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Protein

Glycerol-3-phosphate dehydrogenase [NAD(+)]

Gene

gpd1c

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei120 – 1201SubstrateUniRule annotation
Active sitei204 – 2041Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase [NAD(+)]UniRule annotation (EC:1.1.1.8UniRule annotation)
Gene namesi
Name:gpd1cImported
Synonyms:gpd1Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
ProteomesiUP000000437 Componenti: Chromosome 19

Organism-specific databases

ZFINiZDB-GENE-040426-2576. gpd1c.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053638.

Structurei

3D structure databases

ProteinModelPortaliQ7T3H5.
SMRiQ7T3H5. Positions 1-349.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni269 – 2702Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
OMAiMEKLAIY.
OrthoDBiEOG7ZKSBS.
PhylomeDBiQ7T3H5.
TreeFamiTF300836.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T3H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPGKKVCIIG SGNWGSAIAK IVGHNVKSSN RFEPLVKMWV YEEMIDGRKL
60 70 80 90 100
TEIINTEHEN VKYLPGHKLP KTVVAVPDVT EAASGADFLI FVIPHQFIVR
110 120 130 140 150
VCDQMKPHIK PGAIGISLIK GIDEGPDGLT LISDIIRAKL EIEVCVLMGA
160 170 180 190 200
NIASEVADEK FCETTIGATN EASGKLFKEL LQTPNFRITV VKESDTVELC
210 220 230 240 250
GALKNIVAVG AGFCDGLGFG DNTKAAVIRL GLMEMVAFSK LFCKSSVSSA
260 270 280 290 300
TFLESCGVAD LITTCYGGRN RRVAEAFART QKSIVELEAE MLNGQKLQGP
310 320 330 340
QTSAEVYKIL HKRNITDKFP LFVSVYQICF EGRQVKDFIN CLQNHPEHM
Length:349
Mass (Da):38,179
Last modified:October 1, 2003 - v1
Checksum:i43EFE27743393D0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01067085 Genomic DNA. No translation available.
CABZ01067086 Genomic DNA. No translation available.
CABZ01067087 Genomic DNA. No translation available.
CABZ01068181 Genomic DNA. No translation available.
CABZ01068182 Genomic DNA. No translation available.
CABZ01075159 Genomic DNA. No translation available.
CABZ01075160 Genomic DNA. No translation available.
CABZ01075161 Genomic DNA. No translation available.
CABZ01079940 Genomic DNA. No translation available.
CABZ01079941 Genomic DNA. No translation available.
CABZ01079942 Genomic DNA. No translation available.
CABZ01079943 Genomic DNA. No translation available.
CABZ01079950 Genomic DNA. No translation available.
CABZ01079951 Genomic DNA. No translation available.
CABZ01089718 Genomic DNA. No translation available.
CABZ01090314 Genomic DNA. No translation available.
CABZ01090315 Genomic DNA. No translation available.
CABZ01090434 Genomic DNA. No translation available.
CABZ01090435 Genomic DNA. No translation available.
CABZ01091117 Genomic DNA. No translation available.
CABZ01091118 Genomic DNA. No translation available.
CABZ01101716 Genomic DNA. No translation available.
CABZ01101717 Genomic DNA. No translation available.
CABZ01101718 Genomic DNA. No translation available.
CABZ01101719 Genomic DNA. No translation available.
CABZ01101720 Genomic DNA. No translation available.
CABZ01101985 Genomic DNA. No translation available.
CABZ01101986 Genomic DNA. No translation available.
CABZ01101987 Genomic DNA. No translation available.
CABZ01101988 Genomic DNA. No translation available.
CABZ01103845 Genomic DNA. No translation available.
CABZ01103846 Genomic DNA. No translation available.
CABZ01103847 Genomic DNA. No translation available.
CABZ01103848 Genomic DNA. No translation available.
CABZ01105353 Genomic DNA. No translation available.
CABZ01110638 Genomic DNA. No translation available.
CABZ01111719 Genomic DNA. No translation available.
CR548627 Genomic DNA. No translation available.
CU611039 Genomic DNA. No translation available.
CU633999 Genomic DNA. No translation available.
CU634003 Genomic DNA. No translation available.
BC053116 mRNA. Translation: AAH53116.1.
RefSeqiNP_999918.1. NM_214753.1.
UniGeneiDr.78758.

Genome annotation databases

EnsembliENSDART00000053639; ENSDARP00000053638; ENSDARG00000036942.
ENSDART00000134266; ENSDARP00000113739; ENSDARG00000036942.
GeneIDi406615.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABZ01067085 Genomic DNA. No translation available.
CABZ01067086 Genomic DNA. No translation available.
CABZ01067087 Genomic DNA. No translation available.
CABZ01068181 Genomic DNA. No translation available.
CABZ01068182 Genomic DNA. No translation available.
CABZ01075159 Genomic DNA. No translation available.
CABZ01075160 Genomic DNA. No translation available.
CABZ01075161 Genomic DNA. No translation available.
CABZ01079940 Genomic DNA. No translation available.
CABZ01079941 Genomic DNA. No translation available.
CABZ01079942 Genomic DNA. No translation available.
CABZ01079943 Genomic DNA. No translation available.
CABZ01079950 Genomic DNA. No translation available.
CABZ01079951 Genomic DNA. No translation available.
CABZ01089718 Genomic DNA. No translation available.
CABZ01090314 Genomic DNA. No translation available.
CABZ01090315 Genomic DNA. No translation available.
CABZ01090434 Genomic DNA. No translation available.
CABZ01090435 Genomic DNA. No translation available.
CABZ01091117 Genomic DNA. No translation available.
CABZ01091118 Genomic DNA. No translation available.
CABZ01101716 Genomic DNA. No translation available.
CABZ01101717 Genomic DNA. No translation available.
CABZ01101718 Genomic DNA. No translation available.
CABZ01101719 Genomic DNA. No translation available.
CABZ01101720 Genomic DNA. No translation available.
CABZ01101985 Genomic DNA. No translation available.
CABZ01101986 Genomic DNA. No translation available.
CABZ01101987 Genomic DNA. No translation available.
CABZ01101988 Genomic DNA. No translation available.
CABZ01103845 Genomic DNA. No translation available.
CABZ01103846 Genomic DNA. No translation available.
CABZ01103847 Genomic DNA. No translation available.
CABZ01103848 Genomic DNA. No translation available.
CABZ01105353 Genomic DNA. No translation available.
CABZ01110638 Genomic DNA. No translation available.
CABZ01111719 Genomic DNA. No translation available.
CR548627 Genomic DNA. No translation available.
CU611039 Genomic DNA. No translation available.
CU633999 Genomic DNA. No translation available.
CU634003 Genomic DNA. No translation available.
BC053116 mRNA. Translation: AAH53116.1.
RefSeqiNP_999918.1. NM_214753.1.
UniGeneiDr.78758.

3D structure databases

ProteinModelPortaliQ7T3H5.
SMRiQ7T3H5. Positions 1-349.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000053638.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000053639; ENSDARP00000053638; ENSDARG00000036942.
ENSDART00000134266; ENSDARP00000113739; ENSDARG00000036942.
GeneIDi406615.

Organism-specific databases

CTDi406615.
ZFINiZDB-GENE-040426-2576. gpd1c.

Phylogenomic databases

eggNOGiCOG0240.
GeneTreeiENSGT00390000003114.
HOGENOMiHOG000246855.
HOVERGENiHBG003669.
OMAiMEKLAIY.
OrthoDBiEOG7ZKSBS.
PhylomeDBiQ7T3H5.
TreeFamiTF300836.

Miscellaneous databases

NextBioi20818161.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR013328. 6PGD_dom_2.
IPR006168. G3P_DH_NAD-dep.
IPR006109. G3P_DH_NAD-dep_C.
IPR017751. G3P_DH_NAD-dep_euk.
IPR011128. G3P_DH_NAD-dep_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11728. PTHR11728. 1 hit.
PfamiPF07479. NAD_Gly3P_dh_C. 1 hit.
PF01210. NAD_Gly3P_dh_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000114. Glycerol-3-P_dh. 1 hit.
PRINTSiPR00077. GPDHDRGNASE.
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR03376. glycerol3P_DH. 1 hit.
PROSITEiPS00957. NAD_G3PDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: EmbryoImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Eliott D., Threadgold G., Harden G., Ware D., Mortimer B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ7T3H5_DANRE
AccessioniPrimary (citable) accession number: Q7T3H5
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 27, 2015
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.