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Protein

Transcription factor CP2

Gene

TFCP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the ENS1/ERNI promoter. May be the major transcription activator thus being essential for its expression.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor CP2
Gene namesi
Name:TFCP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 496496Transcription factor CP2PRO_0000228003Add
BLAST

Proteomic databases

PaxDbiQ7T2U9.

Expressioni

Tissue specificityi

Expressed in the epiblast at the pre-primitive streak stage. At the primitive streak stage, expressed in the extending primitive streak and in the prospective neural plate. At stages 7 and 8, expressed in the neural folds, somites and in the regressing primitive streak. At stage 12, ubiquitously expressed in the whole embryo.1 Publication

Interactioni

Subunit structurei

Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028532.

Structurei

3D structure databases

ProteinModelPortaliQ7T2U9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni133 – 386254DNA-bindingBy similarityAdd
BLAST

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ7T2U9.
KOiK09275.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T2U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK
60 70 80 90 100
QEESSLPPEN ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML
110 120 130 140 150
DNRKIGELPE INGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL
160 170 180 190 200
DIDIPMSVGI IDPRANPTQL NTVEFLWDPS KRTSVFIQVH CISTEFTMRK
210 220 230 240 250
HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD
260 270 280 290 300
REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNAP SPGFNSSHSS
310 320 330 340 350
FSIGEGNGSP NHQPEPPPPI ADNLLPTSTP QEAQQWLHRN RFSTFSRLFR
360 370 380 390 400
NFSGADLLKL TREDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESQQ
410 420 430 440 450
LQELQQKHED GDAVTSTFFV YHAIYLEELT AVELTEKLAQ LFSISSQQIS
460 470 480 490
QIYKQGPTGI HVLISDEMIQ NFQDESCFVL DTMKAETNDS YHIILK
Length:496
Mass (Da):56,473
Last modified:October 1, 2003 - v1
Checksum:i94C451AF30BD249B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY298725 mRNA. Translation: AAP56347.1.
RefSeqiNP_989715.1. NM_204384.1.
UniGeneiGga.8699.

Genome annotation databases

GeneIDi378900.
KEGGigga:378900.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY298725 mRNA. Translation: AAP56347.1.
RefSeqiNP_989715.1. NM_204384.1.
UniGeneiGga.8699.

3D structure databases

ProteinModelPortaliQ7T2U9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028532.

Proteomic databases

PaxDbiQ7T2U9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378900.
KEGGigga:378900.

Organism-specific databases

CTDi7024.

Phylogenomic databases

eggNOGiKOG4091. Eukaryota.
ENOG410XNZ6. LUCA.
HOGENOMiHOG000230625.
HOVERGENiHBG053805.
InParanoidiQ7T2U9.
KOiK09275.

Miscellaneous databases

NextBioi20813870.
PROiQ7T2U9.

Family and domain databases

InterProiIPR007604. CP2.
IPR013761. SAM/pointed.
[Graphical view]
PfamiPF04516. CP2. 1 hit.
[Graphical view]
SUPFAMiSSF47769. SSF47769. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Transcription factor cCP2 controls gene expression in chicken embryonic stem cells."
    Acloque H., Mey A., Birot A.-M., Gruffat H., Pain B., Samarut J.
    Nucleic Acids Res. 32:2259-2271(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.

Entry informationi

Entry nameiTFCP2_CHICK
AccessioniPrimary (citable) accession number: Q7T2U9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2003
Last modified: February 17, 2016
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.