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Protein

Bcl-2-related ovarian killer protein homolog B

Gene

bokb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis. Does not appear to show pro-apoptotic activity when expressed ectopically in early embryos.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-related ovarian killer protein homolog BCurated
Short name:
zBok21 Publication
Gene namesi
Name:bokb
Synonyms:bok
ORF Names:zgc:64041
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1346. bokb.

Subcellular locationi

  • Membrane By similarity; Single-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001430901 – 211Bcl-2-related ovarian killer protein homolog BAdd BLAST211

Proteomic databases

PaxDbiQ7T381.

Expressioni

Tissue specificityi

Expressed strongly in ovary and more weakly in eye. Little expression in other tissues examined.1 Publication

Developmental stagei

Expressed maternally but largely absent later in embryonic development. Also expressed in adult.1 Publication

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000123352.

Structurei

3D structure databases

ProteinModelPortaliQ7T381.
SMRiQ7T381.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi32 – 44BH4Add BLAST13
Motifi67 – 83BH3Add BLAST17
Motifi113 – 132BH1Add BLAST20
Motifi165 – 179BH2Add BLAST15

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4728. Eukaryota.
ENOG41123S0. LUCA.
HOVERGENiHBG050709.
InParanoidiQ7T381.
KOiK02561.

Family and domain databases

InterProiView protein in InterPro
IPR002475. Bcl2-like.
IPR003093. Bcl2_BH4.
IPR026298. Blc2_fam.
IPR026309. BOK.
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF53. PTHR11256:SF53. 1 hit.
PfamiView protein in Pfam
PF00452. Bcl-2. 1 hit.
PRINTSiPR01862. BCL2FAMILY.
SUPFAMiSSF56854. SSF56854. 1 hit.
PROSITEiView protein in PROSITE
PS50062. BCL2_FAMILY. 1 hit.
PS50063. BH4_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T381-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNVFARSSVL AAEMIDVFDR THTEKELVFQ SKELCRDFIH SRITREGLSW
60 70 80 90 100
SKVELDLPEP RGVLVDVSVV LLKLGDELEC MRPYVYRNIA KQLNISVSVE
110 120 130 140 150
AVVSDAFLSV ATEVIAMGIT WGKVVAIYAV AAGLAVDCVR LGHPVMVHTI
160 170 180 190 200
VDSLGEFVRR SLVPWLKKRG GWVDILKCVV NMDSRAHVHW LSTAVLTWRE
210
FIKTMYVYLT K
Length:211
Mass (Da):23,834
Last modified:October 1, 2003 - v1
Checksum:i4FE09F1ABDA0D561
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ860157 mRNA. Translation: ABI18128.1.
BC053218 mRNA. Translation: AAH53218.1.
RefSeqiNP_957479.1. NM_201185.1.
UniGeneiDr.18807.

Genome annotation databases

GeneIDi394160.
KEGGidre:394160.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiBOKB_DANRE
AccessioniPrimary (citable) accession number: Q7T381
Secondary accession number(s): Q0GKC3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families