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Q7T291 (ADPRM_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 59. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
EC=3.6.1.13
EC=3.6.1.16
EC=3.6.1.53
Alternative name(s):
ADPRibase-Mn
CDP-choline phosphohydrolase
Gene names
Name:adprm
ORF Names:zgc:64213
OrganismDanio rerio (Zebrafish) (Brachydanio rerio) [Reference proteome]
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length322 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP-choline and CDP-ethanolamine, but not other non-reducing ADP-sugars or CDP-glucose By similarity.

Catalytic activity

CDP-choline + H2O = CMP + phosphocholine.

ADP-D-ribose + H2O = AMP + D-ribose 5-phosphate.

CDP-glycerol + H2O = CMP + sn-glycerol 3-phosphate.

Cofactor

Magnesium By similarity.

Subunit structure

Monomer By similarity.

Sequence similarities

Belongs to the ADPRibase-Mn family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 322322Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase
PRO_0000286570

Sites

Metal binding131Zinc 1 By similarity
Metal binding151Zinc 1 By similarity
Metal binding601Zinc 1 By similarity
Metal binding601Zinc 2
Metal binding961Zinc 2
Metal binding2281Zinc 2
Metal binding2651Zinc 2
Metal binding2671Zinc 1 By similarity

Secondary structure

1 ...................................................... 322
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q7T291 [UniParc].

Last modified October 1, 2003. Version 1.
Checksum: 8C2BB1A16650934F

FASTA32236,645
        10         20         30         40         50         60 
MEDPVFTFGL IADVQYADIE DGENYLRTRR RYYRGSADLL RDAVLQWRRE RVQCVVQLGD 

        70         80         90        100        110        120 
IIDGHNRRRD ASDRALDTVM AELDACSVDV HHVWGNHEFY NFSRPSLLSS RLNSAQRTGT 

       130        140        150        160        170        180 
DTGSDLIGDD IYAYEFSPAP NFRFVLLDAY DLSVIGREEE SEKHTHSWRI LTQHNHNLQD 

       190        200        210        220        230        240 
LNLPPVSVGL EQRFVKFNGG FSEQQLQWLD AVLTLSDHKQ ERVLIFSHLP VHPCAADPIC 

       250        260        270        280        290        300 
LAWNHEAVLS VLRSHQSVLC FIAGHDHDGG RCTDSSGAQH ITLEGVIETP PHSHAFATAY 

       310        320 
LYEDRMVMKG RGRVEDLTIT YS

« Hide

References

« Hide 'large scale' references
[1]NIH - Zebrafish Gene Collection (ZGC) project
Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Embryo.
[2]"Crystal structure of a dimetal phosphatase from Danio rerio loc 393393."
Center for eukaryotic structural genomics (CESG)
Submitted (DEC-2006) to the PDB data bank
Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH ZINC.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		BC054642 mRNA. Translation: AAH54642.1.
IPIIPI00500160.
RefSeqNP_956715.1. NM_200421.1.
UniGeneDr.82669.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXFX-ray1.70A2-322[»]
ProteinModelPortalQ7T291.
SMRQ7T291. Positions 3-322.
ModBaseSearch...

Protein-protein interaction databases

STRING7955.ENSDARP00000096471.

Protocols and materials databases

DNASU393393.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID393393.
KEGGdre:393393.

Organism-specific databases

CTD56985.
ZFINZDB-GENE-040426-1406. adprm.

Phylogenomic databases

eggNOGCOG1409.
HOGENOMHOG000154875.
HOVERGENHBG100432.
KOK01517.
OrthoDBEOG4TXBSP.

Family and domain databases

InterProIPR024654. Calcineurin-like_PEstase_dom.
[Graphical view]
PfamPF12850. Metallophos_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ7T291.
NextBio20814439.

Entry information

Entry nameADPRM_DANRE
AccessionPrimary (citable) accession number: Q7T291
Entry history
Integrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: October 1, 2003
Last modified: April 3, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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