Reviewed,
UniProtKB/Swiss-Prot Q7TMB7 (LPPR4_RAT)
Last modified
March 3, 2009.
Version 33.
History...
Clusters with 100%,
90%,
50% identity |
 Documents (1) |
 Third-party data |
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Names and origin
| Protein names | Recommended name: Lipid phosphate phosphatase-related protein type 4 EC=3.1.3.4 Alternative name(s): Plasticity-related gene 1 protein Short name=PRG-1 Brain-specific phosphatidic acid phosphatase-like protein 1 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 766 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus. Ref.1 |
| Catalytic activity | A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate. |
| Subcellular location | Membrane; Multi-pass membrane protein Potential. |
| Tissue specificity | Specifically expressed in neurons. Ref.1 |
| Developmental stage | Expressed in the subventricular zone and specifically in the hippocampal anlage at embryonic day 19 (E19). From postnatal stages on, expressed in the hippocampus and in the entorhinal cortex. In the dentate gyrus weakly expressed in the infrapyramidal blade at P0 and at P5 expressed in the suprapyramidal blade. This expression remains unchanged during maturation. A reduced expression is seen in adult brain. Ref.1 |
| Sequence similarities | Belongs to the PA-phosphatase related phosphoesterase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Transmembrane |
| Molecular function | Hydrolase |
| PTM | Glycoprotein Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | axonogenesis Ref.1 Inferred from direct assay. Source: RGD phospholipid dephosphorylation Ref.1Inferred from direct assay. Source: RGD |
| Cellular component | external side of plasma membrane Ref.1 Inferred from direct assay. Source: RGD integral to plasma membrane Ref.1Inferred from direct assay. Source: RGD |
| Molecular function | lipid phosphatase activity Ref.1 Inferred from direct assay. Source: RGD phosphatidate phosphatase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 766 | 766 | Lipid phosphate phosphatase-related protein type 4 | PRO_0000317438 | |||||
Regions | |||||||||
| Transmembrane | 68 – 88 | 21 | Potential | ||||||
| Transmembrane | 120 – 140 | 21 | Potential | ||||||
| Transmembrane | 179 – 199 | 21 | Potential | ||||||
| Transmembrane | 248 – 268 | 21 | Potential | ||||||
| Transmembrane | 277 – 297 | 21 | Potential | ||||||
| Transmembrane | 309 – 329 | 21 | Potential | ||||||
| Compositional bias | 698 – 701 | 4 | Poly-His | ||||||
Amino acid modifications | |||||||||
| Modified residue | 218 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 347 | 1 | Phosphoserine By similarity | ||||||
| Modified residue | 417 | 1 | Phosphothreonine By similarity | ||||||
| Glycosylation | 269 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 363 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 433 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 456 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 515 | 1 | N-linked (GlcNAc...) Potential | ||||||
| Glycosylation | 545 | 1 | N-linked (GlcNAc...) Potential | ||||||
Sequences
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References
| [1] | "A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting." Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R. Nat. Neurosci. 6:572-578(2003) [PubMed: 12730698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE. Strain: Sprague-Dawley and Wistar. Tissue: Brain and Testis. |
Cross-references
Sequence databases | |
|---|---|
| AY266268 mRNA. Translation: AAP41101.1. AF541280 mRNA. Translation: AAP57769.1. | |
| IPI | IPI00382127. |
| RefSeq | NP_001001508.1. |
| UniGene | Rn.58355 |
3D structure databases | |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | Q7TMB7. |
Genome annotation databases | |
| Ensembl | ENSRNOG00000016872. Rattus norvegicus. [Contig view] |
| GeneID | 295401. |
| KEGG | rno:295401. |
Organism-specific databases | |
| RGD | 727806. Lppr4. |
Phylogenomic databases | |
| HOVERGEN | Q7TMB7. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.4. 248. |
Gene expression databases | |
| ArrayExpress | Q7TMB7. |
Family and domain databases | |
| InterPro | IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view] |
| Pfam | PF01569. PAP2. 1 hit. [Graphical view] |
| SMART | SM00014. acidPPc. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 639507. |
Entry information
| Entry name | LPPR4_RAT | ||||||||
| Accession | Primary (citable) accession number: Q7TMB7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
