Q7T3I6 (Q7T3I6_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Vascular endothelial growth factor C EMBL AAP44161.1

Submitted name:
Vascular endothelial growth factor c Ensembl ENSDARP00000092263 EMBL AAI14254.1

Gene names

Name:

vegfc Ensembl ENSDARP00000092263 ZFIN ZDB-GENE-040303-4

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAP44161.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	396 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family. RuleBase RU003818

Ontologies

Keywords
Molecular function	Growth factor SAAS SAAS000072 RuleBase RU003818 Mitogen RuleBase RU003819
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	endoderm development Inferred from mutant phenotype Ref.1. Source: ZFIN lymphangiogenesis Inferred from mutant phenotype. Source: ZFIN positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW sprouting angiogenesis Inferred from mutant phenotype. Source: ZFIN
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW vascular endothelial growth factor receptor binding Inferred from physical interaction Ref.1. Source: ZFIN
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7T3I6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: C20F9B3F0307D7C1	FASTA	396	45,288
	10 20 30 40 50 60 MHLFGFSVFC LALFYANLAF ESSHDYYEYD QDQADAMQEH SEPDLVEQLR SAGSVDELMR 70 80 90 100 110 120 IVYPTYRIML KCRSKMGSRL LRREPSSTET RSEEASFAAA FINLELLKSI EIEWRKTLCM 130 140 150 160 170 180 PRQVCLDVGK EFGATNTFYK PPCVSVYRCG GCCNSEELQC RNISTSYISK TLFEITVPVK 190 200 210 220 230 240 QGTKPVTISF ANHTSCSCLS KQNLYRQQHS IIRRALTECH VANKTCPKNH SWSNHLCKCV 250 260 270 280 290 300 LLPDTLHSKP HSDFETDFCG PDKELDEETC QCECRKELRK AGCGPHHYLD KNTCQCVCKA 310 320 330 340 350 360 QPSSCGPQQS FNRDTCQCTC AKVCPRSQPL NRTKCVCECT ESPNKCFLKG RRFHPATCSC 370 380 390 VRPPCNVDPK RRKCKENEYF SEELCHCIPT YWGRLD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Vegfc is required for vascular development and endoderm morphogenesis in zebrafish." Ober E.A., Olofsson B., Makinen T., Jin S.W., Shoji W., Koh G.Y., Alitalo K., Stainier D.Y. EMBO Rep. 5:78-84(2004) [PubMed: 14710191] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"The genomic sequence of Danio rerio." The Danio rerio Sequencing Project at the Sanger Institute Submitted (JUL-2010) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Tuebingen Ensembl ENSDARP00000092263.
[3]	Ensembl Submitted (JUL-2011) to UniProtKB Cited for: IDENTIFICATION. Strain: Tuebingen Ensembl ENSDARP00000092263.
[4]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Whole EMBL AAI14254.1.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BX957306 Genomic DNA. No translation available. CU915762 Genomic DNA. No translation available. BC114253 mRNA. Translation: AAI14254.1. AF466147 mRNA. Translation: AAP44161.1.
IPI	IPI00508485.
RefSeq	NP_991297.1. NM_205734.1.
UniGene	Dr.88903.
3D structure databases
HSSP	HSSP built from PDB template 1FLT based on UniProtKB Q9UH58.
ProteinModelPortal	Q7T3I6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7T3I6.
Proteomic databases
PRIDE	Q7T3I6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSDART00000101489; ENSDARP00000092263; ENSDARG00000069640.
GeneID	403049.
KEGG	dre:403049.
Organism-specific databases
CTD	7424.
ZFIN	ZDB-GENE-040303-4. vegfc.
Phylogenomic databases
eggNOG	fiNOG15957.
GeneTree	ENSGT00530000062930.
HOGENOM	HBG715596.
HOVERGEN	HBG073119.
InParanoid	Q7T3I6.
OrthoDB	EOG4D7Z62.
Gene expression databases
ArrayExpress	Q7T3I6.
Bgee	Q7T3I6.
Family and domain databases
InterPro	IPR004153. CXCXC_repeat. IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. [Graphical view]
KO	K05449.
Pfam	PF03128. CXCXC. 2 hits. PF00341. PDGF. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7T3I6_DANRE

Accession

Primary (citable) accession number: Q7T3I6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)