.

Genome annotation databases

EnsembliENSMUST00000020209; ENSMUSP00000020209; ENSMUSG00000020022.
GeneIDi66414.
KEGGimmu:66414.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010460 mRNA. Translation: BAB26955.2. Different initiation.
AK167943 mRNA. Translation: BAE39946.1.
RefSeqiNP_079827.2. NM_025551.3.
UniGeneiMm.27886.
Mm.461501.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211458. 1 interaction.
IntActiQ7TMF3. 1 interaction.
STRINGi10090.ENSMUSP00000136313.

PTM databases

iPTMnetiQ7TMF3.
PhosphoSiteiQ7TMF3.

Proteomic databases

EPDiQ7TMF3.
MaxQBiQ7TMF3.
PaxDbiQ7TMF3.
PRIDEiQ7TMF3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020209; ENSMUSP00000020209; ENSMUSG00000020022.
GeneIDi66414.
KEGGimmu:66414.

Organism-specific databases

CTDi55967.
MGIiMGI:1913664. Ndufa12.

Phylogenomic databases

eggNOGiKOG3382. Eukaryota.
ENOG4111XVR. LUCA.
GeneTreeiENSGT00390000005848.
HOVERGENiHBG024390.
InParanoidiQ7TMF3.
KOiK11352.
OrthoDBiEOG7M0NT4.
TreeFamiTF106106.

Enzyme and pathway databases

ReactomeiR-MMU-611105. Respiratory electron transport.
R-MMU-6799198. Complex I biogenesis.

Miscellaneous databases

PROiQ7TMF3.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TMF3.
ExpressionAtlasiQ7TMF3. baseline and differential.
GenevisibleiQ7TMF3. MM.

Family and domain databases

InterProiIPR007763. NDUFA12.
[Graphical view]
PANTHERiPTHR12910. PTHR12910. 1 hit.
PfamiPF05071. NDUFA12. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J and DBA/2.
  2. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiNDUAC_MOUSE
AccessioniPrimary (citable) accession number: Q7TMF3
Secondary accession number(s): Q3TIA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 10, 2004
Last sequence update: May 10, 2004
Last modified: June 8, 2016
This is version 96 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.