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Protein

Transcription factor CP2

Gene

TFCP2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds the B-response element 5'-CAAGTCCAGGCAAGT-3' of the ENS1/ERNI promoter. May be the major transcription activator thus being essential for its expression.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor CP2
Gene namesi
Name:TFCP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002280031 – 496Transcription factor CP2Add BLAST496

Proteomic databases

PaxDbiQ7T2U9

Expressioni

Tissue specificityi

Expressed in the epiblast at the pre-primitive streak stage. At the primitive streak stage, expressed in the extending primitive streak and in the prospective neural plate. At stages 7 and 8, expressed in the neural folds, somites and in the regressing primitive streak. At stage 12, ubiquitously expressed in the whole embryo.1 Publication

Gene expression databases

BgeeiENSGALG00000002235

Interactioni

Subunit structurei

Component of the SSP (stage selector protein) complex, which appears to be a heteromer of TFCP2 and 2 copies of NFE4.By similarity

Protein-protein interaction databases

STRINGi9031.ENSGALP00000028532

Structurei

3D structure databases

ProteinModelPortaliQ7T2U9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni133 – 386DNA-bindingBy similarityAdd BLAST254

Sequence similaritiesi

Belongs to the grh/CP2 family. CP2 subfamily.Curated

Phylogenomic databases

eggNOGiKOG4091 Eukaryota
ENOG410XNZ6 LUCA
HOGENOMiHOG000230625
HOVERGENiHBG053805
InParanoidiQ7T2U9
KOiK09275
OrthoDBiEOG091G0YV2

Family and domain databases

CDDicd09589 SAM_TFCP2, 1 hit
InterProiView protein in InterPro
IPR007604 CP2
IPR013761 SAM/pointed_sf
IPR037599 TFCP2_SAM
PfamiView protein in Pfam
PF04516 CP2, 1 hit
SUPFAMiSSF47769 SSF47769, 1 hit

Sequencei

Sequence statusi: Complete.

Q7T2U9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAWALKLPLA DEVIESGLVQ DFDASLSGIG QELGAGAYSM SDVLALPIFK
60 70 80 90 100
QEESSLPPEN ENKILPFQYV LCAATSPAVK LHDETLTYLN QGQSYEIRML
110 120 130 140 150
DNRKIGELPE INGKLVKSIF RVVFHDRRLQ YTEHQQLEGW RWNRPGDRIL
160 170 180 190 200
DIDIPMSVGI IDPRANPTQL NTVEFLWDPS KRTSVFIQVH CISTEFTMRK
210 220 230 240 250
HGGEKGVPFR VQIDTFKENE NGEYTEHLHS ASCQIKVFKP KGADRKQKTD
260 270 280 290 300
REKMEKRTPH EKEKYQPSYE TTILTECSPW PEITYVNNAP SPGFNSSHSS
310 320 330 340 350
FSIGEGNGSP NHQPEPPPPI ADNLLPTSTP QEAQQWLHRN RFSTFSRLFR
360 370 380 390 400
NFSGADLLKL TREDVIQICG PADGIRLFNA LKGRMVRPRL TIYVCQESQQ
410 420 430 440 450
LQELQQKHED GDAVTSTFFV YHAIYLEELT AVELTEKLAQ LFSISSQQIS
460 470 480 490
QIYKQGPTGI HVLISDEMIQ NFQDESCFVL DTMKAETNDS YHIILK
Length:496
Mass (Da):56,473
Last modified:October 1, 2003 - v1
Checksum:i94C451AF30BD249B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY298725 mRNA Translation: AAP56347.1
RefSeqiNP_989715.1, NM_204384.1
UniGeneiGga.8699

Genome annotation databases

GeneIDi378900
KEGGigga:378900

Similar proteinsi

Entry informationi

Entry nameiTFCP2_CHICK
AccessioniPrimary (citable) accession number: Q7T2U9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2003
Last modified: March 28, 2018
This is version 77 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health