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Protein

Gap junction Cx32.2 protein

Gene

cx32.2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.Curated

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction Cx32.2 protein
Alternative name(s):
Connexin-32.2
Gene namesi
Name:cx32.2Imported
Synonyms:gjaeImported
ORF Names:si:dkey-261a18.5, zgc:153825
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 20

Organism-specific databases

ZFINiZDB-GENE-050303-1. cx32.2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini2 – 19CytoplasmicSequence analysisAdd BLAST18
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Topological domaini41 – 76ExtracellularSequence analysisAdd BLAST36
Transmembranei77 – 97HelicalSequence analysisAdd BLAST21
Topological domaini98 – 143CytoplasmicSequence analysisAdd BLAST46
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Topological domaini165 – 189ExtracellularSequence analysisAdd BLAST25
Transmembranei190 – 210HelicalSequence analysisAdd BLAST21
Topological domaini211 – 277CytoplasmicSequence analysisAdd BLAST67

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000578762 – 277Gap junction Cx32.2 proteinAdd BLAST276

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi54 ↔ 175By similarity
Disulfide bondi170 ↔ 180By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ7T047.

Expressioni

Gene expression databases

BgeeiENSDARG00000076789.
ExpressionAtlasiQ7T047. baseline.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.Curated

Protein-protein interaction databases

STRINGi7955.ENSDARP00000112321.

Family & Domainsi

Sequence similaritiesi

Belongs to the connexin family. Alpha-type (group II) subfamily.Sequence analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00900000140773.
HOGENOMiHOG000231127.
HOVERGENiHBG009576.
InParanoidiQ7T047.
KOiK07612.
OMAiFICERSP.
OrthoDBiEOG091G11MN.
PhylomeDBiQ7T047.
TreeFamiTF329606.

Family and domain databases

InterProiView protein in InterPro
IPR000500. Connexin.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
PANTHERiPTHR11984. PTHR11984. 1 hit.
PfamiView protein in Pfam
PF00029. Connexin. 1 hit.
PRINTSiPR00206. CONNEXIN.
SMARTiView protein in SMART
SM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
PROSITEiView protein in PROSITE
PS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q7T047-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWGFLSAL LDKVQSHSTV IGKIWMSVLF IFRILVLGAG AENVWGDERS
60 70 80 90 100
NLVCNTNTPG CDNLCYDWQF PISHIRFWVM QIIFISTPTL VYLGHVVHII
110 120 130 140 150
HQENKQRELL KSNPMAKSPK YTDENGKVEI KGSMLGSYLT QLFIKIILEV
160 170 180 190 200
AFIVGQYYLF GFIIDHKFIC ERSPCMRAEC FVSRPTEKSI FIIFMLVVAC
210 220 230 240 250
VSLALNVLEI FYLLCRRISR RSKKCRQAMY NGESRYPGHF TTELESMNGM
260 270
RHNEFNVAFQ NKWSQRKGSL DAAKPEA
Length:277
Mass (Da):31,885
Last modified:January 23, 2007 - v4
Checksum:i13B84F85FAC1245E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti231N → D in AAQ17184 (PubMed:15895415).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY340236 Genomic DNA. Translation: AAQ17184.1.
CR352322 Genomic DNA. Translation: CAH69064.1.
BC122427 mRNA. Translation: AAI22428.1.
RefSeqiNP_001025381.2. NM_001030210.2.
UniGeneiDr.94164.

Genome annotation databases

EnsembliENSDART00000101014; ENSDARP00000091787; ENSDARG00000076789.
GeneIDi566647.
KEGGidre:566647.

Similar proteinsi

Entry informationi

Entry nameiCX32_DANRE
AccessioniPrimary (citable) accession number: Q7T047
Secondary accession number(s): Q0P3V1, Q5TYN7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: January 23, 2007
Last modified: October 25, 2017
This is version 102 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families