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Protein

CUGBP Elav-like family member 2

Gene

CELF2

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein implicated in the regulation of several post-transcriptional events. May be involved in mRNA translation repression and stability. Mediates exon inclusion in TNNT2 pre-mRNA.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
CUGBP Elav-like family member 2
Short name:
CELF-2
Alternative name(s):
Bruno-like protein 3
CUG triplet repeat RNA-binding protein 2
Short name:
CUG-BP2
CUG-BP- and ETR-3-like factor 2
ELAV-type RNA-binding protein 3
Short name:
ETR-3
RNA-binding protein BRUNOL-3
Gene namesi
Name:CELF2
Synonyms:CUGBP2
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Unplaced

Subcellular locationi

  • Nucleus
  • Cytoplasm

  • Note: Shuttles between the nucleus and the cytoplasm in a CRM1-dependent manner.

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 484484CUGBP Elav-like family member 2PRO_0000295193Add
BLAST

Proteomic databases

PaxDbiQ7T2T1.
PRIDEiQ7T2T1.

Expressioni

Tissue specificityi

Expressed in heart.1 Publication

Developmental stagei

Expressed in heart at embryonic day 12 and 14 (at protein level). Expressed in heart at embryonic day 8.2 Publications

Interactioni

Protein-protein interaction databases

BioGridi675146. 1 interaction.
STRINGi9031.ENSGALP00000039247.

Structurei

3D structure databases

ProteinModelPortaliQ7T2T1.
SMRiQ7T2T1. Positions 1-187, 381-482.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini16 – 9984RRM 1PROSITE-ProRule annotationAdd
BLAST
Domaini108 – 18881RRM 2PROSITE-ProRule annotationAdd
BLAST
Domaini399 – 47779RRM 3PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 8989Necessary for nuclear exportAdd
BLAST
Regioni90 – 17889Necessary for nuclear exportAdd
BLAST
Regioni188 – 24053Necessary for splicing activityAdd
BLAST
Regioni347 – 39953Necessary for nuclear localizationAdd
BLAST
Regioni426 – 48459Necessary for nuclear localization and splicing activityAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi260 – 373114Ala-richAdd
BLAST

Sequence similaritiesi

Belongs to the CELF/BRUNOL family.Curated
Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0146. Eukaryota.
ENOG410XNTW. LUCA.
HOGENOMiHOG000004754.
HOVERGENiHBG107646.
InParanoidiQ7T2T1.
KOiK13207.
PhylomeDBiQ7T2T1.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q7T2T1-1) [UniParc]FASTAAdd to basket

Also known as: Variant L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGALDHSDQ PDPDAIKTFV GQIPRSWSEK ELKELFEPYG AVYQINVLRD
60 70 80 90 100
RSQNPPQSKG CCFVTFYTRK AALEAQNALH NIKTLPGMHH PIQMKPADSE
110 120 130 140 150
KSNAVEDRKL FIGMVSKKCN ENDIRVMFSP FGQIEECRIL RGPDGLSRGC
160 170 180 190 200
AFVTFSTRAM AQNAIKAMHQ SQTMEGCSSP IVVKFADTQK DKEQRRLQQQ
210 220 230 240 250
LAQQMQQLNT ATWGNLTGLG GLTPQYLALL QQATSSSNLG AFSGIQQMAG
260 270 280 290 300
MNALQLQNLA TLAAAAAAAQ TSATTTNANP LSTTTGALGA LTSPVAASTA
310 320 330 340 350
NSTAGAAMNS LTSLGTLQGL AGATVGLNNI NALAGMAALN GGLGATGLTN
360 370 380 390 400
GTAGTMDALT QAYSGIQQYA AAALPTLYSQ SLLQQQSAAG SQKEGPEGAN
410 420 430 440 450
LFIYHLPQEF GDQDILQMFM PFGNVISAKV FIDKQTNLSK CFGFVSYDNP
460 470 480
VSAQAAIQAM NGFQIGMKRL KVQLKRSKND SKPY
Length:484
Mass (Da):51,581
Last modified:July 10, 2007 - v2
Checksum:iDCBFF7303CF7557E
GO
Isoform 2 (identifier: Q7T2T1-2) [UniParc]FASTAAdd to basket

Also known as: Variant 4

The sequence of this isoform differs from the canonical sequence as follows:
     335-335: G → GTVNS

Show »
Length:488
Mass (Da):51,982
Checksum:i1EDC13CB47C0BACE
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei335 – 3351G → GTVNS in isoform 2. 1 PublicationVSP_026816

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288985 mRNA. Translation: AAP57761.1.
AY288986 mRNA. Translation: AAP57762.1.
RefSeqiNP_989591.2. NM_204260.2.
UniGeneiGga.4919.

Genome annotation databases

GeneIDi374111.
KEGGigga:374111.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY288985 mRNA. Translation: AAP57761.1.
AY288986 mRNA. Translation: AAP57762.1.
RefSeqiNP_989591.2. NM_204260.2.
UniGeneiGga.4919.

3D structure databases

ProteinModelPortaliQ7T2T1.
SMRiQ7T2T1. Positions 1-187, 381-482.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi675146. 1 interaction.
STRINGi9031.ENSGALP00000039247.

Proteomic databases

PaxDbiQ7T2T1.
PRIDEiQ7T2T1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi374111.
KEGGigga:374111.

Organism-specific databases

CTDi10659.

Phylogenomic databases

eggNOGiKOG0146. Eukaryota.
ENOG410XNTW. LUCA.
HOGENOMiHOG000004754.
HOVERGENiHBG107646.
InParanoidiQ7T2T1.
KOiK13207.
PhylomeDBiQ7T2T1.

Miscellaneous databases

PROiQ7T2T1.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Multiple domains control the subcellular localization and activity of ETR-3, a regulator of nuclear and cytoplasmic RNA processing events."
    Ladd A.N., Cooper T.A.
    J. Cell Sci. 117:3519-3529(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Tissue: Heart.
  2. "Dynamic balance between activation and repression regulates pre-mRNA alternative splicing during heart development."
    Ladd A.N., Stenberg M.G., Swanson M.S., Cooper T.A.
    Dev. Dyn. 233:783-793(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCELF2_CHICK
AccessioniPrimary (citable) accession number: Q7T2T1
Secondary accession number(s): Q7T2T0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: July 10, 2007
Last modified: June 8, 2016
This is version 78 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.