Q7T1G6 (Q7T1G6_DANRE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Ion channel NompC EMBL AAP86445.1

Gene names

Name:	trpn1 ZFIN ZDB-GENE-030728-7
Synonyms:	nompc EMBL AAP86445.1

Organism

Danio rerio (Zebrafish) (Brachydanio rerio) EMBL AAP86445.1

Taxonomic identifier

7955 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length	1614 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Biological process	Ion transport Transport
Cellular component	Membrane
Domain	ANK repeat RuleBase RU003321 SAAS SAAS005821 Repeat RuleBase RU003536 Transmembrane RuleBase RU003378
Molecular function	Ionic channel RuleBase RU003378
Gene Ontology (GO)
Biological process	detection of mechanical stimulus involved in sensory perception of sound Inferred from mutant phenotype Ref.1. Source: ZFIN
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	calcium channel activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q7T1G6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 773343F37E3CB2DD	FASTA	1,614	175,800
	10 20 30 40 50 60 MSESSCVSGA PQRLVPLALR GEWMALEQKI KTLERGDPDI LQCDEESGMS LLMLAVRESR 70 80 90 100 110 120 LSVLDRLLEL GANPSDKTKD GRSALHIAAA HSKDEIVKLL VRKTDPNSPA GPNDQLPLHY 130 140 150 160 170 180 AASRSTGGLA VVQTLLKFSS KDARLTPDKN GCLPLLLAAE AGNVGIVREL LSSQSEPQIR 190 200 210 220 230 240 AAKTANGDTA LHICCRRRDV EMAKILVEFG ANPDSQNDEG QTPLHIAAHE GDENMLKFLY 250 260 270 280 290 300 LCKANANISD KMDRSPLHIA AERGHTNVVE ILTEKFRSCV LARTKDGNTL LHIASQCGHP 310 320 330 340 350 360 TTALSFLRKG VPLHMPNKSG AVCLHAAAKR GHTAVVKALL QKGAHVDAAA RDGQTALHIA 370 380 390 400 410 420 VENCRPQVVQ MLLGFGAHVQ LRGGKAQETP LHISARVKEG ERAAEMLLKS GAEVNAEQEN 430 440 450 460 470 480 GETALHVAAR HGSLQMIRAL IQEGGDPRWR SRVGESPLHV AVRHCHAHVV QEILTFLTNE 490 500 510 520 530 540 KSRRDAELCV CEGNQDGETA LHLAAELRTD ALHQPEEDIT IIQILMEHQA DITAVTRQTG 550 560 570 580 590 600 ETPLHYSARV GNTAVLQEML RNVPTNQIQT AINKHSKNGW SPLLLAADQG HTEVVKILLQ 610 620 630 640 650 660 NNARVDVFDE EGKAAIHLAA QRGHQDIVDV LLSQKAFVNA KTKQGLTPLH LSAQNGSARL 670 680 690 700 710 720 VRLLVENHQA SVDALSLRKQ TPLHLAAMSG QLDVCSSLLN LRADITATDS RGQTPLHLAA 730 740 750 760 770 780 ESDHSEVVKL FLRLRPELST LANEDGSTCT HIAAAKGSVS VIRELLMFNQ GGVGTLNHKA 790 800 810 820 830 840 HGLCPLHLAA AGGHAEVVKV LLEAGASVTE EDAEGMTAVH LAAKHGHTHI LEVLRGSVPL 850 860 870 880 890 900 KIQSSKTGFT ALHVAASFGQ MNFVREILTK VPATIRSEFP TISGKDDIKR QQPLAESGFT 910 920 930 940 950 960 PLHLASQSGH ESVVRLLLNC PGVQADAETN IQGSSPLHLA AQSGHTAVVG LLLSRSSSLL 970 980 990 1000 1010 1020 HQADRRGRSA LHLAAAHGHV DMVRVLLGQG AEINHTDMSG WTALHYAAEA GCLEVLLFLV 1030 1040 1050 1060 1070 1080 ESGASACAEC HGGRTPLQYA AQQNHESAVI FLLRREKNTL RLLDDKKFIF NLMVCGRMND 1090 1100 1110 1120 1130 1140 NLSLEELVLH TSAPLDTAVR LSRALTLCAL REKERSVDLQ AAAHHCELMA SDLLSLSASA 1150 1160 1170 1180 1190 1200 GGQGAGAGPI LRALDHRGLS VLDCLIEGRQ KGVVSQPAVQ TYLTEVWCGG LQWDSWKILL 1210 1220 1230 1240 1250 1260 LFCCLLLCPP LWLLLALPLT HSFNTIPIVK FMSHLVSHIF LLTLFILTIV YPPVSPLSQA 1270 1280 1290 1300 1310 1320 RLMPSWSECL LLIWLCGMLV SELTFPGERT GLAWIRLLLL GFSAAALLCH LLAVFTQWWP 1330 1340 1350 1360 1370 1380 PTHLHCLFAR NVLLAVAMTL GFIQLLEFLT FHHLFGPWAI IIRDLIKDLC RFAVILMLFH 1390 1400 1410 1420 1430 1440 TAFTLSLTAL CQPLYPQEQH NTTTEVTVPG PLNMSVLLFF ALFGLTEPDK IPDVDRSPPA 1450 1460 1470 1480 1490 1500 TAVLAKMVFG VYLVVTFIVL INLLIAMMSD TYQRIQAQSD TEWKFGRAVL IRDMSRKSGI 1510 1520 1530 1540 1550 1560 PSPFNLFTNL FYSVKVVCKR AGKMCSSESR DVMNEDEDAE GLSESRSLDL LSQASVSGIR 1570 1580 1590 1600 1610 GNKRTQILPE GGQISLAHSG GHVRVENVAD WPSVVQQFLS QRRQRDRSTA ERDE

References

[1]	"NompC TRP channel required for vertebrate sensory hair cell mechanotransduction." Sidi S., Friedrich R.W., Nicolson T. Science 301:96-99(2003) [PubMed: 12805553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AY313897 mRNA. Translation: AAP86445.1.
IPI	IPI00511505.
RefSeq	NP_899192.1. NM_183349.1.
UniGene	Dr.89462.
3D structure databases
HSSP	HSSP built from PDB template 1K1B based on UniProtKB P20749.
ProteinModelPortal	Q7T1G6.
ModBase	Search...
Protein-protein interaction databases
STRING	Q7T1G6.
Protein family/group databases
TCDB	1.A.4.7.1. transient receptor potential Ca2+ channel (TRP-CC) family.
Proteomic databases
PRIDE	Q7T1G6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	368273.
KEGG	dre:368273.
Organism-specific databases
CTD	368273.
ZFIN	ZDB-GENE-030728-7. trpn1.
Phylogenomic databases
eggNOG	veNOG23528.
HOGENOM	HBG378504.
HOVERGEN	HBG066316.
OrthoDB	EOG4W0XFW.
Family and domain databases
InterPro	IPR002110. Ankyrin_rpt. IPR020683. Ankyrin_rpt-contain_dom. IPR005821. Ion_trans. IPR002153. TRPC_channel. [Graphical view]
Gene3D	G3DSA:1.25.40.20. ANK. 6 hits.
Pfam	PF00023. Ank. 3 hits. PF12796. Ank_2. 10 hits. PF00520. Ion_trans. 1 hit. [Graphical view]
PRINTS	PR01415. ANKYRIN. PR01097. TRNSRECEPTRP.
SMART	SM00248. ANK. 29 hits. [Graphical view]
SUPFAM	SSF48403. ANK. 3 hits.
PROSITE	PS50297. ANK_REP_REGION. 1 hit. PS50088. ANK_REPEAT. 23 hits. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q7T1G6_DANRE

Accession

Primary (citable) accession number: Q7T1G6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2003
Last sequence update:	October 1, 2003
Last modified:	October 19, 2011
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)