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Protein

Zinc finger CCCH domain-containing protein 14

Gene

Zc3h14

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri682 – 699C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri701 – 719C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-binding, RNA-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger CCCH domain-containing protein 14
Alternative name(s):
Nuclear protein UKp83/UKp68
Gene namesi
Name:Zc3h14
Synonyms:Npuk68
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621850. Zc3h14.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003313141 – 736Zinc finger CCCH domain-containing protein 14Add BLAST736

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei85PhosphoserineCombined sources1
Cross-linki175Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei240PhosphoserineBy similarity1
Modified residuei309PhosphoserineBy similarity1
Modified residuei327PhosphoserineBy similarity1
Modified residuei343PhosphoserineBy similarity1
Modified residuei357N6-acetyllysineBy similarity1
Modified residuei390PhosphoserineBy similarity1
Modified residuei409PhosphoserineBy similarity1
Cross-linki413Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei498PhosphoserineBy similarity1
Modified residuei515PhosphoserineCombined sources1
Modified residuei527PhosphoserineBy similarity1
Modified residuei620PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PRIDEiQ7TMD5.

PTM databases

iPTMnetiQ7TMD5.
PhosphoSitePlusiQ7TMD5.

Interactioni

Protein-protein interaction databases

BioGridi251412. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ7TMD5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ZC3H14 family.Curated
Contains 5 C3H1-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri595 – 620C3H1-type 1PROSITE-ProRule annotationAdd BLAST26
Zinc fingeri621 – 640C3H1-type 2PROSITE-ProRule annotationAdd BLAST20
Zinc fingeri641 – 656C3H1-type 3PROSITE-ProRule annotationAdd BLAST16
Zinc fingeri682 – 699C3H1-type 4PROSITE-ProRule annotationAdd BLAST18
Zinc fingeri701 – 719C3H1-type 5PROSITE-ProRule annotationAdd BLAST19

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

HOVERGENiHBG108760.
InParanoidiQ7TMD5.
PhylomeDBiQ7TMD5.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7TMD5-1) [UniParc]FASTAAdd to basket
Also known as: UKp83

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEIGTEISRK IRSAIKGKLQ ELGAYVDEEL PDYIMVMVAN KKSQDQMTED
60 70 80 90 100
LSLFLGNNTI RFTVWLHGVL DKLRSVTTEP SSLKSPDTSI FDSNVPSNKS
110 120 130 140 150
SFSRGDERRH EAAIPPLAVS SSRPEKRDSR VSTSSQEHKS TNVRHSYDDG
160 170 180 190 200
ASTRLMSTVK PLREPAPSED VIDIKPEPDD LIDEDLNFVQ ENSLSQKKPT
210 220 230 240 250
VTLTYGSSRP SIEIYRPPAS RNADTGTHLN RPQLQQQQSS THTAKQLDGQ
260 270 280 290 300
SSQVYEAGRL CEPEVLGSVE DTYSPFFRNN LDKMNIEEEN FRKRKLPVVS
310 320 330 340 350
SVVKVKRFSH DGEEEEEDED YGTRVGSLSS SVSVPAKPER RPSLPPSKQA
360 370 380 390 400
NKNLILKAIS EAQESVTKTT NYPAVPQKQT LPVAPRTRTS QEEVLAEMVQ
410 420 430 440 450
GQNRAPRISP PVKEEEAKGD NAEKIEGTQQ RQLLSRLQID PVTVDTMELS
460 470 480 490 500
QDYYDMESMV HADTRSFILK KPKLSEEIVV TPNQDSGMKT ADALRVLSGH
510 520 530 540 550
LMQTRDLVQP DKPASPKFIV TLDGVPSPPG YMSDQEEEMC FEGMKPVNQT
560 570 580 590 600
SASNKGLRGL LHPQQLHLLS RQLEDPDGSF SNAEMTDLSV AQKPEKLLER
610 620 630 640 650
CKYWPACKNG DECVYHHPIS PCKAFPNCKF AEKCLFVHPN CKYDAKCTKA
660 670 680 690 700
DCPFTHMSRR GPVLTPKPAV SSPAPSSNGQ FCRYFPACKK MECPFYHPKH
710 720 730
CRFNTQCTRP DCTFYHPTIT VPPRHALKWI RPQTSE
Length:736
Mass (Da):82,632
Last modified:October 1, 2003 - v1
Checksum:i35A0F305E2B0C7D1
GO
Isoform 2 (identifier: Q7TMD5-2) [UniParc]FASTAAdd to basket
Also known as: UKp68

The sequence of this isoform differs from the canonical sequence as follows:
     452-582: Missing.

Show »
Length:605
Mass (Da):68,062
Checksum:i284B5788E2DDE969
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti681F → L in BAC76891 (Ref. 1) Curated1
Sequence conflicti681F → L in AAH87712 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_033181452 – 582Missing in isoform 2. 2 PublicationsAdd BLAST131

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032932 mRNA. Translation: BAB40453.1.
AB097075 mRNA. Translation: BAC76890.1.
AB097076 mRNA. Translation: BAC76891.1.
AB097077 mRNA. Translation: BAC76892.1.
BC087712 mRNA. Translation: AAH87712.1.
RefSeqiNP_001029123.1. NM_001033951.1. [Q7TMD5-1]
NP_620275.1. NM_138920.1. [Q7TMD5-2]
UniGeneiRn.98359.

Genome annotation databases

GeneIDi192359.
KEGGirno:192359.
UCSCiRGD:621850. rat. [Q7TMD5-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB032932 mRNA. Translation: BAB40453.1.
AB097075 mRNA. Translation: BAC76890.1.
AB097076 mRNA. Translation: BAC76891.1.
AB097077 mRNA. Translation: BAC76892.1.
BC087712 mRNA. Translation: AAH87712.1.
RefSeqiNP_001029123.1. NM_001033951.1. [Q7TMD5-1]
NP_620275.1. NM_138920.1. [Q7TMD5-2]
UniGeneiRn.98359.

3D structure databases

ProteinModelPortaliQ7TMD5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251412. 1 interactor.

PTM databases

iPTMnetiQ7TMD5.
PhosphoSitePlusiQ7TMD5.

Proteomic databases

PRIDEiQ7TMD5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi192359.
KEGGirno:192359.
UCSCiRGD:621850. rat. [Q7TMD5-1]

Organism-specific databases

CTDi79882.
RGDi621850. Zc3h14.

Phylogenomic databases

HOVERGENiHBG108760.
InParanoidiQ7TMD5.
PhylomeDBiQ7TMD5.

Miscellaneous databases

PROiQ7TMD5.

Family and domain databases

InterProiIPR000571. Znf_CCCH.
[Graphical view]
PROSITEiPS50103. ZF_C3H1. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiZC3HE_RAT
AccessioniPrimary (citable) accession number: Q7TMD5
Secondary accession number(s): Q7TSK6, Q99NC1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.