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Protein

Malate dehydrogenase

Gene

mdh2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei199Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotation

Keywords - Biological processi

Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

NADUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-70263. Gluconeogenesis.
R-DRE-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh2Imported
Synonyms:zgc:64133Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040426-2143. mdh2.

Expressioni

Gene expression databases

BgeeiENSDARG00000043371.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063661.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 167Ldh_1_NInterPro annotationAdd BLAST143
Domaini169 – 333Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00390000016686.
HOGENOMiHOG000213792.
HOVERGENiHBG001662.
KOiK00026.
OMAiDVVECAF.
OrthoDBiEOG091G0AVO.
TreeFamiTF300834.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRVARPTA SLVRSLSTSS QNNAKVAVLG ASGGIGQPLS LLLKNSPLVS
60 70 80 90 100
ELSLFDIAHT PGVAADLSHI ETRAHVKGYI GADQLGDALK GCEVVVIPAG
110 120 130 140 150
VPRKPGMTRD DLFNTNATIV ATLVDGCARH CPQAMICIIS NPVNSTIPIT
160 170 180 190 200
SEVMKKHGVY NPNKIFGVTT LDIVRANTFV AELKGLDPAR VNVPVVGGHA
210 220 230 240 250
GITIIPLISQ CTPKVEFPAD QLSALTGRIQ EAGTEVVKAK AGAGSATLSM
260 270 280 290 300
AYAGARFTFS LLDAMNGKEG VVECSFVRSE ETECKYFSTP LLLGKNGIEK
310 320 330
NLGLGKLSAF EEKLVADAMT ELKGSIKKGE DFVANMK
Length:337
Mass (Da):35,420
Last modified:October 1, 2003 - v1
Checksum:iA93FDCEC34C7203F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX088525 Genomic DNA. No translation available.
BC053272 mRNA. Translation: AAH53272.1.
RefSeqiNP_998296.1. NM_213131.1.
UniGeneiDr.25868.

Genome annotation databases

EnsembliENSDART00000063662; ENSDARP00000063661; ENSDARG00000043371.
GeneIDi406405.
KEGGidre:406405.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX088525 Genomic DNA. No translation available.
BC053272 mRNA. Translation: AAH53272.1.
RefSeqiNP_998296.1. NM_213131.1.
UniGeneiDr.25868.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063661.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000063662; ENSDARP00000063661; ENSDARG00000043371.
GeneIDi406405.
KEGGidre:406405.

Organism-specific databases

CTDi4191.
ZFINiZDB-GENE-040426-2143. mdh2.

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00390000016686.
HOGENOMiHOG000213792.
HOVERGENiHBG001662.
KOiK00026.
OMAiDVVECAF.
OrthoDBiEOG091G0AVO.
TreeFamiTF300834.

Enzyme and pathway databases

ReactomeiR-DRE-70263. Gluconeogenesis.
R-DRE-71403. Citric acid cycle (TCA cycle).

Gene expression databases

BgeeiENSDARG00000043371.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiPS00068. MDH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ7T334_DANRE
AccessioniPrimary (citable) accession number: Q7T334
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: November 2, 2016
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.