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Q7T3Q2

- CRIM1_DANRE

UniProt

Q7T3Q2 - CRIM1_DANRE

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Protein
Cysteine-rich motor neuron 1 protein
Gene
crim1
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival By similarity.

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. blood vessel development Source: ZFIN
  2. notochord morphogenesis Source: ZFIN
  3. regulation of cell growth Source: InterPro
  4. somitogenesis Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:crim1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040312-2. crim1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 931903Extracellular Reviewed prediction
Add
BLAST
Transmembranei932 – 95221Helical; Reviewed prediction
Add
BLAST
Topological domaini953 – 102775Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828 Reviewed prediction
Add
BLAST
Chaini29 – 1027999Cysteine-rich motor neuron 1 protein
PRO_0000020999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi324 – 3241N-linked (GlcNAc...) Reviewed prediction
Glycosylationi468 – 4681N-linked (GlcNAc...) Reviewed prediction
Glycosylationi741 – 7411N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7T3Q2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10678IGFBP N-terminal
Add
BLAST
Domaini328 – 38558VWFC 1
Add
BLAST
Domaini395 – 45157VWFC 2
Add
BLAST
Domaini463 – 49230Antistasin-like 1
Add
BLAST
Domaini499 – 52628Antistasin-like 2
Add
BLAST
Domaini533 – 55826Antistasin-like 3
Add
BLAST
Domaini561 – 58626Antistasin-like 4
Add
BLAST
Domaini601 – 65858VWFC 3
Add
BLAST
Domaini672 – 73059VWFC 4
Add
BLAST
Domaini746 – 80459VWFC 5
Add
BLAST
Domaini810 – 86758VWFC 6
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi308 – 3103Cell attachment site Reviewed prediction
Motifi883 – 8853Cell attachment site Reviewed prediction

Sequence similaritiesi

Contains 6 VWFC domains.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ7T3Q2.
PhylomeDBiQ7T3Q2.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T3Q2-1 [UniParc]FASTAAdd to Basket

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MASSRMYLLV KCMLILQLMV LIAKNSRALI CLPCDKSKCE EPKPCTGSVV     50
LGICGCCSVC AKQKNESCGG VYGLYGTCDR GLRCVIRPPL NGGSITQYEV 100
GNCEDENWDD DQLLGFEPCN ENLVTGCNII DGKCECDSVR TCNNPFEFAS 150
QEACQTALQK IEEERPDCSK ARCEVQFSPR CPEDSILIEG YAPPGECCPL 200
PSRCVCSPAG CLRKVCQPGH LNILVSKSSG KPGECCDLYE CKPVFSVDCS 250
TVECPPVKPV QCPADSYETQ VRLTADGCCT LPTRCECLPG LCTFPQCSAG 300
MSPQVMSRGD GTPGRCCDVF ECVNETKPAC TLNGVEYHDG DMFRMDACRF 350
CRCQGGVSVC FTAQCGVLHC ERYYVPDGEC CPVCEDPIYP VLSLAGCYVN 400
GQILAHGDHW REDDCTFCQC VSGDARCVAA ACGHSCLNPV TVPGECCPVC 450
EEPTYITMAP PACGSLDNCT LLEQSCAFGF RLDPSGCRTC ACKSREELCG 500
GLMASCTLKC PFGFQTDIHG CDVCQCRPRH KKCKAVACAK DCPFGYIKNK 550
HGCDTCRCKK CPELPCDKAC PMGFQHDELG CLICQCRDQS SSSVTPAVKL 600
GSCLSMDGRR HENGQSWHDG CRDCYCHAGR EMCALISCPV PPCDNPTIRP 650
GHCCPTCPEE SSSHKPELSE ASVCLAPGGE YFVEGETWNI DSCTQCTCHS 700
GRVLCETEVC PPLLCHSPIR TQDSCCPHCP DDPVTPQTPS NDSMPSYCRN 750
EDGDIFLAAE SWKPNVCSSC VCLDGAISCF SESCPPVNCA RPVLRKGQCC 800
PYCLDATPRA VCHFNGKTYM DEERWDIDSC THCYCLQGQT LCSTVSCPAL 850
PCHQPLTVEG SCCPMCPESY APTNVPIEKT DQRGDKSRHQ PAWPTHSEND 900
VMPQFRGEFG SLQMPYLDGK TPLPSEDAGL HWAWVALPVL MMMLTLAALL 950
LVNQRKQWIP VPCYRTPNKS TCLNNQLVYV DCQKGTKVQV DSSQRMLRIA 1000
DPDSRYSGYY SMQKHNNLQA DNFYQTA 1027
Length:1,027
Mass (Da):112,223
Last modified:October 1, 2003 - v1
Checksum:iE831F8CF174344CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151045 mRNA. Translation: AAN72833.1.
RefSeqiNP_997986.1. NM_212821.1.
UniGeneiDr.87739.

Genome annotation databases

GeneIDi404210.
KEGGidre:404210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151045 mRNA. Translation: AAN72833.1 .
RefSeqi NP_997986.1. NM_212821.1.
UniGenei Dr.87739.

3D structure databases

ProteinModelPortali Q7T3Q2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404210.
KEGGi dre:404210.

Organism-specific databases

CTDi 51232.
ZFINi ZDB-GENE-040312-2. crim1.

Phylogenomic databases

eggNOGi NOG283828.
HOGENOMi HOG000063671.
HOVERGENi HBG081345.
InParanoidi Q7T3Q2.
PhylomeDBi Q7T3Q2.

Miscellaneous databases

NextBioi 20817627.
PROi Q7T3Q2.

Family and domain databases

Gene3Di 2.10.22.10. 3 hits.
InterProi IPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEi PS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of zebrafish crim1 ortholog."
    Kolle G.V., Little M.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCRIM1_DANRE
AccessioniPrimary (citable) accession number: Q7T3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2003
Last modified: April 16, 2014
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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