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Q7T2M9

- Q7T2M9_CARAU

UniProt

Q7T2M9 - Q7T2M9_CARAU

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Protein
Submitted name:

Interferon-inducible and double-stranded-dependent eIF-2kinase

Gene
N/A
Organism
Carassius auratus (Goldfish)
Status
Unreviewed - Annotation score: 1 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. double-stranded RNA adenosine deaminase activity Source: InterPro
  3. protein serine/threonine kinase activity Source: UniProtKB-KW
  4. RNA binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Interferon-inducible and double-stranded-dependent eIF-2kinaseImported
OrganismiCarassius auratus (Goldfish)Imported
Taxonomic identifieri7957 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4KMFX-ray1.70A2-63[»]
ProteinModelPortaliQ7T2M9.

Family & Domainsi

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

HOVERGENiHBG055855.

Family and domain databases

Gene3Di1.10.10.10. 2 hits.
InterProiIPR000607. dsRNA_A_deaminase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00069. Pkinase. 2 hits.
PF02295. z-alpha. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 2 hits.
PROSITEiPS50139. DRADA_REPEAT. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T2M9-1 [UniParc]FASTAAdd to Basket

« Hide

MSAETQMERK IIDFLRQNGK SIALTIAKEI GLDKSTVNRH LYNLQRSNQV    50
FNSNEKPPVW DLMEKTNGIK QTVKTPEQKS LTTTAETCEE KHVRDLLKSG 100
GLKACQIAKD LGQPRKAVNK QLYSMMQTGK VKKCEISSLW LLEGEESNES 150
HSQESDHRLG SVAGLSQSFD VITKLGEGGF GCVFKVKHKF DGKIYAVKKV 200
VLTGEADSEV KALARLDHPN IVRYITCWPD SESCTSNQDR NQVSNTSGSS 250
SCGVTFDRAG CEERNDEDDE DDDDDDDVSD VTSRMESLGS TAELASAAGP 300
SGNLDPLNHS RMYLFIQMEF CEGGTLTTWI RARNRMNKQR IAVEIHKIFY 350
EIVSGVEYIH SNSLIHRDLK PDNILFGMDG KVKIGDFGLV AAQTNHSGGP 400
IERTKRRGTL QYMSPEQENK RNYDEKTDIF PLGLIWFEML WKLSTGMERA 450
ELLKDLRNQR FPEGFCDSYP TENKFIEKML SFAPEDRPPA KDIKEKLEKF 500
FSLDEDLLSQ KTI 513
Length:513
Mass (Da):57,954
Last modified:October 1, 2003 - v1
Checksum:i8DA87682788D9CE7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY293929 mRNA. Translation: AAP49830.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY293929 mRNA. Translation: AAP49830.1 .

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4KMF X-ray 1.70 A 2-63 [» ]
ProteinModelPortali Q7T2M9.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

HOVERGENi HBG055855.

Family and domain databases

Gene3Di 1.10.10.10. 2 hits.
InterProi IPR000607. dsRNA_A_deaminase.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view ]
Pfami PF00069. Pkinase. 2 hits.
PF02295. z-alpha. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 2 hits.
PROSITEi PS50139. DRADA_REPEAT. 1 hit.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of antiviral-relevant genes in the cultured fish cells induced by UV-inactivated virus."
    Zhang Y.-B., Zhang Q.-Y., Xu D.-Q., Hu C.-Y., Gui J.-F.
    Chin. Sci. Bull. 48:581-588(2003)
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BlastulaImported.
  2. Zhang Y., Huang G., Hu C., Gui J.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BlastulaImported.
  3. "Molecular cloning and characterisation of a fish PKR-like gene from cultured CAB cells induced by UV-inactivated virus."
    Hu C.Y., Zhang Y.B., Huang G.P., Zhang Q.Y., Gui J.F.
    Fish Shellfish Immunol. 17:353-366(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Tissue: BlastulaImported.
  4. "Distinct Z-DNA binding mode of a PKR-like protein kinase containing a Z-DNA binding domain (PKZ)."
    Kim D., Hur J., Park K., Bae S., Shin D., Ha S.C., Hwang H.Y., Hohng S., Lee J.H., Lee S., Kim Y.G., Kim K.K.
    Nucleic Acids Res. 42:5937-5948(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-63.

Entry informationi

Entry nameiQ7T2M9_CARAU
AccessioniPrimary (citable) accession number: Q7T2M9
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: September 3, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported

External Data

Dasty 3

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