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Protein

Dead end protein 1

Gene

dnd

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA-binding factor that positively regulates gene expression by prohibiting miRNA-mediated gene suppression. Relieves miRNA repression in germline cells. Prohibits the function of several miRNAs by blocking the accessibility of target mRNAs (By similarity). Sequence-specific RNA-binding factor that binds to U-rich regions (URRs) in the 3'untranslated region (3'-UTR) of several mRNAs (By similarity). Does not bind to miRNAs (By similarity). Germline-specific protein required for the primordial germ cell (PGC) survival and migration during early embryonic development.By similarity2 Publications

GO - Molecular functioni

  • AU-rich element binding Source: UniProtKB
  • mRNA 3'-UTR binding Source: ZFIN
  • mRNA binding Source: ZFIN
  • RNA binding Source: ZFIN

GO - Biological processi

  • germ cell development Source: ZFIN
  • germ cell migration Source: ZFIN
  • heart contraction Source: ZFIN
  • mRNA stabilization Source: ZFIN
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of gene silencing by miRNA Source: UniProtKB
  • positive regulation of gene expression Source: ZFIN
  • regulation of cell motility Source: ZFIN

Keywordsi

Molecular functionDevelopmental protein, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Dead end protein 1
Gene namesi
Name:dnd
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 14

Organism-specific databases

ZFINiZDB-GENE-030828-4 dnd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi104Y → C: Inhibits RNA-binding and the relieve of miRNA repression activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000815701 – 411Dead end protein 1Add BLAST411

Proteomic databases

PaxDbiQ7T1H5
PRIDEiQ7T1H5

Expressioni

Developmental stagei

Expressed in the germ plasm and the primordial germ cells (PGCs). At the onset of embryogenesis, maternal product is located in granules distributed throughout the cortex of the one-cell stage embryo. At 0.5 hour post fertilization (hpf) is expressed at the vegetal part of the blastomere. At 1 hpf expressed at the distal parts of the first two cleavage furrows. At 4 hpf expressed exclusively in PGCs. Expressed in PGCs during their migration and at their arrival in the presumptive gonade. At 5 days post-fertilization (dpf) still expressed in PGCs, albeit at a lower level.1 Publication

Gene expression databases

BgeeiENSDARG00000022813
ExpressionAtlasiQ7T1H5 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000035017

Structurei

3D structure databases

ProteinModelPortaliQ7T1H5
SMRiQ7T1H5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini60 – 138RRMPROSITE-ProRule annotationAdd BLAST79

Phylogenomic databases

eggNOGiENOG410IUE0 Eukaryota
ENOG410YAVC LUCA
GeneTreeiENSGT00550000074366
HOGENOMiHOG000112240
HOVERGENiHBG051370
InParanoidiQ7T1H5
OMAiMQSKREC
OrthoDBiEOG091G0EUB
PhylomeDBiQ7T1H5
TreeFamiTF314932

Family and domain databases

CDDicd12487 RRM1_DND1, 1 hit
Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR034414 DND1_RRM1
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

Q7T1H5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGDMDAQQQ ELQQILNPQK LKSLQEWMQR NSITLTQVNG QRKYGGPPPG
60 70 80 90 100
WQGPAPGSGC EVFISQIPND VYEDRLIPLF QSIGTIYEFR LMMNFSGQTR
110 120 130 140 150
GFAYAKYGDP LTASAAVTTL HQYRLPEGGC LTVRRSTEKR QLRLGDLPVS
160 170 180 190 200
MNESKLLMVL QMLSDGVEDV LLKPPGPKGK EVVALVNYTS HYAASMAKKV
210 220 230 240 250
LVEAFRNRYG ISITVRWTSF SKSKRVEDTP QEDSCVTPLV LKPLSKPSLL
260 270 280 290 300
HYDVPAHQSL LPLFRAVGGP TTSEQRDEMI PQPTIMSRNE LIPQSSIRQR
310 320 330 340 350
DEMVPQLPIR PRDGMAPQSP ISLDAVSHLQ WMCEVNRLGS PQYEVHFHHA
360 370 380 390 400
APDGFLYFAF KVLIPGLPLP LYGFVQILPG TSARAMKSEV YRAAAEQVIQ
410
TLCRVSNLRP F
Length:411
Mass (Da):46,020
Last modified:October 1, 2003 - v1
Checksum:i36CE5A3F12DFFFD1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY225448 mRNA Translation: AAP22373.1
BC095578 mRNA Translation: AAH95578.1
RefSeqiNP_997960.1, NM_212795.1
UniGeneiDr.26907

Genome annotation databases

EnsembliENSDART00000036463; ENSDARP00000035017; ENSDARG00000022813
GeneIDi373074
KEGGidre:373074

Similar proteinsi

Entry informationi

Entry nameiDND1_DANRE
AccessioniPrimary (citable) accession number: Q7T1H5
Secondary accession number(s): Q4VBK4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2005
Last sequence update: October 1, 2003
Last modified: May 23, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health