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Q7TM99 (MOT9_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Monocarboxylate transporter 9

Short name=MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene names
Name:Slc16a9
Synonyms:Mct9
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length508 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein By similarity.

Sequence similarities

Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. [View classification]

Sequence caution

The sequence AAH34205.1 differs from that shown. Reason: Frameshift at position 490.

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processurate metabolic process

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentintegral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 508508Monocarboxylate transporter 9
PRO_0000289333

Regions

Topological domain1 – 1212Extracellular Potential
Transmembrane13 – 3321Helical; Potential
Topological domain34 – 5219Cytoplasmic Potential
Transmembrane53 – 7321Helical; Potential
Topological domain74 – 796Extracellular Potential
Transmembrane80 – 10021Helical; Potential
Topological domain1011Cytoplasmic Potential
Transmembrane102 – 12221Helical; Potential
Topological domain123 – 13614Extracellular Potential
Transmembrane137 – 15721Helical; Potential
Topological domain158 – 1636Cytoplasmic Potential
Transmembrane164 – 18421Helical; Potential
Topological domain185 – 302118Extracellular Potential
Transmembrane303 – 32321Helical; Potential
Topological domain324 – 34017Cytoplasmic Potential
Transmembrane341 – 36121Helical; Potential
Topological domain362 – 3698Extracellular Potential
Transmembrane370 – 39021Helical; Potential
Topological domain391 – 3955Cytoplasmic Potential
Transmembrane396 – 41621Helical; Potential
Topological domain417 – 43014Extracellular Potential
Transmembrane431 – 45121Helical; Potential
Topological domain452 – 4598Cytoplasmic Potential
Transmembrane460 – 48021Helical; Potential
Topological domain481 – 50828Extracellular Potential

Sequences

Sequence LengthMass (Da)Tools
Q7TM99 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: EB86866D96B46AB6

FASTA50855,757
        10         20         30         40         50         60 
MEFQKSPDGG WGWVIVVVSF FTQFLSYGSP LAVGVLYVEW LDAFGEGKGK TAWVGSLASG 

        70         80         90        100        110        120 
VGLLASPVCS LFVSSFGARP VTIFSGFLVA GGLMLSSLAP NIYFLFFSYG IVVGLGCGLL 

       130        140        150        160        170        180 
YTATVTITCQ YFDSRRGLAL GLISTGSSVG LFIYAALQRM LIEFYGLDGC LLIVGALALN 

       190        200        210        220        230        240 
ILACGSLMRP LQTSDCPFPE KTAPENVPDR YSMYNEKEKN PEETMNFQDK GYSSEDKCLP 

       250        260        270        280        290        300 
NGDWGRETSL PKSLAIAAHT KEPETYKKKV VEQTNFCKQL AKRKWQLYRN YCGETASLFK 

       310        320        330        340        350        360 
NKVFSALFIA ILLFDIGGFP PSLLMEDVAR SYHVREEDLT MPLISIFGIM TAVGKLLLGI 

       370        380        390        400        410        420 
LADFKWINTL YLYVATLIIT GLALCAIPFA KSYVTLAILS GILGFLTGNW SIFPYVTTKT 

       430        440        450        460        470        480 
VGIDKLAHAY GILMFFAGLG NSLGPPIVGW FYDWTQTYDI AFYFSGFCVL LGGFILLLAI 

       490        500 
LPCWDMCNKK LPKPAVPTTF FYKVASNV 

« Hide

References

[1]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Lung and Testis.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: FVB/N.
Tissue: Colon and Kidney.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AK004556 mRNA. Translation: BAB23369.2.
AK004599 mRNA. Translation: BAB23400.2.
AK004684 mRNA. Translation: BAB23471.2.
BC034205 mRNA. Translation: AAH34205.1. Frameshift.
BC055839 mRNA. Translation: AAH55839.1.
RefSeqNP_080083.2. NM_025807.3.
XP_006514023.1. XM_006513960.1.
UniGeneMm.19325.

3D structure databases

ProteinModelPortalQ7TM99.
SMRQ7TM99. Positions 429-455.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000047912.

PTM databases

PhosphoSiteQ7TM99.

Proteomic databases

PRIDEQ7TM99.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000046807; ENSMUSP00000047912; ENSMUSG00000037762.
GeneID66859.
KEGGmmu:66859.
UCSCuc007fnq.1. mouse.

Organism-specific databases

CTD220963.
MGIMGI:1914109. Slc16a9.

Phylogenomic databases

eggNOGCOG0477.
GeneTreeENSGT00740000114926.
HOGENOMHOG000113632.
HOVERGENHBG097515.
InParanoidQ7TM99.
KOK08186.
OMAATLIIMG.
OrthoDBEOG7TMZRG.
PhylomeDBQ7TM99.
TreeFamTF313792.

Gene expression databases

ArrayExpressQ7TM99.
BgeeQ7TM99.
GenevestigatorQ7TM99.

Family and domain databases

InterProIPR011701. MFS.
IPR020846. MFS_dom.
IPR016196. MFS_dom_general_subst_transpt.
[Graphical view]
PfamPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMSSF103473. SSF103473. 2 hits.
PROSITEPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio322839.
PROQ7TM99.
SOURCESearch...

Entry information

Entry nameMOT9_MOUSE
AccessionPrimary (citable) accession number: Q7TM99
Secondary accession number(s): Q0P652
Entry history
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot