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Q7TMA5 (APOB_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Apolipoprotein B-100

Short name=Apo B-100

Cleaved into the following chain:

  1. Apolipoprotein B-48
    Short name=Apo B-48
Gene names
Name:Apob
ORF Names:Aa1064, Ac1-060
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length4743 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Apolipoprotein B is a major protein constituent of chylomicrons (apo B-48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. Ref.2

Subunit structure

Interacts with PCSK9 By similarity.

Subcellular location

Cytoplasm By similarity. Secreted Ref.2.

Tissue specificity

Detected in intestine and liver (at protein level). Ref.2

Post-translational modification

Palmitoylated; structural requirement for proper assembly of the hydrophobic core of the lipoprotein particle By similarity.

Sequence similarities

Contains 1 vitellogenin domain.

RNA editing

Edited at position 2147.
The stop codon (UAA) at position 2147 is created by RNA editing. Apo B-48, derived from the fully edited RNA, is produced only in the intestine and is found in chylomicrons. Apo B-48 is a shortened form of apo B-100 which lacks the LDL-receptor region. The unedited version (apo B-100) is produced by the liver and is found in the VLDL and LDL. Ref.4

Ontologies

Keywords
   Biological processCholesterol metabolism
Lipid metabolism
Lipid transport
Steroid metabolism
Sterol metabolism
Transport
   Cellular componentChylomicron
Cytoplasm
LDL
Secreted
VLDL
   Coding sequence diversityRNA editing
   DiseaseAtherosclerosis
   DomainSignal
   LigandHeparin-binding
   PTMAcetylation
Disulfide bond
Glycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processartery morphogenesis

Inferred from electronic annotation. Source: Ensembl

cellular response to prostaglandin stimulus

Inferred from expression pattern PubMed 16545597. Source: RGD

cellular response to tumor necrosis factor

Inferred from expression pattern PubMed 17405916. Source: RGD

cholesterol efflux

Inferred from electronic annotation. Source: Ensembl

cholesterol homeostasis

Inferred from electronic annotation. Source: Ensembl

cholesterol metabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

fertilization

Inferred from electronic annotation. Source: Ensembl

in utero embryonic development

Inferred from electronic annotation. Source: Ensembl

lipid metabolic process

Inferred from direct assay PubMed 9931432. Source: RGD

lipoprotein biosynthetic process

Inferred from electronic annotation. Source: Ensembl

lipoprotein catabolic process

Inferred from electronic annotation. Source: Ensembl

lipoprotein transport

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle clearance

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle remodeling

Inferred from electronic annotation. Source: Ensembl

nervous system development

Inferred from electronic annotation. Source: Ensembl

positive regulation of cholesterol storage

Inferred from electronic annotation. Source: Ensembl

positive regulation of macrophage derived foam cell differentiation

Inferred from electronic annotation. Source: Ensembl

post-embryonic development

Inferred from electronic annotation. Source: Ensembl

regulation of cholesterol biosynthetic process

Inferred from electronic annotation. Source: Ensembl

response to carbohydrate

Inferred from direct assay PubMed 16672736. Source: RGD

response to lipopolysaccharide

Inferred from expression pattern PubMed 16719989. Source: RGD

response to organic substance

Inferred from expression pattern PubMed 15066220PubMed 16227197PubMed 17203948. Source: RGD

response to selenium ion

Inferred from expression pattern PubMed 16581047. Source: RGD

response to virus

Inferred from electronic annotation. Source: Ensembl

sperm motility

Inferred from electronic annotation. Source: Ensembl

spermatogenesis

Inferred from electronic annotation. Source: Ensembl

triglyceride catabolic process

Inferred from mutant phenotype PubMed 9290048. Source: RGD

triglyceride mobilization

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentcytoplasm

Inferred from sequence or structural similarity. Source: UniProtKB

endoplasmic reticulum

Inferred from electronic annotation. Source: Ensembl

extracellular space

Inferred from direct assay PubMed 16227197. Source: RGD

intermediate-density lipoprotein particle

Inferred from electronic annotation. Source: Ensembl

intracellular membrane-bounded organelle

Inferred from direct assay PubMed 12091487. Source: RGD

low-density lipoprotein particle

Inferred from electronic annotation. Source: UniProtKB-KW

mature chylomicron

Inferred from electronic annotation. Source: Ensembl

very-low-density lipoprotein particle

Inferred from direct assay PubMed 17500069. Source: RGD

vesicle lumen

Inferred from direct assay PubMed 12091487. Source: RGD

vesicle membrane

Inferred from direct assay PubMed 12091487. Source: RGD

   Molecular_functioncholesterol transporter activity

Inferred from electronic annotation. Source: Ensembl

heparin binding

Inferred from electronic annotation. Source: UniProtKB-KW

lipid binding

Inferred from mutant phenotype PubMed 12091487. Source: RGD

phospholipid binding

Inferred from electronic annotation. Source: Ensembl

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2727 By similarity
Chain28 – 47434716Apolipoprotein B-100
PRO_0000293536
Chain28 – 21462119Apolipoprotein B-48
PRO_0000293537

Regions

Domain33 – 660628Vitellogenin
Region29 – 11385Heparin-binding By similarity
Region219 – 29375Heparin-binding By similarity
Region890 – 94758Heparin-binding By similarity
Region2010 – 2145136Heparin-binding By similarity
Region3123 – 319876Heparin-binding By similarity
Region3136 – 314611Basic (possible receptor binding region) By similarity
Region3336 – 335621LDL receptor binding By similarity
Region3346 – 3479134Heparin-binding By similarity
Region3349 – 33579Basic (possible receptor binding region) By similarity

Amino acid modifications

Modified residue19731N6-acetyllysine By similarity
Glycosylation1721N-linked (GlcNAc...) Potential
Glycosylation9711N-linked (GlcNAc...) Potential
Glycosylation13361N-linked (GlcNAc...) Potential
Glycosylation13451N-linked (GlcNAc...) Potential
Glycosylation14911N-linked (GlcNAc...) Potential
Glycosylation20941N-linked (GlcNAc...) Potential
Glycosylation25221N-linked (GlcNAc...) Potential
Glycosylation26621N-linked (GlcNAc...) Potential
Glycosylation27411N-linked (GlcNAc...) Potential
Glycosylation27911N-linked (GlcNAc...) Potential
Glycosylation28971N-linked (GlcNAc...) Potential
Glycosylation29441N-linked (GlcNAc...) Potential
Glycosylation30631N-linked (GlcNAc...) Potential
Glycosylation31861N-linked (GlcNAc...) Potential
Glycosylation32991N-linked (GlcNAc...) Potential
Glycosylation33211N-linked (GlcNAc...) Potential
Glycosylation34281N-linked (GlcNAc...) Potential
Glycosylation37151N-linked (GlcNAc...) Potential
Glycosylation38281N-linked (GlcNAc...) Potential
Glycosylation42031N-linked (GlcNAc...) Potential
Glycosylation42321N-linked (GlcNAc...) Potential
Disulfide bond65 ↔ 84 By similarity
Disulfide bond173 ↔ 199 By similarity
Disulfide bond232 ↔ 248 By similarity
Disulfide bond372 ↔ 377 By similarity
Disulfide bond466 ↔ 501 By similarity
Disulfide bond954 ↔ 964 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7TMA5 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: B01AD103F8EC5320

FASTA4,743536,024
        10         20         30         40         50         60 
MGPQRPALRA PLLLLFLLLF LDTSVWAQDA TRFKHLRKYV YSYEAESSSG VRGTADSRSA 

        70         80         90        100        110        120 
TKINCKVELE VPQVCTLIMR TSQCTLKEVY GFNPEGKALM KKTKNSEEFA SAMSRYELKL 

       130        140        150        160        170        180 
AFPEGKRVAL YPDLGEPNYI LNIKRGIISA LLVPPETEED KQVLFQDTVY GNCSTQVTVN 

       190        200        210        220        230        240 
SRKGTVATEM STERNLQHCD GFQPISTSVS PLALIKGLVR PLSTLISSSQ SCQYTLEPKR 

       250        260        270        280        290        300 
KHVSEAICNE QHLFLPFSYK NKYGIMTHVT QKLSLEDTPK INSRFFRGGI NQVGLAFEST 

       310        320        330        340        350        360 
KSTSPPKQAD AVLKTLQELK KLSISEQNAQ RANLFHKLVT ELRGLSGEAI TSLLPQLIEV 

       370        380        390        400        410        420 
SSPITLQALI QCGQPECYTH ILQWLKTEKA HPLLIDIVTY LMALIPNPSV QRLQEIFNTA 

       430        440        450        460        470        480 
KELQSRATLY ALSHAVNSYY AIMDHSRSPV LEDIAGYLMK QIDNECMGDE DRTFLILRVI 

       490        500        510        520        530        540 
GNMGRTMERV MPALKSSVLN CVRSTKPSLQ IQKAALQALR KMEMGDEVRT ILFDTFVNDV 

       550        560        570        580        590        600 
APVEKRLAAY LLLMRSPSSS DINKIAKLLQ WEQSEQVKNF VASHIANILN SEELYVQDLK 

       610        620        630        640        650        660 
NLIKNALVNS RLPTIMDFRK FSRNYQISKS VSIPLFDPVS AKIEGNLVFD PSSYLPKESM 

       670        680        690        700        710        720 
LKTTLTVFGI ASLDLFEIGL EGKGFEPTLE ALFGKQGFFP DSVNKALYWV NGQVPDRVSK 

       730        740        750        760        770        780 
VLVDHFGYTK DDKHEQDMVN GIMPIVDKLI KELKSKEIPE ARAYLRILGK ELGFVRLQDL 

       790        800        810        820        830        840 
QVLGKLLLNG AQTFRGVPQM IVQAIREGSK DDLFLHYIFM ENAFELPTGV GLQLQVSSSG 

       850        860        870        880        890        900 
VFTPGIKAGV RLELANIQAE LVAKPSVSLE FVTNMGIIIP DFAKSGVQMN TNFFHESGLE 

       910        920        930        940        950        960 
ARVALKAGQL KVIIPSPKRP VKLFSGSNTL HLVSTTKTEV IPPLIENRKS WSTCKPFFTG 

       970        980        990       1000       1010       1020 
MNYCTTGAYS NASSTESASY YPLTGDTRYE LELKPTGEVE QYSASATYEL LKEDKSLVDT 

      1030       1040       1050       1060       1070       1080 
LKFLVQAEGV QQSEATAMFK YNRRSRTLSS EVLIPGFDVN FGTILRVNDE SSKDKNTYKL 

      1090       1100       1110       1120       1130       1140 
ILDIQNKKIT EVSVVGHVSY DKKGDGKVKG VVSIPRLQAE ARSEVHTHWS PTKLLFQMDS 

      1150       1160       1170       1180       1190       1200 
SATAYGSTIS KRVAWRYDNE KIEFDWNTGT NVDTKKVASN FPVDLSRYPR MVHEYANGLL 

      1210       1220       1230       1240       1250       1260 
DHRVPQTDMT FRHMGSKLIV DHLNGLSELN LPKVGLPDFH IPDNLFLKTD GRVKYTLNKN 

      1270       1280       1290       1300       1310       1320 
RIEIDIPLPL GGKSSKDLKV PESVRTPALN FKSVGFHLPS QEVQIPTFTI PKTHQLQVPL 

      1330       1340       1350       1360       1370       1380 
LGILDLSTNV YSNLYNWSVS YTGGNTSRDH FSLQAQYRMK ADSVVDLFSY SVQGSGETTY 

      1390       1400       1410       1420       1430       1440 
DSKSTFTLSC DGSLHHKFLD SKFKVSHVEK FGNNPVSKGL LTFETSSALG PQMSATVQLD 

      1450       1460       1470       1480       1490       1500 
SKKKQHLYVK DIKVDGQFRV FSLYAQGEYG LSYERDSMTG QMSGESNMKF NSTYFQGTNQ 

      1510       1520       1530       1540       1550       1560 
IVGMYQDGML SVTSTSDLQD GIFKNTASLK YENYELTLKS DSSGQYENFA ASNKLDMTFS 

      1570       1580       1590       1600       1610       1620 
KQSALLRSEH QANYKSLRLV TLLSGSLTSQ GVELNADILG TDKINTGAHK STLKIAQDGV 

      1630       1640       1650       1660       1670       1680 
STSATTNLKY SPLLLENELN AELGLSGASM KLSTSGRFKE HHAKFSLDGR AALTEVSLGS 

      1690       1700       1710       1720       1730       1740 
IYQAMILGAD SKNVFNFKLS REGLKLSNDM MGSYAEMKLD HTHSLRISGL SLDFFSKMDN 

      1750       1760       1770       1780       1790       1800 
IYSGDKFYKQ NFNLQLQPYS FGITLSNDLK YDALVLTNNG RLRLEPLKLN VGGNFKGTYQ 

      1810       1820       1830       1840       1850       1860 
NNELKHIYTI SYTDLVVASY RADTVATVQG VEFSHRLNAD IEGLASSVDV TTSYSSDPLH 

      1870       1880       1890       1900       1910       1920 
FNNVFRFVLA PFTLGVDTHT SGDGKMSLWG EHTGQMYSKF LLKAEPLALT FSHDYKGSTS 

      1930       1940       1950       1960       1970       1980 
HNLLYKNSVS TALEHTLSAL LTPAEQTSSW KFKTSLNDKV YSQEFEAYNT KDKIGIELSG 

      1990       2000       2010       2020       2030       2040 
RADLSGLYSP IKVPFFYSEP VNVLNSLEIN DAFDEPREFT IDAVVKYDKN QDVHTISLPF 

      2050       2060       2070       2080       2090       2100 
FQSLPDYLER NRRGIISLLE AMKGELQRLS VDQFVRKYRV ALSRLPQQIH DYLNASDWER 

      2110       2120       2130       2140       2150       2160 
QVAGAKEKLT SFMENYRITD NDVLIALDSA KINLNEKLSQ LETYAIQFDQ YIRDNYDAQD 

      2170       2180       2190       2200       2210       2220 
LKRTIAQIID RIIEKLKMLD EQYHIRVNLA KSIHNLYLFV ENVDLNQISS SGASWIQNVD 

      2230       2240       2250       2260       2270       2280 
TKYQIRIQIQ EKLQHLRTQI HNIDIQQLAA ELKQQIEALD VPMHLDQLRT AILFQRISVI 

      2290       2300       2310       2320       2330       2340 
IERVKYFVMN LIEDFKVTEK INTFRVIVRE LIEKYEVDRQ IQVLMDKSIE LAHRYSLSEP 

      2350       2360       2370       2380       2390       2400 
LQKLSNVLQQ IEIKDYYDKL VGFIDDTVEW IKAVSFKNII EELNRLIDMS VKKLKAFDYH 

      2410       2420       2430       2440       2450       2460 
QFVDKTNSKI REMTQRINAE IQALELPQKT EALKLWVEDF KTTVSNSLEK LKDTKVTVVV 

      2470       2480       2490       2500       2510       2520 
DWLQDGLAQI KAQFQDALED VRDRIYQMDI QGELERCLSL VSQVYSTVVT YISDWWTLTA 

      2530       2540       2550       2560       2570       2580 
KNITDFAEQY STQKWAESVK ALVEQGFIVP EIQTFLGTMP AFEVSLHALQ EANFQTPDFI 

      2590       2600       2610       2620       2630       2640 
VPLTDLRIPS IWINFKMLKN VKIPLRFSTP EFTLLNTFRV RSFTIDLLEI KAKIIRTIDQ 

      2650       2660       2670       2680       2690       2700 
MLSSELQWPL PEVYLRDLEM VNISLARLSL PDFHVPEITI PEFTIPNVNL KDLQVPDLHI 

      2710       2720       2730       2740       2750       2760 
PEFQLPHLSC TTEIPAFGKL HSVLKIQSPL FILDASANIQ NITTSENKAE IVASVTARGE 

      2770       2780       2790       2800       2810       2820 
SKFEALNFDF QAQAQFLELN ANPLVLKESV NFSSKHVRME HEGKILVSGK ALEGKSDTVA 

      2830       2840       2850       2860       2870       2880 
RLHTEKNTVE FNNGIVVKIN NQFTLDSQTK YFHKLSVPRL DFSSKASLNN EIKTLLEAGH 

      2890       2900       2910       2920       2930       2940 
MAWTSSGTGS WNWACPNFSD EGIHSSKISF IVDGPIASFG LSNNINGKHL RVVQKLTSES 

      2950       2960       2970       2980       2990       3000 
GFLNYSRFEV ESKVESQHVG SSILTAEGRA LLGDAKAEMT GEHNANLNGK VIGTLKNSLF 

      3010       3020       3030       3040       3050       3060 
FSAQPFEITA STNNEGNLKV SFPLKLTGKI DFLNNYALFL SPHAQQASWQ LSTRFNQYKY 

      3070       3080       3090       3100       3110       3120 
NQNFSAINNE HNMEASIVMN GDANLDFLNI PLTIPEINLP YTRFTTPLLK DFSIWEETGL 

      3130       3140       3150       3160       3170       3180 
KEFLKTTKQS FDLSIKAQYK KNRDKHSVVI PLKMFYEFML NNVNSWDRKF EKVRDNALHF 

      3190       3200       3210       3220       3230       3240 
LTASYNETKI KFDKYKTENS LNQPSRTFQN RGHTIPVLNI EVSPFAVETL ASSHVIPKAI 

      3250       3260       3270       3280       3290       3300 
RTPSVTIPGP NIIVPSYRLV LPSLQLPVFH IPRTLFKFSL PDFKKLSTID NIYIPAMGNF 

      3310       3320       3330       3340       3350       3360 
TYDFSFKSSV ITLNTNAGLY NQSDLVARFL SSSSFVTDAL QYKLEGTSRL MRKKVLKLAT 

      3370       3380       3390       3400       3410       3420 
AVSLTNKFLK GSHDSTISLT KKNMEASVKT TANLHAPIFT MNFKQELNGN TKSKPTVSSS 

      3430       3440       3450       3460       3470       3480 
IELNYDFNSS KLHSAAKGGV DHKFSLESLT SYLSIESFTK GNIKGSFLSQ EYSGSVANEA 

      3490       3500       3510       3520       3530       3540 
NVYLNSKGTR SSVRLQGASN FAGIWNFEVG ENFAGEATLR RIYGTWEHNM INHLQVFSYF 

      3550       3560       3570       3580       3590       3600 
DTKGKQTCRA TLELSPWTMS TLLQVHVSQP SPLFDLHHFD QEVILKASTK NQKVSWKSEV 

      3610       3620       3630       3640       3650       3660 
QVESQVLQHN AHFSNDQEEV RLDIAGSLEG QLWDLENFFL PAFGKSLREL LQIDGKRQYL 

      3670       3680       3690       3700       3710       3720 
QASTSLHYTK NPNGYLLSLP VQELTDRFII PGLKLNDFSG IKIYKKLSTS PFALNLTMLP 

      3730       3740       3750       3760       3770       3780 
KVKFPGVDLL TQYSKPEGSS VPTFETTIPE IQLTVSQFTL PKSFPVGNTV FDLNKLTNLI 

      3790       3800       3810       3820       3830       3840 
ADVDLPSITL PEQTIEIPSL EFSVPAGIFI PFFGELTAHV GMASPLYNVT WSTGWKNKAD 

      3850       3860       3870       3880       3890       3900 
HVETFLDSTC SSTLQFLEYA LKVVGTHRIE NDKFIYKIKG TLQHCDFNVK YNEDGIFEGL 

      3910       3920       3930       3940       3950       3960 
WDLEGEAHLD ITSPALTDFH LHYKEDKTSV SASAASPAIG TVSLDASTDD QSVRLNVYFR 

      3970       3980       3990       4000       4010       4020 
PQSPPDNKLS IFKMEWRDKE SDGETYIKIN WEEEAAFRLL DSLKSNVPKA SEAVYDYVKK 

      4030       4040       4050       4060       4070       4080 
YHLGHASSEL RKSLQNDAEH AIRMVDEMNV NAQRVTRDTY QSLYKKMLAQ ESQSIPEKLK 

      4090       4100       4110       4120       4130       4140 
KMVLGSLVRI TQKYHMAVTW LMDSVIHFLK FNRVQFPGNA GTYTVDELYT IAMRETKKLL 

      4150       4160       4170       4180       4190       4200 
SQLFNGLGHL FSYVQDQVEK SRVINDITFK CPFSPTPCKL KDVLLIFRED LNILSNLGQQ 

      4210       4220       4230       4240       4250       4260 
DINFTTILSD FQSFLERLLD IIEEKIECLK NNESTCVPDH INMFFKTHIP FAFKSLRENI 

      4270       4280       4290       4300       4310       4320 
YSVFSEFNDF VQSILQEGSY KLQQVHQYMK AFREEYFDPS VVGWTVKYYE IEEKMVDLIK 

      4330       4340       4350       4360       4370       4380 
TLLAPLRDFY SEYSVTAADF ASKMSTQVEQ FVSRDIREYL SMLADINGKG REKVAELSIV 

      4390       4400       4410       4420       4430       4440 
VKERIKSWST AVAEITSDYL RQLHSKLQDF SDQLSGYYEK FVAESTRLID LSIQNYHMFL 

      4450       4460       4470       4480       4490       4500 
RYIAELLKKL QVATANNGLL KRGDFEAAVK LGIACLYNEG LSVSDEAYAE VNGLKASRFF 

      4510       4520       4530       4540       4550       4560 
SMDERLNMGS DPFIWLSICP PCFRKLRDFA GKGCWEAQPA LAKDCAGGSQ LGLEGKAFSE 

      4570       4580       4590       4600       4610       4620 
SVCQLFQASQ AVNKQQIFSV QKGLSDTVRY ILIGWLVEVA PMKDFTSLCL HLTVECVGRY 

      4630       4640       4650       4660       4670       4680 
LQRKLVPRYK LQLLGIACMV ICTWFISKEI LTIREAVRLT DNTYKYKDLV RVKREIISAL 

      4690       4700       4710       4720       4730       4740 
EGKIRIPTVV DYKEVLLTLV PVTPRTQYLC SFLCELTLSV YTPAHLASAA LLLARLMHGQ 


TQP 

« Hide

References

« Hide 'large scale' references
[1]"Liver regeneration after PH."
Xu C.S., Li W.Q., Li Y.C., Wang G.P., Chai L.Q., Yuan J.Y., Yang K.J., Yan H.M., Chang C.F., Zhao L.F., Ma H., Wang L., Wang S.F., Han H.P., Shi J.B., Rahman S., Wang Q.N., Zhang J.B.
Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.
[2]"Identification of circulating apolipoproteins synthesized by rat small intestine in vivo."
Wu A.L., Windmueller H.G.
J. Biol. Chem. 253:2525-2528(1978) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
[3]"Apolipoprotein B (B-48) of rat chylomicrons is not a precursor of the apolipoprotein of low density lipoproteins."
Van't Hooft F.M., Hardman D.A., Kane J.P., Havel R.J.
Proc. Natl. Acad. Sci. U.S.A. 79:179-182(1982) [PubMed] [Europe PMC] [Abstract]
Cited for: CHARACTERIZATION.
[4]"Expression of apolipoprotein B mRNAs encoding higher- and lower-molecular weight isoproteins in rat liver and intestine."
Tennyson G.E., Sabatos C.A., Higuchi K., Meglin N., Brewer H.B. Jr.
Proc. Natl. Acad. Sci. U.S.A. 86:500-504(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: RNA EDITING.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY318958 mRNA. Translation: AAP85369.1.
AY321317 mRNA. Translation: AAP86249.1.
RefSeqNP_062160.2. NM_019287.2.
UniGeneRn.33815.

3D structure databases

ProteinModelPortalQ7TMA5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid248449. 1 interaction.
DIPDIP-29910N.

PTM databases

PhosphoSiteQ7TMA5.

Proteomic databases

PaxDbQ7TMA5.
PRIDEQ7TMA5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000046811; ENSRNOP00000039779; ENSRNOG00000005542.
GeneID54225.
KEGGrno:54225.

Organism-specific databases

CTD338.
RGD2129. Apob.

Phylogenomic databases

eggNOGNOG290405.
GeneTreeENSGT00590000083139.
HOGENOMHOG000034000.
HOVERGENHBG050546.
InParanoidQ7TMA5.
KOK14462.
OMAHIPEFQL.
OrthoDBEOG7VB2DG.
PhylomeDBQ7TMA5.
TreeFamTF331316.

Gene expression databases

GenevestigatorQ7TMA5.

Family and domain databases

Gene3D1.10.472.10. 2 hits.
1.25.10.20. 1 hit.
2.20.50.20. 2 hits.
2.20.80.10. 1 hit.
2.30.230.10. 1 hit.
InterProIPR022176. ApoB100_C.
IPR013763. Cyclin-like.
IPR006671. Cyclin_N.
IPR015819. Lipid_transp_b-sht_shell.
IPR001747. Lipid_transpt_N.
IPR009454. Lipid_transpt_open_b-sht.
IPR015816. Vitellinogen_b-sht_N.
IPR015255. Vitellinogen_open_b-sht.
IPR015817. Vitellinogen_open_b-sht_sub1.
IPR015818. Vitellinogen_open_b-sht_sub2.
IPR011030. Vitellinogen_superhlx.
[Graphical view]
PfamPF12491. ApoB100_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF06448. DUF1081. 1 hit.
PF09172. DUF1943. 1 hit.
PF01347. Vitellogenin_N. 1 hit.
[Graphical view]
SMARTSM00385. CYCLIN. 1 hit.
SM00638. LPD_N. 1 hit.
[Graphical view]
SUPFAMSSF47954. SSF47954. 2 hits.
SSF48431. SSF48431. 1 hit.
SSF56968. SSF56968. 2 hits.
PROSITEPS51211. VITELLOGENIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio610644.
PROQ7TMA5.

Entry information

Entry nameAPOB_RAT
AccessionPrimary (citable) accession number: Q7TMA5
Entry history
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families