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Protein

Myotrophin

Gene

mtpn

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Regulates NF-kappa-B transcription factor activity. Promotes growth of cardiomyocytes, but not cardiomyocyte proliferation. Promotes cardiac muscle hypertrophy. Plays a role in the regulation of the growth of actin filaments. Inhibits the activity of the F-actin-capping protein complex (By similarity).By similarity

Names & Taxonomyi

Protein namesi
Recommended name:
Myotrophin
Gene namesi
Name:mtpn
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 4

Organism-specific databases

ZFINiZDB-GENE-040426-2166. mtpn.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003306611 – 118MyotrophinAdd BLAST118

Proteomic databases

PaxDbiQ7T2B9.
PRIDEiQ7T2B9.

Expressioni

Gene expression databases

BgeeiENSDARG00000055562.

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000072408.

Structurei

3D structure databases

ProteinModelPortaliQ7T2B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 30ANK 1Add BLAST30
Repeati34 – 65ANK 2Add BLAST32
Repeati67 – 98ANK 3Add BLAST32

Sequence similaritiesi

Belongs to the myotrophin family.Curated
Contains 3 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiQ7T2B9.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiQ7T2B9.
TreeFamiTF327387.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T2B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDKELMWAL KNGDLDEVKN ILVKAEDVNR TLEGGRKPLH YAADCGQAEM
60 70 80 90 100
LEFLLSKGAD VNAPDKHGIT PLLSATYEGH VTCVKILLEK GADKNRKGPD
110
GLSAFEAAES EAIKALLE
Length:118
Mass (Da):12,749
Last modified:October 1, 2003 - v1
Checksum:iAE51FFECF90388F4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054609 mRNA. Translation: AAH54609.1.
BC154009 mRNA. Translation: AAI54010.1.
BC155200 mRNA. Translation: AAI55201.1.
RefSeqiNP_998137.1. NM_212972.2.
UniGeneiDr.75187.

Genome annotation databases

EnsembliENSDART00000166090; ENSDARP00000133174; ENSDARG00000104018.
ENSDART00000171820; ENSDARP00000137926; ENSDARG00000104018.
ENSDART00000172320; ENSDARP00000141690; ENSDARG00000104018.
GeneIDi406240.
KEGGidre:406240.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054609 mRNA. Translation: AAH54609.1.
BC154009 mRNA. Translation: AAI54010.1.
BC155200 mRNA. Translation: AAI55201.1.
RefSeqiNP_998137.1. NM_212972.2.
UniGeneiDr.75187.

3D structure databases

ProteinModelPortaliQ7T2B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000072408.

Proteomic databases

PaxDbiQ7T2B9.
PRIDEiQ7T2B9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSDART00000166090; ENSDARP00000133174; ENSDARG00000104018.
ENSDART00000171820; ENSDARP00000137926; ENSDARG00000104018.
ENSDART00000172320; ENSDARP00000141690; ENSDARG00000104018.
GeneIDi406240.
KEGGidre:406240.

Organism-specific databases

CTDi136319.
ZFINiZDB-GENE-040426-2166. mtpn.

Phylogenomic databases

eggNOGiKOG4214. Eukaryota.
ENOG4111U90. LUCA.
GeneTreeiENSGT00430000031071.
HOGENOMiHOG000276399.
HOVERGENiHBG019067.
InParanoidiQ7T2B9.
OMAiTALIDCT.
OrthoDBiEOG091G0Y4J.
PhylomeDBiQ7T2B9.
TreeFamiTF327387.

Miscellaneous databases

PROiQ7T2B9.

Gene expression databases

BgeeiENSDARG00000055562.

Family and domain databases

Gene3Di1.25.40.20. 1 hit.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
[Graphical view]
PfamiPF12796. Ank_2. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
SMARTiSM00248. ANK. 3 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 1 hit.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMTPN_DANRE
AccessioniPrimary (citable) accession number: Q7T2B9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 1, 2003
Last modified: October 5, 2016
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.