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Protein

Monocarboxylate transporter 9

Gene

Slc16a9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Proton-linked monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Monocarboxylate transporter 9
Short name:
MCT 9
Alternative name(s):
Solute carrier family 16 member 9
Gene namesi
Name:Slc16a9
Synonyms:Mct9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1914109. Slc16a9.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 1212ExtracellularSequence AnalysisAdd
BLAST
Transmembranei13 – 3321HelicalSequence AnalysisAdd
BLAST
Topological domaini34 – 5219CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei53 – 7321HelicalSequence AnalysisAdd
BLAST
Topological domaini74 – 796ExtracellularSequence Analysis
Transmembranei80 – 10021HelicalSequence AnalysisAdd
BLAST
Topological domaini101 – 1011CytoplasmicSequence Analysis
Transmembranei102 – 12221HelicalSequence AnalysisAdd
BLAST
Topological domaini123 – 13614ExtracellularSequence AnalysisAdd
BLAST
Transmembranei137 – 15721HelicalSequence AnalysisAdd
BLAST
Topological domaini158 – 1636CytoplasmicSequence Analysis
Transmembranei164 – 18421HelicalSequence AnalysisAdd
BLAST
Topological domaini185 – 302118ExtracellularSequence AnalysisAdd
BLAST
Transmembranei303 – 32321HelicalSequence AnalysisAdd
BLAST
Topological domaini324 – 34017CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei341 – 36121HelicalSequence AnalysisAdd
BLAST
Topological domaini362 – 3698ExtracellularSequence Analysis
Transmembranei370 – 39021HelicalSequence AnalysisAdd
BLAST
Topological domaini391 – 3955CytoplasmicSequence Analysis
Transmembranei396 – 41621HelicalSequence AnalysisAdd
BLAST
Topological domaini417 – 43014ExtracellularSequence AnalysisAdd
BLAST
Transmembranei431 – 45121HelicalSequence AnalysisAdd
BLAST
Topological domaini452 – 4598CytoplasmicSequence Analysis
Transmembranei460 – 48021HelicalSequence AnalysisAdd
BLAST
Topological domaini481 – 50828ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 508508Monocarboxylate transporter 9PRO_0000289333Add
BLAST

Proteomic databases

PRIDEiQ7TM99.

PTM databases

PhosphoSiteiQ7TM99.

Expressioni

Gene expression databases

BgeeiQ7TM99.
ExpressionAtlasiQ7TM99. baseline and differential.
GenevisibleiQ7TM99. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047912.

Structurei

3D structure databases

ProteinModelPortaliQ7TM99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7TM99.
KOiK08186.
OMAiEEEFIMP.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7TM99.
TreeFamiTF313792.

Family and domain databases

InterProiIPR030767. MCT9.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF16. PTHR11360:SF16. 1 hit.
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7TM99-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEFQKSPDGG WGWVIVVVSF FTQFLSYGSP LAVGVLYVEW LDAFGEGKGK
60 70 80 90 100
TAWVGSLASG VGLLASPVCS LFVSSFGARP VTIFSGFLVA GGLMLSSLAP
110 120 130 140 150
NIYFLFFSYG IVVGLGCGLL YTATVTITCQ YFDSRRGLAL GLISTGSSVG
160 170 180 190 200
LFIYAALQRM LIEFYGLDGC LLIVGALALN ILACGSLMRP LQTSDCPFPE
210 220 230 240 250
KTAPENVPDR YSMYNEKEKN PEETMNFQDK GYSSEDKCLP NGDWGRETSL
260 270 280 290 300
PKSLAIAAHT KEPETYKKKV VEQTNFCKQL AKRKWQLYRN YCGETASLFK
310 320 330 340 350
NKVFSALFIA ILLFDIGGFP PSLLMEDVAR SYHVREEDLT MPLISIFGIM
360 370 380 390 400
TAVGKLLLGI LADFKWINTL YLYVATLIIT GLALCAIPFA KSYVTLAILS
410 420 430 440 450
GILGFLTGNW SIFPYVTTKT VGIDKLAHAY GILMFFAGLG NSLGPPIVGW
460 470 480 490 500
FYDWTQTYDI AFYFSGFCVL LGGFILLLAI LPCWDMCNKK LPKPAVPTTF

FYKVASNV
Length:508
Mass (Da):55,757
Last modified:October 1, 2003 - v1
Checksum:iEB86866D96B46AB6
GO

Sequence cautioni

The sequence AAH34205.1 differs from that shown. Reason: Frameshift at position 490. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004556 mRNA. Translation: BAB23369.2.
AK004599 mRNA. Translation: BAB23400.2.
AK004684 mRNA. Translation: BAB23471.2.
BC034205 mRNA. Translation: AAH34205.1. Frameshift.
BC055839 mRNA. Translation: AAH55839.1.
CCDSiCCDS23913.1.
RefSeqiNP_080083.2. NM_025807.3.
XP_006514023.1. XM_006513960.2.
UniGeneiMm.19325.

Genome annotation databases

EnsembliENSMUST00000046807; ENSMUSP00000047912; ENSMUSG00000037762.
GeneIDi66859.
KEGGimmu:66859.
UCSCiuc007fnq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK004556 mRNA. Translation: BAB23369.2.
AK004599 mRNA. Translation: BAB23400.2.
AK004684 mRNA. Translation: BAB23471.2.
BC034205 mRNA. Translation: AAH34205.1. Frameshift.
BC055839 mRNA. Translation: AAH55839.1.
CCDSiCCDS23913.1.
RefSeqiNP_080083.2. NM_025807.3.
XP_006514023.1. XM_006513960.2.
UniGeneiMm.19325.

3D structure databases

ProteinModelPortaliQ7TM99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000047912.

PTM databases

PhosphoSiteiQ7TM99.

Proteomic databases

PRIDEiQ7TM99.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046807; ENSMUSP00000047912; ENSMUSG00000037762.
GeneIDi66859.
KEGGimmu:66859.
UCSCiuc007fnq.1. mouse.

Organism-specific databases

CTDi220963.
MGIiMGI:1914109. Slc16a9.

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000118926.
HOGENOMiHOG000113632.
HOVERGENiHBG097515.
InParanoidiQ7TM99.
KOiK08186.
OMAiEEEFIMP.
OrthoDBiEOG7TMZRG.
PhylomeDBiQ7TM99.
TreeFamiTF313792.

Miscellaneous databases

NextBioi322839.
PROiQ7TM99.
SOURCEiSearch...

Gene expression databases

BgeeiQ7TM99.
ExpressionAtlasiQ7TM99. baseline and differential.
GenevisibleiQ7TM99. MM.

Family and domain databases

InterProiIPR030767. MCT9.
IPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PANTHERiPTHR11360:SF16. PTHR11360:SF16. 1 hit.
PfamiPF07690. MFS_1. 2 hits.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Lung and Testis.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Colon and Kidney.

Entry informationi

Entry nameiMOT9_MOUSE
AccessioniPrimary (citable) accession number: Q7TM99
Secondary accession number(s): Q0P652
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 1, 2003
Last modified: June 24, 2015
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.