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Q7T0L6

- CCNF_XENLA

UniProt

Q7T0L6 - CCNF_XENLA

Protein

Cyclin-F

Gene

ccnf

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 1 (01 Oct 2003)
      Previous versions | rss
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    Functioni

    Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins during G2 phase.By similarity

    GO - Biological processi

    1. mitotic nuclear division Source: UniProtKB-KW
    2. negative regulation of centrosome duplication Source: UniProtKB
    3. protein ubiquitination Source: UniProtKB
    4. SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB

    Keywords - Molecular functioni

    Cyclin

    Keywords - Biological processi

    Cell cycle, Cell division, Mitosis, Ubl conjugation pathway

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-F
    Gene namesi
    Name:ccnf
    OrganismiXenopus laevis (African clawed frog)
    Taxonomic identifieri8355 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

    Organism-specific databases

    XenbaseiXB-GENE-963734. ccnf.

    Subcellular locationi

    Nucleus By similarity. Cytoplasmcytoskeletonmicrotubule organizing centercentrosomecentriole By similarity
    Note: Localization in the centrosome is rare in S phase cells and increases in G2 cells, Localizes on both the mother and daughter centrioles. Also localizes to the nucleus By similarity.By similarity

    GO - Cellular componenti

    1. centriole Source: UniProtKB
    2. nucleus Source: UniProtKB
    3. SCF ubiquitin ligase complex Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 761761Cyclin-FPRO_0000398637Add
    BLAST

    Interactioni

    Subunit structurei

    Component of the SCF(CCNF) complex.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ7T0L6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini28 – 7548F-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini301 – 411111Cyclin N-terminalAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni589 – 745157PESTAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi19 – 279Nuclear localization signal 1By similarity
    Motifi575 – 5817Nuclear localization signal 2By similarity

    Domaini

    The nuclear localization signals mediate the localization to the nucleus.By similarity

    Sequence similaritiesi

    Belongs to the cyclin family. Cyclin AB subfamily.Curated
    Contains 1 cyclin N-terminal domain.Curated
    Contains 1 F-box domain.PROSITE-ProRule annotation

    Phylogenomic databases

    HOVERGENiHBG050838.
    KOiK10289.

    Family and domain databases

    Gene3Di1.10.472.10. 2 hits.
    1.25.40.10. 2 hits.
    InterProiIPR028857. CCNF_metazoan.
    IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    IPR001810. F-box_dom.
    IPR011990. TPR-like_helical.
    [Graphical view]
    PANTHERiPTHR10177:SF183. PTHR10177:SF183. 1 hit.
    PfamiPF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    PF00646. F-box. 1 hit.
    [Graphical view]
    SMARTiSM00385. CYCLIN. 2 hits.
    SM00256. FBOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF47954. SSF47954. 2 hits.
    SSF81383. SSF81383. 1 hit.
    PROSITEiPS00292. CYCLINS. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q7T0L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MKGGGLHCRC SKCFAAPPRR RIKRRPRVLT LLSLPEDVLL YVLECLPAVD    50
    ILSMREVHPH LRSLVDSHSS VWARASFQDV WPSSENLNLF ERAAECGNFE 100
    ACVKLGIAYL YNEGLSVSDD GRAEVNGLKA SRFFSLTERL NAGADPFVWL 150
    FIRPPWSSSG SCCKAVVFDS LNEECGTVTS GEGATGALKG SIQYCLAKVL 200
    SLFEDDDKKR EALGMLESSA SNGCLHSAYL LWETKQKAAL SDPGRYLQSF 250
    RQLRDYAARG CWDAQISLAK ACGHKNPLNQ EQRSAGELVN QVFQSSLPIN 300
    KSSIFTTQKG MNDTMRYILI DWLVEVATMK DFSSLCLHMT VGLVDRYLKL 350
    RSVPRAKLQL VGIACMVICT RFISKEILTI REAVWLTDNT YKYEDLVRMM 400
    GEIISALEGK IRMPTVVDYK DVLSHLIPLD RNTLHLCSYI SELSLLYTEL 450
    SMYSPAQLAA GALLLARILH RQARPWPAQL AETTGFTLEH LTPCVVLLHK 500
    KCFHDDAPRD YRQVSLTAVK QRFQDDLYDQ ISKEKVMDHT HLCELLGVPC 550
    HDSESPATCP NAADFHQFLC SPSGNKTKRR REESIQEDRG SFVTTPTAEL 600
    SNQEEDLLGD FLDWSLETSC SGYEGDRESE GEREGEVTAP SGVLDLSLLL 650
    TEHPQCQDST TDDDSITLHP IPLLSKAENG TDSIEGCVEK SSGYSSVSSG 700
    GSPTSSSSPG LPFTPTPGLN HSKLTPIPFP QPCSPLLKAS RRQVKRKNQA 750
    QHSEDNLSDE L 761
    Length:761
    Mass (Da):84,500
    Last modified:October 1, 2003 - v1
    Checksum:i8BFB3EA39C602A81
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056134 mRNA. Translation: AAH56134.1.
    RefSeqiNP_001079901.1. NM_001086432.1.
    UniGeneiXl.25446.

    Genome annotation databases

    GeneIDi379591.
    KEGGixla:379591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC056134 mRNA. Translation: AAH56134.1 .
    RefSeqi NP_001079901.1. NM_001086432.1.
    UniGenei Xl.25446.

    3D structure databases

    ProteinModelPortali Q7T0L6.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 379591.
    KEGGi xla:379591.

    Organism-specific databases

    CTDi 899.
    Xenbasei XB-GENE-963734. ccnf.

    Phylogenomic databases

    HOVERGENi HBG050838.
    KOi K10289.

    Family and domain databases

    Gene3Di 1.10.472.10. 2 hits.
    1.25.40.10. 2 hits.
    InterProi IPR028857. CCNF_metazoan.
    IPR013763. Cyclin-like.
    IPR004367. Cyclin_C-dom.
    IPR006671. Cyclin_N.
    IPR001810. F-box_dom.
    IPR011990. TPR-like_helical.
    [Graphical view ]
    PANTHERi PTHR10177:SF183. PTHR10177:SF183. 1 hit.
    Pfami PF02984. Cyclin_C. 1 hit.
    PF00134. Cyclin_N. 1 hit.
    PF00646. F-box. 1 hit.
    [Graphical view ]
    SMARTi SM00385. CYCLIN. 2 hits.
    SM00256. FBOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47954. SSF47954. 2 hits.
    SSF81383. SSF81383. 1 hit.
    PROSITEi PS00292. CYCLINS. 1 hit.
    PS50181. FBOX. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. NIH - Xenopus Gene Collection (XGC) project
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.

    Entry informationi

    Entry nameiCCNF_XENLA
    AccessioniPrimary (citable) accession number: Q7T0L6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 5, 2010
    Last sequence update: October 1, 2003
    Last modified: October 1, 2014
    This is version 73 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3