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Protein

Phospholipid phosphatase-related protein type 4

Gene

Plppr4

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes lysophosphatidic acid (LPA). Facilitates axonal outgrowth during development and regenerative sprouting. In the outgrowing axons acts as an ecto-enzyme and attenuates phospholipid-induced axon collapse in neurons and facilitates outgrowth in the hippocampus.1 Publication

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

  • lipid phosphatase activity Source: RGD
  • phosphatidate phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  • axonogenesis Source: RGD
  • phospholipid dephosphorylation Source: RGD
  • phospholipid metabolic process Source: GO_Central
  • signal transduction Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Chemistry databases

SwissLipidsiSLP:000000722.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase-related protein type 4By similarity (EC:3.1.3.4)
Alternative name(s):
Brain-specific phosphatidic acid phosphatase-like protein 1By similarity
Lipid phosphate phosphatase-related protein type 4By similarity
Plasticity-related gene 1 protein1 Publication
Short name:
PRG-11 Publication
Gene namesi
Name:Plppr4Imported
Synonyms:Lppr4By similarity, Php1By similarity, Prg11 Publication
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi727806. Plppr4.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei68 – 88HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei179 – 199HelicalSequence analysisAdd BLAST21
Transmembranei248 – 268HelicalSequence analysisAdd BLAST21
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • external side of plasma membrane Source: RGD
  • integral component of plasma membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003174381 – 766Phospholipid phosphatase-related protein type 4Add BLAST766

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei37PhosphoserineBy similarity1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Modified residuei347PhosphoserineCombined sources1
Glycosylationi363N-linked (GlcNAc...)Sequence analysis1
Modified residuei386PhosphoserineCombined sources1
Glycosylationi433N-linked (GlcNAc...)Sequence analysis1
Modified residuei439PhosphoserineBy similarity1
Glycosylationi456N-linked (GlcNAc...)Sequence analysis1
Modified residuei462PhosphoserineBy similarity1
Modified residuei474PhosphoserineCombined sources1
Glycosylationi515N-linked (GlcNAc...)Sequence analysis1
Glycosylationi545N-linked (GlcNAc...)Sequence analysis1
Modified residuei608PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ7TMB7.
PRIDEiQ7TMB7.

PTM databases

iPTMnetiQ7TMB7.
PhosphoSitePlusiQ7TMB7.

Expressioni

Tissue specificityi

Specifically expressed in neurons.1 Publication

Developmental stagei

Expressed in the subventricular zone and specifically in the hippocampal anlage at embryonic day 19 (E19). From postnatal stages on, expressed in the hippocampus and in the entorhinal cortex. In the dentate gyrus weakly expressed in the infrapyramidal blade at P0 and at P5 expressed in the suprapyramidal blade. This expression remains unchanged during maturation. A reduced expression is seen in adult brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022625.

Structurei

3D structure databases

ProteinModelPortaliQ7TMB7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi698 – 701Poly-His4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7TMB7.
PhylomeDBiQ7TMB7.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7TMB7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQRAGSSGAR GECDISGTGR LRLEQAARLG GRAVHTSPTG GLGARQVAGM
60 70 80 90 100
SAKERPKGKV IKDSVTLLPC FYFVELPILA SSVVSLYFLE LTDVFKPVHS
110 120 130 140 150
GFSCYDRSLS MPYIEPTQEA IPFLMLLSLA FAGPAITIMV GEGILYCCLS
160 170 180 190 200
KRRNGAGLEP NINAGGCNFN SFLRRAVRFV GVHVVGLCST ALITDIIQLA
210 220 230 240 250
TGYQAPYFLT VCKPMYTSLE GSCKENSYIV EEICSGSDLT VINNGKKSFP
260 270 280 290 300
SQHATLAAFA AVYVSMYFNS TLTDSSKLLK PLLVFTFIIC GIICGLTRIT
310 320 330 340 350
QYKNHPVDVY CGFLIGGGIA LYLGLYAVGN FLPSEDSMLQ HRDALRSLTD
360 370 380 390 400
LNQDPSRVLS AKNGSSGDGI AHTEGILNRN HRDASSLTNL KRANADVEII
410 420 430 440 450
TPRSPMGKES MVTFSNTLPR ANTPSVEDPV RRNASIHASM DSARSKQLLT
460 470 480 490 500
QWKSKNESRK MSLQVMDSEP EGQSPPRSIE MRSSSEPSRV GVNGDHHVPG
510 520 530 540 550
NQYLKIQPGT VPGCNNSMPA GPRVSIQSRP GSSQLVHIPE ETQENISTSP
560 570 580 590 600
KSSSARAKWL KAAEKTVACN RGNNQPRIMQ VIAMSKQQGV LQSSPKNAEG
610 620 630 640 650
STVTCTGSIR YKTLTDHEPS GIVRVEAHPE NNRPIIQIPS STEGEGSGSW
660 670 680 690 700
KWKAPEKSSL RQTYELNDLN RDSESCESLK DSFGSGDRKR KHIDSNEHHH
710 720 730 740 750
HGITTIRVTP VEGSEIGSET LSVSSSRDST LRRKGNIILI PERSNSPENT
760
RNIFYKGTSP TRPYKD
Length:766
Mass (Da):83,362
Last modified:October 1, 2003 - v1
Checksum:i7986E59DD4BC6C62
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266268 mRNA. Translation: AAP41101.1.
AF541280 mRNA. Translation: AAP57769.1.
UniGeneiRn.58355.

Genome annotation databases

UCSCiRGD:727806. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY266268 mRNA. Translation: AAP41101.1.
AF541280 mRNA. Translation: AAP57769.1.
UniGeneiRn.58355.

3D structure databases

ProteinModelPortaliQ7TMB7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000022625.

Chemistry databases

SwissLipidsiSLP:000000722.

PTM databases

iPTMnetiQ7TMB7.
PhosphoSitePlusiQ7TMB7.

Proteomic databases

PaxDbiQ7TMB7.
PRIDEiQ7TMB7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:727806. rat.

Organism-specific databases

RGDi727806. Plppr4.

Phylogenomic databases

eggNOGiENOG410ITB1. Eukaryota.
ENOG410ZGFZ. LUCA.
HOGENOMiHOG000043094.
HOVERGENiHBG103365.
InParanoidiQ7TMB7.
PhylomeDBiQ7TMB7.

Miscellaneous databases

PROiQ7TMB7.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPLPR4_RAT
AccessioniPrimary (citable) accession number: Q7TMB7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.