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Q7T019 (DZIP1_DANRE) Reviewed, UniProtKB/Swiss-Prot

Last modified September 21, 2011. Version 57. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Zinc finger protein Dzip1
Alternative name(s):
DAZ-interacting protein 1 homolog
Iguana protein
Gene names
Name:dzip1
Synonyms:igu
ORF Names:si:dz52i16.1
OrganismDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifier7955 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Protein attributes

Sequence length898 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Acts as a permissive factor that is required for the proper regulation of Hedgehog (Hh) target genes in response to Hh signals. Acts downstream of the Smoothened protein to modulate Gli activity in the somites of the developing embryo. Ref.1 Ref.2

Subcellular location

Nucleus. Cytoplasm. Note: In the cytoplasm, it is localized in large vesicles. These vesicles correspond to lysosomes and/or endosomes. Can shuttle between the cytoplasm and the nucleus in a manner correlated with Hh activity. Ref.1 Ref.2

Tissue specificity

Expressed throughout the embryo starting at 12 hours. Ref.1

Disruption phenotype

Defects are a cause of reduced expression of Hh target genes in the ventral neural tube, similar to the phenotype seen in zebrafish mutants known to affect Hh signaling. Ref.1 Ref.2

Sequence similarities

Belongs to the DZIP C2H2-type zinc-finger protein family.

Contains 1 C2H2-type zinc finger.

Sequence caution

The sequence CAE30370.2 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q7T019-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q7T019-2)

The sequence of this isoform differs from the canonical sequence as follows:
     473-492: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 898898Zinc finger protein Dzip1
PRO_0000047108

Regions

Zinc finger207 – 23024C2H2-type
Coiled coil145 – 19753 Potential
Coiled coil242 – 353112 Potential
Coiled coil407 – 44741 Potential
Coiled coil573 – 59018 Potential
Compositional bias664 – 68320Glu-rich
Compositional bias816 – 82611Asp-rich

Natural variations

Alternative sequence473 – 49220Missing in isoform 2.
VSP_010970

Experimental info

Sequence conflict324 – 3252IN → MH in AAS58471. Ref.2
Sequence conflict3581T → A in AAS58471. Ref.2
Sequence conflict501 – 5044PTEN → LMES in CAD24437. Ref.3
Sequence conflict5991S → P in AAS58471. Ref.2
Sequence conflict5991S → P in CAD24437. Ref.3
Sequence conflict6421T → S in AAS58471. Ref.2
Sequence conflict6421T → S in CAD24437. Ref.3
Sequence conflict7041T → I in CAD24437. Ref.3
Sequence conflict7371T → S in AAS58471. Ref.2
Sequence conflict7371T → S in CAD24437. Ref.3
Sequence conflict8011V → I in CAD24437. Ref.3
Sequence conflict8161Missing in AAS58471. Ref.2
Sequence conflict8161Missing in CAD24437. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified July 19, 2004. Version 2.
Checksum: 13B26E5457EEF1B7

FASTA898101,728
        10         20         30         40         50         60 
MPFYDNVYYP YPSDPPGTHS SAGIPSLLSS PQSQPSSGSQ SRPAPSTMSG PLTSSGASTS 

        70         80         90        100        110        120 
IPPPFKFRSR RENVDWRRIN AVDVDRVACE MDFQALQEHI NAVTFCSVEG ERCHRCQSPV 

       130        140        150        160        170        180 
DPALIKLFRL AQLTVEYLLH SQDCLSISLQ AAEERLLAEA REREQICVQL QKKTQDAKAL 

       190        200        210        220        230        240 
KEELKQRKKI IASQQAMFSA GISANYHKCQ HCEKAFMNAS FLQSHMQRRH PSEFDMKLMT 

       250        260        270        280        290        300 
DNQKKIQTVK LQDEINKLQE QLTLVTSQME TQQKDYTAKQ EKELIQRQEE FKRQLEIWKE 

       310        320        330        340        350        360 
EEKMRMNSKI DEVKQACQRD MDSINQRNRN LETELLKLQQ KNIQESMQSV QTQPNASTSN 

       370        380        390        400        410        420 
EHWQEVVKLQ QKLHKQEVKW TGKMQKMKED HDREKSLLQE ELCKVSSAVS EGMEESRRQV 

       430        440        450        460        470        480 
QELSHRLQEQ QQIITSQNKQ MKQISSKPPT ITVQREGVST PSPETKAKVV VSEQSNSVHK 

       490        500        510        520        530        540 
LDPIVELSEE DKDSSSISES PTENRSWQKE VQELLKNPGL RRDMRLAAQH NLDDRLQSLG 

       550        560        570        580        590        600 
IKGVSGLSKN LYKSSMTQII SDRRKKLEED PVYRRALKEI SHKLEQRVKE RNTEQPVKSK 

       610        620        630        640        650        660 
LHEQVVQSRP RSSSFPSTVT RVMSGPASKQ QRTPQPVPRS RTNVPHKTST PLQHRRTPPF 

       670        680        690        700        710        720 
SSDEDSSEEE EEEEEEEESS DEESPQMQKK TVLVNSSTAK AQNTAKTQST AQSVRSAVAL 

       730        740        750        760        770        780 
TSAEPTNVTT LSDSDWTDGS EMEEINLSQL HKHTDQNGNL KNVTHSNVKA LGKSLEKQLA 

       790        800        810        820        830        840 
ARGPKKPAGG VNTFLEKPTD VRNTRQNAKK ELKYSDDDDD DDDDWDISSL EDVPAVAKPT 

       850        860        870        880        890 
QCPVPVRKSL DKSQDTSTSV WGSSTGKGHK PGLTDAGTAS TLKSSLVTVS DWDDSDEI

« Hide

Isoform 2 [UniParc].

Checksum: F8F05D60857C73C2
Show »

FASTA87899,449

References

« Hide 'large scale' references
[1]"The zebrafish iguana locus encodes Dzip1, a novel zinc-finger protein required for proper regulation of Hedgehog signaling."
Sekimizu K., Nishioka N., Sasaki H., Takeda H., Karlstrom R.O., Kawakami K.
Development 131:2521-2532(2004) [PubMed: 15115751] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
[2]"Iguana encodes a novel zinc-finger protein with coiled-coil domains essential for Hedgehog signal transduction in the zebrafish embryo."
Wolff C., Roy S., Lewis K.E., Schauerte H., Joerg-Rauch G., Kirn A., Weiler C., Geisler R., Haffter P., Ingham P.W.
Genes Dev. 18:1565-1576(2004) [PubMed: 15198976] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, SUBCELLULAR LOCATION, DISRUPTION PHENOTYPE.
[3]The Danio rerio sequencing project at the Sanger Institute
Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: AB and Tuebingen.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB106357 mRNA. Translation: BAC87859.1.
AB106358 mRNA. Translation: BAC87860.1.
AY551927 mRNA. Translation: AAS58471.1.
AL591370 Genomic DNA. Translation: CAD24437.2.
AL591510 Genomic DNA. Translation: CAE30370.2. Sequence problems.
BX663606 Genomic DNA. No translation available.
IPIIPI00486248.
IPI00494296.
RefSeqNP_001001501.1. NM_001001501.1.
UniGeneDr.28200.

3D structure databases

ProteinModelPortalQ7T019.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ7T019.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID402875.
KEGGdre:402875.

Organism-specific databases

CTD22873.
ZFINZDB-GENE-040526-1. dzip1.

Phylogenomic databases

eggNOGfiNOG09364.
GeneTreeENSGT00530000063572.
HOGENOMHBG715411.
HOVERGENHBG101343.
InParanoidQ7T019.
OrthoDBEOG4QJRMK.

Gene expression databases

BgeeQ7T019.

Family and domain databases

InterProIPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
[Graphical view]
SMARTSM00355. ZnF_C2H2. 1 hit.
[Graphical view]
PROSITEPS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDZIP1_DANRE
AccessionPrimary (citable) accession number: Q7T019
Secondary accession number(s): Q8QFL8
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: July 19, 2004
Last modified: September 21, 2011
This is version 57 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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