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Protein

Casein kinase I isoform delta-A

Gene

csnk1da

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. Central component of the circadian clock. May act as a negative regulator of circadian rhythmicity by phosphorylating per1 and per2, which may lead to their degradation. Participates in wnt signaling (By similarity).By similarity

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Enzyme regulationi

Exhibits substrate-dependent heparin activation.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei38ATPPROSITE-ProRule annotation1
Active sitei128Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 23ATPPROSITE-ProRule annotation9

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processWnt signaling pathway
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-DRE-204005 COPII-mediated vesicle transport
R-DRE-2565942 Regulation of PLK1 Activity at G2/M Transition
R-DRE-380259 Loss of Nlp from mitotic centrosomes
R-DRE-380270 Recruitment of mitotic centrosome proteins and complexes
R-DRE-380320 Recruitment of NuMA to mitotic centrosomes
R-DRE-5620912 Anchoring of the basal body to the plasma membrane
R-DRE-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-DRE-8854518 AURKA Activation by TPX2

Names & Taxonomyi

Protein namesi
Recommended name:
Casein kinase I isoform delta-A (EC:2.7.11.1)
Short name:
CKI-delta-A
Short name:
CKId-A
Alternative name(s):
Casein kinase I isoform delta-like
Gene namesi
Name:csnk1da
Synonyms:csnk1dl
ORF Names:si:ch211-234h8.6
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 3

Organism-specific databases

ZFINiZDB-GENE-030131-825 csnk1da

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003540871 – 403Casein kinase I isoform delta-AAdd BLAST403

Post-translational modificationi

Autophosphorylated on serine and threonine residues.By similarity

Proteomic databases

PaxDbiQ7T2E3
PRIDEiQ7T2E3

Expressioni

Developmental stagei

Ubiquitously expressed in embryos until eight hours after fertilization. Detected throughout the embryo, but particularly in the cephalic region, at 10 to 24 hours after fertilization. Detected in retina, tegmentum and myencephalon at 38 and 48 hours after fertilization.1 Publication

Gene expression databases

BgeeiENSDARG00000008370

Interactioni

Subunit structurei

Monomer (By similarity). Interacts with per1 and per2. Component of the circadian core oscillator (By similarity).By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000003101

Structurei

3D structure databases

ProteinModelPortaliQ7T2E3
SMRiQ7T2E3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini9 – 277Protein kinasePROSITE-ProRule annotationAdd BLAST269

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni315 – 340AutoinhibitoryBy similarityAdd BLAST26

Sequence similaritiesi

Belongs to the protein kinase superfamily.Curated

Phylogenomic databases

eggNOGiKOG1164 Eukaryota
ENOG410XPGP LUCA
GeneTreeiENSGT00920000148982
HOGENOMiHOG000182055
HOVERGENiHBG000176
InParanoidiQ7T2E3
KOiK08959
OrthoDBiEOG091G0AFG
PhylomeDBiQ7T2E3
TreeFamiTF354246

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Complete.

Q7T2E3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELRVGNRYR LGRKIGSGSF GDIYLGTDIT TGEEVAIKLE CVKTKHPQLH
60 70 80 90 100
IESKIYKMMQ GGVGIPTIKW CGAEGDYNVM VMELLGPSLE DLFNFCSRKF
110 120 130 140 150
SLKTVLLLAD QMISRIEYIH SKNFIHRDVK PDNFLMGLGK KGNLVYIIDF
160 170 180 190 200
GLAKKYRDAR THQHIPYREN KNLTGTARYA SINTHLGIEQ SRRDDLESLG
210 220 230 240 250
YVLMYFNLGS LPWQGLKAAT KRQKYERISE KKMSTPIEVL CKGYPSEFAT
260 270 280 290 300
YLNFCRSLRF DDKPDYSYLR QLFRNLFHRQ GFSYDYVFDW NMLKFGGARE
310 320 330 340 350
DPERDRRDRE ERIRQGRIPL PRVMLPTSSG RPRGTQEVAP APPLTPDSHT
360 370 380 390 400
GMERERKVSM RLHRGAPVNV SSSDLTGRQD CSRISTSQAH SRVPSGLQSA

VPR
Length:403
Mass (Da):46,243
Last modified:October 1, 2003 - v1
Checksum:i58A49386B6DF6D70
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU127826 mRNA Translation: ABV29338.1
BX897685 Genomic DNA Translation: CAQ15428.1
BC054583 mRNA Translation: AAH54583.1
RefSeqiNP_955877.1, NM_199583.1
UniGeneiDr.6448

Genome annotation databases

EnsembliENSDART00000025326; ENSDARP00000003101; ENSDARG00000008370
GeneIDi322106
KEGGidre:322106

Similar proteinsi

Entry informationi

Entry nameiKC1DA_DANRE
AccessioniPrimary (citable) accession number: Q7T2E3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 25, 2008
Last sequence update: October 1, 2003
Last modified: June 20, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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