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Q7T9E0

- VSGP_EBOSU

UniProt

Q7T9E0 - VSGP_EBOSU

Protein

Pre-small/secreted glycoprotein

Gene

SGP

Organism
Sudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 37 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    sGP seems to possess an anti-inflammatory activity as it can reverse the barrier-decreasing effects of TNF alpha. Might therefore contribute to the lack of inflammatory reaction seen during infection in spite the of extensive necrosis and massive virus production. Does not seem to be involved in activation of primary macrophages. Does not seem to interact specifically with neutrophils By similarity.By similarity
    Delta-peptide does not seem to be involved in activation of primary macrophages.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei324 – 3252Cleavage; by host furinBy similarity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pre-small/secreted glycoprotein
    Short name:
    pre-sGP
    Cleaved into the following 2 chains:
    Gene namesi
    Name:SGP
    Synonyms:GP
    OrganismiSudan ebolavirus (strain Uganda-00) (SEBOV) (Sudan Ebola virus)
    Taxonomic identifieri386033 [NCBI]
    Taxonomic lineageiVirusesssRNA negative-strand virusesMononegaviralesFiloviridaeEbolavirus
    Virus hostiEpomops franqueti (Franquet's epauleted fruit bat) [TaxID: 77231]
    Homo sapiens (Human) [TaxID: 9606]
    Myonycteris torquata (Little collared fruit bat) [TaxID: 77243]
    ProteomesiUP000000277: Genome

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232Sequence AnalysisAdd
    BLAST
    Chaini33 – 372340Pre-small/secreted glycoproteinBy similarityPRO_0000245090Add
    BLAST
    Chaini33 – 324292Small/secreted glycoproteinBy similarityPRO_0000245091Add
    BLAST
    Chaini325 – 37248Delta-peptideBy similarityPRO_0000245092Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi53 – 53InterchainBy similarity
    Disulfide bondi108 ↔ 135By similarity
    Disulfide bondi121 ↔ 147By similarity
    Glycosylationi204 – 2041N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi208 – 2081N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi238 – 2381N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi257 – 2571N-linked (GlcNAc...); by hostSequence Analysis
    Glycosylationi268 – 2681N-linked (GlcNAc...); by hostSequence Analysis
    Disulfide bondi306 – 306InterchainBy similarity

    Post-translational modificationi

    Pre-sGP is N-glycosylated. This precursor is processed into mature sGP and delta-peptide by host furin or furin-like proteases. The cleavage site corresponds to the furin optimal cleavage sequence [KR]-X-[KR]-R. Both cleavage fragments contain sialic acid, but only the delta-peptide is O-glycosylated By similarity.By similarity

    Keywords - PTMi

    Cleavage on pair of basic residues, Disulfide bond, Glycoprotein

    Interactioni

    Subunit structurei

    sGP is a homodimer; disulfide-linked. The homodimers are linked by two disulfide bonds in a parallel orientation. Delta-peptide is a monomer By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7T9E0.
    SMRiQ7T9E0. Positions 32-284.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the filoviruses glycoprotein family.Curated

    Keywords - Domaini

    Signal

    Family and domain databases

    InterProiIPR002561. GPC_filovir-type_extra_dom.
    [Graphical view]
    PfamiPF01611. Filo_glycop. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7T9E0-1 [UniParc]FASTAAdd to Basket

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    MGGLSLLQLP RDKFRKSSFF VWVIILFQKA FSMPLGVVTN STLEVTEIDQ    50
    LVCKDHLAST DQLKSVGLNL EGSGVSTDIP SATKRWGFRS GVPPKVVSYE 100
    AGEWAENCYN LEIKKPDGSE CLPPPPDGVR GFPRCRYVHK AQGTGPCPGD 150
    YAFHKDGAFF LYDRLASTVI YRGVNFAEGV IAFLILAKPK ETFLQSPPIR 200
    EAVNYTENTS SYYATSYLEY EIENFGAQHS TTLFKIDNNT FVRLDRPHTP 250
    QFLFQLNDTI HLHQQLSNTT GRLIWTLDAN INADIGEWAF WENKKISPNN 300
    YVEKSCLSKL YRSTRQKTMM RHRRELQREE SPTGPPGSIR TWFQRIPLGW 350
    FHCTYQKGKQ HCRLRIRQKV EE 372
    Length:372
    Mass (Da):42,584
    Last modified:October 1, 2003 - v1
    Checksum:i19307E2085FBC6A4
    GO

    RNA editingi

    Partially edited. RNA editing at this position consists of an insertion of one or two adenine nucleotides. The sequence displayed here is the small secreted glycoprotein, derived from the unedited RNA. The sequence derived from the +1A edited gives rise to the full-length transmembrane glycoprotein GP (AC Q7T9D9), the +2A edited RNA gives rise to the super small secreted glycoprotein ssGP (AC P0C772).

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY316199 Genomic RNA. Translation: AAP88030.1.
    AY344234 Genomic RNA. Translation: AAR11464.1.
    AY729654 Genomic RNA. Translation: AAU43886.1.
    RefSeqiYP_138524.1. NC_006432.1.

    Genome annotation databases

    GeneIDi3160774.

    Keywords - Coding sequence diversityi

    RNA editing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY316199 Genomic RNA. Translation: AAP88030.1 .
    AY344234 Genomic RNA. Translation: AAR11464.1 .
    AY729654 Genomic RNA. Translation: AAU43886.1 .
    RefSeqi YP_138524.1. NC_006432.1.

    3D structure databases

    ProteinModelPortali Q7T9E0.
    SMRi Q7T9E0. Positions 32-284.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 3160774.

    Family and domain databases

    InterProi IPR002561. GPC_filovir-type_extra_dom.
    [Graphical view ]
    Pfami PF01611. Filo_glycop. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of human peripheral blood samples from fatal and nonfatal cases of Ebola (Sudan) hemorrhagic fever: cellular responses, virus load, and nitric oxide levels."
      Sanchez A., Lukwiya M., Bausch D., Mahanty S., Sanchez A.J., Wagoner K.D., Rollin P.E.
      J. Virol. 78:10370-10377(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    2. "Rapid diagnosis of Ebola hemorrhagic fever by reverse transcription-PCR in an outbreak setting and assessment of patient viral load as a predictor of outcome."
      Towner J.S., Rollin P.E., Bausch D.G., Sanchez A., Crary S.M., Vincent M., Lee W.F., Spiropoulou C.F., Ksiazek T.G., Lukwiya M., Kaducu F., Downing R., Nichol S.T.
      J. Virol. 78:4330-4341(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].
    3. "Complete genome sequence of an Ebola virus (Sudan species) responsible for a 2000 outbreak of human disease in Uganda."
      Sanchez A., Rollin P.E.
      Virus Res. 113:16-25(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC RNA].

    Entry informationi

    Entry nameiVSGP_EBOSU
    AccessioniPrimary (citable) accession number: Q7T9E0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 37 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3