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Protein

Kynurenine--oxoglutarate transaminase 3

Gene

kyat3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). May catalyze the beta-elimination of S-conjugates and Se-conjugates of L-(seleno)cysteine, resulting in the cleavage of the C-S or C-Se bond (By similarity). Has transaminase activity towards L-kynurenine, tryptophan, phenylalanine, serine, cysteine, methionine, histidine, glutamine and asparagine with glyoxylate as an amino group acceptor (in vitro). Has lower activity with 2-oxoglutarate as amino group acceptor (in vitro) (By similarity).By similarity

Catalytic activityi

L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate.
An L-cysteine-S-conjugate + H2O = RSH + NH3 + pyruvate.
L-kynurenine + glyoxylate = 4-(2-aminophenyl)-2,4-dioxobutanoate + glycine.

Cofactori

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei51SubstrateBy similarity1
Binding sitei69Substrate; via amide nitrogenBy similarity1
Binding sitei216SubstrateBy similarity1
Binding sitei427SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Lyase, Transferase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Kynurenine--oxoglutarate transaminase 3 (EC:2.6.1.7)
Alternative name(s):
Cysteine-S-conjugate beta-lyase 2 (EC:4.4.1.13)
Kynurenine aminotransferase 3By similarity
Kynurenine aminotransferase III
Short name:
KATIII
Kynurenine--glyoxylate transaminase (EC:2.6.1.63)
Kynurenine--oxoglutarate transaminase III
Gene namesi
Name:kyat3By similarity
Synonyms:ccbl2, kat3
ORF Names:zgc:63929
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1299 kyat3

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002877071 – 450Kynurenine--oxoglutarate transaminase 3Add BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei278N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ7T3E5

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063535

Structurei

3D structure databases

ProteinModelPortaliQ7T3E5
SMRiQ7T3E5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0257 Eukaryota
COG0436 LUCA
HOGENOMiHOG000223045
HOVERGENiHBG008391
InParanoidiQ7T3E5
PhylomeDBiQ7T3E5

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR034612 KAT_III
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR43807:SF6 PTHR43807:SF6, 1 hit
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q7T3E5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHPIHLLRIV SSVRRLLQTN RCRSFSSCQH NMASIKHKNA RRIEGLDKNV
60 70 80 90 100
WVAFTSVAAD PSIVNLGQGY PDIPPPSYVK EGLAQAAMVD RLNQYTRGFG
110 120 130 140 150
HPTLVKALSK VYGKVYDRQL DPFKEILVTV GGYGSLFSTM QALVEEGDEV
160 170 180 190 200
IIIEPFFDCY VPMVKMAGAK PVLIPLRLKS TATTGISSAD WVLDQEELAS
210 220 230 240 250
KFNSKTKAII VNTPNNPIGK IFSRSELQAI ADLCIKHDTL CFSDEVYEWL
260 270 280 290 300
IYKGHEHVKI ATLPGMWDRT ITVGSAGKTF SVTGWKLGWS IGPEHLIRHL
310 320 330 340 350
QTVMQNSLYT CPTPLQEAVG RGLLRDFELM GQPDCYFSAL ALELEGKRDR
360 370 380 390 400
MAAMLAQTGM TPVVPEGGYF MIVDVTALNQ DLTHMGDDEP YDYKFVKWMI
410 420 430 440 450
KEKKLAAIPV TAFVGEDSVK QFEKYIRLCF IKQESTLDAA EAILKNWNKG
Length:450
Mass (Da):50,345
Last modified:May 15, 2007 - v2
Checksum:i473A55EBF1401312
GO

Sequence cautioni

The sequence AAH53152 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053152 mRNA Translation: AAH53152.1 Different initiation.
UniGeneiDr.82010

Similar proteinsi

Entry informationi

Entry nameiKAT3_DANRE
AccessioniPrimary (citable) accession number: Q7T3E5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: May 23, 2018
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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