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Protein

14-3-3 protein beta/alpha-B

Gene

ywhabb

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
14-3-3 protein beta/alpha-B
Gene namesi
Name:ywhabb
Synonyms:ywhab, ywhab2
ORF Names:zgc:64092
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-2160. ywhabb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 24224214-3-3 protein beta/alpha-BPRO_0000058601Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ7T356.
PRIDEiQ7T356.

Interactioni

Subunit structurei

Homodimer, and heterodimer with other family members.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei56 – 561Interaction with phosphoserine on interacting proteinBy similarity
Sitei127 – 1271Interaction with phosphoserine on interacting proteinBy similarity

Protein-protein interaction databases

BioGridi91034. 1 interaction.
STRINGi7955.ENSDARP00000101100.

Structurei

3D structure databases

ProteinModelPortaliQ7T356.
SMRiQ7T356. Positions 1-231.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
HOVERGENiHBG050423.
InParanoidiQ7T356.
KOiK16197.
PhylomeDBiQ7T356.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T356-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKSDLVQKA KLAEQAERYD DMAAAMKAVT EGGVELSNEE RNLLSVAYKN
60 70 80 90 100
VVGARRSSWR VISSIEQKTE GNEKKQQMAR EYREKIETEL QDICSDVLGL
110 120 130 140 150
LEKYLIANAS QAESKVFYLK MKGDYYRYLS EVASGDSKAT TVENSQKAYQ
160 170 180 190 200
DAFDISKKDM QPTHPIRLGL ALNFSVFYYE ILNSPENACQ LAKTAFDEAI
210 220 230 240
AELDTLNEDS YKDSTLIMQL LRDNLTLWTS ENQGEEAGEN EN
Length:242
Mass (Da):27,393
Last modified:October 1, 2003 - v1
Checksum:i5F9F0AAA69636022
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053247 mRNA. Translation: AAH53247.1.
RefSeqiNP_998310.1. NM_213145.1.
UniGeneiDr.5301.

Genome annotation databases

GeneIDi406419.
KEGGidre:406419.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053247 mRNA. Translation: AAH53247.1.
RefSeqiNP_998310.1. NM_213145.1.
UniGeneiDr.5301.

3D structure databases

ProteinModelPortaliQ7T356.
SMRiQ7T356. Positions 1-231.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi91034. 1 interaction.
STRINGi7955.ENSDARP00000101100.

Proteomic databases

PaxDbiQ7T356.
PRIDEiQ7T356.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi406419.
KEGGidre:406419.

Organism-specific databases

CTDi406419.
ZFINiZDB-GENE-040426-2160. ywhabb.

Phylogenomic databases

eggNOGiKOG0841. Eukaryota.
COG5040. LUCA.
HOVERGENiHBG050423.
InParanoidiQ7T356.
KOiK16197.
PhylomeDBiQ7T356.

Miscellaneous databases

PROiQ7T356.

Family and domain databases

InterProiIPR000308. 14-3-3.
IPR023409. 14-3-3_CS.
IPR023410. 14-3-3_domain.
[Graphical view]
PANTHERiPTHR18860. PTHR18860. 1 hit.
PfamiPF00244. 14-3-3. 1 hit.
[Graphical view]
PIRSFiPIRSF000868. 14-3-3. 1 hit.
PRINTSiPR00305. 1433ZETA.
SMARTiSM00101. 14_3_3. 1 hit.
[Graphical view]
SUPFAMiSSF48445. SSF48445. 1 hit.
PROSITEiPS00796. 1433_1. 1 hit.
PS00797. 1433_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry namei143BB_DANRE
AccessioniPrimary (citable) accession number: Q7T356
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.