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Q7T3Q2

- CRIM1_DANRE

UniProt

Q7T3Q2 - CRIM1_DANRE

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Protein

Cysteine-rich motor neuron 1 protein

Gene

crim1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.By similarity

GO - Molecular functioni

  1. serine-type endopeptidase inhibitor activity Source: InterPro

GO - Biological processi

  1. blood vessel development Source: ZFIN
  2. notochord morphogenesis Source: ZFIN
  3. regulation of cell growth Source: InterPro
  4. somitogenesis Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:crim1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040312-2. crim1.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2828Sequence AnalysisAdd
BLAST
Chaini29 – 1027999Cysteine-rich motor neuron 1 proteinPRO_0000020999Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ7T3Q2.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini29 – 931903ExtracellularSequence AnalysisAdd
BLAST
Topological domaini953 – 102775CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei932 – 95221HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini29 – 10678IGFBP N-terminalPROSITE-ProRule annotationAdd
BLAST
Domaini328 – 38558VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini395 – 45157VWFC 2PROSITE-ProRule annotationAdd
BLAST
Domaini463 – 49230Antistasin-like 1PROSITE-ProRule annotationAdd
BLAST
Domaini499 – 52628Antistasin-like 2PROSITE-ProRule annotationAdd
BLAST
Domaini533 – 55826Antistasin-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini561 – 58626Antistasin-like 4PROSITE-ProRule annotationAdd
BLAST
Domaini601 – 65858VWFC 3PROSITE-ProRule annotationAdd
BLAST
Domaini672 – 73059VWFC 4PROSITE-ProRule annotationAdd
BLAST
Domaini746 – 80459VWFC 5PROSITE-ProRule annotationAdd
BLAST
Domaini810 – 86758VWFC 6PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi308 – 3103Cell attachment siteSequence Analysis
Motifi883 – 8853Cell attachment siteSequence Analysis

Sequence similaritiesi

Contains 4 antistasin-like domains.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG283828.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ7T3Q2.
PhylomeDBiQ7T3Q2.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T3Q2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MASSRMYLLV KCMLILQLMV LIAKNSRALI CLPCDKSKCE EPKPCTGSVV
60 70 80 90 100
LGICGCCSVC AKQKNESCGG VYGLYGTCDR GLRCVIRPPL NGGSITQYEV
110 120 130 140 150
GNCEDENWDD DQLLGFEPCN ENLVTGCNII DGKCECDSVR TCNNPFEFAS
160 170 180 190 200
QEACQTALQK IEEERPDCSK ARCEVQFSPR CPEDSILIEG YAPPGECCPL
210 220 230 240 250
PSRCVCSPAG CLRKVCQPGH LNILVSKSSG KPGECCDLYE CKPVFSVDCS
260 270 280 290 300
TVECPPVKPV QCPADSYETQ VRLTADGCCT LPTRCECLPG LCTFPQCSAG
310 320 330 340 350
MSPQVMSRGD GTPGRCCDVF ECVNETKPAC TLNGVEYHDG DMFRMDACRF
360 370 380 390 400
CRCQGGVSVC FTAQCGVLHC ERYYVPDGEC CPVCEDPIYP VLSLAGCYVN
410 420 430 440 450
GQILAHGDHW REDDCTFCQC VSGDARCVAA ACGHSCLNPV TVPGECCPVC
460 470 480 490 500
EEPTYITMAP PACGSLDNCT LLEQSCAFGF RLDPSGCRTC ACKSREELCG
510 520 530 540 550
GLMASCTLKC PFGFQTDIHG CDVCQCRPRH KKCKAVACAK DCPFGYIKNK
560 570 580 590 600
HGCDTCRCKK CPELPCDKAC PMGFQHDELG CLICQCRDQS SSSVTPAVKL
610 620 630 640 650
GSCLSMDGRR HENGQSWHDG CRDCYCHAGR EMCALISCPV PPCDNPTIRP
660 670 680 690 700
GHCCPTCPEE SSSHKPELSE ASVCLAPGGE YFVEGETWNI DSCTQCTCHS
710 720 730 740 750
GRVLCETEVC PPLLCHSPIR TQDSCCPHCP DDPVTPQTPS NDSMPSYCRN
760 770 780 790 800
EDGDIFLAAE SWKPNVCSSC VCLDGAISCF SESCPPVNCA RPVLRKGQCC
810 820 830 840 850
PYCLDATPRA VCHFNGKTYM DEERWDIDSC THCYCLQGQT LCSTVSCPAL
860 870 880 890 900
PCHQPLTVEG SCCPMCPESY APTNVPIEKT DQRGDKSRHQ PAWPTHSEND
910 920 930 940 950
VMPQFRGEFG SLQMPYLDGK TPLPSEDAGL HWAWVALPVL MMMLTLAALL
960 970 980 990 1000
LVNQRKQWIP VPCYRTPNKS TCLNNQLVYV DCQKGTKVQV DSSQRMLRIA
1010 1020
DPDSRYSGYY SMQKHNNLQA DNFYQTA
Length:1,027
Mass (Da):112,223
Last modified:October 1, 2003 - v1
Checksum:iE831F8CF174344CC
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151045 mRNA. Translation: AAN72833.1.
RefSeqiNP_997986.1. NM_212821.1.
UniGeneiDr.87739.

Genome annotation databases

GeneIDi404210.
KEGGidre:404210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY151045 mRNA. Translation: AAN72833.1 .
RefSeqi NP_997986.1. NM_212821.1.
UniGenei Dr.87739.

3D structure databases

ProteinModelPortali Q7T3Q2.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 404210.
KEGGi dre:404210.

Organism-specific databases

CTDi 51232.
ZFINi ZDB-GENE-040312-2. crim1.

Phylogenomic databases

eggNOGi NOG283828.
HOGENOMi HOG000063671.
HOVERGENi HBG081345.
InParanoidi Q7T3Q2.
PhylomeDBi Q7T3Q2.

Miscellaneous databases

NextBioi 20817627.
PROi Q7T3Q2.

Family and domain databases

Gene3Di 2.10.22.10. 3 hits.
InterProi IPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view ]
SMARTi SM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view ]
SUPFAMi SSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEi PS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Characterization of zebrafish crim1 ortholog."
    Kolle G.V., Little M.
    Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCRIM1_DANRE
AccessioniPrimary (citable) accession number: Q7T3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3