ID   Q7TMA9_RAT              Unreviewed;      1015 AA.
AC   Q7TMA9; A0A0G2K8V5;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 137.
DE   SubName: Full=Aa1249 {ECO:0000313|EMBL:AAP85372.1};
DE   SubName: Full=Ab1-341 {ECO:0000313|EMBL:AAP92619.1};
DE   SubName: Full=Ab2-196 {ECO:0000313|EMBL:AAP92597.1};
DE   SubName: Full=Ac1-114 {ECO:0000313|EMBL:AAP86250.1};
DE   SubName: Full=Ac1262 {ECO:0000313|EMBL:AAP78761.1};
DE   SubName: Full=Ac2-069 {ECO:0000313|EMBL:AAP86256.1};
DE   SubName: Full=Ba2-693 {ECO:0000313|EMBL:AAP92633.1};
DE   SubName: Full=C-reactive protein {ECO:0000313|Ensembl:ENSRNOP00000074751.2};
GN   Name=Crp {ECO:0000313|Ensembl:ENSRNOP00000074751.2,
GN   ECO:0000313|RGD:2411};
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116 {ECO:0000313|EMBL:AAP78761.1};
RN   [1] {ECO:0000313|EMBL:AAP78761.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=Sprague-Dawley {ECO:0000313|EMBL:AAP78761.1};
RA   Xu C.S., Li W.Q., Li Y.C., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA   Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:AAP86250.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu C.S., Li W.Q., Li Y.C., Wang L., Wang S.F., Han H.P., Wang G.P.,
RA   Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|EMBL:AAP86256.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu C.S., Li W.Q., Li Y.C., Chang C.F., Han H.P., Wang G.P., Chai L.Q.,
RA   Yuan J.Y., Yang K.J., Yan H.M., Zhao L.F., Ma H., Wang L., Wang S.F.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4] {ECO:0000313|EMBL:AAP92633.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu C.S., Li W.Q., Li Y.C., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M.,
RA   Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P., Wang G.P.,
RA   Chai L.Q., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [5] {ECO:0000313|EMBL:AAP85372.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu C.S., Li W.Q., Li Y.C., Yang K.J., Yan H.M., Chang C.F., Zhao L.F.,
RA   Ma H., Wang L., Wang S.F., Han H.P., Wang G.P., Chai L.Q., Yuan J.Y.,
RA   Shi J.B., Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [6] {ECO:0000313|EMBL:AAP92619.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Xu C.S., Li W.Q., Li Y.C., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P.,
RA   Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Shi J.B.,
RA   Rahman S., Wang Q.N., Zhang J.B.;
RT   "Liver regeneration after PH.";
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
RN   [7] {ECO:0000313|Ensembl:ENSRNOP00000074751.2, ECO:0000313|Proteomes:UP000002494}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074751.2,
RC   ECO:0000313|Proteomes:UP000002494};
RX   PubMed=15057822; DOI=10.1038/nature02426;
RG   Rat Genome Sequencing Project Consortium;
RA   Gibbs R.A., Weinstock G.M., Metzker M.L., Muzny D.M., Sodergren E.J.,
RA   Scherer S., Scott G., Steffen D., Worley K.C., Burch P.E., Okwuonu G.,
RA   Hines S., Lewis L., Deramo C., Delgado O., Dugan-Rocha S., Miner G.,
RA   Morgan M., Hawes A., Gill R., Holt R.A., Adams M.D., Amanatides P.G.,
RA   Baden-Tillson H., Barnstead M., Chin S., Evans C.A., Ferriera S.,
RA   Fosler C., Glodek A., Gu Z., Jennings D., Kraft C.L., Nguyen T.,
RA   Pfannkoch C.M., Sitter C., Sutton G.G., Venter J.C., Woodage T., Smith D.,
RA   Lee H.-M., Gustafson E., Cahill P., Kana A., Doucette-Stamm L.,
RA   Weinstock K., Fechtel K., Weiss R.B., Dunn D.M., Green E.D.,
RA   Blakesley R.W., Bouffard G.G., De Jong P.J., Osoegawa K., Zhu B., Marra M.,
RA   Schein J., Bosdet I., Fjell C., Jones S., Krzywinski M., Mathewson C.,
RA   Siddiqui A., Wye N., McPherson J., Zhao S., Fraser C.M., Shetty J.,
RA   Shatsman S., Geer K., Chen Y., Abramzon S., Nierman W.C., Havlak P.H.,
RA   Chen R., Durbin K.J., Egan A., Ren Y., Song X.-Z., Li B., Liu Y., Qin X.,
RA   Cawley S., Cooney A.J., D'Souza L.M., Martin K., Wu J.Q.,
RA   Gonzalez-Garay M.L., Jackson A.R., Kalafus K.J., McLeod M.P.,
RA   Milosavljevic A., Virk D., Volkov A., Wheeler D.A., Zhang Z., Bailey J.A.,
RA   Eichler E.E., Tuzun E., Birney E., Mongin E., Ureta-Vidal A., Woodwark C.,
RA   Zdobnov E., Bork P., Suyama M., Torrents D., Alexandersson M., Trask B.J.,
RA   Young J.M., Huang H., Wang H., Xing H., Daniels S., Gietzen D., Schmidt J.,
RA   Stevens K., Vitt U., Wingrove J., Camara F., Mar Alba M., Abril J.F.,
RA   Guigo R., Smit A., Dubchak I., Rubin E.M., Couronne O., Poliakov A.,
RA   Huebner N., Ganten D., Goesele C., Hummel O., Kreitler T., Lee Y.-A.,
RA   Monti J., Schulz H., Zimdahl H., Himmelbauer H., Lehrach H., Jacob H.J.,
RA   Bromberg S., Gullings-Handley J., Jensen-Seaman M.I., Kwitek A.E.,
RA   Lazar J., Pasko D., Tonellato P.J., Twigger S., Ponting C.P., Duarte J.M.,
RA   Rice S., Goodstadt L., Beatson S.A., Emes R.D., Winter E.E., Webber C.,
RA   Brandt P., Nyakatura G., Adetobi M., Chiaromonte F., Elnitski L.,
RA   Eswara P., Hardison R.C., Hou M., Kolbe D., Makova K., Miller W.,
RA   Nekrutenko A., Riemer C., Schwartz S., Taylor J., Yang S., Zhang Y.,
RA   Lindpaintner K., Andrews T.D., Caccamo M., Clamp M., Clarke L., Curwen V.,
RA   Durbin R.M., Eyras E., Searle S.M., Cooper G.M., Batzoglou S., Brudno M.,
RA   Sidow A., Stone E.A., Payseur B.A., Bourque G., Lopez-Otin C., Puente X.S.,
RA   Chakrabarti K., Chatterji S., Dewey C., Pachter L., Bray N., Yap V.B.,
RA   Caspi A., Tesler G., Pevzner P.A., Haussler D., Roskin K.M., Baertsch R.,
RA   Clawson H., Furey T.S., Hinrichs A.S., Karolchik D., Kent W.J.,
RA   Rosenbloom K.R., Trumbower H., Weirauch M., Cooper D.N., Stenson P.D.,
RA   Ma B., Brent M., Arumugam M., Shteynberg D., Copley R.R., Taylor M.S.,
RA   Riethman H., Mudunuri U., Peterson J., Guyer M., Felsenfeld A., Old S.,
RA   Mockrin S., Collins F.S.;
RT   "Genome sequence of the Brown Norway rat yields insights into mammalian
RT   evolution.";
RL   Nature 428:493-521(2004).
RN   [8] {ECO:0000313|Ensembl:ENSRNOP00000074751.2}
RP   IDENTIFICATION.
RC   STRAIN=Brown Norway {ECO:0000313|Ensembl:ENSRNOP00000074751.2};
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY310153; AAP78761.1; -; mRNA.
DR   EMBL; AY318961; AAP85372.1; -; mRNA.
DR   EMBL; AY321318; AAP86250.1; -; mRNA.
DR   EMBL; AY321324; AAP86256.1; -; mRNA.
DR   EMBL; AY325196; AAP92597.1; -; mRNA.
DR   EMBL; AY325218; AAP92619.1; -; mRNA.
DR   EMBL; AY325232; AAP92633.1; -; mRNA.
DR   PaxDb; 10116-ENSRNOP00000066806; -.
DR   Ensembl; ENSRNOT00000091089.2; ENSRNOP00000074751.2; ENSRNOG00000000053.8.
DR   RGD; 2411; Crp.
DR   VEuPathDB; HostDB:ENSRNOG00000000053; -.
DR   GeneTree; ENSGT01100000263543; -.
DR   OrthoDB; 4615547at2759; -.
DR   Proteomes; UP000002494; Chromosome 13.
DR   Bgee; ENSRNOG00000000053; Expressed in liver and 17 other cell types or tissues.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006953; P:acute-phase response; IEA:UniProtKB-KW.
DR   CDD; cd00152; PTX; 1.
DR   Gene3D; 2.60.120.200; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR013544; DUF1725.
DR   InterPro; IPR030476; Pentaxin_CS.
DR   InterPro; IPR001759; Pentraxin-related.
DR   PANTHER; PTHR25952; ENDO/EXONUCLEASE/PHOSPHATASE DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR25952:SF246; LINE-1 RETROTRANSPOSABLE ELEMENT ORF2 PROTEIN; 1.
DR   Pfam; PF08333; DUF1725; 1.
DR   Pfam; PF00354; Pentaxin; 1.
DR   PRINTS; PR00895; PENTAXIN.
DR   SMART; SM00159; PTX; 1.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   PROSITE; PS00289; PTX_1; 1.
DR   PROSITE; PS51828; PTX_2; 1.
PE   1: Evidence at protein level;
KW   Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU01172};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0007829|PeptideAtlas:Q7TMA9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000002494};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        12..33
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          615..632
FT                   /note="DUF1725"
FT                   /evidence="ECO:0000259|Pfam:PF08333"
FT   REGION          915..936
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          969..1015
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        673..732
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU01172"
SQ   SEQUENCE   1015 AA;  116462 MW;  94904AC6BB979A76 CRC64;
     MYRIATKTWH VQVLFVYSVP GSSALFAGVP AALLHALVLW LLSSVEAIAT LLSLVLYSFH
     DASSVHSCQV IPSEADSGFV NYIKAMIWEK ELLLKGDLNH SEADELGAKQ ALALGAYRLL
     ISPRWGVYRK EGGTQDPNNI KYLGVTLTKQ VKDLYNKNFK TLKKEIEEDL RRWKDLPCSW
     IGRINIVKMP ILPKAIYRFN AIPIKIPIQF FKELDRTICK FIWNNKKPRI AKAILNNKRT
     SGGITIPELK QYYRAIAIKT AWYWYRDRQI DQWNRIEDPE MNPHTYGHLI FDKGAKTIQW
     KKDSIFSKWC WFNWRSTCRR MQIDPCLSPC TKLKSKWIKD LHIKADTLKL IEEKLGKHLE
     HMGTGKNFLN KTPMAYALRS RIDKWDLIKL QSFCKAKDTV VRTNRQPTDW EKIFTNPTTD
     RGLISKIYKE LKKLDRRETN NPIKKWGSEL NKEFTAEECR MAEKHLKKCS TSLVIREMQI
     KTTLRFHLTP VRMAKIKNSD DSRCWRGCGE RGTLLHCWWG CKLVQPFWKS VWRILRKLDI
     ELPEDPAIPL LGIYPKDAPT YKKDTCSTMF IAALFIIARS WKEPRCPSTE EWIQKMWYIY
     TMEYYSAIKN NDFMKFVGKW LELENIILSE LTQSQKDIHD MSKQAFVFPG VSATAYVSLE
     AESKKPLEAF TVCLYAHADV SRSFSIFSYA TKTSFNEILL FWTRGQGFSI AVGGPEILFS
     ASEIPEVPTH ICATWESATG IVELWLDGKP RVRKSLQKGY IVGTNASIIL GQEQDSYGGG
     FDANQSLVGD IGDVNMWDFV LSPEQINAVY VGRVFSPNVL NWRALKYETH GDVFIKPQLW
     PLTDCSQVQV GQRPPHKTDT LKLIEEKVGK NLGHMGTGPH EAQEGKTKVW MLQSFLEGGT
     KILTGGNMER KCGIEERPSR DCPTWGSSPH SATKPRQHCG YQEVHADRNL IQLSPERLCQ
     SLTNTEVDAH SQPLTEKEVP NGGVREKTEG VEGVCNPIRR TVSSNQPYPV RDPRD
//