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Protein

Zinc finger CCCH domain-containing protein 14

Gene

Zc3h14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64020C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 65616C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri682 – 69918C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri701 – 71919C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 14
Alternative name(s):
Nuclear protein UKp83/UKp68
Gene namesi
Name:Zc3h14
Synonyms:Npuk68
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621850. Zc3h14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 736736Zinc finger CCCH domain-containing protein 14PRO_0000331314Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei85 – 851PhosphoserineCombined sources
Cross-linki175 – 175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei240 – 2401PhosphoserineBy similarity
Modified residuei309 – 3091PhosphoserineBy similarity
Modified residuei327 – 3271PhosphoserineBy similarity
Modified residuei343 – 3431PhosphoserineBy similarity
Modified residuei357 – 3571N6-acetyllysineBy similarity
Modified residuei390 – 3901PhosphoserineBy similarity
Modified residuei409 – 4091PhosphoserineBy similarity
Cross-linki413 – 413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei498 – 4981PhosphoserineBy similarity
Modified residuei515 – 5151PhosphoserineCombined sources
Modified residuei527 – 5271PhosphoserineBy similarity
Modified residuei620 – 6201PhosphoserineBy similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ7TMD5.

PTM databases

iPTMnetiQ7TMD5.
PhosphoSiteiQ7TMD5.

Interactioni

Protein-protein interaction databases

BioGridi251412. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ7TMD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H14 family.Curated
Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri595 – 62026C3H1-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri621 – 64020C3H1-type 2PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri641 – 65616C3H1-type 3PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri682 – 69918C3H1-type 4PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri701 – 71919C3H1-type 5PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG108760.
InParanoidiQ7TMD5.
PhylomeDBiQ7TMD5.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TMD5-1) [UniParc]FASTAAdd to basket

Also known as: UKp83

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSPDTSI FDSNVPSNKS
110 120 130 140 150
SFSRGDERRH EAAIPPLAVS SSRPEKRDSR VSTSSQEHKS TNVRHSYDDG
160 170 180 190 200
ASTRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENSLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADTGTHLN RPQLQQQQSS THTAKQLDGQ
260 270 280 290 300
SSQVYEAGRL CEPEVLGSVE DTYSPFFRNN LDKMNIEEEN FRKRKLPVVS
310 320 330 340 350
SVVKVKRFSH DGEEEEEDED YGTRVGSLSS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYPAVPQKQT LPVAPRTRTS QEEVLAEMVQ
410 420 430 440 450
GQNRAPRISP PVKEEEAKGD NAEKIEGTQQ RQLLSRLQID PVTVDTMELS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEIVV TPNQDSGMKT ADALRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEEMC FEGMKPVNQT
560 570 580 590 600
SASNKGLRGL LHPQQLHLLS RQLEDPDGSF SNAEMTDLSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECVYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKA
660 670 680 690 700
DCPFTHMSRR GPVLTPKPAV SSPAPSSNGQ FCRYFPACKK MECPFYHPKH
710 720 730
CRFNTQCTRP DCTFYHPTIT VPPRHALKWI RPQTSE
Length:736
Mass (Da):82,632
Last modified:October 1, 2003 - v1
Checksum:i35A0F305E2B0C7D1
GO
Isoform 2 (identifier: Q7TMD5-2) [UniParc]FASTAAdd to basket

Also known as: UKp68

The sequence of this isoform differs from the canonical sequence as follows:
     452-582: Missing.

Show »
Length:605
Mass (Da):68,062
Checksum:i284B5788E2DDE969
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti681 – 6811F → L in BAC76891 (Ref. 1) Curated
Sequence conflicti681 – 6811F → L in AAH87712 (PubMed:15489334).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei452 – 582131Missing in isoform 2. 2 PublicationsVSP_033181Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032932 mRNA. Translation: BAB40453.1.
AB097075 mRNA. Translation: BAC76890.1.
AB097076 mRNA. Translation: BAC76891.1.
AB097077 mRNA. Translation: BAC76892.1.
BC087712 mRNA. Translation: AAH87712.1.
RefSeqiNP_001029123.1. NM_001033951.1. [Q7TMD5-1]
NP_620275.1. NM_138920.1. [Q7TMD5-2]
UniGeneiRn.98359.

Genome annotation databases

GeneIDi192359.
KEGGirno:192359.
UCSCiRGD:621850. rat. [Q7TMD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032932 mRNA. Translation: BAB40453.1.
AB097075 mRNA. Translation: BAC76890.1.
AB097076 mRNA. Translation: BAC76891.1.
AB097077 mRNA. Translation: BAC76892.1.
BC087712 mRNA. Translation: AAH87712.1.
RefSeqiNP_001029123.1. NM_001033951.1. [Q7TMD5-1]
NP_620275.1. NM_138920.1. [Q7TMD5-2]
UniGeneiRn.98359.

3D structure databases

ProteinModelPortaliQ7TMD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251412. 1 interaction.

PTM databases

iPTMnetiQ7TMD5.
PhosphoSiteiQ7TMD5.

Proteomic databases

PRIDEiQ7TMD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192359.
KEGGirno:192359.
UCSCiRGD:621850. rat. [Q7TMD5-1]

Organism-specific databases

CTDi79882.
RGDi621850. Zc3h14.

Phylogenomic databases

HOVERGENiHBG108760.
InParanoidiQ7TMD5.
PhylomeDBiQ7TMD5.

Miscellaneous databases

PROiQ7TMD5.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Antigens recognized by antibody against isolated chromatin fraction from rat liver cells."
    Hara M., Watabe S., Igarashi J., Yamashita K., Yokosuka M., Iigo M., Ohtani-Kaneko R., Hirata K.
    Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Brain.
  3. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-85 AND SER-515, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiZC3HE_RAT
AccessioniPrimary (citable) accession number: Q7TMD5
Secondary accession number(s): Q7TSK6, Q99NC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.