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Q7T6X6

- GFAT_MIMIV

UniProt

Q7T6X6 - GFAT_MIMIV

Protein

Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

MIMI_L619

Organism
Acanthamoeba polyphaga mimivirus (APMV)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 59 (01 Oct 2014)
      Sequence version 4 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for glycosylation of proteins Potential.Curated

    Catalytic activityi

    L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei2 – 21For GATase activityBy similarity

    GO - Molecular functioni

    1. carbohydrate binding Source: InterPro
    2. glutamine-fructose-6-phosphate transaminase (isomerizing) activity Source: UniProtKB-EC

    GO - Biological processi

    1. carbohydrate biosynthetic process Source: InterPro
    2. glutamine metabolic process Source: UniProtKB-KW
    3. UDP-N-acetylglucosamine biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Aminotransferase, Transferase

    Enzyme and pathway databases

    UniPathwayiUPA00113; UER00528.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing] (EC:2.6.1.16)
    Short name:
    GFAT
    Alternative name(s):
    D-fructose-6-phosphate amidotransferase
    Hexosephosphate aminotransferase
    Gene namesi
    Ordered Locus Names:MIMI_L619
    OrganismiAcanthamoeba polyphaga mimivirus (APMV)
    Taxonomic identifieri212035 [NCBI]
    Taxonomic lineageiVirusesdsDNA viruses, no RNA stageMimiviridaeMimivirus
    Virus hostiAcanthamoeba polyphaga (Amoeba) [TaxID: 5757]
    ProteomesiUP000001134: Genome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed; by hostBy similarity
    Chaini2 – 606605Probable glutamine--fructose-6-phosphate aminotransferase [isomerizing]PRO_0000135286Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliQ7T6X6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini2 – 224223Glutamine amidotransferase type-2PROSITE-ProRule annotationAdd
    BLAST
    Domaini282 – 427146SIS 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini458 – 596139SIS 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 glutamine amidotransferase type-2 domain.PROSITE-ProRule annotation
    Contains 2 SIS domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Glutamine amidotransferase, Repeat

    Family and domain databases

    Gene3Di3.60.20.10. 1 hit.
    InterProiIPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view]
    PANTHERiPTHR10937:SF0. PTHR10937:SF0. 1 hit.
    PfamiPF01380. SIS. 2 hits.
    [Graphical view]
    SUPFAMiSSF56235. SSF56235. 1 hit.
    TIGRFAMsiTIGR01135. glmS. 1 hit.
    PROSITEiPS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7T6X6-1 [UniParc]FASTAAdd to Basket

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    MCGISACLNH TNNSAMTSVV NALTKLQNRG YDSAGICTTS NGKFNFVKSV    50
    SDDTNNAIHY IKNNPLANHH CSIAIGHTRW ATHGEKTIEN AHPHFDASGR 100
    FSLIHNGIIE NYDQIKSMLV ESQNYQFYGQ TDTEVAVAYL SYLLSENKTW 150
    FDFNESLKGS WAIIALDKFN PEKLYFMRNG SPLIIGFNET NTKAMIVSEL 200
    SGFDSDISQY CIVGDNDYGY ITNNNDKYII KSQQHYQMIS MGKIVMDLTP 250
    SPYKHWTQRE IYDQPNAIHS LITERIVDSQ LFFPEFNTIN FTLVEHIVLL 300
    GCGTSYHAAQ IGRRYIREFR PNITVDVIDG ADFEETDIPK SRNTLLILLS 350
    QSGETKDLYR ALVIGKQHSL KTIGIINVEN SLIAREVDTV LYLRAGRENA 400
    VASTKSFTNQ VLMLFMLALK INLSLDNSQL DYYTMSLNNF PIEFKKIIDQ 450
    SVNEIPKLLE FFDNQTSCFI LGKFGLEWIA KEGSLKIKEI SYVHSEGYSS 500
    AALKHGPFAL LHQNIPVVLL ANDDSYFSKI ENANSEIRSR KAKVIFITNK 550
    LIDNHCTDYL IHINTKSPLF HLLCIVPLQL LAYHLALSKG INPDYPRNLA 600
    KVVTVE 606
    Length:606
    Mass (Da):68,570
    Last modified:January 23, 2007 - v4
    Checksum:i9C0644BDC1C80CFC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAQ09584.2.
    RefSeqiYP_003987136.1. NC_014649.1.

    Genome annotation databases

    GeneIDi9925259.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY653733 Genomic DNA. Translation: AAQ09584.2 .
    RefSeqi YP_003987136.1. NC_014649.1.

    3D structure databases

    ProteinModelPortali Q7T6X6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 9925259.

    Enzyme and pathway databases

    UniPathwayi UPA00113 ; UER00528 .

    Family and domain databases

    Gene3Di 3.60.20.10. 1 hit.
    InterProi IPR017932. GATase_2_dom.
    IPR005855. GlmS_trans.
    IPR029055. Ntn_hydrolases_N.
    IPR001347. SIS.
    [Graphical view ]
    PANTHERi PTHR10937:SF0. PTHR10937:SF0. 1 hit.
    Pfami PF01380. SIS. 2 hits.
    [Graphical view ]
    SUPFAMi SSF56235. SSF56235. 1 hit.
    TIGRFAMsi TIGR01135. glmS. 1 hit.
    PROSITEi PS51278. GATASE_TYPE_2. 1 hit.
    PS51464. SIS. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Rowbotham-Bradford.

    Entry informationi

    Entry nameiGFAT_MIMIV
    AccessioniPrimary (citable) accession number: Q7T6X6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 13, 2005
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 59 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programViral Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3