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Protein

Zinc finger C4H2 domain-containing protein

Gene

zc4h2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in motoneuron development and in neuromuscular junction formation.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 221210C4H2-typeAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • nervous system development Source: UniProtKB
  • neuromuscular junction development Source: UniProtKB
  • neuron development Source: ZFIN
  • neuron fate specification Source: ZFIN
  • spinal cord motor neuron differentiation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger C4H2 domain-containing protein
Alternative name(s):
Hepatocellular carcinoma-associated antigen 127 homolog
Hepatocellular carcinoma-associated antigen 127-like
Gene namesi
Name:zc4h2
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 5

Organism-specific databases

ZFINiZDB-GENE-030131-2207. zc4h2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cytoplasm, Membrane, Nucleus, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 224224Zinc finger C4H2 domain-containing proteinPRO_0000423169Add
BLAST

Proteomic databases

PaxDbiQ7T3I0.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010952.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili12 – 9786Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi156 – 1627Poly-Ala

Sequence similaritiesi

Contains 1 C4H2-type zinc finger.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri12 – 221210C4H2-typeAdd
BLAST

Keywords - Domaini

Coiled coil, Zinc-finger

Phylogenomic databases

eggNOGiKOG4451. Eukaryota.
ENOG4111GRM. LUCA.
GeneTreeiENSGT00390000018389.
HOGENOMiHOG000008107.
HOVERGENiHBG051885.
InParanoidiQ7T3I0.
OMAiYYTANKS.
OrthoDBiEOG7DRJ4F.
PhylomeDBiQ7T3I0.
TreeFamiTF315275.

Family and domain databases

InterProiIPR018482. Znf-C4H2.
[Graphical view]
PfamiPF10146. zf-C4H2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T3I0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEQEIMCK LENIKEIRNK TIQMEKIKSR LRTEFEALES EEKHLREYKQ
60 70 80 90 100
EMDLLLQEKM AHVEELRLIH ADINVMENTI KQSESDLNKL LESTRRLHDE
110 120 130 140 150
YKPLKEHVDA LRMTLGLQRL PDLSQEEEKL SLDYFEKQKA EWQTEPQEPP
160 170 180 190 200
IPESLAAAAA AAQQLQAARK QDARQTATFR QQPPPMKACL SCHQQIHRNA
210 220
PICPLCKAKS RSRNPKKPKR KPDE
Length:224
Mass (Da):26,212
Last modified:October 1, 2003 - v1
Checksum:iA1101403DB8D756A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648796 mRNA. Translation: AAT68114.1.
CR812469 Genomic DNA. No translation available.
BC053110 mRNA. Translation: AAH53110.1.
RefSeqiNP_955936.1. NM_199642.1.
UniGeneiDr.77787.

Genome annotation databases

EnsembliENSDART00000020908; ENSDARP00000010952; ENSDARG00000015314.
GeneIDi323487.
KEGGidre:323487.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY648796 mRNA. Translation: AAT68114.1.
CR812469 Genomic DNA. No translation available.
BC053110 mRNA. Translation: AAH53110.1.
RefSeqiNP_955936.1. NM_199642.1.
UniGeneiDr.77787.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000010952.

Proteomic databases

PaxDbiQ7T3I0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000020908; ENSDARP00000010952; ENSDARG00000015314.
GeneIDi323487.
KEGGidre:323487.

Organism-specific databases

CTDi55906.
ZFINiZDB-GENE-030131-2207. zc4h2.

Phylogenomic databases

eggNOGiKOG4451. Eukaryota.
ENOG4111GRM. LUCA.
GeneTreeiENSGT00390000018389.
HOGENOMiHOG000008107.
HOVERGENiHBG051885.
InParanoidiQ7T3I0.
OMAiYYTANKS.
OrthoDBiEOG7DRJ4F.
PhylomeDBiQ7T3I0.
TreeFamiTF315275.

Miscellaneous databases

PROiQ7T3I0.

Family and domain databases

InterProiIPR018482. Znf-C4H2.
[Graphical view]
PfamiPF10146. zf-C4H2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Tuebingen.
  3. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  4. Cited for: FUNCTION.

Entry informationi

Entry nameiZC4H2_DANRE
AccessioniPrimary (citable) accession number: Q7T3I0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 24, 2013
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.