Reviewed,
UniProtKB/Swiss-Prot Q7T2V3 (M3K10_XENLA)
Last modified
October 13, 2009.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (1) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Mitogen-activated protein kinase kinase kinase 10 EC=2.7.11.25 Alternative name(s): Mixed lineage kinase 2 | ||||
| Gene names |
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| Organism | Xenopus laevis (African clawed frog) | ||||
| Taxonomic identifier | 8355 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Mesobatrachia › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Protein attributes
| Sequence length | 1005 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Activates the JUN N-terminal pathway By similarity. |
| Catalytic activity | ATP + a protein = ADP + a phosphoprotein. |
| Cofactor | Magnesium By similarity. |
| Enzyme regulation | Homodimerization via the leucine zipper domains is required for autophosphorylation and subsequent activation By similarity. |
| Subunit structure | Homodimer By similarity. |
| Post-translational modification | Autophosphorylation on serine and threonine residues within the activation loop plays a role in enzyme activation By similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Contains 1 protein kinase domain. Contains 1 SH3 domain. |
Ontologies
| Keywords | |
|---|---|
| Domain | Repeat SH3 domain |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Kinase Serine/threonine-protein kinase Transferase |
| Gene Ontology (GO) | |
| Biological process | protein amino acid phosphorylation Inferred from electronic annotation. Source: InterPro |
| Molecular function | ATP binding Inferred from electronic annotation. Source: UniProtKB-KW MAP kinase kinase kinase activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 1005 | 1005 | Mitogen-activated protein kinase kinase kinase 10 | PRO_0000277827 | |||||
Regions | |||||||||
| Domain | 32 – 96 | 65 | SH3 | ||||||
| Domain | 118 – 380 | 263 | Protein kinase | ||||||
| Domain | 404 – 425 | 22 | Leucine-zipper 1 By similarity | ||||||
| Domain | 439 – 460 | 22 | Leucine-zipper 2 By similarity | ||||||
| Nucleotide binding | 124 – 132 | 9 | ATP By similarity | ||||||
| Compositional bias | 724 – 765 | 42 | Ser-rich | ||||||
Sites | |||||||||
| Active site | 242 | 1 | Proton acceptor By similarity | ||||||
| Binding site | 145 | 1 | ATP By similarity | ||||||
Sequences
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References
| [1] | "PAK interacts with NCK and MLK2 to regulate the activation of jun N-terminal kinase." Poitras L., Jean S., Islam N., Moss T. FEBS Lett. 543:129-135(2003) [PubMed: 12753919] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
Cross-references
Sequence databases | |
|---|---|
| AF510499 mRNA. Translation: AAP46399.1. | |
| RefSeq | NP_001082629.1. |
| UniGene | Xl.26500 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1R1W based on UniProtKB P08581. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 398612. |
| KEGG | xla:398612. |
Organism-specific databases | |
| CTD | 398612. |
| Xenbase | XB-FEAT-920943. map3k10. |
Phylogenomic databases | |
| HOVERGEN | Q7T2V3. |
Enzyme and pathway databases | |
| BRENDA | 2.7.11.25. 648. |
Family and domain databases | |
| InterPro | IPR015785. MAPKKK-like. IPR016231. MAPKKK9/10/11. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_BS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. IPR001452. SH3_domain. IPR020473. SH3_region. IPR001245. Tyr_pkinase. [Graphical view] |
| PANTHER | PTHR23257:SF87. MAPKKK-like. 1 hit. |
| Pfam | PF00069. Pkinase. 1 hit. PF00018. SH3_1. 1 hit. [Graphical view] |
| PIRSF | PIRSF000556. MAPKKK9_11. 1 hit. |
| PRINTS | PR00452. SH3DOMAIN. PR00109. TYRKINASE. |
| ProDom | PD000001. Prot_kinase. 1 hit. PD000066. SH3. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| SMART | SM00326. SH3. 1 hit. SM00219. TyrKc. 1 hit. [Graphical view] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. 1 hit. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. PS50002. SH3. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | M3K10_XENLA | ||||||||
| Accession | Primary (citable) accession number: Q7T2V3 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | Xenopus annotation project | ||||||||

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