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Q7TM99

- MOT9_MOUSE

UniProt

Q7TM99 - MOT9_MOUSE

Protein

Monocarboxylate transporter 9

Gene

Slc16a9

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 87 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.By similarity

    GO - Molecular functioni

    1. symporter activity Source: UniProtKB-KW

    GO - Biological processi

    1. urate metabolic process Source: Ensembl

    Keywords - Biological processi

    Symport, Transport

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Monocarboxylate transporter 9
    Short name:
    MCT 9
    Alternative name(s):
    Solute carrier family 16 member 9
    Gene namesi
    Name:Slc16a9
    Synonyms:Mct9
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 10

    Organism-specific databases

    MGIiMGI:1914109. Slc16a9.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 508508Monocarboxylate transporter 9PRO_0000289333Add
    BLAST

    Proteomic databases

    PRIDEiQ7TM99.

    PTM databases

    PhosphoSiteiQ7TM99.

    Expressioni

    Gene expression databases

    ArrayExpressiQ7TM99.
    BgeeiQ7TM99.
    GenevestigatoriQ7TM99.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000047912.

    Structurei

    3D structure databases

    ProteinModelPortaliQ7TM99.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini34 – 5219CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini74 – 796ExtracellularSequence Analysis
    Topological domaini101 – 1011CytoplasmicSequence Analysis
    Topological domaini123 – 13614ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini158 – 1636CytoplasmicSequence Analysis
    Topological domaini185 – 302118ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini324 – 34017CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini362 – 3698ExtracellularSequence Analysis
    Topological domaini391 – 3955CytoplasmicSequence Analysis
    Topological domaini417 – 43014ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini452 – 4598CytoplasmicSequence Analysis
    Topological domaini481 – 50828ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei13 – 3321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei80 – 10021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei102 – 12221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei137 – 15721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei164 – 18421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei303 – 32321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei341 – 36121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei370 – 39021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei396 – 41621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei460 – 48021HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    GeneTreeiENSGT00740000114926.
    HOGENOMiHOG000113632.
    HOVERGENiHBG097515.
    InParanoidiQ7TM99.
    KOiK08186.
    OMAiATLIIMG.
    OrthoDBiEOG7TMZRG.
    PhylomeDBiQ7TM99.
    TreeFamiTF313792.

    Family and domain databases

    InterProiIPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view]
    PfamiPF07690. MFS_1. 2 hits.
    [Graphical view]
    SUPFAMiSSF103473. SSF103473. 2 hits.
    PROSITEiPS50850. MFS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7TM99-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEFQKSPDGG WGWVIVVVSF FTQFLSYGSP LAVGVLYVEW LDAFGEGKGK    50
    TAWVGSLASG VGLLASPVCS LFVSSFGARP VTIFSGFLVA GGLMLSSLAP 100
    NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDSRRGLAL GLISTGSSVG 150
    LFIYAALQRM LIEFYGLDGC LLIVGALALN ILACGSLMRP LQTSDCPFPE 200
    KTAPENVPDR YSMYNEKEKN PEETMNFQDK GYSSEDKCLP NGDWGRETSL 250
    PKSLAIAAHT KEPETYKKKV VEQTNFCKQL AKRKWQLYRN YCGETASLFK 300
    NKVFSALFIA ILLFDIGGFP PSLLMEDVAR SYHVREEDLT MPLISIFGIM 350
    TAVGKLLLGI LADFKWINTL YLYVATLIIT GLALCAIPFA KSYVTLAILS 400
    GILGFLTGNW SIFPYVTTKT VGIDKLAHAY GILMFFAGLG NSLGPPIVGW 450
    FYDWTQTYDI AFYFSGFCVL LGGFILLLAI LPCWDMCNKK LPKPAVPTTF 500
    FYKVASNV 508
    Length:508
    Mass (Da):55,757
    Last modified:October 1, 2003 - v1
    Checksum:iEB86866D96B46AB6
    GO

    Sequence cautioni

    The sequence AAH34205.1 differs from that shown. Reason: Frameshift at position 490.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004556 mRNA. Translation: BAB23369.2.
    AK004599 mRNA. Translation: BAB23400.2.
    AK004684 mRNA. Translation: BAB23471.2.
    BC034205 mRNA. Translation: AAH34205.1. Frameshift.
    BC055839 mRNA. Translation: AAH55839.1.
    CCDSiCCDS23913.1.
    RefSeqiNP_080083.2. NM_025807.3.
    XP_006514023.1. XM_006513960.1.
    UniGeneiMm.19325.

    Genome annotation databases

    EnsembliENSMUST00000046807; ENSMUSP00000047912; ENSMUSG00000037762.
    GeneIDi66859.
    KEGGimmu:66859.
    UCSCiuc007fnq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK004556 mRNA. Translation: BAB23369.2 .
    AK004599 mRNA. Translation: BAB23400.2 .
    AK004684 mRNA. Translation: BAB23471.2 .
    BC034205 mRNA. Translation: AAH34205.1 . Frameshift.
    BC055839 mRNA. Translation: AAH55839.1 .
    CCDSi CCDS23913.1.
    RefSeqi NP_080083.2. NM_025807.3.
    XP_006514023.1. XM_006513960.1.
    UniGenei Mm.19325.

    3D structure databases

    ProteinModelPortali Q7TM99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000047912.

    PTM databases

    PhosphoSitei Q7TM99.

    Proteomic databases

    PRIDEi Q7TM99.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000046807 ; ENSMUSP00000047912 ; ENSMUSG00000037762 .
    GeneIDi 66859.
    KEGGi mmu:66859.
    UCSCi uc007fnq.1. mouse.

    Organism-specific databases

    CTDi 220963.
    MGIi MGI:1914109. Slc16a9.

    Phylogenomic databases

    eggNOGi COG0477.
    GeneTreei ENSGT00740000114926.
    HOGENOMi HOG000113632.
    HOVERGENi HBG097515.
    InParanoidi Q7TM99.
    KOi K08186.
    OMAi ATLIIMG.
    OrthoDBi EOG7TMZRG.
    PhylomeDBi Q7TM99.
    TreeFami TF313792.

    Miscellaneous databases

    NextBioi 322839.
    PROi Q7TM99.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q7TM99.
    Bgeei Q7TM99.
    Genevestigatori Q7TM99.

    Family and domain databases

    InterProi IPR011701. MFS.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    [Graphical view ]
    Pfami PF07690. MFS_1. 2 hits.
    [Graphical view ]
    SUPFAMi SSF103473. SSF103473. 2 hits.
    PROSITEi PS50850. MFS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Lung and Testis.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Colon and Kidney.

    Entry informationi

    Entry nameiMOT9_MOUSE
    AccessioniPrimary (citable) accession number: Q7TM99
    Secondary accession number(s): Q0P652
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 29, 2007
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 87 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3