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Protein
Submitted name:

Ion channel NompC

Gene

trpn1

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

  • calcium channel activity Source: InterPro
  • mechanically-gated ion channel activity Source: ZFIN

GO - Biological processi

  • detection of mechanical stimulus involved in sensory perception of sound Source: ZFIN
  • sensory perception of sound Source: ZFIN
Complete GO annotation...

Keywords - Molecular functioni

Ion channelUniRule annotationSAAS annotation

Keywords - Biological processi

Ion transport, Transport

Protein family/group databases

TCDBi1.A.4.7.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Names & Taxonomyi

Protein namesi
Submitted name:
Ion channel NompCImported
Gene namesi
Name:trpn1Imported
Synonyms:nompcImported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

ZFINiZDB-GENE-030728-7. trpn1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1198 – 121922HelicalSequence analysisAdd
BLAST
Transmembranei1231 – 125121HelicalSequence analysisAdd
BLAST
Transmembranei1263 – 128523HelicalSequence analysisAdd
BLAST
Transmembranei1297 – 132024HelicalSequence analysisAdd
BLAST
Transmembranei1332 – 135120HelicalSequence analysisAdd
BLAST
Transmembranei1372 – 139524HelicalSequence analysisAdd
BLAST
Transmembranei1447 – 146822HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL1293245.

PTM / Processingi

Proteomic databases

PRIDEiQ7T1G6.

Structurei

3D structure databases

ProteinModelPortaliQ7T1G6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini47 – 10551009ANK_REP_REGIONInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the transient receptor (TC 1.A.4) family. [View classification]SAAS annotation
Contains 23 ANK repeats.UniRule annotation

Keywords - Domaini

ANK repeatUniRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOVERGENiHBG066316.
PhylomeDBiQ7T1G6.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR002153. TRPC_channel.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 7 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR01097. TRNSRECEPTRP.
SMARTiSM00248. ANK. 29 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T1G6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSESSCVSGA PQRLVPLALR GEWMALEQKI KTLERGDPDI LQCDEESGMS
60 70 80 90 100
LLMLAVRESR LSVLDRLLEL GANPSDKTKD GRSALHIAAA HSKDEIVKLL
110 120 130 140 150
VRKTDPNSPA GPNDQLPLHY AASRSTGGLA VVQTLLKFSS KDARLTPDKN
160 170 180 190 200
GCLPLLLAAE AGNVGIVREL LSSQSEPQIR AAKTANGDTA LHICCRRRDV
210 220 230 240 250
EMAKILVEFG ANPDSQNDEG QTPLHIAAHE GDENMLKFLY LCKANANISD
260 270 280 290 300
KMDRSPLHIA AERGHTNVVE ILTEKFRSCV LARTKDGNTL LHIASQCGHP
310 320 330 340 350
TTALSFLRKG VPLHMPNKSG AVCLHAAAKR GHTAVVKALL QKGAHVDAAA
360 370 380 390 400
RDGQTALHIA VENCRPQVVQ MLLGFGAHVQ LRGGKAQETP LHISARVKEG
410 420 430 440 450
ERAAEMLLKS GAEVNAEQEN GETALHVAAR HGSLQMIRAL IQEGGDPRWR
460 470 480 490 500
SRVGESPLHV AVRHCHAHVV QEILTFLTNE KSRRDAELCV CEGNQDGETA
510 520 530 540 550
LHLAAELRTD ALHQPEEDIT IIQILMEHQA DITAVTRQTG ETPLHYSARV
560 570 580 590 600
GNTAVLQEML RNVPTNQIQT AINKHSKNGW SPLLLAADQG HTEVVKILLQ
610 620 630 640 650
NNARVDVFDE EGKAAIHLAA QRGHQDIVDV LLSQKAFVNA KTKQGLTPLH
660 670 680 690 700
LSAQNGSARL VRLLVENHQA SVDALSLRKQ TPLHLAAMSG QLDVCSSLLN
710 720 730 740 750
LRADITATDS RGQTPLHLAA ESDHSEVVKL FLRLRPELST LANEDGSTCT
760 770 780 790 800
HIAAAKGSVS VIRELLMFNQ GGVGTLNHKA HGLCPLHLAA AGGHAEVVKV
810 820 830 840 850
LLEAGASVTE EDAEGMTAVH LAAKHGHTHI LEVLRGSVPL KIQSSKTGFT
860 870 880 890 900
ALHVAASFGQ MNFVREILTK VPATIRSEFP TISGKDDIKR QQPLAESGFT
910 920 930 940 950
PLHLASQSGH ESVVRLLLNC PGVQADAETN IQGSSPLHLA AQSGHTAVVG
960 970 980 990 1000
LLLSRSSSLL HQADRRGRSA LHLAAAHGHV DMVRVLLGQG AEINHTDMSG
1010 1020 1030 1040 1050
WTALHYAAEA GCLEVLLFLV ESGASACAEC HGGRTPLQYA AQQNHESAVI
1060 1070 1080 1090 1100
FLLRREKNTL RLLDDKKFIF NLMVCGRMND NLSLEELVLH TSAPLDTAVR
1110 1120 1130 1140 1150
LSRALTLCAL REKERSVDLQ AAAHHCELMA SDLLSLSASA GGQGAGAGPI
1160 1170 1180 1190 1200
LRALDHRGLS VLDCLIEGRQ KGVVSQPAVQ TYLTEVWCGG LQWDSWKILL
1210 1220 1230 1240 1250
LFCCLLLCPP LWLLLALPLT HSFNTIPIVK FMSHLVSHIF LLTLFILTIV
1260 1270 1280 1290 1300
YPPVSPLSQA RLMPSWSECL LLIWLCGMLV SELTFPGERT GLAWIRLLLL
1310 1320 1330 1340 1350
GFSAAALLCH LLAVFTQWWP PTHLHCLFAR NVLLAVAMTL GFIQLLEFLT
1360 1370 1380 1390 1400
FHHLFGPWAI IIRDLIKDLC RFAVILMLFH TAFTLSLTAL CQPLYPQEQH
1410 1420 1430 1440 1450
NTTTEVTVPG PLNMSVLLFF ALFGLTEPDK IPDVDRSPPA TAVLAKMVFG
1460 1470 1480 1490 1500
VYLVVTFIVL INLLIAMMSD TYQRIQAQSD TEWKFGRAVL IRDMSRKSGI
1510 1520 1530 1540 1550
PSPFNLFTNL FYSVKVVCKR AGKMCSSESR DVMNEDEDAE GLSESRSLDL
1560 1570 1580 1590 1600
LSQASVSGIR GNKRTQILPE GGQISLAHSG GHVRVENVAD WPSVVQQFLS
1610
QRRQRDRSTA ERDE
Length:1,614
Mass (Da):175,800
Last modified:October 1, 2003 - v1
Checksum:i773343F37E3CB2DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313897 mRNA. Translation: AAP86445.1.
RefSeqiNP_899192.1. NM_183349.1.
UniGeneiDr.89462.

Genome annotation databases

GeneIDi368273.
KEGGidre:368273.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY313897 mRNA. Translation: AAP86445.1.
RefSeqiNP_899192.1. NM_183349.1.
UniGeneiDr.89462.

3D structure databases

ProteinModelPortaliQ7T1G6.
ModBaseiSearch...
MobiDBiSearch...

Chemistry

ChEMBLiCHEMBL1293245.

Protein family/group databases

TCDBi1.A.4.7.1. the transient receptor potential ca(2+) channel (trp-cc) family.

Proteomic databases

PRIDEiQ7T1G6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi368273.
KEGGidre:368273.

Organism-specific databases

CTDi368273.
ZFINiZDB-GENE-030728-7. trpn1.

Phylogenomic databases

HOVERGENiHBG066316.
PhylomeDBiQ7T1G6.

Miscellaneous databases

NextBioi20812843.

Family and domain databases

Gene3Di1.25.40.20. 4 hits.
InterProiIPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR005821. Ion_trans_dom.
IPR002153. TRPC_channel.
[Graphical view]
PfamiPF00023. Ank. 1 hit.
PF12796. Ank_2. 7 hits.
PF00520. Ion_trans. 1 hit.
[Graphical view]
PRINTSiPR01415. ANKYRIN.
PR01097. TRNSRECEPTRP.
SMARTiSM00248. ANK. 29 hits.
[Graphical view]
SUPFAMiSSF48403. SSF48403. 4 hits.
PROSITEiPS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 23 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "NompC TRP channel required for vertebrate sensory hair cell mechanotransduction."
    Sidi S., Friedrich R.W., Nicolson T.
    Science 301:96-99(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ7T1G6_DANRE
AccessioniPrimary (citable) accession number: Q7T1G6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: May 11, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.