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Protein

Cyclin-F

Gene

ccnf

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase.By similarity

GO - Biological processi

  1. cell division Source: UniProtKB-KW
  2. mitotic nuclear division Source: UniProtKB-KW
  3. negative regulation of centrosome duplication Source: UniProtKB
  4. protein ubiquitination Source: UniProtKB
  5. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Cyclin

Keywords - Biological processi

Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-F
Gene namesi
Name:ccnf
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-963734. ccnf.

Subcellular locationi

Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus (By similarity).By similarity

GO - Cellular componenti

  1. centriole Source: UniProtKB
  2. nucleus Source: UniProtKB
  3. SCF ubiquitin ligase complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 761761Cyclin-FPRO_0000398637Add
BLAST

Interactioni

Subunit structurei

Component of the SCF(CCNF) complex.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ7T0L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini28 – 7548F-boxPROSITE-ProRule annotationAdd
BLAST
Domaini301 – 411111Cyclin N-terminalAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni589 – 745157PESTAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi19 – 279Nuclear localization signal 1By similarity
Motifi575 – 5817Nuclear localization signal 2By similarity

Domaini

The nuclear localization signals mediate the localization to the nucleus.By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated
Contains 1 cyclin N-terminal domain.Curated
Contains 1 F-box domain.PROSITE-ProRule annotation

Phylogenomic databases

HOVERGENiHBG050838.
KOiK10289.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q7T0L6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKGGGLHCRC SKCFAAPPRR RIKRRPRVLT LLSLPEDVLL YVLECLPAVD
60 70 80 90 100
ILSMREVHPH LRSLVDSHSS VWARASFQDV WPSSENLNLF ERAAECGNFE
110 120 130 140 150
ACVKLGIAYL YNEGLSVSDD GRAEVNGLKA SRFFSLTERL NAGADPFVWL
160 170 180 190 200
FIRPPWSSSG SCCKAVVFDS LNEECGTVTS GEGATGALKG SIQYCLAKVL
210 220 230 240 250
SLFEDDDKKR EALGMLESSA SNGCLHSAYL LWETKQKAAL SDPGRYLQSF
260 270 280 290 300
RQLRDYAARG CWDAQISLAK ACGHKNPLNQ EQRSAGELVN QVFQSSLPIN
310 320 330 340 350
KSSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL
360 370 380 390 400
RSVPRAKLQL VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM
410 420 430 440 450
GEIISALEGK IRMPTVVDYK DVLSHLIPLD RNTLHLCSYI SELSLLYTEL
460 470 480 490 500
SMYSPAQLAA GALLLARILH RQARPWPAQL AETTGFTLEH LTPCVVLLHK
510 520 530 540 550
KCFHDDAPRD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHT HLCELLGVPC
560 570 580 590 600
HDSESPATCP NAADFHQFLC SPSGNKTKRR REESIQEDRG SFVTTPTAEL
610 620 630 640 650
SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLL
660 670 680 690 700
TEHPQCQDST TDDDSITLHP IPLLSKAENG TDSIEGCVEK SSGYSSVSSG
710 720 730 740 750
GSPTSSSSPG LPFTPTPGLN HSKLTPIPFP QPCSPLLKAS RRQVKRKNQA
760
QHSEDNLSDE L
Length:761
Mass (Da):84,500
Last modified:September 30, 2003 - v1
Checksum:i8BFB3EA39C602A81
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056134 mRNA. Translation: AAH56134.1.
RefSeqiNP_001079901.1. NM_001086432.1.
UniGeneiXl.25446.

Genome annotation databases

GeneIDi379591.
KEGGixla:379591.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC056134 mRNA. Translation: AAH56134.1.
RefSeqiNP_001079901.1. NM_001086432.1.
UniGeneiXl.25446.

3D structure databases

ProteinModelPortaliQ7T0L6.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi379591.
KEGGixla:379591.

Organism-specific databases

CTDi899.
XenbaseiXB-GENE-963734. ccnf.

Phylogenomic databases

HOVERGENiHBG050838.
KOiK10289.

Family and domain databases

Gene3Di1.10.472.10. 2 hits.
1.25.40.10. 2 hits.
InterProiIPR028857. CCNF_metazoan.
IPR013763. Cyclin-like.
IPR004367. Cyclin_C-dom.
IPR006671. Cyclin_N.
IPR001810. F-box_dom.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
PfamiPF02984. Cyclin_C. 1 hit.
PF00134. Cyclin_N. 1 hit.
PF00646. F-box. 1 hit.
[Graphical view]
SMARTiSM00385. CYCLIN. 2 hits.
SM00256. FBOX. 1 hit.
[Graphical view]
SUPFAMiSSF47954. SSF47954. 2 hits.
SSF81383. SSF81383. 1 hit.
PROSITEiPS00292. CYCLINS. 1 hit.
PS50181. FBOX. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. NIH - Xenopus Gene Collection (XGC) project
    Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.

Entry informationi

Entry nameiCCNF_XENLA
AccessioniPrimary (citable) accession number: Q7T0L6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 4, 2010
Last sequence update: September 30, 2003
Last modified: February 3, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.