Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q7T6Y9 (RIR2_MIMIV) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
Name:RNR2
Ordered Locus Names:MIMI_L312
OrganismAcanthamoeba polyphaga mimivirus (APMV) [Reference proteome]
Taxonomic identifier212035 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]

Protein attributes

Sequence length417 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 417417Ribonucleoside-diphosphate reductase small chain
PRO_0000190494

Sites

Active site2061 By similarity
Metal binding1681Iron 1 By similarity
Metal binding1991Iron 1 By similarity
Metal binding1991Iron 2 By similarity
Metal binding2021Iron 1 By similarity
Metal binding2611Iron 2 By similarity
Metal binding2971Iron 2 By similarity
Metal binding3001Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q7T6Y9 [UniParc].

Last modified December 7, 2004. Version 2.
Checksum: 9A87CB964C4D3DC3

FASTA41748,607
        10         20         30         40         50         60 
MSSEKIKLVD EVFGSVKNTI TYEQLHNING KFHNISDKFV ENISESISEP TTINSKKKTS 

        70         80         90        100        110        120 
ELIFSEETLN NVEIIDTEPY LSDYHKHAID FENDVIMKEP ILSLKSEQYT VHPIKYQKVW 

       130        140        150        160        170        180 
DNYKDQMKNY WTVEEVDLAK DVNDWNNHLS DDDRNFIMHV LAFFAAADGI VNANIKENLI 

       190        200        210        220        230        240 
DVVKIKEAEC AYGFQYAMEN AHGEMYSLML TTFVKDDALR NKLINSIKTM PSIKKKADWC 

       250        260        270        280        290        300 
NKWIKSDKTY AHKLVAFSIV EGVFFSGSFA SIFWLKTREM HVMPGLIISN QFIARDENKH 

       310        320        330        340        350        360 
VELACIMYSL LNNRLKESVV YQIIDEAIEI EEEFINDSLP CKLLGMNSEL MSQYIKYVAD 

       370        380        390        400        410 
RLLVDLGYRK KFNVDNPFEY MKKIDVFVKA NFFEKRNDAY SNANIDNEKK IVFLENF 

« Hide

References

[1]"The 1.2-megabase genome sequence of Mimivirus."
Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M.
Science 306:1344-1350(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Rowbotham-Bradford.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AY653733 Genomic DNA. Translation: AAQ09571.2.
RefSeqYP_003986815.1. NC_014649.1.

3D structure databases

ProteinModelPortalQ7T6Y9.
SMRQ7T6Y9. Positions 93-382.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID9924929.

Phylogenomic databases

ProtClustDBCLSP2509773.

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_MIMIV
AccessionPrimary (citable) accession number: Q7T6Y9
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: December 7, 2004
Last modified: December 11, 2013
This is version 63 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways