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Q7TM99

- MOT9_MOUSE

UniProt

Q7TM99 - MOT9_MOUSE

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Protein
Monocarboxylate transporter 9
Gene
Slc16a9, Mct9
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.

GO - Molecular functioni

  1. symporter activity Source: UniProtKB-KW

GO - Biological processi

  1. urate metabolic process Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 9
Short name:
MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene namesi
Name:Slc16a9
Synonyms:Mct9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:1914109. Slc16a9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212Extracellular Reviewed prediction
Add
BLAST
Transmembranei13 – 3321Helical; Reviewed prediction
Add
BLAST
Topological domaini34 – 5219Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei53 – 7321Helical; Reviewed prediction
Add
BLAST
Topological domaini74 – 796Extracellular Reviewed prediction
Transmembranei80 – 10021Helical; Reviewed prediction
Add
BLAST
Topological domaini101 – 1011Cytoplasmic Reviewed prediction
Transmembranei102 – 12221Helical; Reviewed prediction
Add
BLAST
Topological domaini123 – 13614Extracellular Reviewed prediction
Add
BLAST
Transmembranei137 – 15721Helical; Reviewed prediction
Add
BLAST
Topological domaini158 – 1636Cytoplasmic Reviewed prediction
Transmembranei164 – 18421Helical; Reviewed prediction
Add
BLAST
Topological domaini185 – 302118Extracellular Reviewed prediction
Add
BLAST
Transmembranei303 – 32321Helical; Reviewed prediction
Add
BLAST
Topological domaini324 – 34017Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei341 – 36121Helical; Reviewed prediction
Add
BLAST
Topological domaini362 – 3698Extracellular Reviewed prediction
Transmembranei370 – 39021Helical; Reviewed prediction
Add
BLAST
Topological domaini391 – 3955Cytoplasmic Reviewed prediction
Transmembranei396 – 41621Helical; Reviewed prediction
Add
BLAST
Topological domaini417 – 43014Extracellular Reviewed prediction
Add
BLAST
Transmembranei431 – 45121Helical; Reviewed prediction
Add
BLAST
Topological domaini452 – 4598Cytoplasmic Reviewed prediction
Transmembranei460 – 48021Helical; Reviewed prediction
Add
BLAST
Topological domaini481 – 50828Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Monocarboxylate transporter 9
PRO_0000289333Add
BLAST

Proteomic databases

PRIDEiQ7TM99.

PTM databases

PhosphoSiteiQ7TM99.

Expressioni

Gene expression databases

ArrayExpressiQ7TM99.
BgeeiQ7TM99.
GenevestigatoriQ7TM99.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047912.

Structurei

3D structure databases

ProteinModelPortaliQ7TM99.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00740000114926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7TM99.
KOiK08186.
OMAiATLIIMG.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7TM99.
TreeFamiTF313792.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TM99-1 [UniParc]FASTAAdd to Basket

« Hide

MEFQKSPDGG WGWVIVVVSF FTQFLSYGSP LAVGVLYVEW LDAFGEGKGK    50
TAWVGSLASG VGLLASPVCS LFVSSFGARP VTIFSGFLVA GGLMLSSLAP 100
NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDSRRGLAL GLISTGSSVG 150
LFIYAALQRM LIEFYGLDGC LLIVGALALN ILACGSLMRP LQTSDCPFPE 200
KTAPENVPDR YSMYNEKEKN PEETMNFQDK GYSSEDKCLP NGDWGRETSL 250
PKSLAIAAHT KEPETYKKKV VEQTNFCKQL AKRKWQLYRN YCGETASLFK 300
NKVFSALFIA ILLFDIGGFP PSLLMEDVAR SYHVREEDLT MPLISIFGIM 350
TAVGKLLLGI LADFKWINTL YLYVATLIIT GLALCAIPFA KSYVTLAILS 400
GILGFLTGNW SIFPYVTTKT VGIDKLAHAY GILMFFAGLG NSLGPPIVGW 450
FYDWTQTYDI AFYFSGFCVL LGGFILLLAI LPCWDMCNKK LPKPAVPTTF 500
FYKVASNV 508
Length:508
Mass (Da):55,757
Last modified:October 1, 2003 - v1
Checksum:iEB86866D96B46AB6
GO

Sequence cautioni

The sequence AAH34205.1 differs from that shown. Reason: Frameshift at position 490.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004556 mRNA. Translation: BAB23369.2.
AK004599 mRNA. Translation: BAB23400.2.
AK004684 mRNA. Translation: BAB23471.2.
BC034205 mRNA. Translation: AAH34205.1. Frameshift.
BC055839 mRNA. Translation: AAH55839.1.
CCDSiCCDS23913.1.
RefSeqiNP_080083.2. NM_025807.3.
XP_006514023.1. XM_006513960.1.
UniGeneiMm.19325.

Genome annotation databases

EnsembliENSMUST00000046807; ENSMUSP00000047912; ENSMUSG00000037762.
GeneIDi66859.
KEGGimmu:66859.
UCSCiuc007fnq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK004556 mRNA. Translation: BAB23369.2 .
AK004599 mRNA. Translation: BAB23400.2 .
AK004684 mRNA. Translation: BAB23471.2 .
BC034205 mRNA. Translation: AAH34205.1 . Frameshift.
BC055839 mRNA. Translation: AAH55839.1 .
CCDSi CCDS23913.1.
RefSeqi NP_080083.2. NM_025807.3.
XP_006514023.1. XM_006513960.1.
UniGenei Mm.19325.

3D structure databases

ProteinModelPortali Q7TM99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000047912.

PTM databases

PhosphoSitei Q7TM99.

Proteomic databases

PRIDEi Q7TM99.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000046807 ; ENSMUSP00000047912 ; ENSMUSG00000037762 .
GeneIDi 66859.
KEGGi mmu:66859.
UCSCi uc007fnq.1. mouse.

Organism-specific databases

CTDi 220963.
MGIi MGI:1914109. Slc16a9.

Phylogenomic databases

eggNOGi COG0477.
GeneTreei ENSGT00740000114926.
HOGENOMi HOG000113632.
HOVERGENi HBG097515.
InParanoidi Q7TM99.
KOi K08186.
OMAi ATLIIMG.
OrthoDBi EOG7TMZRG.
PhylomeDBi Q7TM99.
TreeFami TF313792.

Miscellaneous databases

NextBioi 322839.
PROi Q7TM99.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q7TM99.
Bgeei Q7TM99.
Genevestigatori Q7TM99.

Family and domain databases

InterProi IPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view ]
Pfami PF07690. MFS_1. 2 hits.
[Graphical view ]
SUPFAMi SSF103473. SSF103473. 2 hits.
PROSITEi PS50850. MFS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Kidney.

Entry informationi

Entry nameiMOT9_MOUSE
AccessioniPrimary (citable) accession number: Q7TM99
Secondary accession number(s): Q0P652
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2003
Last modified: July 9, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi