Reviewed, UniProtKB/Swiss-Prot Q7TMB0 (LPPR3_RAT)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphatase-related protein type 3
    EC=3.1.3.4
Alternative name(s):
    Plasticity-related gene 2 protein
      Short name=PRG-2

Gene names

Name:	Lppr3
Synonyms:	Prg-2, Prg2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 716	716	Lipid phosphate phosphatase-related protein type 3		PRO_0000317531
Regions
	Transmembrane	18 – 38	21	Potential
	Transmembrane	70 – 90	21	Potential
	Transmembrane	131 – 151	21	Potential
	Transmembrane	205 – 225	21	Potential
	Transmembrane	231 – 251	21	Potential
	Transmembrane	261 – 281	21	Potential
	Compositional bias	435 – 459	25	Glu-rich
	Compositional bias	562 – 571	10	Poly-Ser
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7TMB0-1 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9440C6F2DC76CE36	FASTA	716	76,786
	10 20 30 40 50 60 MIAKKEKNKT PKDSMTLLPC FYFVELPIVA SSVVSLYFLE LTDLFQPAKV GFQCHDRSLS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV GEGMVYCLQS RLWGRGPGGV EGSINAGGCN 130 140 150 160 170 180 FNSFLRRTVR FVGVHVFGLC ATALVTDVIQ LATGYHTPFF LTVCKPNYTL LGTSCEANPY 190 200 210 220 230 240 ITQDICSGHD THAILSARKT FPSQHATLSA FAAVYVSMYF NSVISDATKL LKPILVFAFA 250 260 270 280 290 300 IAAGVCGLTQ ITQYRSHPVD VYAGFLIGAG IAAYLACHAV GNFQAPPAEK VPTPAPAKDA 310 320 330 340 350 360 LRVLTQRGHE SMYQQNKSVS TDELGPPGRL EGVPRPVARE KTSLGSLKRA SVDVDLLAPR 370 380 390 400 410 420 SPMGKEGMVT FSNTLPRVST PSLDDPSRRH MTIHVPLDAS RSRQLISEWK QKSLEGRGLG 430 440 450 460 470 480 LPDEASPAHL RAPAEQVAEE EEEEEEEEEE EEEEEEEEEG PVPPSLYPTV QARPGLGPRV 490 500 510 520 530 540 ILPPRPGPQP LIHIPEEVVQ AGAGLSPKSS ASVRAKWLSM VEKGGGPVAV APPQPRVANP 550 560 570 580 590 600 PRLLQVIAMS KAAGGPKAET ASSSSASSDS SQYRSPSDRD SASIVTIDAH APHHPVVHLS 610 620 630 640 650 660 AGSTPWEWKA KVVEGEGGYE LGDLARGFRS SCKQPGIGPG SPVSDVDQEE PRFGAVATVN 670 680 690 700 710 LATGEGLPPP GASEGALGAG SRESTLRRQV GALGEREVEA EAESYYRRMQ ARRYQD

References

[1]	"A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting." Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R. Nat. Neurosci. 6:572-578(2003) [PubMed: 12730698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley and Wistar. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY147866 mRNA. Translation: AAN37411.1. AY300027 mRNA. Translation: AAP57099.1.
IPI	IPI00382123.
RefSeq	NP_853665.1.
UniGene	Rn.107771
3D structure databases
ModBase	Search...
Proteomic databases
PRIDE	Q7TMB0.
Genome annotation databases
Ensembl	ENSRNOT00000031315; ENSRNOP00000029601; ENSRNOG00000027940; Rattus norvegicus. [Genome view]
GeneID	314614.
KEGG	rno:314614.
Organism-specific databases
CTD	314614.
RGD	727823. Prg-2.
Phylogenomic databases
eggNOG	maNOG08937.
HOVERGEN	Q7TMB0.
InParanoid	Q7TMB0.
Enzyme and pathway databases
BRENDA	3.1.3.4. 248.
Gene expression databases
ArrayExpress	Q7TMB0.
Genevestigator	Q7TMB0.
Family and domain databases
InterPro	IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	667908.

Entry information

Entry name

LPPR3_RAT

Accession

Primary (citable) accession number: Q7TMB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 1, 2003
Last modified:	January 19, 2010
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)