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Q7T6Y9

- RIR2_MIMIV

UniProt

Q7T6Y9 - RIR2_MIMIV

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Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RNR2

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).By similarity

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

Cofactori

Binds 2 iron ions per subunit.By similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi168 – 1681Iron 1PROSITE-ProRule annotation
Metal bindingi199 – 1991Iron 1PROSITE-ProRule annotation
Metal bindingi199 – 1991Iron 2By similarity
Metal bindingi202 – 2021Iron 1PROSITE-ProRule annotation
Active sitei206 – 2061PROSITE-ProRule annotation
Metal bindingi261 – 2611Iron 2By similarity
Metal bindingi297 – 2971Iron 2By similarity
Metal bindingi300 – 3001Iron 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
  2. DNA replication Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
Name:RNR2
Ordered Locus Names:MIMI_L312
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 417417Ribonucleoside-diphosphate reductase small chainPRO_0000190494Add
BLAST

Interactioni

Subunit structurei

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7T6Y9.
SMRiQ7T6Y9. Positions 93-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T6Y9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSEKIKLVD EVFGSVKNTI TYEQLHNING KFHNISDKFV ENISESISEP
60 70 80 90 100
TTINSKKKTS ELIFSEETLN NVEIIDTEPY LSDYHKHAID FENDVIMKEP
110 120 130 140 150
ILSLKSEQYT VHPIKYQKVW DNYKDQMKNY WTVEEVDLAK DVNDWNNHLS
160 170 180 190 200
DDDRNFIMHV LAFFAAADGI VNANIKENLI DVVKIKEAEC AYGFQYAMEN
210 220 230 240 250
AHGEMYSLML TTFVKDDALR NKLINSIKTM PSIKKKADWC NKWIKSDKTY
260 270 280 290 300
AHKLVAFSIV EGVFFSGSFA SIFWLKTREM HVMPGLIISN QFIARDENKH
310 320 330 340 350
VELACIMYSL LNNRLKESVV YQIIDEAIEI EEEFINDSLP CKLLGMNSEL
360 370 380 390 400
MSQYIKYVAD RLLVDLGYRK KFNVDNPFEY MKKIDVFVKA NFFEKRNDAY
410
SNANIDNEKK IVFLENF
Length:417
Mass (Da):48,607
Last modified:December 7, 2004 - v2
Checksum:i9A87CB964C4D3DC3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAQ09571.2.
RefSeqiYP_003986815.1. NC_014649.1.

Genome annotation databases

GeneIDi9924929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAQ09571.2 .
RefSeqi YP_003986815.1. NC_014649.1.

3D structure databases

ProteinModelPortali Q7T6Y9.
SMRi Q7T6Y9. Positions 93-382.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9924929.

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiRIR2_MIMIV
AccessioniPrimary (citable) accession number: Q7T6Y9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: October 1, 2014
This is version 65 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3