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Protein

Pyruvate dehydrogenase E1 component subunit beta

Gene

pdhb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

Catalytic activityi

Pyruvate + [dihydrolipoyllysine-residue acetyltransferase] lipoyllysine = [dihydrolipoyllysine-residue acetyltransferase] S-acetyldihydrolipoyllysine + CO2.UniRule annotation

Cofactori

thiamine diphosphateUniRule annotation

GO - Molecular functioni

  • pyruvate dehydrogenase (acetyl-transferring) activity Source: InterPro
  • pyruvate dehydrogenase activity Source: ZFIN

GO - Biological processi

  • acetyl-CoA biosynthetic process from pyruvate Source: InterPro
  • pigmentation Source: ZFIN

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
LigandPyruvateUniRule annotationImported, Thiamine pyrophosphateUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-DRE-389661. Glyoxylate metabolism and glycine degradation.
R-DRE-5362517. Signaling by Retinoic Acid.
R-DRE-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate dehydrogenase E1 component subunit betaUniRule annotation (EC:1.2.4.1UniRule annotation)
Gene namesi
Name:pdhbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-2173. pdhb.

Subcellular locationi

  • Mitochondrion matrix UniRule annotation

Keywords - Cellular componenti

MitochondrionUniRule annotation

Expressioni

Gene expression databases

BgeeiENSDARG00000021346.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 208Transket_pyrInterPro annotationAdd BLAST176

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
GeneTreeiENSGT00530000063423.
HOGENOMiHOG000281450.
HOVERGENiHBG000917.
KOiK00162.
OMAiSRMRHHC.
OrthoDBiEOG091G0D37.
TreeFamiTF105674.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
InterProiView protein in InterPro
IPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
PANTHERiPTHR11624:SF89. PTHR11624:SF89. 1 hit.
PfamiView protein in Pfam
PF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
SMARTiView protein in SMART
SM00861. Transket_pyr. 1 hit.
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRCFLRS GKSAVSAVLR REFHRTPPAA VQVTVRDALN QAMDEELERD
60 70 80 90 100
ERVFLLGEEV AQYDGAYKVS RGLWKKYGDK RIIDTPITEM GFAGIAVGAA
110 120 130 140 150
MAGLRPICEF MTFNFSMQAI DQVINSAAKT YYMSAGLQAV PIVFRGPNGA
160 170 180 190 200
SAGVAAQHSQ CFAAWYGHCP GLKVLSPWNS EDARGLLKAA IRDDNPVVFL
210 220 230 240 250
ENELMYGVPF EMSEEVQSKD FVIPIGKAKI ERQGNHITLV SHSRMVGLCL
260 270 280 290 300
DAAAVLAKEG IECEVINLRS IRPLDADTIE TSITKTNHLV TVEGGWPQFG
310 320 330 340 350
VGAEILARIM EGPAFNYLDA PAVRVTGVDI PMPYAKILED NSIPQIKDII

FSVKKTLNV
Length:359
Mass (Da):39,308
Last modified:October 1, 2003 - v1
Checksum:i06B31C8784F75DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649457 Genomic DNA. No translation available.
BC053233 mRNA. Translation: AAH53233.1.
RefSeqiNP_998319.1. NM_213154.1.
UniGeneiDr.3570.

Genome annotation databases

EnsembliENSDART00000006513; ENSDARP00000002122; ENSDARG00000021346.
GeneIDi406428.
KEGGidre:406428.

Similar proteinsi

Entry informationi

Entry nameiQ7T368_DANRE
AccessioniPrimary (citable) accession number: Q7T368
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported