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Protein
Submitted name:

Arrb2b protein

Gene

arrb2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • muscle organ development Source: ZFIN
  • regulation of chemokine activity Source: ZFIN
  • regulation of receptor recycling Source: ZFIN
  • regulation of smoothened signaling pathway Source: ZFIN
  • signal transduction Source: InterPro
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-DRE-418555. G alpha (s) signalling events.
R-DRE-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-DRE-5099900. WNT5A-dependent internalization of FZD4.

Names & Taxonomyi

Protein namesi
Submitted name:
Arrb2b proteinImported
Submitted name:
Arrestin, beta 2bImported
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:arrb2bImported
Synonyms:arrb2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 7

Organism-specific databases

ZFINiZDB-GENE-040426-1332. arrb2b.

Expressioni

Gene expression databases

ExpressionAtlasiQ7T2D2. differential.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024694.

Structurei

3D structure databases

SMRiQ7T2D2. Positions 6-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini194 – 349156Arrestin_CInterPro annotationAdd
BLAST

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
KOiK04439.
OMAiEFETNNF.
OrthoDBiEOG79W954.
PhylomeDBiQ7T2D2.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T2D2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKAGTRVF KKSSPNCKLT VYLGKRDFVD HLDHVDPVDG VLLIDPEYLK
60 70 80 90 100
DRKVFVTLTC AFRYGREDLD VLGLSFRKDL FISSFQAYPP LPDERKPLSR
110 120 130 140 150
LQERLLKKLG QNAYPFNFTI PQNLPCSVTL QPGPEDTGKA CGVDFEVRAF
160 170 180 190 200
CAKTVDEKTH KRNSVRLVIR KVQYAPEKPG PQPMVETTRS FLMSDRSLHL
210 220 230 240 250
EASLDKELYY HGEPISVNVH VTNNSTKTVK RVKISVRQYA DICLFSTAQY
260 270 280 290 300
KCPVAQVEAD DQVSSSSTFC KVYTLTPTLS NNREKRGLAL DGQLKHEDTN
310 320 330 340 350
LASSTIVKDV SNKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPS
360 370 380 390 400
EQPNSRPQSA VPETDVPVDA NLIEFETNNF SQDDDFVFED FARLRLKGMK

DEEDDHFC
Length:408
Mass (Da):46,057
Last modified:October 1, 2003 - v1
Checksum:iDCC7FE40A8E67A00
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005022 Genomic DNA. No translation available.
BC054595 mRNA. Translation: AAH54595.1.
BC164508 mRNA. Translation: AAI64508.1.
RefSeqiNP_957418.1. NM_201124.1.
UniGeneiDr.132395.

Genome annotation databases

EnsembliENSDART00000026295; ENSDARP00000024694; ENSDARG00000011545.
GeneIDi394099.
KEGGidre:394099.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BX005022 Genomic DNA. No translation available.
BC054595 mRNA. Translation: AAH54595.1.
BC164508 mRNA. Translation: AAI64508.1.
RefSeqiNP_957418.1. NM_201124.1.
UniGeneiDr.132395.

3D structure databases

SMRiQ7T2D2. Positions 6-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000024694.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000026295; ENSDARP00000024694; ENSDARG00000011545.
GeneIDi394099.
KEGGidre:394099.

Organism-specific databases

CTDi394099.
ZFINiZDB-GENE-040426-1332. arrb2b.

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
KOiK04439.
OMAiEFETNNF.
OrthoDBiEOG79W954.
PhylomeDBiQ7T2D2.
TreeFamiTF314260.

Enzyme and pathway databases

ReactomeiR-DRE-418555. G alpha (s) signalling events.
R-DRE-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-DRE-5099900. WNT5A-dependent internalization of FZD4.

Gene expression databases

ExpressionAtlasiQ7T2D2. differential.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: KidneyImported.
  2. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: PCR rescueImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: TuebingenImported.
  4. "The zebrafish reference genome sequence and its relationship to the human genome."
    Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.
    , White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M., Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J., Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J., Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.
    Nature 496:498-503(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: TuebingenImported.

Entry informationi

Entry nameiQ7T2D2_DANRE
AccessioniPrimary (citable) accession number: Q7T2D2
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.