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Protein

Malate dehydrogenase

Gene

mdh2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei199Proton acceptorUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processTricarboxylic acid cycleUniRule annotation
LigandNADUniRule annotation

Enzyme and pathway databases

ReactomeiR-DRE-70263. Gluconeogenesis.
R-DRE-71403. Citric acid cycle (TCA cycle).

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseUniRule annotation (EC:1.1.1.37UniRule annotation)
Gene namesi
Name:mdh2Imported
Synonyms:zgc:64133Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-040426-2143. mdh2.

Expressioni

Gene expression databases

BgeeiENSDARG00000043371.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000063661.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 167Ldh_1_NInterPro annotationAdd BLAST143
Domaini169 – 333Ldh_1_CInterPro annotationAdd BLAST165

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1494. Eukaryota.
COG0039. LUCA.
GeneTreeiENSGT00390000016686.
HOGENOMiHOG000213792.
HOVERGENiHBG001662.
KOiK00026.
OMAiICIIANP.
OrthoDBiEOG091G0AVO.
TreeFamiTF300834.

Family and domain databases

InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR001252. Malate_DH_AS.
IPR010097. Malate_DH_type1.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01772. MDH_euk_gproteo. 1 hit.
PROSITEiView protein in PROSITE
PS00068. MDH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T334-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFSRVARPTA SLVRSLSTSS QNNAKVAVLG ASGGIGQPLS LLLKNSPLVS
60 70 80 90 100
ELSLFDIAHT PGVAADLSHI ETRAHVKGYI GADQLGDALK GCEVVVIPAG
110 120 130 140 150
VPRKPGMTRD DLFNTNATIV ATLVDGCARH CPQAMICIIS NPVNSTIPIT
160 170 180 190 200
SEVMKKHGVY NPNKIFGVTT LDIVRANTFV AELKGLDPAR VNVPVVGGHA
210 220 230 240 250
GITIIPLISQ CTPKVEFPAD QLSALTGRIQ EAGTEVVKAK AGAGSATLSM
260 270 280 290 300
AYAGARFTFS LLDAMNGKEG VVECSFVRSE ETECKYFSTP LLLGKNGIEK
310 320 330
NLGLGKLSAF EEKLVADAMT ELKGSIKKGE DFVANMK
Length:337
Mass (Da):35,420
Last modified:October 1, 2003 - v1
Checksum:iA93FDCEC34C7203F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX088525 Genomic DNA. No translation available.
BC053272 mRNA. Translation: AAH53272.1.
RefSeqiNP_998296.1. NM_213131.1.
UniGeneiDr.25868.

Genome annotation databases

EnsembliENSDART00000063662; ENSDARP00000063661; ENSDARG00000043371.
GeneIDi406405.
KEGGidre:406405.

Similar proteinsi

Entry informationi

Entry nameiQ7T334_DANRE
AccessioniPrimary (citable) accession number: Q7T334
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: August 30, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported