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Protein

Cysteine-rich motor neuron 1 protein

Gene

crim1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival.By similarity

GO - Molecular functioni

GO - Biological processi

  • blood vessel development Source: ZFIN
  • notochord morphogenesis Source: ZFIN
  • regulation of cell growth Source: InterPro
  • somitogenesis Source: ZFIN
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Cysteine-rich motor neuron 1 protein
Short name:
CRIM-1
Gene namesi
Name:crim1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040312-2. crim1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini29 – 931ExtracellularSequence analysisAdd BLAST903
Transmembranei932 – 952HelicalSequence analysisAdd BLAST21
Topological domaini953 – 1027CytoplasmicSequence analysisAdd BLAST75

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000002099929 – 1027Cysteine-rich motor neuron 1 proteinAdd BLAST999

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi65N-linked (GlcNAc...)Sequence analysis1
Glycosylationi324N-linked (GlcNAc...)Sequence analysis1
Glycosylationi468N-linked (GlcNAc...)Sequence analysis1
Glycosylationi741N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ7T3Q2.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000050533.

Structurei

3D structure databases

ProteinModelPortaliQ7T3Q2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini29 – 106IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST78
Domaini328 – 385VWFC 1PROSITE-ProRule annotationAdd BLAST58
Domaini395 – 451VWFC 2PROSITE-ProRule annotationAdd BLAST57
Domaini463 – 492Antistasin-like 1PROSITE-ProRule annotationAdd BLAST30
Domaini499 – 526Antistasin-like 2PROSITE-ProRule annotationAdd BLAST28
Domaini533 – 558Antistasin-like 3PROSITE-ProRule annotationAdd BLAST26
Domaini561 – 586Antistasin-like 4PROSITE-ProRule annotationAdd BLAST26
Domaini601 – 658VWFC 3PROSITE-ProRule annotationAdd BLAST58
Domaini672 – 730VWFC 4PROSITE-ProRule annotationAdd BLAST59
Domaini746 – 804VWFC 5PROSITE-ProRule annotationAdd BLAST59
Domaini810 – 867VWFC 6PROSITE-ProRule annotationAdd BLAST58

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi308 – 310Cell attachment siteSequence analysis3
Motifi883 – 885Cell attachment siteSequence analysis3

Sequence similaritiesi

Contains 4 antistasin-like domains.PROSITE-ProRule annotation
Contains 1 IGFBP N-terminal domain.PROSITE-ProRule annotation
Contains 6 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IR8F. Eukaryota.
ENOG410Z6K0. LUCA.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ7T3Q2.
PhylomeDBiQ7T3Q2.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T3Q2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSRMYLLV KCMLILQLMV LIAKNSRALI CLPCDKSKCE EPKPCTGSVV
60 70 80 90 100
LGICGCCSVC AKQKNESCGG VYGLYGTCDR GLRCVIRPPL NGGSITQYEV
110 120 130 140 150
GNCEDENWDD DQLLGFEPCN ENLVTGCNII DGKCECDSVR TCNNPFEFAS
160 170 180 190 200
QEACQTALQK IEEERPDCSK ARCEVQFSPR CPEDSILIEG YAPPGECCPL
210 220 230 240 250
PSRCVCSPAG CLRKVCQPGH LNILVSKSSG KPGECCDLYE CKPVFSVDCS
260 270 280 290 300
TVECPPVKPV QCPADSYETQ VRLTADGCCT LPTRCECLPG LCTFPQCSAG
310 320 330 340 350
MSPQVMSRGD GTPGRCCDVF ECVNETKPAC TLNGVEYHDG DMFRMDACRF
360 370 380 390 400
CRCQGGVSVC FTAQCGVLHC ERYYVPDGEC CPVCEDPIYP VLSLAGCYVN
410 420 430 440 450
GQILAHGDHW REDDCTFCQC VSGDARCVAA ACGHSCLNPV TVPGECCPVC
460 470 480 490 500
EEPTYITMAP PACGSLDNCT LLEQSCAFGF RLDPSGCRTC ACKSREELCG
510 520 530 540 550
GLMASCTLKC PFGFQTDIHG CDVCQCRPRH KKCKAVACAK DCPFGYIKNK
560 570 580 590 600
HGCDTCRCKK CPELPCDKAC PMGFQHDELG CLICQCRDQS SSSVTPAVKL
610 620 630 640 650
GSCLSMDGRR HENGQSWHDG CRDCYCHAGR EMCALISCPV PPCDNPTIRP
660 670 680 690 700
GHCCPTCPEE SSSHKPELSE ASVCLAPGGE YFVEGETWNI DSCTQCTCHS
710 720 730 740 750
GRVLCETEVC PPLLCHSPIR TQDSCCPHCP DDPVTPQTPS NDSMPSYCRN
760 770 780 790 800
EDGDIFLAAE SWKPNVCSSC VCLDGAISCF SESCPPVNCA RPVLRKGQCC
810 820 830 840 850
PYCLDATPRA VCHFNGKTYM DEERWDIDSC THCYCLQGQT LCSTVSCPAL
860 870 880 890 900
PCHQPLTVEG SCCPMCPESY APTNVPIEKT DQRGDKSRHQ PAWPTHSEND
910 920 930 940 950
VMPQFRGEFG SLQMPYLDGK TPLPSEDAGL HWAWVALPVL MMMLTLAALL
960 970 980 990 1000
LVNQRKQWIP VPCYRTPNKS TCLNNQLVYV DCQKGTKVQV DSSQRMLRIA
1010 1020
DPDSRYSGYY SMQKHNNLQA DNFYQTA
Length:1,027
Mass (Da):112,223
Last modified:October 1, 2003 - v1
Checksum:iE831F8CF174344CC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151045 mRNA. Translation: AAN72833.1.
RefSeqiNP_997986.1. NM_212821.1.
UniGeneiDr.87739.

Genome annotation databases

GeneIDi404210.
KEGGidre:404210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY151045 mRNA. Translation: AAN72833.1.
RefSeqiNP_997986.1. NM_212821.1.
UniGeneiDr.87739.

3D structure databases

ProteinModelPortaliQ7T3Q2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000050533.

Proteomic databases

PaxDbiQ7T3Q2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi404210.
KEGGidre:404210.

Organism-specific databases

CTDi51232.
ZFINiZDB-GENE-040312-2. crim1.

Phylogenomic databases

eggNOGiENOG410IR8F. Eukaryota.
ENOG410Z6K0. LUCA.
HOGENOMiHOG000063671.
HOVERGENiHBG081345.
InParanoidiQ7T3Q2.
PhylomeDBiQ7T3Q2.

Miscellaneous databases

PROiQ7T3Q2.

Family and domain databases

Gene3Di2.10.22.10. 3 hits.
InterProiIPR004094. Antistasin-like.
IPR009030. Growth_fac_rcpt_.
IPR011061. Hirudin/antistatin.
IPR000867. IGFBP-like.
IPR001007. VWF_dom.
[Graphical view]
PfamiPF02822. Antistasin. 4 hits.
PF00219. IGFBP. 1 hit.
PF00093. VWC. 6 hits.
[Graphical view]
SMARTiSM00121. IB. 1 hit.
SM00214. VWC. 6 hits.
SM00215. VWC_out. 5 hits.
[Graphical view]
SUPFAMiSSF57184. SSF57184. 1 hit.
SSF57262. SSF57262. 3 hits.
PROSITEiPS51252. ANTISTASIN. 4 hits.
PS51323. IGFBP_N_2. 1 hit.
PS01208. VWFC_1. 6 hits.
PS50184. VWFC_2. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRIM1_DANRE
AccessioniPrimary (citable) accession number: Q7T3Q2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.