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Q7T3Q2

- CRIM1_DANRE

UniProt

Q7T3Q2 - CRIM1_DANRE

Protein

Cysteine-rich motor neuron 1 protein

Gene

crim1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 70 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.By similarity

    GO - Molecular functioni

    1. serine-type endopeptidase inhibitor activity Source: InterPro

    GO - Biological processi

    1. blood vessel development Source: ZFIN
    2. notochord morphogenesis Source: ZFIN
    3. regulation of cell growth Source: InterPro
    4. somitogenesis Source: ZFIN

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cysteine-rich motor neuron 1 protein
    Short name:
    CRIM-1
    Gene namesi
    Name:crim1
    OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
    Taxonomic identifieri7955 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
    ProteomesiUP000000437: Unplaced

    Organism-specific databases

    ZFINiZDB-GENE-040312-2. crim1.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2828Sequence AnalysisAdd
    BLAST
    Chaini29 – 1027999Cysteine-rich motor neuron 1 proteinPRO_0000020999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi65 – 651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi468 – 4681N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi741 – 7411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Structurei

    3D structure databases

    ProteinModelPortaliQ7T3Q2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini29 – 931903ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini953 – 102775CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei932 – 95221HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini29 – 10678IGFBP N-terminalPROSITE-ProRule annotationAdd
    BLAST
    Domaini328 – 38558VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini395 – 45157VWFC 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini463 – 49230Antistasin-like 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini499 – 52628Antistasin-like 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini533 – 55826Antistasin-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini561 – 58626Antistasin-like 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini601 – 65858VWFC 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini672 – 73059VWFC 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini746 – 80459VWFC 5PROSITE-ProRule annotationAdd
    BLAST
    Domaini810 – 86758VWFC 6PROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi308 – 3103Cell attachment siteSequence Analysis
    Motifi883 – 8853Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Contains 4 antistasin-like domains.PROSITE-ProRule annotation
    Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
    Contains 6 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG283828.
    HOGENOMiHOG000063671.
    HOVERGENiHBG081345.
    InParanoidiQ7T3Q2.
    PhylomeDBiQ7T3Q2.

    Family and domain databases

    Gene3Di2.10.22.10. 3 hits.
    InterProiIPR004094. Antistasin-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011061. Hirudin/antistatin.
    IPR000867. IGFBP-like.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF02822. Antistasin. 4 hits.
    PF00093. VWC. 6 hits.
    [Graphical view]
    SMARTiSM00121. IB. 1 hit.
    SM00214. VWC. 6 hits.
    [Graphical view]
    SUPFAMiSSF57184. SSF57184. 1 hit.
    SSF57262. SSF57262. 3 hits.
    PROSITEiPS51252. ANTISTASIN. 4 hits.
    PS51323. IGFBP_N_2. 1 hit.
    PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7T3Q2-1 [UniParc]FASTAAdd to Basket

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    MASSRMYLLV KCMLILQLMV LIAKNSRALI CLPCDKSKCE EPKPCTGSVV     50
    LGICGCCSVC AKQKNESCGG VYGLYGTCDR GLRCVIRPPL NGGSITQYEV 100
    GNCEDENWDD DQLLGFEPCN ENLVTGCNII DGKCECDSVR TCNNPFEFAS 150
    QEACQTALQK IEEERPDCSK ARCEVQFSPR CPEDSILIEG YAPPGECCPL 200
    PSRCVCSPAG CLRKVCQPGH LNILVSKSSG KPGECCDLYE CKPVFSVDCS 250
    TVECPPVKPV QCPADSYETQ VRLTADGCCT LPTRCECLPG LCTFPQCSAG 300
    MSPQVMSRGD GTPGRCCDVF ECVNETKPAC TLNGVEYHDG DMFRMDACRF 350
    CRCQGGVSVC FTAQCGVLHC ERYYVPDGEC CPVCEDPIYP VLSLAGCYVN 400
    GQILAHGDHW REDDCTFCQC VSGDARCVAA ACGHSCLNPV TVPGECCPVC 450
    EEPTYITMAP PACGSLDNCT LLEQSCAFGF RLDPSGCRTC ACKSREELCG 500
    GLMASCTLKC PFGFQTDIHG CDVCQCRPRH KKCKAVACAK DCPFGYIKNK 550
    HGCDTCRCKK CPELPCDKAC PMGFQHDELG CLICQCRDQS SSSVTPAVKL 600
    GSCLSMDGRR HENGQSWHDG CRDCYCHAGR EMCALISCPV PPCDNPTIRP 650
    GHCCPTCPEE SSSHKPELSE ASVCLAPGGE YFVEGETWNI DSCTQCTCHS 700
    GRVLCETEVC PPLLCHSPIR TQDSCCPHCP DDPVTPQTPS NDSMPSYCRN 750
    EDGDIFLAAE SWKPNVCSSC VCLDGAISCF SESCPPVNCA RPVLRKGQCC 800
    PYCLDATPRA VCHFNGKTYM DEERWDIDSC THCYCLQGQT LCSTVSCPAL 850
    PCHQPLTVEG SCCPMCPESY APTNVPIEKT DQRGDKSRHQ PAWPTHSEND 900
    VMPQFRGEFG SLQMPYLDGK TPLPSEDAGL HWAWVALPVL MMMLTLAALL 950
    LVNQRKQWIP VPCYRTPNKS TCLNNQLVYV DCQKGTKVQV DSSQRMLRIA 1000
    DPDSRYSGYY SMQKHNNLQA DNFYQTA 1027
    Length:1,027
    Mass (Da):112,223
    Last modified:October 1, 2003 - v1
    Checksum:iE831F8CF174344CC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY151045 mRNA. Translation: AAN72833.1.
    RefSeqiNP_997986.1. NM_212821.1.
    UniGeneiDr.87739.

    Genome annotation databases

    GeneIDi404210.
    KEGGidre:404210.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY151045 mRNA. Translation: AAN72833.1 .
    RefSeqi NP_997986.1. NM_212821.1.
    UniGenei Dr.87739.

    3D structure databases

    ProteinModelPortali Q7T3Q2.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 404210.
    KEGGi dre:404210.

    Organism-specific databases

    CTDi 51232.
    ZFINi ZDB-GENE-040312-2. crim1.

    Phylogenomic databases

    eggNOGi NOG283828.
    HOGENOMi HOG000063671.
    HOVERGENi HBG081345.
    InParanoidi Q7T3Q2.
    PhylomeDBi Q7T3Q2.

    Miscellaneous databases

    NextBioi 20817627.
    PROi Q7T3Q2.

    Family and domain databases

    Gene3Di 2.10.22.10. 3 hits.
    InterProi IPR004094. Antistasin-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR011061. Hirudin/antistatin.
    IPR000867. IGFBP-like.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF02822. Antistasin. 4 hits.
    PF00093. VWC. 6 hits.
    [Graphical view ]
    SMARTi SM00121. IB. 1 hit.
    SM00214. VWC. 6 hits.
    [Graphical view ]
    SUPFAMi SSF57184. SSF57184. 1 hit.
    SSF57262. SSF57262. 3 hits.
    PROSITEi PS51252. ANTISTASIN. 4 hits.
    PS51323. IGFBP_N_2. 1 hit.
    PS01208. VWFC_1. 6 hits.
    PS50184. VWFC_2. 6 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of zebrafish crim1 ortholog."
      Kolle G.V., Little M.
      Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCRIM1_DANRE
    AccessioniPrimary (citable) accession number: Q7T3Q2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 70 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3