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Q7T3L1 (BRK1A_BOMMX) Reviewed, UniProtKB/Swiss-Prot

Last modified November 13, 2013. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Kininogen-1a

Cleaved into the following 3 chains:

  1. Maximakinin
    Alternative name(s):
    Bombinakinin M
  2. Bradykinin
  3. Bombinakinin-GAP
    Alternative name(s):
    Bombinakinin M gene-associated protein
OrganismBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifier161274 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Protein attributes

Sequence length294 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Bombinakinin-GAP: plays a role in the control of feeding by the brain; intracerebroventricular administration of the peptide induced significant decrease in food intake in rats. Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle. May target bradykinin receptors (BDKRB). Ref.1 Ref.2

Subcellular location

Secreted Ref.1.

Tissue specificity

Expressed by the skin glands. Ref.1

Sequence similarities

Belongs to the bradykinin-related peptide family.

Mass spectrometry

Molecular mass is 3228±0.4 Da from positions 265 - 292. Determined by FAB. Ref.1

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 Potential
Chain24 – 294271Kininogen-1a
PRO_0000003385
Peptide41 – 5919Maximakinin By similarity UniProtKB Q90W88
PRO_0000003386
Peptide51 – 6616Bradykinin By similarity UniProtKB Q90W88
PRO_0000003387
Peptide69 – 8719Maximakinin By similarity UniProtKB Q90W88
PRO_0000003388
Peptide79 – 9416Bradykinin By similarity UniProtKB Q90W88
PRO_0000003389
Peptide97 – 11519Maximakinin By similarity UniProtKB Q90W88
PRO_0000003390
Peptide107 – 12216Bradykinin By similarity UniProtKB Q90W88
PRO_0000003391
Peptide125 – 14319Maximakinin By similarity UniProtKB Q90W88
PRO_0000003392
Peptide135 – 15016Bradykinin By similarity
PRO_0000003393
Peptide153 – 17119Maximakinin By similarity UniProtKB Q90W88
PRO_0000003394
Peptide163 – 17816Bradykinin By similarity UniProtKB Q90W88
PRO_0000003395
Peptide181 – 19919Maximakinin By similarity UniProtKB Q90W88
PRO_0000003396
Peptide191 – 20616Bradykinin By similarity UniProtKB Q90W88
PRO_0000003397
Peptide209 – 22719Maximakinin By similarity UniProtKB Q90W88
PRO_0000003398
Peptide219 – 23416Bradykinin By similarity UniProtKB Q90W88
PRO_0000003399
Peptide237 – 25519Maximakinin By similarity UniProtKB Q90W88
PRO_0000003400
Peptide247 – 26216Bradykinin By similarity UniProtKB Q90W88
PRO_0000003401
Peptide265 – 29228Bombinakinin-GAP Ref.1
PRO_0000003402

Amino acid modifications

Modified residue2921Valine amide Ref.1
Disulfide bond282 ↔ 288 Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q7T3L1 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 7C87B4D88482C530

FASTA29433,857
        10         20         30         40         50         60 
MRLWFCLSFF IVLCLEHFTG TLADERNVPE SEEKTEQFLR DLPKINRKGP RPPGFSPFRG 

        70         80         90        100        110        120 
KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK INRKGPRPPG FSPFRGKFHS 

       130        140        150        160        170        180 
QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS LRDLPKINRK GPRPPGFSPF RGKFHSQSLR 

       190        200        210        220        230        240 
DLPKINRKGP RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK 

       250        260        270        280        290 
INRKGPRPPG FSPFRGKFHS QSLRDMYEIK QYKTAHGRPP ICAPGEQCPI WVGK 

« Hide

References

[1]"Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima."
Lai R., Liu H., Lee W.H., Zhang Y.
Peptides 24:199-204(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 265-292, SYNTHESIS OF 265-292, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, DISULFIDE BOND, AMIDATION AT VAL-292.
Tissue: Skin secretion.
[2]"Peptide DV-28 amide: An inhibitor of bradykinin-induced arterial smooth muscle relaxation encoded by Bombina orientalis skin kininogen-2."
Wang L., Chen Y., Yang M., Zhou M., Chen T., Sui D.Y., Shaw C.
Peptides 31:979-982(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: SYNTHESIS OF 265-292, FUNCTION.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF515613 mRNA. Translation: AAP47179.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Phylogenomic databases

HOVERGENHBG031664.

Family and domain databases

InterProIPR009608. Bradykinin.
[Graphical view]
PfamPF06753. Bradykinin. 8 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameBRK1A_BOMMX
AccessionPrimary (citable) accession number: Q7T3L1
Entry history
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2003
Last modified: November 13, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families