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Protein

Phospholipid phosphatase-related protein type 4

Gene

Plppr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-MMU-419408. Lysosphingolipid and LPA receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4By similarity (EC:3.1.3.4)
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 1By similarity
Lipid phosphate phosphatase-related protein type 4By similarity
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
Gene namesi
Name:Plppr4Imported
Synonyms:D3Bwg0562e1 Publication, Kiaa04551 Publication, Lppr4By similarity, Php1By similarity, Prg11 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106530. Plppr4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174371 – 766Phospholipid phosphatase-related protein type 4Add BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineCombined sources1
Glycosylationi215N-linked (GlcNAc...)Sequence analysis1
Glycosylationi220N-linked (GlcNAc...)Sequence analysis1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Modified residuei347PhosphoserineCombined sources1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Modified residuei386PhosphoserineBy similarity1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Modified residuei439PhosphoserineCombined sources1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Modified residuei462PhosphoserineCombined sources1
Modified residuei474PhosphoserineBy similarity1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Modified residuei608PhosphoserineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ7TME0.
PaxDbiQ7TME0.
PeptideAtlasiQ7TME0.
PRIDEiQ7TME0.

PTM databases

iPTMnetiQ7TME0.
PhosphoSitePlusiQ7TME0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000044667.
ExpressionAtlasiQ7TME0. baseline and differential.
GenevisibleiQ7TME0. MM.

Interactioni

Protein-protein interaction databases

BioGridi230903. 2 interactors.
IntActiQ7TME0. 2 interactors.
MINTiMINT-4113362.
STRINGi10090.ENSMUSP00000052306.

Structurei

3D structure databases

ProteinModelPortaliQ7TME0.
SMRiQ7TME0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 701Poly-His4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7TME0.
KOiK19582.
OMAiNQDPSRV.
OrthoDBiEOG091G02D7.
PhylomeDBiQ7TME0.
TreeFamiTF316040.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TME0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAGSSGAR GECDISGAGR LRLEQAARLG GRTVHTSPGG GLGARQAAGM
60 70 80 90 100
SAKERPKGKV IKDSVTLLPC FYFVELPILA SSVVSLYFLE LTDVFKPVHS
110 120 130 140 150
GFSCYDRSLS MPYIEPTQEA IPFLMLLSLA FAGPAITIMV GEGILYCCLS
160 170 180 190 200
KRRNGAGLEP NINAGGCNFN SFLRRAVRFV GVHVFGLCST ALITDIIQLS
210 220 230 240 250
TGYQAPYFLT VCKPNYTSLN VSCKENSYIV EDICSGSDLT VINSGRKSFP
260 270 280 290 300
SQHATLAAFA AVYVSMYFNS TLTDSSKLLK PLLVFTFIIC GIICGLTRIT
310 320 330 340 350
QYKNHPVDVY CGFLIGGGIA LYLGLYAVGN FLPSEDSMLQ HRDALRSLTD
360 370 380 390 400
LNQDPSRVLS AKNGSSGDGI AHTEGILNRN HRDASSLTNL KRANADVEII
410 420 430 440 450
TPRSPMGKES MVTFSNTLPR ANTPSVEDPV RRNASIHASM DSARSKQLLT
460 470 480 490 500
QWKSKNESRK MSLQVMDTEP EGQSPPRSIE MRSSSEPSRV GVNGDHHVPG
510 520 530 540 550
NQYLKIQPGT VPGCNNSMPG GPRVSIQSRP GSSQLVHIPE ETQENISTSP
560 570 580 590 600
KSSSARAKWL KAAEKTVACN RSNNQPRIMQ VIAMSKQQGV LQSSPKNAEG
610 620 630 640 650
STVTCTGSIR YKTLTDHEPS GIVRVEAHPE NNRPIIQIPS STEGEGSGSW
660 670 680 690 700
KWKAPEKSSL RQTYELNDLN RDSESCESLK DSFGSGDRKR SNIDSNEHHH
710 720 730 740 750
HGITTIRVTP VEGSEIGSET LSVSSSRDST LRRKGNIILI PERSNSPENT
760
RNIFYKGTSP TRAYKD
Length:766
Mass (Da):83,290
Last modified:February 5, 2008 - v2
Checksum:i371D9FA1A829B5B1
GO

Sequence cautioni

The sequence BAC37711 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAC97959 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti451Q → R in BAC32865 (PubMed:16141072).Curated1
Sequence conflicti495 – 496DH → ED in AAH24711 (PubMed:15489334).Curated2
Sequence conflicti500G → S in AAH24711 (PubMed:15489334).Curated1
Sequence conflicti543Q → K in BAC32865 (PubMed:16141072).Curated1
Sequence conflicti568A → D in AAP41099 (PubMed:12730698).Curated1
Sequence conflicti568A → D in AAP41100 (PubMed:12730698).Curated1
Sequence conflicti568A → D in AAP57768 (PubMed:12730698).Curated1
Sequence conflicti653K → E in BAC37711 (PubMed:16141072).Curated1
Sequence conflicti654A → V in AAP41099 (PubMed:12730698).Curated1
Sequence conflicti654A → V in AAP41100 (PubMed:12730698).Curated1
Sequence conflicti654A → V in AAP57768 (PubMed:12730698).Curated1
Sequence conflicti737I → V in BAC32865 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266266 mRNA. Translation: AAP41099.1.
AY266267 mRNA. Translation: AAP41100.1.
AF541279 mRNA. Translation: AAP57768.1.
AK129149 mRNA. Translation: BAC97959.1. Different initiation.
AK046782 mRNA. Translation: BAC32865.1.
AK079635 mRNA. Translation: BAC37711.1. Different initiation.
BC024711 mRNA. Translation: AAH24711.1.
BC137701 mRNA. Translation: AAI37702.1.
BC137702 mRNA. Translation: AAI37703.1.
CCDSiCCDS17795.1.
RefSeqiNP_808332.3. NM_177664.5.
UniGeneiMm.140138.

Genome annotation databases

EnsembliENSMUST00000061071; ENSMUSP00000052306; ENSMUSG00000044667.
GeneIDi229791.
KEGGimmu:229791.
UCSCiuc008rcz.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266266 mRNA. Translation: AAP41099.1.
AY266267 mRNA. Translation: AAP41100.1.
AF541279 mRNA. Translation: AAP57768.1.
AK129149 mRNA. Translation: BAC97959.1. Different initiation.
AK046782 mRNA. Translation: BAC32865.1.
AK079635 mRNA. Translation: BAC37711.1. Different initiation.
BC024711 mRNA. Translation: AAH24711.1.
BC137701 mRNA. Translation: AAI37702.1.
BC137702 mRNA. Translation: AAI37703.1.
CCDSiCCDS17795.1.
RefSeqiNP_808332.3. NM_177664.5.
UniGeneiMm.140138.

3D structure databases

ProteinModelPortaliQ7TME0.
SMRiQ7TME0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230903. 2 interactors.
IntActiQ7TME0. 2 interactors.
MINTiMINT-4113362.
STRINGi10090.ENSMUSP00000052306.

PTM databases

iPTMnetiQ7TME0.
PhosphoSitePlusiQ7TME0.

Proteomic databases

MaxQBiQ7TME0.
PaxDbiQ7TME0.
PeptideAtlasiQ7TME0.
PRIDEiQ7TME0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000061071; ENSMUSP00000052306; ENSMUSG00000044667.
GeneIDi229791.
KEGGimmu:229791.
UCSCiuc008rcz.2. mouse.

Organism-specific databases

CTDi9890.
MGIiMGI:106530. Plppr4.
RougeiSearch...

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7TME0.
KOiK19582.
OMAiNQDPSRV.
OrthoDBiEOG091G02D7.
PhylomeDBiQ7TME0.
TreeFamiTF316040.

Enzyme and pathway databases

ReactomeiR-MMU-419408. Lysosphingolipid and LPA receptors.

Miscellaneous databases

PROiQ7TME0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044667.
ExpressionAtlasiQ7TME0. baseline and differential.
GenevisibleiQ7TME0. MM.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR4_MOUSE
AccessioniPrimary (citable) accession number: Q7TME0
Secondary accession number(s): B2RQ15
, Q6ZQA8, Q8BV73, Q8BXK2, Q8R3R6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: February 5, 2008
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.