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Q7T6X6

- GFAT_MIMIV

UniProt

Q7T6X6 - GFAT_MIMIV

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Protein

Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene
MIMI_L619
Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for glycosylation of proteins Reviewed prediction.

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei2 – 21For GATase activity By similarity

GO - Molecular functioni

  1. carbohydrate binding Source: InterPro
  2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

GO - Biological processi

  1. carbohydrate biosynthetic process Source: InterPro
  2. glutamine metabolic process Source: UniProtKB-KW
  3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00113; UER00528.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
Short name:
GFAT
Alternative name(s):
D-fructose-6-phosphate amidotransferase
Hexosephosphate aminotransferase
Gene namesi
Ordered Locus Names:MIMI_L619
OrganismiAcanthamoeba polyphaga mimivirus (APMV)
Taxonomic identifieri212035 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
ProteomesiUP000001134: Genome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed; by host By similarity
Chaini2 – 606605Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135286Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ7T6X6.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 224223Glutamine amidotransferase type-2Add
BLAST
Domaini282 – 427146SIS 1Add
BLAST
Domaini458 – 596139SIS 2Add
BLAST

Sequence similaritiesi

Contains 2 SIS domains.

Keywords - Domaini

Glutamine amidotransferase, Repeat

Family and domain databases

Gene3Di3.60.20.10. 1 hit.
InterProiIPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view]
PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
PfamiPF01380. SIS. 2 hits.
[Graphical view]
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T6X6-1 [UniParc]FASTAAdd to Basket

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MCGISACLNH TNNSAMTSVV NALTKLQNRG YDSAGICTTS NGKFNFVKSV    50
SDDTNNAIHY IKNNPLANHH CSIAIGHTRW ATHGEKTIEN AHPHFDASGR 100
FSLIHNGIIE NYDQIKSMLV ESQNYQFYGQ TDTEVAVAYL SYLLSENKTW 150
FDFNESLKGS WAIIALDKFN PEKLYFMRNG SPLIIGFNET NTKAMIVSEL 200
SGFDSDISQY CIVGDNDYGY ITNNNDKYII KSQQHYQMIS MGKIVMDLTP 250
SPYKHWTQRE IYDQPNAIHS LITERIVDSQ LFFPEFNTIN FTLVEHIVLL 300
GCGTSYHAAQ IGRRYIREFR PNITVDVIDG ADFEETDIPK SRNTLLILLS 350
QSGETKDLYR ALVIGKQHSL KTIGIINVEN SLIAREVDTV LYLRAGRENA 400
VASTKSFTNQ VLMLFMLALK INLSLDNSQL DYYTMSLNNF PIEFKKIIDQ 450
SVNEIPKLLE FFDNQTSCFI LGKFGLEWIA KEGSLKIKEI SYVHSEGYSS 500
AALKHGPFAL LHQNIPVVLL ANDDSYFSKI ENANSEIRSR KAKVIFITNK 550
LIDNHCTDYL IHINTKSPLF HLLCIVPLQL LAYHLALSKG INPDYPRNLA 600
KVVTVE 606
Length:606
Mass (Da):68,570
Last modified:January 23, 2007 - v4
Checksum:i9C0644BDC1C80CFC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAQ09584.2.
RefSeqiYP_003987136.1. NC_014649.1.

Genome annotation databases

GeneIDi9925259.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY653733 Genomic DNA. Translation: AAQ09584.2 .
RefSeqi YP_003987136.1. NC_014649.1.

3D structure databases

ProteinModelPortali Q7T6X6.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 9925259.

Enzyme and pathway databases

UniPathwayi UPA00113 ; UER00528 .

Family and domain databases

Gene3Di 3.60.20.10. 1 hit.
InterProi IPR017932. GATase_2_dom.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
[Graphical view ]
PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
Pfami PF01380. SIS. 2 hits.
[Graphical view ]
SUPFAMi SSF56235. SSF56235. 1 hit.
TIGRFAMsi TIGR01135. glmS. 1 hit.
PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Rowbotham-Bradford.

Entry informationi

Entry nameiGFAT_MIMIV
AccessioniPrimary (citable) accession number: Q7T6X6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: June 11, 2014
This is version 58 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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