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Q7T2M9

- Q7T2M9_CARAU

UniProt

Q7T2M9 - Q7T2M9_CARAU

Protein
Submitted name:

Interferon-inducible and double-stranded-dependent eIF-2kinase

Gene
N/A
Organism
Carassius auratus (Goldfish)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. double-stranded RNA adenosine deaminase activity Source: InterPro
    3. protein serine/threonine kinase activity Source: UniProtKB-KW
    4. RNA binding Source: InterPro

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinaseUniRule annotation, Transferase

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Interferon-inducible and double-stranded-dependent eIF-2kinaseImported
    OrganismiCarassius auratus (Goldfish)Imported
    Taxonomic identifieri7957 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeCarassius

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4KMFX-ray1.70A2-63[»]
    ProteinModelPortaliQ7T2M9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the protein kinase superfamily.UniRule annotation

    Phylogenomic databases

    HOVERGENiHBG055855.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR000607. dsRNA_A_deaminase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00069. Pkinase. 2 hits.
    PF02295. z-alpha. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 2 hits.
    PROSITEiPS50139. DRADA_REPEAT. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7T2M9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSAETQMERK IIDFLRQNGK SIALTIAKEI GLDKSTVNRH LYNLQRSNQV    50
    FNSNEKPPVW DLMEKTNGIK QTVKTPEQKS LTTTAETCEE KHVRDLLKSG 100
    GLKACQIAKD LGQPRKAVNK QLYSMMQTGK VKKCEISSLW LLEGEESNES 150
    HSQESDHRLG SVAGLSQSFD VITKLGEGGF GCVFKVKHKF DGKIYAVKKV 200
    VLTGEADSEV KALARLDHPN IVRYITCWPD SESCTSNQDR NQVSNTSGSS 250
    SCGVTFDRAG CEERNDEDDE DDDDDDDVSD VTSRMESLGS TAELASAAGP 300
    SGNLDPLNHS RMYLFIQMEF CEGGTLTTWI RARNRMNKQR IAVEIHKIFY 350
    EIVSGVEYIH SNSLIHRDLK PDNILFGMDG KVKIGDFGLV AAQTNHSGGP 400
    IERTKRRGTL QYMSPEQENK RNYDEKTDIF PLGLIWFEML WKLSTGMERA 450
    ELLKDLRNQR FPEGFCDSYP TENKFIEKML SFAPEDRPPA KDIKEKLEKF 500
    FSLDEDLLSQ KTI 513
    Length:513
    Mass (Da):57,954
    Last modified:October 1, 2003 - v1
    Checksum:i8DA87682788D9CE7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY293929 mRNA. Translation: AAP49830.1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY293929 mRNA. Translation: AAP49830.1 .

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4KMF X-ray 1.70 A 2-63 [» ]
    ProteinModelPortali Q7T2M9.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Phylogenomic databases

    HOVERGENi HBG055855.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR000607. dsRNA_A_deaminase.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR008271. Ser/Thr_kinase_AS.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00069. Pkinase. 2 hits.
    PF02295. z-alpha. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 2 hits.
    PROSITEi PS50139. DRADA_REPEAT. 1 hit.
    PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of antiviral-relevant genes in the cultured fish cells induced by UV-inactivated virus."
      Zhang Y.-B., Zhang Q.-Y., Xu D.-Q., Hu C.-Y., Gui J.-F.
      Chin. Sci. Bull. 48:581-588(2003)
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BlastulaImported.
    2. Zhang Y., Huang G., Hu C., Gui J.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BlastulaImported.
    3. "Molecular cloning and characterisation of a fish PKR-like gene from cultured CAB cells induced by UV-inactivated virus."
      Hu C.Y., Zhang Y.B., Huang G.P., Zhang Q.Y., Gui J.F.
      Fish Shellfish Immunol. 17:353-366(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Tissue: BlastulaImported.
    4. "Distinct Z-DNA binding mode of a PKR-like protein kinase containing a Z-DNA binding domain (PKZ)."
      Kim D., Hur J., Park K., Bae S., Shin D., Ha S.C., Hwang H.Y., Hohng S., Lee J.H., Lee S., Kim Y.G., Kim K.K.
      Nucleic Acids Res. 42:5937-5948(2014) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 2-63.

    Entry informationi

    Entry nameiQ7T2M9_CARAU
    AccessioniPrimary (citable) accession number: Q7T2M9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2003
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported

    External Data

    Dasty 3