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Protein
Submitted name:

Pyruvate dehydrogenase (Lipoamide) beta

Gene

pdhb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • pyruvate dehydrogenase (acetyl-transferring) activity Source: InterPro
  • pyruvate dehydrogenase activity Source: ZFIN

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

PyruvateImported

Enzyme and pathway databases

ReactomeiR-DRE-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-DRE-389661. Glyoxylate metabolism and glycine degradation.
R-DRE-5362517. Signaling by Retinoic Acid.
R-DRE-70268. Pyruvate metabolism.

Names & Taxonomyi

Protein namesi
Submitted name:
Pyruvate dehydrogenase (Lipoamide) betaImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:pdhbImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 22

Organism-specific databases

ZFINiZDB-GENE-040426-2173. pdhb.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002122.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini33 – 208176Transket_pyrInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
GeneTreeiENSGT00530000063423.
HOGENOMiHOG000281450.
HOVERGENiHBG000917.
KOiK00162.
OMAiMYGDKGE.
OrthoDBiEOG7KSX8S.
TreeFamiTF105674.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PTHR11624:SF56. PTHR11624:SF56. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T368-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLRCFLRS GKSAVSAVLR REFHRTPPAA VQVTVRDALN QAMDEELERD
60 70 80 90 100
ERVFLLGEEV AQYDGAYKVS RGLWKKYGDK RIIDTPITEM GFAGIAVGAA
110 120 130 140 150
MAGLRPICEF MTFNFSMQAI DQVINSAAKT YYMSAGLQAV PIVFRGPNGA
160 170 180 190 200
SAGVAAQHSQ CFAAWYGHCP GLKVLSPWNS EDARGLLKAA IRDDNPVVFL
210 220 230 240 250
ENELMYGVPF EMSEEVQSKD FVIPIGKAKI ERQGNHITLV SHSRMVGLCL
260 270 280 290 300
DAAAVLAKEG IECEVINLRS IRPLDADTIE TSITKTNHLV TVEGGWPQFG
310 320 330 340 350
VGAEILARIM EGPAFNYLDA PAVRVTGVDI PMPYAKILED NSIPQIKDII

FSVKKTLNV
Length:359
Mass (Da):39,308
Last modified:October 1, 2003 - v1
Checksum:i06B31C8784F75DE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649457 Genomic DNA. No translation available.
BC053233 mRNA. Translation: AAH53233.1.
RefSeqiNP_998319.1. NM_213154.1.
UniGeneiDr.3570.

Genome annotation databases

EnsembliENSDART00000006513; ENSDARP00000002122; ENSDARG00000021346.
GeneIDi406428.
KEGGidre:406428.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX649457 Genomic DNA. No translation available.
BC053233 mRNA. Translation: AAH53233.1.
RefSeqiNP_998319.1. NM_213154.1.
UniGeneiDr.3570.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000002122.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000006513; ENSDARP00000002122; ENSDARG00000021346.
GeneIDi406428.
KEGGidre:406428.

Organism-specific databases

CTDi5162.
ZFINiZDB-GENE-040426-2173. pdhb.

Phylogenomic databases

eggNOGiKOG0524. Eukaryota.
COG0022. LUCA.
GeneTreeiENSGT00530000063423.
HOGENOMiHOG000281450.
HOVERGENiHBG000917.
KOiK00162.
OMAiMYGDKGE.
OrthoDBiEOG7KSX8S.
TreeFamiTF105674.

Enzyme and pathway databases

ReactomeiR-DRE-204174. Regulation of pyruvate dehydrogenase (PDH) complex.
R-DRE-389661. Glyoxylate metabolism and glycine degradation.
R-DRE-5362517. Signaling by Retinoic Acid.
R-DRE-70268. Pyruvate metabolism.

Family and domain databases

Gene3Di3.40.50.920. 1 hit.
3.40.50.970. 1 hit.
InterProiIPR027110. PDHB.
IPR029061. THDP-binding.
IPR009014. Transketo_C/PFOR_II.
IPR005475. Transketolase-like_Pyr-bd.
IPR033248. Transketolase_C.
IPR033247. Transketolase_fam.
[Graphical view]
PANTHERiPTHR11624. PTHR11624. 1 hit.
PTHR11624:SF56. PTHR11624:SF56. 1 hit.
PfamiPF02779. Transket_pyr. 1 hit.
PF02780. Transketolase_C. 1 hit.
[Graphical view]
SMARTiSM00861. Transket_pyr. 1 hit.
[Graphical view]
SUPFAMiSSF52518. SSF52518. 1 hit.
SSF52922. SSF52922. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  3. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ7T368_DANRE
AccessioniPrimary (citable) accession number: Q7T368
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 6, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.