Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phospholipid phosphatase-related protein type 4

Gene

Plppr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

ReactomeiR-MMU-419408 Lysosphingolipid and LPA receptors

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4By similarity (EC:3.1.3.4)
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 1By similarity
Lipid phosphate phosphatase-related protein type 4By similarity
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
Gene namesi
Name:Plppr4Imported
Synonyms:D3Bwg0562e1 Publication, Kiaa04551 Publication, Lppr4By similarity, Php1By similarity, Prg11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106530 Plppr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174371 – 766Phospholipid phosphatase-related protein type 4Add BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi220N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei347PhosphoserineCombined sources1
Glycosylationi363N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei386PhosphoserineBy similarity1
Glycosylationi433N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei439PhosphoserineCombined sources1
Glycosylationi456N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei462PhosphoserineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Glycosylationi515N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi545N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei608PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7TME0
PaxDbiQ7TME0
PeptideAtlasiQ7TME0
PRIDEiQ7TME0

PTM databases

iPTMnetiQ7TME0
PhosphoSitePlusiQ7TME0
SwissPalmiQ7TME0

Expressioni

Gene expression databases

BgeeiENSMUSG00000044667
ExpressionAtlasiQ7TME0 baseline and differential
GenevisibleiQ7TME0 MM

Interactioni

Protein-protein interaction databases

BioGridi230903, 3 interactors
IntActiQ7TME0, 3 interactors
MINTiQ7TME0
STRINGi10090.ENSMUSP00000052306

Structurei

3D structure databases

ProteinModelPortaliQ7TME0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 701Poly-His4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB1 Eukaryota
ENOG410ZGFZ LUCA
GeneTreeiENSGT00620000087654
HOGENOMiHOG000043094
HOVERGENiHBG103365
InParanoidiQ7TME0
KOiK19582
OMAiNQDPSRV
OrthoDBiEOG091G02D7
PhylomeDBiQ7TME0
TreeFamiTF316040

Family and domain databases

InterProiView protein in InterPro
IPR028684 LPPR4
IPR036938 P_Acid_Pase_2/haloperoxi_sf
IPR000326 P_Acid_Pase_2/haloperoxidase
PANTHERiPTHR10165:SF13 PTHR10165:SF13, 1 hit
PfamiView protein in Pfam
PF01569 PAP2, 1 hit
SMARTiView protein in SMART
SM00014 acidPPc, 1 hit
SUPFAMiSSF48317 SSF48317, 1 hit

Sequencei

Sequence statusi: Complete.

Q7TME0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAGSSGAR GECDISGAGR LRLEQAARLG GRTVHTSPGG GLGARQAAGM
60 70 80 90 100
SAKERPKGKV IKDSVTLLPC FYFVELPILA SSVVSLYFLE LTDVFKPVHS
110 120 130 140 150
GFSCYDRSLS MPYIEPTQEA IPFLMLLSLA FAGPAITIMV GEGILYCCLS
160 170 180 190 200
KRRNGAGLEP NINAGGCNFN SFLRRAVRFV GVHVFGLCST ALITDIIQLS
210 220 230 240 250
TGYQAPYFLT VCKPNYTSLN VSCKENSYIV EDICSGSDLT VINSGRKSFP
260 270 280 290 300
SQHATLAAFA AVYVSMYFNS TLTDSSKLLK PLLVFTFIIC GIICGLTRIT
310 320 330 340 350
QYKNHPVDVY CGFLIGGGIA LYLGLYAVGN FLPSEDSMLQ HRDALRSLTD
360 370 380 390 400
LNQDPSRVLS AKNGSSGDGI AHTEGILNRN HRDASSLTNL KRANADVEII
410 420 430 440 450
TPRSPMGKES MVTFSNTLPR ANTPSVEDPV RRNASIHASM DSARSKQLLT
460 470 480 490 500
QWKSKNESRK MSLQVMDTEP EGQSPPRSIE MRSSSEPSRV GVNGDHHVPG
510 520 530 540 550
NQYLKIQPGT VPGCNNSMPG GPRVSIQSRP GSSQLVHIPE ETQENISTSP
560 570 580 590 600
KSSSARAKWL KAAEKTVACN RSNNQPRIMQ VIAMSKQQGV LQSSPKNAEG
610 620 630 640 650
STVTCTGSIR YKTLTDHEPS GIVRVEAHPE NNRPIIQIPS STEGEGSGSW
660 670 680 690 700
KWKAPEKSSL RQTYELNDLN RDSESCESLK DSFGSGDRKR SNIDSNEHHH
710 720 730 740 750
HGITTIRVTP VEGSEIGSET LSVSSSRDST LRRKGNIILI PERSNSPENT
760
RNIFYKGTSP TRAYKD
Length:766
Mass (Da):83,290
Last modified:February 5, 2008 - v2
Checksum:i371D9FA1A829B5B1
GO

Sequence cautioni

The sequence BAC37711 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC97959 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti451Q → R in BAC32865 (PubMed:16141072).Curated1
Sequence conflicti495 – 496DH → ED in AAH24711 (PubMed:15489334).Curated2
Sequence conflicti500G → S in AAH24711 (PubMed:15489334).Curated1
Sequence conflicti543Q → K in BAC32865 (PubMed:16141072).Curated1
Sequence conflicti568A → D in AAP41099 (PubMed:12730698).Curated1
Sequence conflicti568A → D in AAP41100 (PubMed:12730698).Curated1
Sequence conflicti568A → D in AAP57768 (PubMed:12730698).Curated1
Sequence conflicti653K → E in BAC37711 (PubMed:16141072).Curated1
Sequence conflicti654A → V in AAP41099 (PubMed:12730698).Curated1
Sequence conflicti654A → V in AAP41100 (PubMed:12730698).Curated1
Sequence conflicti654A → V in AAP57768 (PubMed:12730698).Curated1
Sequence conflicti737I → V in BAC32865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266266 mRNA Translation: AAP41099.1
AY266267 mRNA Translation: AAP41100.1
AF541279 mRNA Translation: AAP57768.1
AK129149 mRNA Translation: BAC97959.1 Different initiation.
AK046782 mRNA Translation: BAC32865.1
AK079635 mRNA Translation: BAC37711.1 Different initiation.
BC024711 mRNA Translation: AAH24711.1
BC137701 mRNA Translation: AAI37702.1
BC137702 mRNA Translation: AAI37703.1
CCDSiCCDS17795.1
RefSeqiNP_808332.3, NM_177664.5
UniGeneiMm.140138

Genome annotation databases

EnsembliENSMUST00000061071; ENSMUSP00000052306; ENSMUSG00000044667
GeneIDi229791
KEGGimmu:229791
UCSCiuc008rcz.2 mouse

Similar proteinsi

Entry informationi

Entry nameiPLPR4_MOUSE
AccessioniPrimary (citable) accession number: Q7TME0
Secondary accession number(s): B2RQ15
, Q6ZQA8, Q8BV73, Q8BXK2, Q8R3R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: May 23, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health