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Protein

GPI mannosyltransferase 1

Gene

pigm

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly (By similarity).By similarity

Pathwayi: glycosylphosphatidylinositol-anchor biosynthesis

This protein is involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis, which is part of Glycolipid biosynthesis.
View all proteins of this organism that are known to be involved in the pathway glycosylphosphatidylinositol-anchor biosynthesis and in Glycolipid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

GPI-anchor biosynthesis

Enzyme and pathway databases

ReactomeiR-DRE-162710. Synthesis of glycosylphosphatidylinositol (GPI).
UniPathwayiUPA00196.

Protein family/group databases

CAZyiGT50. Glycosyltransferase Family 50.

Names & Taxonomyi

Protein namesi
Recommended name:
GPI mannosyltransferase 1 (EC:2.4.1.-)
Alternative name(s):
GPI mannosyltransferase I
Short name:
GPI-MT-I
Phosphatidylinositol-glycan biosynthesis class M protein
Short name:
PIG-M
Gene namesi
Name:pigm
ORF Names:zgc:64177
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 24

Organism-specific databases

ZFINiZDB-GENE-040426-1393. pigm.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4CytoplasmicSequence analysis4
Transmembranei5 – 25HelicalSequence analysisAdd BLAST21
Topological domaini26 – 65LumenalSequence analysisAdd BLAST40
Transmembranei66 – 86HelicalSequence analysisAdd BLAST21
Topological domaini87 – 125CytoplasmicSequence analysisAdd BLAST39
Transmembranei126 – 148HelicalSequence analysisAdd BLAST23
Topological domaini149 – 156LumenalSequence analysis8
Transmembranei157 – 177HelicalSequence analysisAdd BLAST21
Topological domaini178 – 198CytoplasmicSequence analysisAdd BLAST21
Transmembranei199 – 219HelicalSequence analysisAdd BLAST21
Topological domaini220 – 261LumenalSequence analysisAdd BLAST42
Transmembranei262 – 282HelicalSequence analysisAdd BLAST21
Topological domaini283 – 302CytoplasmicSequence analysisAdd BLAST20
Transmembranei303 – 323HelicalSequence analysisAdd BLAST21
Topological domaini324 – 330LumenalSequence analysis7
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 360CytoplasmicSequence analysis9
Transmembranei361 – 381HelicalSequence analysisAdd BLAST21
Topological domaini382 – 392LumenalSequence analysisAdd BLAST11

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002462191 – 392GPI mannosyltransferase 1Add BLAST392

Proteomic databases

PaxDbiQ7T310.

Expressioni

Gene expression databases

BgeeiENSDARG00000024277.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000036819.

Family & Domainsi

Sequence similaritiesi

Belongs to the PIGM family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3893. Eukaryota.
ENOG410XRDY. LUCA.
GeneTreeiENSGT00390000017728.
HOGENOMiHOG000186884.
HOVERGENiHBG082137.
InParanoidiQ7T310.
KOiK05284.
OMAiIQIISHY.
OrthoDBiEOG091G092W.
PhylomeDBiQ7T310.
TreeFamiTF314752.

Family and domain databases

InterProiIPR007704. Mannosyltransferase_DXD.
[Graphical view]
PANTHERiPTHR12886. PTHR12886. 1 hit.
PfamiPF05007. Mannosyl_trans. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T310-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEARVCVLFG AAALLRLLLL CVGVYQDQTL KLKYTDVDYH VFTDAARFIT
60 70 80 90 100
QGESPYRRST FRYTPLLALL LVPNVYLSLL FGKLLFGFCD LLSGLLMFRL
110 120 130 140 150
LVLRGASHGS ACVSCGLWLL NPLPMAVSTR GNAESVLAVL VLSTLLCLQL
160 170 180 190 200
RKHTTAALLF GLSVHMKIYP VTYALPIALA LTAAPARGRG VLLRFFSPAL
210 220 230 240 250
LRFAAVSAAV FLSLGLIFYC RYGWEFLQEA YLYHLTRRDL RHNFSPFFYL
260 270 280 290 300
QYVCAERCWS SGLLPLLLLP QLLLLLLASA AFSSDLPFCC FLHTAVFVSF
310 320 330 340 350
NRVCTSQYFL WYLCLLPVVL PRLRLRLGRG LLLLLLWLLL QGLWLAPAYL
360 370 380 390
LEFQGWNSFS WIWAASLLFL LTNTFILAQI IQHYRPHDRK AD
Length:392
Mass (Da):44,409
Last modified:October 1, 2003 - v1
Checksum:i189C1A8615AA79B9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053299 mRNA. Translation: AAH53299.1.
RefSeqiNP_956684.1. NM_200390.1.
UniGeneiDr.86984.

Genome annotation databases

EnsembliENSDART00000032722; ENSDARP00000036819; ENSDARG00000024277.
GeneIDi393361.
KEGGidre:393361.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC053299 mRNA. Translation: AAH53299.1.
RefSeqiNP_956684.1. NM_200390.1.
UniGeneiDr.86984.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000036819.

Protein family/group databases

CAZyiGT50. Glycosyltransferase Family 50.

Proteomic databases

PaxDbiQ7T310.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000032722; ENSDARP00000036819; ENSDARG00000024277.
GeneIDi393361.
KEGGidre:393361.

Organism-specific databases

CTDi93183.
ZFINiZDB-GENE-040426-1393. pigm.

Phylogenomic databases

eggNOGiKOG3893. Eukaryota.
ENOG410XRDY. LUCA.
GeneTreeiENSGT00390000017728.
HOGENOMiHOG000186884.
HOVERGENiHBG082137.
InParanoidiQ7T310.
KOiK05284.
OMAiIQIISHY.
OrthoDBiEOG091G092W.
PhylomeDBiQ7T310.
TreeFamiTF314752.

Enzyme and pathway databases

UniPathwayiUPA00196.
ReactomeiR-DRE-162710. Synthesis of glycosylphosphatidylinositol (GPI).

Miscellaneous databases

PROiQ7T310.

Gene expression databases

BgeeiENSDARG00000024277.

Family and domain databases

InterProiIPR007704. Mannosyltransferase_DXD.
[Graphical view]
PANTHERiPTHR12886. PTHR12886. 1 hit.
PfamiPF05007. Mannosyl_trans. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIGM_DANRE
AccessioniPrimary (citable) accession number: Q7T310
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.