Q7TMB0 (LPPR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Lipid phosphate phosphatase-related protein type 3
EC=3.1.3.4

Alternative name(s):
Plasticity-related gene 2 protein
Short name=PRG-2

Gene names

Name:	Lppr3
Synonyms:	Prg-2, Prg2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	716 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subcellular location	Membrane; Multi-pass membrane protein Potential.
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Hydrolase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	phosphatidate phosphatase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 716	716	Lipid phosphate phosphatase-related protein type 3		PRO_0000317531
Regions
	Transmembrane	18 – 38	21	Helical; Potential
	Transmembrane	70 – 90	21	Helical; Potential
	Transmembrane	131 – 151	21	Helical; Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Transmembrane	231 – 251	21	Helical; Potential
	Transmembrane	261 – 281	21	Helical; Potential
	Compositional bias	435 – 459	25	Glu-rich
	Compositional bias	562 – 571	10	Poly-Ser
Amino acid modifications
	Glycosylation	167	1	N-linked (GlcNAc...) Potential
	Glycosylation	316	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q7TMB0 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 9440C6F2DC76CE36	FASTA	716	76,786
	10 20 30 40 50 60 MIAKKEKNKT PKDSMTLLPC FYFVELPIVA SSVVSLYFLE LTDLFQPAKV GFQCHDRSLS 70 80 90 100 110 120 MPYVETNEEL IPLLMLLSLA FAAPAASIMV GEGMVYCLQS RLWGRGPGGV EGSINAGGCN 130 140 150 160 170 180 FNSFLRRTVR FVGVHVFGLC ATALVTDVIQ LATGYHTPFF LTVCKPNYTL LGTSCEANPY 190 200 210 220 230 240 ITQDICSGHD THAILSARKT FPSQHATLSA FAAVYVSMYF NSVISDATKL LKPILVFAFA 250 260 270 280 290 300 IAAGVCGLTQ ITQYRSHPVD VYAGFLIGAG IAAYLACHAV GNFQAPPAEK VPTPAPAKDA 310 320 330 340 350 360 LRVLTQRGHE SMYQQNKSVS TDELGPPGRL EGVPRPVARE KTSLGSLKRA SVDVDLLAPR 370 380 390 400 410 420 SPMGKEGMVT FSNTLPRVST PSLDDPSRRH MTIHVPLDAS RSRQLISEWK QKSLEGRGLG 430 440 450 460 470 480 LPDEASPAHL RAPAEQVAEE EEEEEEEEEE EEEEEEEEEG PVPPSLYPTV QARPGLGPRV 490 500 510 520 530 540 ILPPRPGPQP LIHIPEEVVQ AGAGLSPKSS ASVRAKWLSM VEKGGGPVAV APPQPRVANP 550 560 570 580 590 600 PRLLQVIAMS KAAGGPKAET ASSSSASSDS SQYRSPSDRD SASIVTIDAH APHHPVVHLS 610 620 630 640 650 660 AGSTPWEWKA KVVEGEGGYE LGDLARGFRS SCKQPGIGPG SPVSDVDQEE PRFGAVATVN 670 680 690 700 710 LATGEGLPPP GASEGALGAG SRESTLRRQV GALGEREVEA EAESYYRRMQ ARRYQD

References

[1]

"A new phospholipid phosphatase, PRG-1, is involved in axon growth and regenerative sprouting." Braeuer A.U., Savaskan N.E., Kuehn H., Prehn S., Ninnemann O., Nitsch R. Nat. Neurosci. 6:572-578(2003) [PubMed: 12730698] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley and Wistar. Tissue: Brain.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY147866 mRNA. Translation: AAN37411.1. AY300027 mRNA. Translation: AAP57099.1.
IPI	IPI00382123.
RefSeq	NP_853665.1. NM_181634.2.
UniGene	Rn.107771.
3D structure databases
ProteinModelPortal	Q7TMB0.
ModBase	Search...
Proteomic databases
PRIDE	Q7TMB0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	314614.
KEGG	rno:314614.
Organism-specific databases
CTD	79948.
RGD	727823. Lppr3.
Phylogenomic databases
eggNOG	maNOG08937.
GeneTree	ENSGT00550000074203.
HOVERGEN	HBG103365.
InParanoid	Q7TMB0.
OrthoDB	EOG4BRWK9.
Gene expression databases
ArrayExpress	Q7TMB0.
Genevestigator	Q7TMB0.
Family and domain databases
InterPro	IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
SUPFAM	SSF48317. AcPase_VanPerase. 1 hit.
ProtoNet	Search...
Other
NextBio	667908.

Entry information

Entry name

LPPR3_RAT

Accession

Primary (citable) accession number: Q7TMB0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 5, 2008
Last sequence update:	October 1, 2003
Last modified:	September 21, 2011
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program