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Protein

Cytochrome b-245 light chain

Gene

p22phox

Organism
Takifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Biological processElectron transportUniRule annotation, Transport
LigandHemeUniRule annotation, Iron, Metal-binding, NADPUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-245 light chainUniRule annotation
Alternative name(s):
Cytochrome b(558) alpha chainUniRule annotation
Cytochrome b558 subunit alphaUniRule annotation
Neutrophil cytochrome b 22 kDa polypeptideUniRule annotation
Superoxide-generating NADPH oxidase light chain subunitUniRule annotation
p22 phagocyte B-cytochromeUniRule annotation
p22-phoxUniRule annotation
Gene namesi
Name:p22phoxImported
OrganismiTakifugu rubripes (Japanese pufferfish) (Fugu rubripes)
Taxonomic identifieri31033 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiNeoteleosteiAcanthomorphataEupercariaTetraodontiformesTetradontoideaTetraodontidaeTakifugu
Proteomesi
  • UP000005226 Componenti: Unplaced

Subcellular locationi

  • Cell membrane UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei38 – 54HelicalSequence analysisAdd BLAST17
Transmembranei91 – 124HelicalSequence analysisAdd BLAST34

GO - Cellular componenti

Keywords - Cellular componenti

Cell membraneUniRule annotation, Membrane

Interactioni

Subunit structurei

Composed of a heavy chain (beta) and a light chain (alpha). Component of an NADPH oxidase complex composed of a heterodimer formed by the membrane proteins CYBA and CYBB and the cytosolic subunits NCF1, NCF2 and NCF4. Interacts with NCF1 (via SH3 domain).UniRule annotation

Protein-protein interaction databases

STRINGi31033.ENSTRUP00000046518.

Family & Domainsi

Sequence similaritiesi

Belongs to the p22phox family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiENOG410IXYN. Eukaryota.
ENOG4111MI6. LUCA.
GeneTreeiENSGT00390000002290.
HOGENOMiHOG000001585.
KOiK08009.
OMAiEQWTPIE.
OrthoDBiEOG091G0NNC.
TreeFamiTF328901.

Family and domain databases

InterProiView protein in InterPro
IPR007732. Cyt_b558_asu.
PANTHERiPTHR15168. PTHR15168. 1 hit.
PfamiView protein in Pfam
PF05038. Cytochrom_B558a. 1 hit.
PIRSFiPIRSF019635. Cytochr_b558a. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7T1Q0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKIEWAMWA NEQALASGFI LLTGGVVGVA GQFRGWQFAA YAVAAGVLVC
60 70 80 90 100
LLEYPRSKRS KGTSVERPGQ RCFTVCVKAF GPVTRNYYVR AVLHAAICVP
110 120 130 140 150
GGFMLATVLG CVCLGIASII YLVAAIRGEH WEPILPSKEI RKPVAESIKN
160 170 180
PPQNPPPRPP ADTRRKRVED LEAASYDNPI SVTANE
Length:186
Mass (Da):20,153
Last modified:October 1, 2003 - v1
Checksum:i3B45A838A7DE1ED1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB099895 mRNA. Translation: BAC79220.1.
RefSeqiNP_001027717.1. NM_001032545.1.
UniGeneiTru.2047.

Genome annotation databases

EnsembliENSTRUT00000046676; ENSTRUP00000046518; ENSTRUG00000018180.
GeneIDi445889.
KEGGitru:445889.

Similar proteinsi

Entry informationi

Entry nameiQ7T1Q0_TAKRU
AccessioniPrimary (citable) accession number: Q7T1Q0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: July 5, 2017
This is version 63 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported