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Protein

Annexin

Gene

anxa1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • fin regeneration Source: ZFIN

Keywordsi

LigandCalcium, Calcium/phospholipid-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
AnnexinUniRule annotation
Gene namesi
Name:anxa1aImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030131-6664 anxa1a

Family & Domainsi

Domaini

The full-length protein can bind eight Ca2+ ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca2+, these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.UniRule annotation

Sequence similaritiesi

Belongs to the annexin family.UniRule annotation

Keywords - Domaini

AnnexinUniRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
HOGENOMiHOG000158803
HOVERGENiHBG061815

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002388 ANX1
PANTHERiPTHR10502:SF17 PTHR10502:SF17, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00197 ANNEXINI
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 2 hits

Sequencei

Sequence statusi: Complete.

Q7T3A8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSFVSSFLEQ LAYQGMQETT VQDITEVQGT VKPYAQFNAA ADAAVLDKAI
60 70 80 90 100
KAKGVDEPTI IDTLVHRSNA QRQQIKAAYQ QATSKPLDVA LKNALKGELE
110 120 130 140 150
DVVLGLLMTP AQYDAFQLKY AMKGAGTTED TLIEILASRT NKEIGDIKQV
160 170 180 190 200
YKQEYKKDLE ADIKSDTSGD FRNALLSLCK ATRSEDNIVK DDLADKDARA
210 220 230 240 250
LYEAGEKRKG TDCSVFIDIL TSRNGPHLRK VFQQYNKYSK VDVAKAIDLE
260 270 280 290 300
LKGDIESCLI AVVKCVSNKP AFFAEKLNLA MKGSGYRGQI LTRILVSRSE
310 320 330 340
IDLANIKQEY QKKYGKSLYQ DIQDDTKGDY ETILLALCGN
Length:340
Mass (Da):37,754
Last modified:October 1, 2003 - v1
Checksum:i8AA35E5597CB679D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053190 mRNA Translation: AAH53190.1
BC164376 mRNA Translation: AAI64376.1
UniGeneiDr.59

Similar proteinsi

Entry informationi

Entry nameiQ7T3A8_DANRE
AccessioniPrimary (citable) accession number: Q7T3A8
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: October 25, 2017
This is version 91 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

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