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Protein

WD repeat and SOCS box-containing protein 1

Gene

wsb1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.By similarity

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
WD repeat and SOCS box-containing protein 1
Short name:
WSB-1
Gene namesi
Name:wsb1
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 15

Organism-specific databases

ZFINiZDB-GENE-030131-1946. wsb1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 423423WD repeat and SOCS box-containing protein 1PRO_0000347227Add
BLAST

Proteomic databases

PaxDbiQ7T2F6.

Expressioni

Gene expression databases

BgeeiENSDARG00000021343.

Interactioni

Subunit structurei

Component of a probable ECS E3 ubiquitin-protein ligase complex that contains the Elongin BC complex.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005989.

Structurei

3D structure databases

ProteinModelPortaliQ7T2F6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati125 – 16642WD 1Add
BLAST
Repeati169 – 20941WD 2Add
BLAST
Repeati213 – 25240WD 3Add
BLAST
Repeati255 – 29440WD 4Add
BLAST
Repeati310 – 34738WD 5Add
BLAST
Domaini373 – 42351SOCS boxPROSITE-ProRule annotationAdd
BLAST

Domaini

The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes.By similarity

Sequence similaritiesi

Contains 1 SOCS box domain.PROSITE-ProRule annotation
Contains 5 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiENOG410IQ0Y. Eukaryota.
ENOG411010D. LUCA.
GeneTreeiENSGT00830000128308.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiQ7T2F6.
KOiK10341.
OMAiGHHNDVV.
OrthoDBiEOG091G06GY.
PhylomeDBiQ7T2F6.
TreeFamiTF329216.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T2F6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASFPDCVNE NEIGKAKFIG ELIPPVAPFD QKSGRETWTV AFAPDGSYFA
60 70 80 90 100
WSQGHRIVRL VPWKKCLASF SVRKEDRSSG AGPRRLSRQN SEGSLLPGEP
110 120 130 140 150
REHTIDCGDI VWGLAFGSSV PEKQSRCVNI EWHRFKFGQD QLLLATGLNN
160 170 180 190 200
GRIKIWDVYT GKLLLNLMDH TDIVRDLTFA PDGSLVLVSA SRDKTLRVWD
210 220 230 240 250
LKDDGNMVKV LRGHQNWVYC SAFSPDSSVL CSVGAGKAVF LWDMDKYTLI
260 270 280 290 300
RKLEGHHNDV VCCEFSPDGA LLATASYDTR VIVWDPHTAT VLLELGHLFP
310 320 330 340 350
PPSPIFAGGA NDRWVRSVAF CHDGRHIASV TDDRLVRFWS IDEKSPQAIG
360 370 380 390 400
PLTNGLCCAF STDGSVLSAG SRDGSVHFWA SPRSIASLQH LCRMTLRRVM
410 420
PTQQVYTLPI PFSMQDYLAY KTL
Length:423
Mass (Da):47,086
Last modified:October 1, 2003 - v1
Checksum:i2E83C845634562E1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054567 mRNA. Translation: AAH54567.1.
RefSeqiNP_955927.1. NM_199633.1.
UniGeneiDr.33037.

Genome annotation databases

EnsembliENSDART00000008854; ENSDARP00000005989; ENSDARG00000021343.
GeneIDi323226.
KEGGidre:323226.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054567 mRNA. Translation: AAH54567.1.
RefSeqiNP_955927.1. NM_199633.1.
UniGeneiDr.33037.

3D structure databases

ProteinModelPortaliQ7T2F6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000005989.

Proteomic databases

PaxDbiQ7T2F6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000008854; ENSDARP00000005989; ENSDARG00000021343.
GeneIDi323226.
KEGGidre:323226.

Organism-specific databases

CTDi26118.
ZFINiZDB-GENE-030131-1946. wsb1.

Phylogenomic databases

eggNOGiENOG410IQ0Y. Eukaryota.
ENOG411010D. LUCA.
GeneTreeiENSGT00830000128308.
HOGENOMiHOG000063727.
HOVERGENiHBG034543.
InParanoidiQ7T2F6.
KOiK10341.
OMAiGHHNDVV.
OrthoDBiEOG091G06GY.
PhylomeDBiQ7T2F6.
TreeFamiTF329216.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-DRE-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

PROiQ7T2F6.

Gene expression databases

BgeeiENSDARG00000021343.

Family and domain databases

Gene3Di2.130.10.10. 2 hits.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR011045. N2O_reductase_N.
IPR001496. SOCS_box.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF07525. SOCS_box. 1 hit.
PF00400. WD40. 5 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00253. SOCS. 1 hit.
SM00969. SOCS_box. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF158235. SSF158235. 1 hit.
SSF50974. SSF50974. 1 hit.
SSF50978. SSF50978. 1 hit.
PROSITEiPS50225. SOCS. 1 hit.
PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiWSB1_DANRE
AccessioniPrimary (citable) accession number: Q7T2F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2003
Last modified: September 7, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.