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Protein

Snaclec EMS16 subunit alpha

Gene
N/A
Organism
Echis multisquamatus (Central Asian sand viper)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

EMS16 is a potent and selective inhibitor of alpha-2/beta-1 (ITGA2/ITGB1) integrin and acts as a potent antagonist of platelet aggregation and cell migration. Binds specifically to the I domain of the alpha-2 subunit, in a metal ion-independent fashion.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei84Key residue for binding with integrin1
Sitei90Key residue for binding with integrin1
Sitei133Key residue for binding with integrin1

Keywords - Molecular functioni

Hemostasis impairing toxin, Platelet aggregation inhibiting toxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Snaclec EMS16 subunit alpha
Short name:
EMS16A
OrganismiEchis multisquamatus (Central Asian sand viper)
Taxonomic identifieri93050 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaViperidaeViperinaeEchis

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 232 PublicationsAdd BLAST23
ChainiPRO_000031880224 – 157Snaclec EMS16 subunit alphaAdd BLAST134

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 38PROSITE-ProRule annotation1 Publication
Disulfide bondi55 ↔ 152PROSITE-ProRule annotation1 Publication
Disulfide bondi104Interchain (with C-100 in subunit B)PROSITE-ProRule annotation1 Publication
Disulfide bondi127 ↔ 144PROSITE-ProRule annotation1 Publication

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.

Interactioni

Subunit structurei

Heterodimer of subunits A and B; disulfide-linked.2 Publications

Structurei

Secondary structure

1157
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi32 – 34Combined sources3
Beta strandi37 – 46Combined sources10
Helixi48 – 58Combined sources11
Helixi70 – 79Combined sources10
Helixi81 – 85Combined sources5
Beta strandi90 – 97Combined sources8
Beta strandi100 – 102Combined sources3
Beta strandi127 – 131Combined sources5
Helixi132 – 134Combined sources3
Beta strandi138 – 142Combined sources5
Beta strandi148 – 155Combined sources8

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UKMX-ray1.90A24-157[»]
1V7PX-ray1.90A24-157[»]
ProteinModelPortaliQ7T2Q1.
SMRiQ7T2Q1.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7T2Q1.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 153C-type lectinPROSITE-ProRule annotationAdd BLAST120

Sequence similaritiesi

Belongs to the snaclec family.Curated
Contains 1 C-type lectin domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG004151.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T2Q1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGRFISVSFG LLVVFLSLSG TGADFDCPSD WTAYDQHCYL AIGEPQNWYE
60 70 80 90 100
AERFCTEQAK DGHLVSIQSR EEGNFVAQLV SGFMHRSEIY VWIGLRDRRE
110 120 130 140 150
EQQCNPEWND GSKIIYVNWK EGESKMCQGL TKWTNFHDWN NINCEDLYPF

VCKFSAV
Length:157
Mass (Da):18,214
Last modified:October 1, 2003 - v1
Checksum:iF0D9638C6D622AB3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098253 mRNA. Translation: BAC77706.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB098253 mRNA. Translation: BAC77706.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1UKMX-ray1.90A24-157[»]
1V7PX-ray1.90A24-157[»]
ProteinModelPortaliQ7T2Q1.
SMRiQ7T2Q1.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG004151.

Miscellaneous databases

EvolutionaryTraceiQ7T2Q1.

Family and domain databases

Gene3Di3.10.100.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
[Graphical view]
SMARTiSM00034. CLECT. 1 hit.
[Graphical view]
SUPFAMiSSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSLA_ECHML
AccessioniPrimary (citable) accession number: Q7T2Q1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: October 1, 2003
Last modified: November 30, 2016
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.