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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

kyat3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei51 – 511SubstrateBy similarity
Binding sitei69 – 691Substrate; via amide nitrogenBy similarity
Binding sitei216 – 2161SubstrateBy similarity
Binding sitei427 – 4271SubstrateBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminotransferase, Lyase, Transferase

Keywords - Ligandi

Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase 3By similarity
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:kyat3By similarity
Synonyms:ccbl2, kat3
ORF Names:zgc:63929
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1299. ccbl2.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 450450Kynurenine--oxoglutarate transaminase 3PRO_0000287707Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei278 – 2781N6-(pyridoxal phosphate)lysineBy similarity

Proteomic databases

PaxDbiQ7T3E5.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063535.

Structurei

3D structure databases

ProteinModelPortaliQ7T3E5.
SMRiQ7T3E5. Positions 37-449.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0257. Eukaryota.
COG0436. LUCA.
HOGENOMiHOG000223045.
HOVERGENiHBG008391.
InParanoidiQ7T3E5.
KOiK00816.
PhylomeDBiQ7T3E5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T3E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPIHLLRIV SSVRRLLQTN RCRSFSSCQH NMASIKHKNA RRIEGLDKNV
60 70 80 90 100
WVAFTSVAAD PSIVNLGQGY PDIPPPSYVK EGLAQAAMVD RLNQYTRGFG
110 120 130 140 150
HPTLVKALSK VYGKVYDRQL DPFKEILVTV GGYGSLFSTM QALVEEGDEV
160 170 180 190 200
IIIEPFFDCY VPMVKMAGAK PVLIPLRLKS TATTGISSAD WVLDQEELAS
210 220 230 240 250
KFNSKTKAII VNTPNNPIGK IFSRSELQAI ADLCIKHDTL CFSDEVYEWL
260 270 280 290 300
IYKGHEHVKI ATLPGMWDRT ITVGSAGKTF SVTGWKLGWS IGPEHLIRHL
310 320 330 340 350
QTVMQNSLYT CPTPLQEAVG RGLLRDFELM GQPDCYFSAL ALELEGKRDR
360 370 380 390 400
MAAMLAQTGM TPVVPEGGYF MIVDVTALNQ DLTHMGDDEP YDYKFVKWMI
410 420 430 440 450
KEKKLAAIPV TAFVGEDSVK QFEKYIRLCF IKQESTLDAA EAILKNWNKG
Length:450
Mass (Da):50,345
Last modified:May 15, 2007 - v2
Checksum:i473A55EBF1401312
GO

Sequence cautioni

The sequence AAH53152 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053152 mRNA. Translation: AAH53152.1. Different initiation.
RefSeqiNP_956638.1. NM_200344.1.
UniGeneiDr.82010.

Genome annotation databases

GeneIDi393315.
KEGGidre:393315.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053152 mRNA. Translation: AAH53152.1. Different initiation.
RefSeqiNP_956638.1. NM_200344.1.
UniGeneiDr.82010.

3D structure databases

ProteinModelPortaliQ7T3E5.
SMRiQ7T3E5. Positions 37-449.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063535.

Proteomic databases

PaxDbiQ7T3E5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393315.
KEGGidre:393315.

Organism-specific databases

CTDi229905.
ZFINiZDB-GENE-040426-1299. ccbl2.

Phylogenomic databases

eggNOGiKOG0257. Eukaryota.
COG0436. LUCA.
HOGENOMiHOG000223045.
HOVERGENiHBG008391.
InParanoidiQ7T3E5.
KOiK00816.
PhylomeDBiQ7T3E5.

Miscellaneous databases

PROiQ7T3E5.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProiIPR004839. Aminotransferase_I/II.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PfamiPF00155. Aminotran_1_2. 1 hit.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAT3_DANRE
AccessioniPrimary (citable) accession number: Q7T3E5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: July 6, 2016
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.