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Q7T3Q2 (CRIM1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 63. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Cysteine-rich motor neuron 1 protein
Short name=CRIM-1
Gene names
Name:crim1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length1027 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Contains 4 antistasin-like domains.

Contains 1 IGFBP N-terminal domain.

Contains 6 VWFC domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2828 Potential
Chain29 – 1027999Cysteine-rich motor neuron 1 protein
PRO_0000020999

Regions

Topological domain29 – 931903Extracellular Potential
Transmembrane932 – 95221Helical; Potential
Topological domain953 – 102775Cytoplasmic Potential
Domain29 – 10678IGFBP N-terminal
Domain328 – 38558VWFC 1
Domain395 – 45157VWFC 2
Domain463 – 49230Antistasin-like 1
Domain499 – 52628Antistasin-like 2
Domain533 – 55826Antistasin-like 3
Domain561 – 58626Antistasin-like 4
Domain601 – 65858VWFC 3
Domain672 – 73059VWFC 4
Domain746 – 80459VWFC 5
Domain810 – 86758VWFC 6
Motif308 – 3103Cell attachment site Potential
Motif883 – 8853Cell attachment site Potential

Amino acid modifications

Glycosylation651N-linked (GlcNAc...) Potential
Glycosylation3241N-linked (GlcNAc...) Potential
Glycosylation4681N-linked (GlcNAc...) Potential
Glycosylation7411N-linked (GlcNAc...) Potential

Sequences

Sequence LengthMass (Da)Tools
Q7T3Q2 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: E831F8CF174344CC

FASTA1,027112,223
        10         20         30         40         50         60 
MASSRMYLLV KCMLILQLMV LIAKNSRALI CLPCDKSKCE EPKPCTGSVV LGICGCCSVC 

        70         80         90        100        110        120 
AKQKNESCGG VYGLYGTCDR GLRCVIRPPL NGGSITQYEV GNCEDENWDD DQLLGFEPCN 

       130        140        150        160        170        180 
ENLVTGCNII DGKCECDSVR TCNNPFEFAS QEACQTALQK IEEERPDCSK ARCEVQFSPR 

       190        200        210        220        230        240 
CPEDSILIEG YAPPGECCPL PSRCVCSPAG CLRKVCQPGH LNILVSKSSG KPGECCDLYE 

       250        260        270        280        290        300 
CKPVFSVDCS TVECPPVKPV QCPADSYETQ VRLTADGCCT LPTRCECLPG LCTFPQCSAG 

       310        320        330        340        350        360 
MSPQVMSRGD GTPGRCCDVF ECVNETKPAC TLNGVEYHDG DMFRMDACRF CRCQGGVSVC 

       370        380        390        400        410        420 
FTAQCGVLHC ERYYVPDGEC CPVCEDPIYP VLSLAGCYVN GQILAHGDHW REDDCTFCQC 

       430        440        450        460        470        480 
VSGDARCVAA ACGHSCLNPV TVPGECCPVC EEPTYITMAP PACGSLDNCT LLEQSCAFGF 

       490        500        510        520        530        540 
RLDPSGCRTC ACKSREELCG GLMASCTLKC PFGFQTDIHG CDVCQCRPRH KKCKAVACAK 

       550        560        570        580        590        600 
DCPFGYIKNK HGCDTCRCKK CPELPCDKAC PMGFQHDELG CLICQCRDQS SSSVTPAVKL 

       610        620        630        640        650        660 
GSCLSMDGRR HENGQSWHDG CRDCYCHAGR EMCALISCPV PPCDNPTIRP GHCCPTCPEE 

       670        680        690        700        710        720 
SSSHKPELSE ASVCLAPGGE YFVEGETWNI DSCTQCTCHS GRVLCETEVC PPLLCHSPIR 

       730        740        750        760        770        780 
TQDSCCPHCP DDPVTPQTPS NDSMPSYCRN EDGDIFLAAE SWKPNVCSSC VCLDGAISCF 

       790        800        810        820        830        840 
SESCPPVNCA RPVLRKGQCC PYCLDATPRA VCHFNGKTYM DEERWDIDSC THCYCLQGQT 

       850        860        870        880        890        900 
LCSTVSCPAL PCHQPLTVEG SCCPMCPESY APTNVPIEKT DQRGDKSRHQ PAWPTHSEND 

       910        920        930        940        950        960 
VMPQFRGEFG SLQMPYLDGK TPLPSEDAGL HWAWVALPVL MMMLTLAALL LVNQRKQWIP 

       970        980        990       1000       1010       1020 
VPCYRTPNKS TCLNNQLVYV DCQKGTKVQV DSSQRMLRIA DPDSRYSGYY SMQKHNNLQA 


DNFYQTA

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References

[1]"Characterization of zebrafish crim1 ortholog."
Kolle G.V., Little M.
Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY151045 mRNA. Translation: AAN72833.1.
IPIIPI00492954.
RefSeqNP_997986.1. NM_212821.1.
UniGeneDr.87739.

3D structure databases

ProteinModelPortalQ7T3Q2.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID404210.
KEGGdre:404210.

Organism-specific databases

CTD51232.
ZFINZDB-GENE-040312-2. crim1.

Phylogenomic databases

eggNOGNOG283828.
HOGENOMHOG000063671.
HOVERGENHBG081345.
InParanoidQ7T3Q2.
OrthoDBEOG4JQ3WR.

Family and domain databases

Gene3D2.10.22.10. 3 hits.
InterProIPR000867. IGFBP-like.
IPR011061. Prot_inh_I14/15_hirudin/antisn.
IPR018112. Prot_inh_I15_antistasin.
IPR004094. Prot_inh_I15_antistasin-like.
IPR001007. VWF_C.
[Graphical view]
PfamPF02822. Antistasin. 4 hits.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
[Graphical view]
SUPFAMSSF57262. Antihaemostatic. 2 hits.
PROSITEPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio20817627.

Entry information

Entry nameCRIM1_DANRE
AccessionPrimary (citable) accession number: Q7T3Q2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2003
Last modified: April 3, 2013
This is version 63 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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