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Q7T3L1

- BRK1A_BOMMX

UniProt

Q7T3L1 - BRK1A_BOMMX

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Protein

Kininogen-1a

Gene
N/A
Organism
Bombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Bombinakinin-GAP: plays a role in the control of feeding by the brain; intracerebroventricular administration of the peptide induced significant decrease in food intake in rats. Inhibits the bradykinin-induced in vitro relaxation of rat arterial smooth muscle. May target bradykinin receptors (BDKRB).2 Publications

GO - Molecular functioni

  1. hormone activity Source: UniProtKB

GO - Biological processi

  1. defense response Source: UniProtKB
  2. eating behavior Source: UniProtKB
  3. vasodilation Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Amphibian defense peptide, G-protein coupled receptor impairing toxin, Toxin, Vasoactive, Vasodilator

Names & Taxonomyi

Protein namesi
Recommended name:
Kininogen-1a
Cleaved into the following 3 chains:
Alternative name(s):
Bombinakinin M
Alternative name(s):
Bombinakinin M gene-associated protein
OrganismiBombina maxima (Giant fire-bellied toad) (Chinese red belly toad)
Taxonomic identifieri161274 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraBombinatoridaeBombina

Subcellular locationi

Secreted 1 Publication

GO - Cellular componenti

  1. extracellular region Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed predictionAdd
BLAST
Chaini24 – 294271Kininogen-1aPRO_0000003385Add
BLAST
Peptidei41 – 5919Maximakinin By similarityBy similarityPRO_0000003386Add
BLAST
Peptidei51 – 6616Bradykinin By similarityBy similarityPRO_0000003387Add
BLAST
Peptidei69 – 8719Maximakinin By similarityBy similarityPRO_0000003388Add
BLAST
Peptidei79 – 9416Bradykinin By similarityBy similarityPRO_0000003389Add
BLAST
Peptidei97 – 11519Maximakinin By similarityBy similarityPRO_0000003390Add
BLAST
Peptidei107 – 12216Bradykinin By similarityBy similarityPRO_0000003391Add
BLAST
Peptidei125 – 14319Maximakinin By similarityBy similarityPRO_0000003392Add
BLAST
Peptidei135 – 15016Bradykinin By similarityPRO_0000003393Add
BLAST
Peptidei153 – 17119Maximakinin By similarityBy similarityPRO_0000003394Add
BLAST
Peptidei163 – 17816Bradykinin By similarityBy similarityPRO_0000003395Add
BLAST
Peptidei181 – 19919Maximakinin By similarityBy similarityPRO_0000003396Add
BLAST
Peptidei191 – 20616Bradykinin By similarityBy similarityPRO_0000003397Add
BLAST
Peptidei209 – 22719Maximakinin By similarityBy similarityPRO_0000003398Add
BLAST
Peptidei219 – 23416Bradykinin By similarityBy similarityPRO_0000003399Add
BLAST
Peptidei237 – 25519Maximakinin By similarityBy similarityPRO_0000003400Add
BLAST
Peptidei247 – 26216Bradykinin By similarityBy similarityPRO_0000003401Add
BLAST
Peptidei265 – 29228Bombinakinin-GAP1 PublicationPRO_0000003402Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi282 ↔ 2881 Publication
Modified residuei292 – 2921Valine amide1 Publication

Keywords - PTMi

Amidation, Cleavage on pair of basic residues, Disulfide bond

Expressioni

Tissue specificityi

Expressed by the skin glands.1 Publication

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG031664.

Family and domain databases

InterProiIPR009608. Bradykinin.
[Graphical view]
PfamiPF06753. Bradykinin. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T3L1-1 [UniParc]FASTAAdd to Basket

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MRLWFCLSFF IVLCLEHFTG TLADERNVPE SEEKTEQFLR DLPKINRKGP    50
RPPGFSPFRG KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK 100
INRKGPRPPG FSPFRGKFHS QSLRDLPKIN RKGPRPPGFS PFRGKFHSQS 150
LRDLPKINRK GPRPPGFSPF RGKFHSQSLR DLPKINRKGP RPPGFSPFRG 200
KFHSQSLRDL PKINRKGPRP PGFSPFRGKF HSQSLRDLPK INRKGPRPPG 250
FSPFRGKFHS QSLRDMYEIK QYKTAHGRPP ICAPGEQCPI WVGK 294
Length:294
Mass (Da):33,857
Last modified:October 1, 2003 - v1
Checksum:i7C87B4D88482C530
GO

Mass spectrometryi

Molecular mass is 3228±0.4 Da from positions 265 - 292. Determined by FAB. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF515613 mRNA. Translation: AAP47179.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF515613 mRNA. Translation: AAP47179.1 .

3D structure databases

ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG031664.

Family and domain databases

InterProi IPR009608. Bradykinin.
[Graphical view ]
Pfami PF06753. Bradykinin. 8 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Bombinakinin M gene associated peptide, a novel bioactive peptide from skin secretions of the toad Bombina maxima."
    Lai R., Liu H., Lee W.H., Zhang Y.
    Peptides 24:199-204(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 265-292, SYNTHESIS OF 265-292, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MASS SPECTROMETRY, DISULFIDE BOND, AMIDATION AT VAL-292.
    Tissue: Skin secretion.
  2. "Peptide DV-28 amide: An inhibitor of bradykinin-induced arterial smooth muscle relaxation encoded by Bombina orientalis skin kininogen-2."
    Wang L., Chen Y., Yang M., Zhou M., Chen T., Sui D.Y., Shaw C.
    Peptides 31:979-982(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: SYNTHESIS OF 265-292, FUNCTION.

Entry informationi

Entry nameiBRK1A_BOMMX
AccessioniPrimary (citable) accession number: Q7T3L1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2003
Last modified: November 13, 2013
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3