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Protein

Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase

Gene

adprm

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose.By similarity

Catalytic activityi

CDP-choline + H2O = CMP + phosphocholine.
ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.
CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi13 – 131Zinc 1By similarity
Metal bindingi15 – 151Zinc 1By similarity
Metal bindingi60 – 601Zinc 1By similarity
Metal bindingi60 – 601Zinc 21 Publication
Metal bindingi96 – 961Zinc 21 Publication
Metal bindingi228 – 2281Zinc 21 Publication
Metal bindingi265 – 2651Zinc 21 Publication
Metal bindingi267 – 2671Zinc 1By similarity

GO - Molecular functioni

  • 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity Source: ZFIN
  • ADP-ribose diphosphatase activity Source: ZFIN
  • CDP-glycerol diphosphatase activity Source: ZFIN
  • manganese ion binding Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase (EC:3.6.1.13, EC:3.6.1.16, EC:3.6.1.53)
Alternative name(s):
ADPRibase-Mn
CDP-choline phosphohydrolase
Gene namesi
Name:adprm
ORF Names:zgc:64213
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Unplaced

Organism-specific databases

ZFINiZDB-GENE-040426-1406. adprm.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 322322Manganese-dependent ADP-ribose/CDP-alcohol diphosphatasePRO_0000286570Add
BLAST

Proteomic databases

PaxDbiQ7T291.

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096471.

Structurei

Secondary structure

1
322
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi5 – 117Combined sources
Beta strandi27 – 315Combined sources
Helixi35 – 4915Combined sources
Beta strandi53 – 575Combined sources
Helixi65 – 684Combined sources
Helixi72 – 8413Combined sources
Beta strandi88 – 925Combined sources
Helixi96 – 1016Combined sources
Helixi104 – 1085Combined sources
Helixi127 – 1293Combined sources
Beta strandi134 – 1396Combined sources
Beta strandi142 – 1465Combined sources
Beta strandi154 – 1574Combined sources
Helixi162 – 17413Combined sources
Beta strandi187 – 1893Combined sources
Helixi190 – 1934Combined sources
Helixi203 – 21917Combined sources
Beta strandi222 – 2298Combined sources
Helixi238 – 2403Combined sources
Helixi245 – 2539Combined sources
Beta strandi258 – 2636Combined sources
Beta strandi270 – 2734Combined sources
Beta strandi279 – 2824Combined sources
Helixi286 – 2883Combined sources
Beta strandi295 – 3017Combined sources
Beta strandi303 – 31210Combined sources
Beta strandi317 – 3204Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXFX-ray1.70A2-322[»]
ProteinModelPortaliQ7T291.
SMRiQ7T291. Positions 3-322.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ7T291.

Family & Domainsi

Sequence similaritiesi

Belongs to the ADPRibase-Mn family.Curated

Phylogenomic databases

eggNOGiENOG410IJ2N. Eukaryota.
COG1409. LUCA.
HOGENOMiHOG000154875.
HOVERGENiHBG100432.
InParanoidiQ7T291.
KOiK01517.
PhylomeDBiQ7T291.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T291-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEDPVFTFGL IADVQYADIE DGENYLRTRR RYYRGSADLL RDAVLQWRRE
60 70 80 90 100
RVQCVVQLGD IIDGHNRRRD ASDRALDTVM AELDACSVDV HHVWGNHEFY
110 120 130 140 150
NFSRPSLLSS RLNSAQRTGT DTGSDLIGDD IYAYEFSPAP NFRFVLLDAY
160 170 180 190 200
DLSVIGREEE SEKHTHSWRI LTQHNHNLQD LNLPPVSVGL EQRFVKFNGG
210 220 230 240 250
FSEQQLQWLD AVLTLSDHKQ ERVLIFSHLP VHPCAADPIC LAWNHEAVLS
260 270 280 290 300
VLRSHQSVLC FIAGHDHDGG RCTDSSGAQH ITLEGVIETP PHSHAFATAY
310 320
LYEDRMVMKG RGRVEDLTIT YS
Length:322
Mass (Da):36,645
Last modified:October 1, 2003 - v1
Checksum:i8C2BB1A16650934F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054642 mRNA. Translation: AAH54642.1.
RefSeqiNP_956715.1. NM_200421.1.
UniGeneiDr.82669.

Genome annotation databases

GeneIDi393393.
KEGGidre:393393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC054642 mRNA. Translation: AAH54642.1.
RefSeqiNP_956715.1. NM_200421.1.
UniGeneiDr.82669.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXFX-ray1.70A2-322[»]
ProteinModelPortaliQ7T291.
SMRiQ7T291. Positions 3-322.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000096471.

Proteomic databases

PaxDbiQ7T291.

Protocols and materials databases

DNASUi393393.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi393393.
KEGGidre:393393.

Organism-specific databases

CTDi56985.
ZFINiZDB-GENE-040426-1406. adprm.

Phylogenomic databases

eggNOGiENOG410IJ2N. Eukaryota.
COG1409. LUCA.
HOGENOMiHOG000154875.
HOVERGENiHBG100432.
InParanoidiQ7T291.
KOiK01517.
PhylomeDBiQ7T291.

Miscellaneous databases

EvolutionaryTraceiQ7T291.
PROiQ7T291.

Family and domain databases

Gene3Di3.60.21.10. 1 hit.
InterProiIPR004843. Calcineurin-like_PHP_apaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
SUPFAMiSSF56300. SSF56300. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. NIH - Zebrafish Gene Collection (ZGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Embryo.
  2. "Crystal structure of a dimetal phosphatase from Danio rerio loc 393393."
    Center for eukaryotic structural genomics (CESG)
    Submitted (DEC-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH ZINC.

Entry informationi

Entry nameiADPRM_DANRE
AccessioniPrimary (citable) accession number: Q7T291
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: June 8, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.