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Protein

CUGBP Elav-like family member 2

Gene

CELF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation repression and stability. Mediates exon inclusion in TNNT2 pre-mRNA.1 Publication

GO - Molecular functioni

  • BRE binding Source: AgBase
  • nucleic acid binding Source: AgBase
  • nucleotide binding Source: AgBase
  • RNA binding Source: AgBase
  • translation repressor activity, mRNA regulatory element binding Source: AgBase

GO - Biological processi

  • alternative mRNA splicing, via spliceosome Source: AgBase

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
RNA-binding protein BRUNOL-3
Gene namesi
Name:CELF2
Synonyms:CUGBP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002951931 – 484CUGBP Elav-like family member 2Add BLAST484

Proteomic databases

PaxDbiQ7T2T1

Expressioni

Tissue specificityi

Expressed in heart.1 Publication

Developmental stagei

Expressed in heart at embryonic day 12 and 14 (at protein level). Expressed in heart at embryonic day 8.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi675146, 1 interactor
STRINGi9031.ENSGALP00000039247

Structurei

3D structure databases

ProteinModelPortaliQ7T2T1
SMRiQ7T2T1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 99RRM 1PROSITE-ProRule annotationAdd BLAST84
Domaini108 – 188RRM 2PROSITE-ProRule annotationAdd BLAST81
Domaini399 – 477RRM 3PROSITE-ProRule annotationAdd BLAST79

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 89Necessary for nuclear exportAdd BLAST89
Regioni90 – 178Necessary for nuclear exportAdd BLAST89
Regioni188 – 240Necessary for splicing activityAdd BLAST53
Regioni347 – 399Necessary for nuclear localizationAdd BLAST53
Regioni426 – 484Necessary for nuclear localization and splicing activityAdd BLAST59

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi260 – 373Ala-richAdd BLAST114

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146 Eukaryota
ENOG410XNTW LUCA
HOGENOMiHOG000004754
HOVERGENiHBG107646
InParanoidiQ7T2T1
KOiK13207
PhylomeDBiQ7T2T1

Family and domain databases

CDDicd12631 RRM1_CELF1_2_Bruno, 1 hit
cd12634 RRM2_CELF1_2, 1 hit
cd12638 RRM3_CELF1_2, 1 hit
Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR034196 CELF1/2_RRM1
IPR034198 CELF1/2_RRM2
IPR034199 CELF1/2_RRM3
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7T2T1-1) [UniParc]FASTAAdd to basket
Also known as: Variant L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGALDHSDQ PDPDAIKTFV GQIPRSWSEK ELKELFEPYG AVYQINVLRD
60 70 80 90 100
RSQNPPQSKG CCFVTFYTRK AALEAQNALH NIKTLPGMHH PIQMKPADSE
110 120 130 140 150
KSNAVEDRKL FIGMVSKKCN ENDIRVMFSP FGQIEECRIL RGPDGLSRGC
160 170 180 190 200
AFVTFSTRAM AQNAIKAMHQ SQTMEGCSSP IVVKFADTQK DKEQRRLQQQ
210 220 230 240 250
LAQQMQQLNT ATWGNLTGLG GLTPQYLALL QQATSSSNLG AFSGIQQMAG
260 270 280 290 300
MNALQLQNLA TLAAAAAAAQ TSATTTNANP LSTTTGALGA LTSPVAASTA
310 320 330 340 350
NSTAGAAMNS LTSLGTLQGL AGATVGLNNI NALAGMAALN GGLGATGLTN
360 370 380 390 400
GTAGTMDALT QAYSGIQQYA AAALPTLYSQ SLLQQQSAAG SQKEGPEGAN
410 420 430 440 450
LFIYHLPQEF GDQDILQMFM PFGNVISAKV FIDKQTNLSK CFGFVSYDNP
460 470 480
VSAQAAIQAM NGFQIGMKRL KVQLKRSKND SKPY
Length:484
Mass (Da):51,581
Last modified:July 10, 2007 - v2
Checksum:iDCBFF7303CF7557E
GO
Isoform 2 (identifier: Q7T2T1-2) [UniParc]FASTAAdd to basket
Also known as: Variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: G → GTVNS

Show »
Length:488
Mass (Da):51,982
Checksum:i1EDC13CB47C0BACE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_026816335G → GTVNS in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288985 mRNA Translation: AAP57761.1
AY288986 mRNA Translation: AAP57762.1
RefSeqiNP_989591.2, NM_204260.2
UniGeneiGga.4919

Genome annotation databases

GeneIDi374111
KEGGigga:374111

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCELF2_CHICK
AccessioniPrimary (citable) accession number: Q7T2T1
Secondary accession number(s): Q7T2T0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: April 25, 2018
This is version 85 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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