ID   Q7T0N9_XENLA            Unreviewed;       580 AA.
AC   Q7T0N9;
DT   01-OCT-2003, integrated into UniProtKB/TrEMBL.
DT   01-OCT-2003, sequence version 1.
DT   27-MAR-2024, entry version 106.
DE   SubName: Full=Cell division cycle 23 L homeolog {ECO:0000313|RefSeq:NP_001079890.1};
DE   SubName: Full=MGC69122 protein {ECO:0000313|EMBL:AAH56107.1};
GN   Name=cdc23.L {ECO:0000313|RefSeq:NP_001079890.1,
GN   ECO:0000313|Xenbase:XB-GENE-1015909};
GN   Synonyms=cdc23 {ECO:0000313|RefSeq:NP_001079890.1,
GN   ECO:0000313|Xenbase:XB-GENE-1015909};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355 {ECO:0000313|EMBL:AAH56107.1};
RN   [1] {ECO:0000313|RefSeq:NP_001079890.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=12454917; DOI=10.1002/dvdy.10174;
RA   Klein S.L., Strausberg R.L., Wagner L., Pontius J., Clifton S.W.,
RA   Richardson P.;
RT   "Genetic and genomic tools for Xenopus research: The NIH Xenopus
RT   initiative.";
RL   Dev. Dyn. 225:384-391(2002).
RN   [2] {ECO:0000313|EMBL:AAH56107.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Ovary {ECO:0000313|EMBL:AAH56107.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN   [3] {ECO:0000313|RefSeq:NP_001079890.1}
RP   IDENTIFICATION.
RG   RefSeq;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- INTERACTION:
CC       Q7T0N9; Q8AVG7: cdc20.S; NbExp=2; IntAct=EBI-2944054, EBI-7935057;
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DR   EMBL; BC056107; AAH56107.1; -; mRNA.
DR   RefSeq; NP_001079890.1; NM_001086421.1.
DR   IntAct; Q7T0N9; 3.
DR   DNASU; 379580; -.
DR   GeneID; 379580; -.
DR   KEGG; xla:379580; -.
DR   AGR; Xenbase:XB-GENE-1015909; -.
DR   CTD; 379580; -.
DR   Xenbase; XB-GENE-1015909; cdc23.L.
DR   OrthoDB; 3131281at2759; -.
DR   Proteomes; UP000186698; Chromosome 3L.
DR   Bgee; 379580; Expressed in egg cell and 19 other cell types or tissues.
DR   GO; GO:0005680; C:anaphase-promoting complex; IEA:InterPro.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR   InterPro; IPR007192; APC8.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   PANTHER; PTHR12558; CELL DIVISION CYCLE 16,23,27; 1.
DR   PANTHER; PTHR12558:SF10; CELL DIVISION CYCLE PROTEIN 23 HOMOLOG; 1.
DR   Pfam; PF04049; ANAPC8; 1.
DR   Pfam; PF13414; TPR_11; 1.
DR   Pfam; PF13181; TPR_8; 1.
DR   SMART; SM00028; TPR; 6.
DR   SUPFAM; SSF48452; TPR-like; 2.
DR   PROSITE; PS50005; TPR; 2.
PE   1: Evidence at protein level;
KW   Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW   Cell division {ECO:0000256|ARBA:ARBA00022618,
KW   ECO:0000313|RefSeq:NP_001079890.1};
KW   Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW   Reference proteome {ECO:0000313|Proteomes:UP000186698};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   DOMAIN          13..252
FT                   /note="Cdc23"
FT                   /evidence="ECO:0000259|Pfam:PF04049"
FT   REPEAT          313..346
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          347..380
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REGION          543..580
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        556..580
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   580 AA;  67420 MW;  AF133D82C9C52118 CRC64;
     MAATIGMFSD LKEIKRQLLS VTWLCRERGL MNSVKWASEL AFSLESVPLN ELPSTPALTE
     EDAQDLDAYM LAKSYFDLKE YDRAAYFLRG CKSQKAYFMY MYSRYLSGEK KKDDETVDSL
     GPLEKGQVKN EALREVRVEL SKKHKARELD GFGLYLYGVV LRKLDLAKEA LDVFVEATHV
     LPLHWGTWLE LCNLITDKEM LKFLSLPDSW IKEFFLAHIY TELQLIEEAL QKYQSLIDAG
     FSKSTYIISQ IAVAYHNIRD IDKALSIFNE LRKQDPYRIE NMDTFSNLLY VRGLKPELSY
     LAHNLCDIDK YRVETCCVIG NYYSLRSQHE KAALYFQRAL KLNPRYLGAW TLMGHEYMEM
     KNTSAAIQAY RHAIEVNKRD YRAWYGLGQT YEILKMPFYC LYYYRRAHQL RPNDSRMLVA
     LGECYEKLNQ LVEAKKCYWR AYAVGDVEKM ALVKLAKLHE QLNESEQAAQ CYIKYIQDIY
     SCGEIVEHQE VSTAFRYLAQ YYFKCKLWDE ASACAQKCFN FNDTREEGKA LLRQILQLRN
     QSESPSAEPA TAPFFLPQSL SANNTPTRRV SPLNLSSVTP
//