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Q7T3L1

- BRK1A_BOMMX

UniProt

Q7T3L1 - BRK1A_BOMMX

Protein

Kininogen-1a

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Bombinakinin-GAP: plays a role in the control of feeding by the brain; intracerebroventricular administration of the peptide induced significant decrease in food intake in rats. Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle. May target bradykinin receptors (BDKRB).2 Publications

    GO - Molecular functioni

    1. hormone activity Source: UniProtKB

    GO - Biological processi

    1. defense response Source: UniProtKB
    2. eating behavior Source: UniProtKB
    3. vasodilation Source: UniProtKB-KW

    Keywords - Molecular functioni

    Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Kininogen-1a
    Cleaved into the following 3 chains:
    Alternative name(s):
    Bombinakinin M
    Alternative name(s):
    Bombinakinin M gene-associated protein
    OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
    Taxonomic identifieri161274 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

    Subcellular locationi

    Secreted 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323Sequence AnalysisAdd
    BLAST
    Chaini24 – 294271Kininogen-1aSequence AnalysisPRO_0000003385Add
    BLAST
    Peptidei41 – 5919MaximakininBy similarityPRO_0000003386Add
    BLAST
    Peptidei51 – 6616BradykininBy similarityPRO_0000003387Add
    BLAST
    Peptidei69 – 8719MaximakininBy similarityPRO_0000003388Add
    BLAST
    Peptidei79 – 9416BradykininBy similarityPRO_0000003389Add
    BLAST
    Peptidei97 – 11519MaximakininBy similarityPRO_0000003390Add
    BLAST
    Peptidei107 – 12216BradykininBy similarityPRO_0000003391Add
    BLAST
    Peptidei125 – 14319MaximakininBy similarityPRO_0000003392Add
    BLAST
    Peptidei135 – 15016BradykininBy similarityPRO_0000003393Add
    BLAST
    Peptidei153 – 17119MaximakininBy similarityPRO_0000003394Add
    BLAST
    Peptidei163 – 17816BradykininBy similarityPRO_0000003395Add
    BLAST
    Peptidei181 – 19919MaximakininBy similarityPRO_0000003396Add
    BLAST
    Peptidei191 – 20616BradykininBy similarityPRO_0000003397Add
    BLAST
    Peptidei209 – 22719MaximakininBy similarityPRO_0000003398Add
    BLAST
    Peptidei219 – 23416BradykininBy similarityPRO_0000003399Add
    BLAST
    Peptidei237 – 25519MaximakininBy similarityPRO_0000003400Add
    BLAST
    Peptidei247 – 26216BradykininBy similarityPRO_0000003401Add
    BLAST
    Peptidei265 – 29228Bombinakinin-GAP1 PublicationPRO_0000003402Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi282 ↔ 2881 Publication
    Modified residuei292 – 2921Valine amide1 Publication

    Keywords - PTMi

    Amidation, Cleavage on pair of basic residues, Disulfide bond

    Expressioni

    Tissue specificityi

    Expressed by the skin glands.1 Publication

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the bradykinin-related peptide family.Curated

    Keywords - Domaini

    Repeat, Signal

    Phylogenomic databases

    HOVERGENiHBG031664.

    Family and domain databases

    InterProiIPR009608. Bradykinin.
    [Graphical view]
    PfamiPF06753. Bradykinin. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q7T3L1-1 [UniParc]FASTAAdd to Basket

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    MRLWFCLSFF IVLCLEHFTG TLADERNVPE SEEKTEQFLR DLPKINRKGP    50
    RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK 100
    INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS 150
    LRDLPKINRK GPRPPGFSPF RGKFHSQSLR DLPKINRKGP RPPGFSPFRG 200
    KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK INRKGPRPPG 250
    FSPFRGKFHS QSLRDMYEIK QYKTAHGRPP ICAPGEQCPI WVGK 294
    Length:294
    Mass (Da):33,857
    Last modified:October 1, 2003 - v1
    Checksum:i7C87B4D88482C530
    GO

    Mass spectrometryi

    Molecular mass is 3228±0.4 Da from positions 265 - 292. Determined by FAB. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF515613 mRNA. Translation: AAP47179.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF515613 mRNA. Translation: AAP47179.1 .

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG031664.

    Family and domain databases

    InterProi IPR009608. Bradykinin.
    [Graphical view ]
    Pfami PF06753. Bradykinin. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima."
      Lai R., Liu H., Lee W.H., Zhang Y.
      Peptides 24:199-204(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 265-292, SYNTHESIS OF 265-292, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, DISULFIDE BOND, AMIDATION AT VAL-292.
      Tissue: Skin secretion1 Publication.
    2. "Peptide DV-28 amide: An inhibitor of bradykinin-induced arterial smooth muscle relaxation encoded by Bombina orientalis skin kininogen-2."
      Wang L., Chen Y., Yang M., Zhou M., Chen T., Sui D.Y., Shaw C.
      Peptides 31:979-982(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: SYNTHESIS OF 265-292, FUNCTION.

    Entry informationi

    Entry nameiBRK1A_BOMMX
    AccessioniPrimary (citable) accession number: Q7T3L1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 4, 2005
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    Annotation programAnimal Toxin Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Direct protein sequencing

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3