Q7T0L6 (CCNF_XENLA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cyclin-F

Gene names

Name:

ccnf

Organism

Xenopus laevis (African clawed frog)

Taxonomic identifier

8355 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Protein attributes

Sequence length	761 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase By similarity.
Subunit structure	Component of the SCF(CCNF) complex By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm › cytoskeleton › centrosome › centriole By similarity. Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus By similarity.
Domain	The nuclear localization signals mediate the localization to the nucleus By similarity.
Sequence similarities	Belongs to the cyclin family. Cyclin AB subfamily. Contains 1 cyclin N-terminal domain. Contains 1 F-box domain.

Ontologies

Keywords
Biological process	Cell cycle Cell division Mitosis Ubl conjugation pathway
Cellular component	Cytoplasm Cytoskeleton Nucleus
Molecular function	Cyclin
Gene Ontology (GO)
Biological_process	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Inferred from sequence or structural similarity. Source: UniProtKB cell division Inferred from electronic annotation. Source: UniProtKB-KW mitosis Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of centrosome duplication Inferred from sequence or structural similarity. Source: UniProtKB protein ubiquitination Inferred from sequence or structural similarity. Source: UniProtKB
Cellular_component	SCF ubiquitin ligase complex Inferred from sequence or structural similarity. Source: UniProtKB centriole Inferred from sequence or structural similarity. Source: UniProtKB nucleus Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 761	761	Cyclin-F		PRO_0000398637
Regions
	Domain	28 – 75	48	F-box
	Domain	301 – 411	111	Cyclin N-terminal
	Region	589 – 745	157	PEST
	Motif	19 – 27	9	Nuclear localization signal 1 By similarity
	Motif	575 – 581	7	Nuclear localization signal 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q7T0L6 [UniParc]. Last modified October 1, 2003. Version 1. Checksum: 8BFB3EA39C602A81	FASTA	761	84,500
	10 20 30 40 50 60 MKGGGLHCRC SKCFAAPPRR RIKRRPRVLT LLSLPEDVLL YVLECLPAVD ILSMREVHPH 70 80 90 100 110 120 LRSLVDSHSS VWARASFQDV WPSSENLNLF ERAAECGNFE ACVKLGIAYL YNEGLSVSDD 130 140 150 160 170 180 GRAEVNGLKA SRFFSLTERL NAGADPFVWL FIRPPWSSSG SCCKAVVFDS LNEECGTVTS 190 200 210 220 230 240 GEGATGALKG SIQYCLAKVL SLFEDDDKKR EALGMLESSA SNGCLHSAYL LWETKQKAAL 250 260 270 280 290 300 SDPGRYLQSF RQLRDYAARG CWDAQISLAK ACGHKNPLNQ EQRSAGELVN QVFQSSLPIN 310 320 330 340 350 360 KSSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL RSVPRAKLQL 370 380 390 400 410 420 VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM GEIISALEGK IRMPTVVDYK 430 440 450 460 470 480 DVLSHLIPLD RNTLHLCSYI SELSLLYTEL SMYSPAQLAA GALLLARILH RQARPWPAQL 490 500 510 520 530 540 AETTGFTLEH LTPCVVLLHK KCFHDDAPRD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHT 550 560 570 580 590 600 HLCELLGVPC HDSESPATCP NAADFHQFLC SPSGNKTKRR REESIQEDRG SFVTTPTAEL 610 620 630 640 650 660 SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLL TEHPQCQDST 670 680 690 700 710 720 TDDDSITLHP IPLLSKAENG TDSIEGCVEK SSGYSSVSSG GSPTSSSSPG LPFTPTPGLN 730 740 750 760 HSKLTPIPFP QPCSPLLKAS RRQVKRKNQA QHSEDNLSDE L

References

[1]	NIH - Xenopus Gene Collection (XGC) project Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC056134 mRNA. Translation: AAH56134.1.
RefSeq	NP_001079901.1. NM_001086432.1.
UniGene	Xl.25446.
3D structure databases
ProteinModelPortal	Q7T0L6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	379591.
KEGG	xla:379591.
Organism-specific databases
CTD	899.
Xenbase	XB-GENE-963734. ccnf.
Phylogenomic databases
HOVERGEN	HBG050838.
KO	K10289.
Family and domain databases
Gene3D	1.10.472.10. 2 hits. 1.25.40.10. 2 hits.
InterPro	IPR013763. Cyclin-like. IPR004367. Cyclin_C-dom. IPR006671. Cyclin_N. IPR001810. F-box_dom_cyclin-like. IPR011990. TPR-like_helical. [Graphical view]
Pfam	PF02984. Cyclin_C. 1 hit. PF00134. Cyclin_N. 1 hit. PF00646. F-box. 1 hit. [Graphical view]
SMART	SM00385. CYCLIN. 2 hits. SM00256. FBOX. 1 hit. [Graphical view]
SUPFAM	SSF47954. Cyclin_like. 2 hits. SSF81383. F-box_dom_Skp2-like. 1 hit.
PROSITE	PS00292. CYCLINS. 1 hit. PS50181. FBOX. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

CCNF_XENLA

Accession

Primary (citable) accession number: Q7T0L6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 5, 2010
Last sequence update:	October 1, 2003
Last modified:	May 1, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program