Reviewed, UniProtKB/Swiss-Prot Q7T3E5 (KAT3_DANRE)

Names and origin

Protein names

Recommended name:
    Kynurenine--oxoglutarate transaminase 3
    EC=2.6.1.7
Alternative name(s):
    Kynurenine--oxoglutarate transaminase III
    Kynurenine aminotransferase III
      Short name=KATIII
    Cysteine-S-conjugate beta-lyase 2
    EC=4.4.1.13

Gene names

Name:	ccbl2
Synonyms:	kat3
ORF Names:	zgc:63929

Organism

Danio rerio (Zebrafish) (Brachydanio rerio)

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	450 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond By similarity.
Catalytic activity	L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate. RS-CH(2)-CH(NH3+)COO- = RSH + NH3 + pyruvate.
Cofactor	Pyridoxal phosphate By similarity.
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.

Ontologies

Keywords
Ligand	Pyridoxal phosphate
Molecular function	Aminotransferase Lyase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	1-aminocyclopropane-1-carboxylate synthase activity Inferred from electronic annotation. Source: InterPro cysteine-S-conjugate beta-lyase activity Inferred from electronic annotation. Source: EC kynurenine-oxoglutarate transaminase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 450	450	Kynurenine--oxoglutarate transaminase 3		PRO_0000287707
Amino acid modifications
	Modified residue	278	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7T3E5-1 [UniParc]. Last modified May 15, 2007. Version 2. Checksum: 473A55EBF1401312	FASTA	450	50,345
	10 20 30 40 50 60 MHPIHLLRIV SSVRRLLQTN RCRSFSSCQH NMASIKHKNA RRIEGLDKNV WVAFTSVAAD 70 80 90 100 110 120 PSIVNLGQGY PDIPPPSYVK EGLAQAAMVD RLNQYTRGFG HPTLVKALSK VYGKVYDRQL 130 140 150 160 170 180 DPFKEILVTV GGYGSLFSTM QALVEEGDEV IIIEPFFDCY VPMVKMAGAK PVLIPLRLKS 190 200 210 220 230 240 TATTGISSAD WVLDQEELAS KFNSKTKAII VNTPNNPIGK IFSRSELQAI ADLCIKHDTL 250 260 270 280 290 300 CFSDEVYEWL IYKGHEHVKI ATLPGMWDRT ITVGSAGKTF SVTGWKLGWS IGPEHLIRHL 310 320 330 340 350 360 QTVMQNSLYT CPTPLQEAVG RGLLRDFELM GQPDCYFSAL ALELEGKRDR MAAMLAQTGM 370 380 390 400 410 420 TPVVPEGGYF MIVDVTALNQ DLTHMGDDEP YDYKFVKWMI KEKKLAAIPV TAFVGEDSVK 430 440 450 QFEKYIRLCF IKQESTLDAA EAILKNWNKG

References

[1]	NIH - Zebrafish Gene Collection (ZGC) project Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Kidney.

Cross-references

Sequence databases
EMBLGenBankDDBJ	BC053152 mRNA. Translation: AAH53152.1. Different initiation.
IPI	IPI00485588.
RefSeq	NP_956638.1.
UniGene	Dr.82010
3D structure databases
HSSP	HSSP built from PDB template 1DJU based on UniProtKB O59096.
ModBase	Search...
Genome annotation databases
Ensembl	ENSDARG00000013423. Danio rerio. [Contig view]
GeneID	393315.
KEGG	dre:393315.
Organism-specific databases
ZFIN	ZDB-GENE-040426-1299. ccbl2.
Phylogenomic databases
HOGENOM	Q7T3E5.
HOVERGEN	Q7T3E5.
Enzyme and pathway databases
BRENDA	2.6.1.7. 96826. 4.4.1.13. 96826.
Gene expression databases
Bgee	Q7T3E5.
Family and domain databases
InterPro	IPR001176. ACC_synthase. IPR004839. Aminotrans_I/II. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
Pfam	PF00155. Aminotran_1_2. 1 hit. [Graphical view]
PRINTS	PR00753. ACCSYNTHASE.
ProtoNet	Search...

Entry information

Entry name

KAT3_DANRE

Accession

Primary (citable) accession number: Q7T3E5

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 15, 2007
Last sequence update:	May 15, 2007
Last modified:	May 26, 2009
This is version 40 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

Zebrafish annotation project