Reviewed,
UniProtKB/Swiss-Prot Q7T6Y8 (RIR1_MIMIV)
Last modified
June 16, 2009.
Version 38.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Ribonucleoside-diphosphate reductase large subunit EC=1.17.4.1 Alternative name(s): Ribonucleotide reductase large subunit | ||||
| Gene names |
| ||||
| Organism | Acanthamoeba polyphaga mimivirus (APMV) [Complete proteome] | ||||
| Taxonomic identifier | 212035 [NCBI] | ||||
| Taxonomic lineage | Viruses › dsDNA viruses, no RNA stage › Mimiviridae › Mimivirus | ||||
| Virus host | Acanthamoeba polyphaga (Amoeba) [TaxID: 5757] |
Protein attributes
| Sequence length | 881 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity. |
| Catalytic activity | 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. |
| Pathway | |
| Subunit structure | Heterodimer of a large and a small chain By similarity. |
| Sequence similarities | Belongs to the ribonucleoside diphosphate reductase large chain family. Contains 1 ATP-cone domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | DNA replication |
| Developmental stage | Early protein |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Oxidoreductase |
| Technical term | Allosteric enzyme Complete proteome |
| Gene Ontology (GO) | |
| Biological process | DNA replication Inferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | ribonucleoside-diphosphate reductase complex Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW protein bindingInferred from electronic annotation. Source: InterPro ribonucleoside-diphosphate reductase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 881 | 881 | Ribonucleoside-diphosphate reductase large subunit | PRO_0000187229 | |||||
Regions | |||||||||
| Domain | 69 – 160 | 92 | ATP-cone | ||||||
Sites | |||||||||
| Active site | 287 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 493 | 1 | Proton acceptor By similarity | ||||||
| Active site | 495 | 1 | Proton acceptor By similarity | ||||||
| Active site | 497 | 1 | Proton acceptor By similarity | ||||||
| Active site | 510 | 1 | Hydrogen atom transfer By similarity | ||||||
| Active site | 809 | 1 | Electron transfer By similarity | ||||||
| Active site | 810 | 1 | Electron transfer By similarity | ||||||
| Site | 294 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 324 | 1 | Allosteric effector binding By similarity | ||||||
| Site | 876 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
| Site | 879 | 1 | Interacts with thioredoxin/glutaredoxin By similarity | ||||||
Sequences
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References
| [1] | "The 1.2-megabase genome sequence of Mimivirus." Raoult D., Audic S., Robert C., Abergel C., Renesto P., Ogata H., La Scola B., Susan M., Claverie J.-M. Science 306:1344-1350(2004) [PubMed: 15486256] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Rowbotham-Bradford. |
Cross-references
Sequence databases | |
|---|---|
| AY653733 Genomic DNA. Translation: AAQ09572.2. | |
| RefSeq | YP_142667.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 3162147. |
Enzyme and pathway databases | |
| BRENDA | 1.17.4.1. 281366. |
Family and domain databases | |
| InterPro | IPR005144. ATP-cone. IPR013346. NrdE_NrdA. IPR013509. Ribncl_Rdtase_lsu_N. IPR000788. Ribncl_red_lg_C. [Graphical view] |
| PANTHER | PTHR11573. Ribncl_red_lg_C. 1 hit. |
| Pfam | PF02867. Ribonuc_red_lgC. 1 hit. PF00317. Ribonuc_red_lgN. 1 hit. [Graphical view] |
| PRINTS | PR01183. RIBORDTASEM1. |
| TIGRFAMs | TIGR02506. NrdE_NrdA. 1 hit. |
| PROSITE | PS51161. ATP_CONE. 1 hit. PS00089. RIBORED_LARGE. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | RIR1_MIMIV | ||||||||
| Accession | Primary (citable) accession number: Q7T6Y8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Virus (Virus annotation project) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


