Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q7TMA5

- APOB_RAT

UniProt

Q7TMA5 - APOB_RAT

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Apolipoprotein B-100

Gene

Apob

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor.1 Publication

GO - Molecular functioni

  1. cholesterol transporter activity Source: Ensembl
  2. heparin binding Source: UniProtKB-KW
  3. lipid binding Source: RGD
  4. phospholipid binding Source: Ensembl

GO - Biological processi

  1. artery morphogenesis Source: Ensembl
  2. cellular response to prostaglandin stimulus Source: RGD
  3. cellular response to tumor necrosis factor Source: RGD
  4. cholesterol efflux Source: Ensembl
  5. cholesterol homeostasis Source: Ensembl
  6. cholesterol metabolic process Source: UniProtKB-KW
  7. fertilization Source: Ensembl
  8. in utero embryonic development Source: Ensembl
  9. lipid metabolic process Source: RGD
  10. lipoprotein biosynthetic process Source: Ensembl
  11. lipoprotein catabolic process Source: Ensembl
  12. lipoprotein transport Source: Ensembl
  13. low-density lipoprotein particle clearance Source: Ensembl
  14. low-density lipoprotein particle remodeling Source: Ensembl
  15. nervous system development Source: Ensembl
  16. positive regulation of cholesterol storage Source: Ensembl
  17. positive regulation of macrophage derived foam cell differentiation Source: Ensembl
  18. post-embryonic development Source: Ensembl
  19. regulation of cholesterol biosynthetic process Source: Ensembl
  20. response to carbohydrate Source: RGD
  21. response to lipopolysaccharide Source: RGD
  22. response to organic substance Source: RGD
  23. response to selenium ion Source: RGD
  24. response to virus Source: Ensembl
  25. spermatogenesis Source: Ensembl
  26. sperm motility Source: Ensembl
  27. triglyceride catabolic process Source: RGD
  28. triglyceride mobilization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Cholesterol metabolism, Lipid metabolism, Lipid transport, Steroid metabolism, Sterol metabolism, Transport

Keywords - Ligandi

Heparin-binding

Enzyme and pathway databases

ReactomeiREACT_198722. Scavenging by Class H Receptors.
REACT_198733. Scavenging by Class A Receptors.
REACT_198734. Scavenging by Class B Receptors.
REACT_198755. Scavenging by Class F Receptors.
REACT_199015. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein B-100
Short name:
Apo B-100
Cleaved into the following chain:
Apolipoprotein B-48
Short name:
Apo B-48
Gene namesi
Name:Apob
ORF Names:Aa1064, Ac1-060
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 6

Organism-specific databases

RGDi2129. Apob.

Subcellular locationi

Cytoplasm By similarity. Secreted 1 Publication

GO - Cellular componenti

  1. actin cytoskeleton Source: Ensembl
  2. cytoplasm Source: UniProtKB
  3. endoplasmic reticulum Source: Ensembl
  4. extracellular space Source: RGD
  5. Golgi apparatus Source: Ensembl
  6. intermediate-density lipoprotein particle Source: Ensembl
  7. intracellular membrane-bounded organelle Source: RGD
  8. low-density lipoprotein particle Source: UniProtKB-KW
  9. mature chylomicron Source: Ensembl
  10. plasma membrane Source: Ensembl
  11. very-low-density lipoprotein particle Source: RGD
  12. vesicle lumen Source: RGD
  13. vesicle membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Chylomicron, Cytoplasm, LDL, Secreted, VLDL

Pathology & Biotechi

Keywords - Diseasei

Atherosclerosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2727By similarityAdd
BLAST
Chaini28 – 47434716Apolipoprotein B-100PRO_0000293536Add
BLAST
Chaini28 – 21462119Apolipoprotein B-48PRO_0000293537Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi65 ↔ 84PROSITE-ProRule annotation
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi173 ↔ 199PROSITE-ProRule annotation
Disulfide bondi232 ↔ 248PROSITE-ProRule annotation
Disulfide bondi372 ↔ 377PROSITE-ProRule annotation
Disulfide bondi466 ↔ 501PROSITE-ProRule annotation
Disulfide bondi954 ↔ 964PROSITE-ProRule annotation
Glycosylationi971 – 9711N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1336 – 13361N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1345 – 13451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1491 – 14911N-linked (GlcNAc...)Sequence Analysis
Modified residuei1973 – 19731N6-acetyllysineBy similarity
Glycosylationi2094 – 20941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2522 – 25221N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2662 – 26621N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2741 – 27411N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2791 – 27911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2897 – 28971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi2944 – 29441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3063 – 30631N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3186 – 31861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3299 – 32991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3321 – 33211N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3428 – 34281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3715 – 37151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi3828 – 38281N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4203 – 42031N-linked (GlcNAc...)Sequence Analysis
Glycosylationi4232 – 42321N-linked (GlcNAc...)Sequence Analysis

Post-translational modificationi

Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiQ7TMA5.
PRIDEiQ7TMA5.

PTM databases

PhosphoSiteiQ7TMA5.

Expressioni

Tissue specificityi

Detected in intestine and liver (at protein level).1 Publication

Gene expression databases

ExpressionAtlasiQ7TMA5. baseline and differential.
GenevestigatoriQ7TMA5.

Interactioni

Subunit structurei

Interacts with PCSK9.By similarity

Protein-protein interaction databases

BioGridi248449. 1 interaction.
DIPiDIP-29910N.

Structurei

3D structure databases

ProteinModelPortaliQ7TMA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 660628VitellogeninPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni29 – 11385Heparin-bindingBy similarityAdd
BLAST
Regioni219 – 29375Heparin-bindingBy similarityAdd
BLAST
Regioni890 – 94758Heparin-bindingBy similarityAdd
BLAST
Regioni2010 – 2145136Heparin-bindingBy similarityAdd
BLAST
Regioni3123 – 319876Heparin-bindingBy similarityAdd
BLAST
Regioni3136 – 314611Basic (possible receptor binding region)By similarityAdd
BLAST
Regioni3336 – 335621LDL receptor bindingBy similarityAdd
BLAST
Regioni3346 – 3479134Heparin-bindingBy similarityAdd
BLAST
Regioni3349 – 33579Basic (possible receptor binding region)By similarity

Sequence similaritiesi

Contains 1 vitellogenin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG290405.
GeneTreeiENSGT00590000083139.
HOGENOMiHOG000034000.
HOVERGENiHBG050546.
InParanoidiQ7TMA5.
KOiK14462.
OMAiHIPEFQL.
OrthoDBiEOG7VB2DG.
PhylomeDBiQ7TMA5.
TreeFamiTF331316.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProiIPR022176. ApoB100_C.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
[Graphical view]
PfamiPF12491. ApoB100_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 1 hit.
SM00638. LPD_N. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEiPS51211. VITELLOGENIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7TMA5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGPQRPALRA PLLLLFLLLF LDTSVWAQDA TRFKHLRKYV YSYEAESSSG
60 70 80 90 100
VRGTADSRSA TKINCKVELE VPQVCTLIMR TSQCTLKEVY GFNPEGKALM
110 120 130 140 150
KKTKNSEEFA SAMSRYELKL AFPEGKRVAL YPDLGEPNYI LNIKRGIISA
160 170 180 190 200
LLVPPETEED KQVLFQDTVY GNCSTQVTVN SRKGTVATEM STERNLQHCD
210 220 230 240 250
GFQPISTSVS PLALIKGLVR PLSTLISSSQ SCQYTLEPKR KHVSEAICNE
260 270 280 290 300
QHLFLPFSYK NKYGIMTHVT QKLSLEDTPK INSRFFRGGI NQVGLAFEST
310 320 330 340 350
KSTSPPKQAD AVLKTLQELK KLSISEQNAQ RANLFHKLVT ELRGLSGEAI
360 370 380 390 400
TSLLPQLIEV SSPITLQALI QCGQPECYTH ILQWLKTEKA HPLLIDIVTY
410 420 430 440 450
LMALIPNPSV QRLQEIFNTA KELQSRATLY ALSHAVNSYY AIMDHSRSPV
460 470 480 490 500
LEDIAGYLMK QIDNECMGDE DRTFLILRVI GNMGRTMERV MPALKSSVLN
510 520 530 540 550
CVRSTKPSLQ IQKAALQALR KMEMGDEVRT ILFDTFVNDV APVEKRLAAY
560 570 580 590 600
LLLMRSPSSS DINKIAKLLQ WEQSEQVKNF VASHIANILN SEELYVQDLK
610 620 630 640 650
NLIKNALVNS RLPTIMDFRK FSRNYQISKS VSIPLFDPVS AKIEGNLVFD
660 670 680 690 700
PSSYLPKESM LKTTLTVFGI ASLDLFEIGL EGKGFEPTLE ALFGKQGFFP
710 720 730 740 750
DSVNKALYWV NGQVPDRVSK VLVDHFGYTK DDKHEQDMVN GIMPIVDKLI
760 770 780 790 800
KELKSKEIPE ARAYLRILGK ELGFVRLQDL QVLGKLLLNG AQTFRGVPQM
810 820 830 840 850
IVQAIREGSK DDLFLHYIFM ENAFELPTGV GLQLQVSSSG VFTPGIKAGV
860 870 880 890 900
RLELANIQAE LVAKPSVSLE FVTNMGIIIP DFAKSGVQMN TNFFHESGLE
910 920 930 940 950
ARVALKAGQL KVIIPSPKRP VKLFSGSNTL HLVSTTKTEV IPPLIENRKS
960 970 980 990 1000
WSTCKPFFTG MNYCTTGAYS NASSTESASY YPLTGDTRYE LELKPTGEVE
1010 1020 1030 1040 1050
QYSASATYEL LKEDKSLVDT LKFLVQAEGV QQSEATAMFK YNRRSRTLSS
1060 1070 1080 1090 1100
EVLIPGFDVN FGTILRVNDE SSKDKNTYKL ILDIQNKKIT EVSVVGHVSY
1110 1120 1130 1140 1150
DKKGDGKVKG VVSIPRLQAE ARSEVHTHWS PTKLLFQMDS SATAYGSTIS
1160 1170 1180 1190 1200
KRVAWRYDNE KIEFDWNTGT NVDTKKVASN FPVDLSRYPR MVHEYANGLL
1210 1220 1230 1240 1250
DHRVPQTDMT FRHMGSKLIV DHLNGLSELN LPKVGLPDFH IPDNLFLKTD
1260 1270 1280 1290 1300
GRVKYTLNKN RIEIDIPLPL GGKSSKDLKV PESVRTPALN FKSVGFHLPS
1310 1320 1330 1340 1350
QEVQIPTFTI PKTHQLQVPL LGILDLSTNV YSNLYNWSVS YTGGNTSRDH
1360 1370 1380 1390 1400
FSLQAQYRMK ADSVVDLFSY SVQGSGETTY DSKSTFTLSC DGSLHHKFLD
1410 1420 1430 1440 1450
SKFKVSHVEK FGNNPVSKGL LTFETSSALG PQMSATVQLD SKKKQHLYVK
1460 1470 1480 1490 1500
DIKVDGQFRV FSLYAQGEYG LSYERDSMTG QMSGESNMKF NSTYFQGTNQ
1510 1520 1530 1540 1550
IVGMYQDGML SVTSTSDLQD GIFKNTASLK YENYELTLKS DSSGQYENFA
1560 1570 1580 1590 1600
ASNKLDMTFS KQSALLRSEH QANYKSLRLV TLLSGSLTSQ GVELNADILG
1610 1620 1630 1640 1650
TDKINTGAHK STLKIAQDGV STSATTNLKY SPLLLENELN AELGLSGASM
1660 1670 1680 1690 1700
KLSTSGRFKE HHAKFSLDGR AALTEVSLGS IYQAMILGAD SKNVFNFKLS
1710 1720 1730 1740 1750
REGLKLSNDM MGSYAEMKLD HTHSLRISGL SLDFFSKMDN IYSGDKFYKQ
1760 1770 1780 1790 1800
NFNLQLQPYS FGITLSNDLK YDALVLTNNG RLRLEPLKLN VGGNFKGTYQ
1810 1820 1830 1840 1850
NNELKHIYTI SYTDLVVASY RADTVATVQG VEFSHRLNAD IEGLASSVDV
1860 1870 1880 1890 1900
TTSYSSDPLH FNNVFRFVLA PFTLGVDTHT SGDGKMSLWG EHTGQMYSKF
1910 1920 1930 1940 1950
LLKAEPLALT FSHDYKGSTS HNLLYKNSVS TALEHTLSAL LTPAEQTSSW
1960 1970 1980 1990 2000
KFKTSLNDKV YSQEFEAYNT KDKIGIELSG RADLSGLYSP IKVPFFYSEP
2010 2020 2030 2040 2050
VNVLNSLEIN DAFDEPREFT IDAVVKYDKN QDVHTISLPF FQSLPDYLER
2060 2070 2080 2090 2100
NRRGIISLLE AMKGELQRLS VDQFVRKYRV ALSRLPQQIH DYLNASDWER
2110 2120 2130 2140 2150
QVAGAKEKLT SFMENYRITD NDVLIALDSA KINLNEKLSQ LETYAIQFDQ
2160 2170 2180 2190 2200
YIRDNYDAQD LKRTIAQIID RIIEKLKMLD EQYHIRVNLA KSIHNLYLFV
2210 2220 2230 2240 2250
ENVDLNQISS SGASWIQNVD TKYQIRIQIQ EKLQHLRTQI HNIDIQQLAA
2260 2270 2280 2290 2300
ELKQQIEALD VPMHLDQLRT AILFQRISVI IERVKYFVMN LIEDFKVTEK
2310 2320 2330 2340 2350
INTFRVIVRE LIEKYEVDRQ IQVLMDKSIE LAHRYSLSEP LQKLSNVLQQ
2360 2370 2380 2390 2400
IEIKDYYDKL VGFIDDTVEW IKAVSFKNII EELNRLIDMS VKKLKAFDYH
2410 2420 2430 2440 2450
QFVDKTNSKI REMTQRINAE IQALELPQKT EALKLWVEDF KTTVSNSLEK
2460 2470 2480 2490 2500
LKDTKVTVVV DWLQDGLAQI KAQFQDALED VRDRIYQMDI QGELERCLSL
2510 2520 2530 2540 2550
VSQVYSTVVT YISDWWTLTA KNITDFAEQY STQKWAESVK ALVEQGFIVP
2560 2570 2580 2590 2600
EIQTFLGTMP AFEVSLHALQ EANFQTPDFI VPLTDLRIPS IWINFKMLKN
2610 2620 2630 2640 2650
VKIPLRFSTP EFTLLNTFRV RSFTIDLLEI KAKIIRTIDQ MLSSELQWPL
2660 2670 2680 2690 2700
PEVYLRDLEM VNISLARLSL PDFHVPEITI PEFTIPNVNL KDLQVPDLHI
2710 2720 2730 2740 2750
PEFQLPHLSC TTEIPAFGKL HSVLKIQSPL FILDASANIQ NITTSENKAE
2760 2770 2780 2790 2800
IVASVTARGE SKFEALNFDF QAQAQFLELN ANPLVLKESV NFSSKHVRME
2810 2820 2830 2840 2850
HEGKILVSGK ALEGKSDTVA RLHTEKNTVE FNNGIVVKIN NQFTLDSQTK
2860 2870 2880 2890 2900
YFHKLSVPRL DFSSKASLNN EIKTLLEAGH MAWTSSGTGS WNWACPNFSD
2910 2920 2930 2940 2950
EGIHSSKISF IVDGPIASFG LSNNINGKHL RVVQKLTSES GFLNYSRFEV
2960 2970 2980 2990 3000
ESKVESQHVG SSILTAEGRA LLGDAKAEMT GEHNANLNGK VIGTLKNSLF
3010 3020 3030 3040 3050
FSAQPFEITA STNNEGNLKV SFPLKLTGKI DFLNNYALFL SPHAQQASWQ
3060 3070 3080 3090 3100
LSTRFNQYKY NQNFSAINNE HNMEASIVMN GDANLDFLNI PLTIPEINLP
3110 3120 3130 3140 3150
YTRFTTPLLK DFSIWEETGL KEFLKTTKQS FDLSIKAQYK KNRDKHSVVI
3160 3170 3180 3190 3200
PLKMFYEFML NNVNSWDRKF EKVRDNALHF LTASYNETKI KFDKYKTENS
3210 3220 3230 3240 3250
LNQPSRTFQN RGHTIPVLNI EVSPFAVETL ASSHVIPKAI RTPSVTIPGP
3260 3270 3280 3290 3300
NIIVPSYRLV LPSLQLPVFH IPRTLFKFSL PDFKKLSTID NIYIPAMGNF
3310 3320 3330 3340 3350
TYDFSFKSSV ITLNTNAGLY NQSDLVARFL SSSSFVTDAL QYKLEGTSRL
3360 3370 3380 3390 3400
MRKKVLKLAT AVSLTNKFLK GSHDSTISLT KKNMEASVKT TANLHAPIFT
3410 3420 3430 3440 3450
MNFKQELNGN TKSKPTVSSS IELNYDFNSS KLHSAAKGGV DHKFSLESLT
3460 3470 3480 3490 3500
SYLSIESFTK GNIKGSFLSQ EYSGSVANEA NVYLNSKGTR SSVRLQGASN
3510 3520 3530 3540 3550
FAGIWNFEVG ENFAGEATLR RIYGTWEHNM INHLQVFSYF DTKGKQTCRA
3560 3570 3580 3590 3600
TLELSPWTMS TLLQVHVSQP SPLFDLHHFD QEVILKASTK NQKVSWKSEV
3610 3620 3630 3640 3650
QVESQVLQHN AHFSNDQEEV RLDIAGSLEG QLWDLENFFL PAFGKSLREL
3660 3670 3680 3690 3700
LQIDGKRQYL QASTSLHYTK NPNGYLLSLP VQELTDRFII PGLKLNDFSG
3710 3720 3730 3740 3750
IKIYKKLSTS PFALNLTMLP KVKFPGVDLL TQYSKPEGSS VPTFETTIPE
3760 3770 3780 3790 3800
IQLTVSQFTL PKSFPVGNTV FDLNKLTNLI ADVDLPSITL PEQTIEIPSL
3810 3820 3830 3840 3850
EFSVPAGIFI PFFGELTAHV GMASPLYNVT WSTGWKNKAD HVETFLDSTC
3860 3870 3880 3890 3900
SSTLQFLEYA LKVVGTHRIE NDKFIYKIKG TLQHCDFNVK YNEDGIFEGL
3910 3920 3930 3940 3950
WDLEGEAHLD ITSPALTDFH LHYKEDKTSV SASAASPAIG TVSLDASTDD
3960 3970 3980 3990 4000
QSVRLNVYFR PQSPPDNKLS IFKMEWRDKE SDGETYIKIN WEEEAAFRLL
4010 4020 4030 4040 4050
DSLKSNVPKA SEAVYDYVKK YHLGHASSEL RKSLQNDAEH AIRMVDEMNV
4060 4070 4080 4090 4100
NAQRVTRDTY QSLYKKMLAQ ESQSIPEKLK KMVLGSLVRI TQKYHMAVTW
4110 4120 4130 4140 4150
LMDSVIHFLK FNRVQFPGNA GTYTVDELYT IAMRETKKLL SQLFNGLGHL
4160 4170 4180 4190 4200
FSYVQDQVEK SRVINDITFK CPFSPTPCKL KDVLLIFRED LNILSNLGQQ
4210 4220 4230 4240 4250
DINFTTILSD FQSFLERLLD IIEEKIECLK NNESTCVPDH INMFFKTHIP
4260 4270 4280 4290 4300
FAFKSLRENI YSVFSEFNDF VQSILQEGSY KLQQVHQYMK AFREEYFDPS
4310 4320 4330 4340 4350
VVGWTVKYYE IEEKMVDLIK TLLAPLRDFY SEYSVTAADF ASKMSTQVEQ
4360 4370 4380 4390 4400
FVSRDIREYL SMLADINGKG REKVAELSIV VKERIKSWST AVAEITSDYL
4410 4420 4430 4440 4450
RQLHSKLQDF SDQLSGYYEK FVAESTRLID LSIQNYHMFL RYIAELLKKL
4460 4470 4480 4490 4500
QVATANNGLL KRGDFEAAVK LGIACLYNEG LSVSDEAYAE VNGLKASRFF
4510 4520 4530 4540 4550
SMDERLNMGS DPFIWLSICP PCFRKLRDFA GKGCWEAQPA LAKDCAGGSQ
4560 4570 4580 4590 4600
LGLEGKAFSE SVCQLFQASQ AVNKQQIFSV QKGLSDTVRY ILIGWLVEVA
4610 4620 4630 4640 4650
PMKDFTSLCL HLTVECVGRY LQRKLVPRYK LQLLGIACMV ICTWFISKEI
4660 4670 4680 4690 4700
LTIREAVRLT DNTYKYKDLV RVKREIISAL EGKIRIPTVV DYKEVLLTLV
4710 4720 4730 4740
PVTPRTQYLC SFLCELTLSV YTPAHLASAA LLLARLMHGQ TQP
Length:4,743
Mass (Da):536,024
Last modified:October 1, 2003 - v1
Checksum:iB01AD103F8EC5320
GO

RNA editingi

The stop codon (UAA) at position 2147 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY318958 mRNA. Translation: AAP85369.1.
AY321317 mRNA. Translation: AAP86249.1.
RefSeqiNP_062160.2. NM_019287.2.
UniGeneiRn.33815.

Genome annotation databases

EnsembliENSRNOT00000046811; ENSRNOP00000039779; ENSRNOG00000005542.
GeneIDi54225.
KEGGirno:54225.

Keywords - Coding sequence diversityi

RNA editing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY318958 mRNA. Translation: AAP85369.1 .
AY321317 mRNA. Translation: AAP86249.1 .
RefSeqi NP_062160.2. NM_019287.2.
UniGenei Rn.33815.

3D structure databases

ProteinModelPortali Q7TMA5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 248449. 1 interaction.
DIPi DIP-29910N.

PTM databases

PhosphoSitei Q7TMA5.

Proteomic databases

PaxDbi Q7TMA5.
PRIDEi Q7TMA5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000046811 ; ENSRNOP00000039779 ; ENSRNOG00000005542 .
GeneIDi 54225.
KEGGi rno:54225.

Organism-specific databases

CTDi 338.
RGDi 2129. Apob.

Phylogenomic databases

eggNOGi NOG290405.
GeneTreei ENSGT00590000083139.
HOGENOMi HOG000034000.
HOVERGENi HBG050546.
InParanoidi Q7TMA5.
KOi K14462.
OMAi HIPEFQL.
OrthoDBi EOG7VB2DG.
PhylomeDBi Q7TMA5.
TreeFami TF331316.

Enzyme and pathway databases

Reactomei REACT_198722. Scavenging by Class H Receptors.
REACT_198733. Scavenging by Class A Receptors.
REACT_198734. Scavenging by Class B Receptors.
REACT_198755. Scavenging by Class F Receptors.
REACT_199015. Retinoid metabolism and transport.

Miscellaneous databases

NextBioi 610644.
PROi Q7TMA5.

Gene expression databases

ExpressionAtlasi Q7TMA5. baseline and differential.
Genevestigatori Q7TMA5.

Family and domain databases

Gene3Di 1.10.472.10. 2 hits.
1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProi IPR022176. ApoB100_C.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
[Graphical view ]
Pfami PF12491. ApoB100_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
[Graphical view ]
SMARTi SM00385. CYCLIN. 1 hit.
SM00638. LPD_N. 1 hit.
[Graphical view ]
SUPFAMi SSF47954. SSF47954. 2 hits.
SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEi PS51211. VITELLOGENIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Liver regeneration after PH."
    Xu C.S., Li W.Q., Li Y.C., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  2. "Identification of circulating apolipoproteins synthesized by rat small intestine in vivo."
    Wu A.L., Windmueller H.G.
    J. Biol. Chem. 253:2525-2528(1978) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  3. "Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins."
    Van't Hooft F.M., Hardman D.A., Kane J.P., Havel R.J.
    Proc. Natl. Acad. Sci. U.S.A. 79:179-182(1982) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.
  4. "Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine."
    Tennyson G.E., Sabatos C.A., Higuchi K., Meglin N., Brewer H.B. Jr.
    Proc. Natl. Acad. Sci. U.S.A. 86:500-504(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: RNA EDITING.

Entry informationi

Entry nameiAPOB_RAT
AccessioniPrimary (citable) accession number: Q7TMA5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2003
Last modified: October 29, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3