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Q7T6Y9

- RIR2_MIMIV

UniProt

Q7T6Y9 - RIR2_MIMIV

Protein

Ribonucleoside-diphosphate reductase small chain

Gene

RNR2

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (07 Dec 2004)
      Previous versions | rss
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    Functioni

    Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.By similarity

    Catalytic activityi

    2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.PROSITE-ProRule annotation

    Cofactori

    Binds 2 iron ions per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi168 – 1681Iron 1PROSITE-ProRule annotation
    Metal bindingi199 – 1991Iron 1PROSITE-ProRule annotation
    Metal bindingi199 – 1991Iron 2By similarity
    Metal bindingi202 – 2021Iron 1PROSITE-ProRule annotation
    Active sitei206 – 2061PROSITE-ProRule annotation
    Metal bindingi261 – 2611Iron 2By similarity
    Metal bindingi297 – 2971Iron 2By similarity
    Metal bindingi300 – 3001Iron 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

    GO - Biological processi

    1. deoxyribonucleoside diphosphate metabolic process Source: InterPro
    2. DNA replication Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    DNA replication

    Keywords - Ligandi

    Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00326.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
    Alternative name(s):
    Ribonucleotide reductase small subunit
    Gene namesi
    Name:RNR2
    Ordered Locus Names:MIMI_L312
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 417417Ribonucleoside-diphosphate reductase small chainPRO_0000190494Add
    BLAST

    Interactioni

    Subunit structurei

    Heterotetramer composed of a homodimer of the large subunit (R1) and a homodimer of the small subunit (R2). Larger multisubunit protein complex are also active, composed of (R1)n(R2)n By similarity.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7T6Y9.
    SMRiQ7T6Y9. Positions 93-382.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di1.10.620.20. 1 hit.
    InterProiIPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view]
    PANTHERiPTHR23409. PTHR23409. 1 hit.
    PfamiPF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view]
    SUPFAMiSSF47240. SSF47240. 1 hit.
    PROSITEiPS00368. RIBORED_SMALL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7T6Y9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSSEKIKLVD EVFGSVKNTI TYEQLHNING KFHNISDKFV ENISESISEP    50
    TTINSKKKTS ELIFSEETLN NVEIIDTEPY LSDYHKHAID FENDVIMKEP 100
    ILSLKSEQYT VHPIKYQKVW DNYKDQMKNY WTVEEVDLAK DVNDWNNHLS 150
    DDDRNFIMHV LAFFAAADGI VNANIKENLI DVVKIKEAEC AYGFQYAMEN 200
    AHGEMYSLML TTFVKDDALR NKLINSIKTM PSIKKKADWC NKWIKSDKTY 250
    AHKLVAFSIV EGVFFSGSFA SIFWLKTREM HVMPGLIISN QFIARDENKH 300
    VELACIMYSL LNNRLKESVV YQIIDEAIEI EEEFINDSLP CKLLGMNSEL 350
    MSQYIKYVAD RLLVDLGYRK KFNVDNPFEY MKKIDVFVKA NFFEKRNDAY 400
    SNANIDNEKK IVFLENF 417
    Length:417
    Mass (Da):48,607
    Last modified:December 7, 2004 - v2
    Checksum:i9A87CB964C4D3DC3
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAQ09571.2.
    RefSeqiYP_003986815.1. NC_014649.1.

    Genome annotation databases

    GeneIDi9924929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAQ09571.2 .
    RefSeqi YP_003986815.1. NC_014649.1.

    3D structure databases

    ProteinModelPortali Q7T6Y9.
    SMRi Q7T6Y9. Positions 93-382.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9924929.

    Enzyme and pathway databases

    UniPathwayi UPA00326 .

    Family and domain databases

    Gene3Di 1.10.620.20. 1 hit.
    InterProi IPR009078. Ferritin-like_SF.
    IPR012348. RNR-rel.
    IPR000358. RNR_small.
    [Graphical view ]
    PANTHERi PTHR23409. PTHR23409. 1 hit.
    Pfami PF00268. Ribonuc_red_sm. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47240. SSF47240. 1 hit.
    PROSITEi PS00368. RIBORED_SMALL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rowbotham-Bradford.

    Entry informationi

    Entry nameiRIR2_MIMIV
    AccessioniPrimary (citable) accession number: Q7T6Y9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: December 7, 2004
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3