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Protein

Kininogen-1a

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Bombinakinin-GAP: plays a role in the control of feeding by the brain; intracerebroventricular administration of the peptide induced significant decrease in food intake in rats. Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle. May target bradykinin receptors (BDKRB).2 Publications

GO - Molecular functioni

  • hormone activity Source: UniProtKB

GO - Biological processi

  • defense response Source: UniProtKB
  • eating behavior Source: UniProtKB
  • vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1a
Cleaved into the following 3 chains:
Alternative name(s):
Bombinakinin M
Alternative name(s):
Bombinakinin M gene-associated protein
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

  • Secreted 1 Publication

GO - Cellular componenti

  • extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000338524 – 294Kininogen-1aSequence analysisAdd BLAST271
PeptideiPRO_000000338641 – 59MaximakininBy similarityAdd BLAST19
PeptideiPRO_000000338751 – 66BradykininBy similarityAdd BLAST16
PeptideiPRO_000000338869 – 87MaximakininBy similarityAdd BLAST19
PeptideiPRO_000000338979 – 94BradykininBy similarityAdd BLAST16
PeptideiPRO_000000339097 – 115MaximakininBy similarityAdd BLAST19
PeptideiPRO_0000003391107 – 122BradykininBy similarityAdd BLAST16
PeptideiPRO_0000003392125 – 143MaximakininBy similarityAdd BLAST19
PeptideiPRO_0000003393135 – 150BradykininBy similarityAdd BLAST16
PeptideiPRO_0000003394153 – 171MaximakininBy similarityAdd BLAST19
PeptideiPRO_0000003395163 – 178BradykininBy similarityAdd BLAST16
PeptideiPRO_0000003396181 – 199MaximakininBy similarityAdd BLAST19
PeptideiPRO_0000003397191 – 206BradykininBy similarityAdd BLAST16
PeptideiPRO_0000003398209 – 227MaximakininBy similarityAdd BLAST19
PeptideiPRO_0000003399219 – 234BradykininBy similarityAdd BLAST16
PeptideiPRO_0000003400237 – 255MaximakininBy similarityAdd BLAST19
PeptideiPRO_0000003401247 – 262BradykininBy similarityAdd BLAST16
PeptideiPRO_0000003402265 – 292Bombinakinin-GAP1 PublicationAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi282 ↔ 2881 Publication
Modified residuei292Valine amide1 Publication1

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Interactioni

GO - Molecular functioni

  • hormone activity Source: UniProtKB

Family & Domainsi

Sequence similaritiesi

Belongs to the bradykinin-related peptide family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T3L1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRLWFCLSFF IVLCLEHFTG TLADERNVPE SEEKTEQFLR DLPKINRKGP
60 70 80 90 100
RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK
110 120 130 140 150
INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS
160 170 180 190 200
LRDLPKINRK GPRPPGFSPF RGKFHSQSLR DLPKINRKGP RPPGFSPFRG
210 220 230 240 250
KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK INRKGPRPPG
260 270 280 290
FSPFRGKFHS QSLRDMYEIK QYKTAHGRPP ICAPGEQCPI WVGK
Length:294
Mass (Da):33,857
Last modified:October 1, 2003 - v1
Checksum:i7C87B4D88482C530
GO

Mass spectrometryi

Molecular mass is 3228±0.4 Da from positions 265 - 292. Determined by FAB. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515613 mRNA. Translation: AAP47179.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF515613 mRNA. Translation: AAP47179.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBRK1A_BOMMX
AccessioniPrimary (citable) accession number: Q7T3L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2003
Last modified: October 1, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.