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Protein
Submitted name:

Vesicle-associated membrane protein 2

Gene

vamp2

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-DRE-181430. Norepinephrine Neurotransmitter Release Cycle.
R-DRE-210500. Glutamate Neurotransmitter Release Cycle.
R-DRE-264642. Acetylcholine Neurotransmitter Release Cycle.
R-DRE-421837. Clathrin derived vesicle budding.
R-DRE-432720. Lysosome Vesicle Biogenesis.
R-DRE-432722. Golgi Associated Vesicle Biogenesis.
R-DRE-8856825. Cargo recognition for clathrin-mediated endocytosis.
R-DRE-8856828. Clathrin-mediated endocytosis.
R-DRE-888590. GABA synthesis, release, reuptake and degradation.

Names & Taxonomyi

Protein namesi
Submitted name:
Vesicle-associated membrane protein 2Imported
Gene namesi
Name:vamp2Imported
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 10

Organism-specific databases

ZFINiZDB-GENE-030131-8225. vamp2.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei89 – 108HelicalSequence analysisAdd BLAST20

GO - Cellular componenti

  • cleavage furrow Source: ZFIN
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: ZFIN
  • SNARE complex Source: GO_Central
  • vesicle Source: ZFIN

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSDARG00000056877.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073910.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 85V-SNARE coiled-coil homologyInterPro annotationAdd BLAST61

Keywords - Domaini

Coiled coilPROSITE-ProRule annotationSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG0860. Eukaryota.
COG5143. LUCA.
GeneTreeiENSGT00550000074449.
HOGENOMiHOG000042711.
HOVERGENiHBG006675.
KOiK13504.
OMAiYQADDRI.
OrthoDBiEOG091G0MPE.
TreeFamiTF313666.

Family and domain databases

InterProiView protein in InterPro
IPR001388. Synaptobrevin.
IPR016444. Synaptobrevin/VAMP.
PfamiView protein in Pfam
PF00957. Synaptobrevin. 1 hit.
PIRSFiPIRSF005409. Synaptobrevin_euk. 1 hit.
PRINTSiPR00219. SYNAPTOBREVN.
PROSITEiView protein in PROSITE
PS00417. SYNAPTOBREVIN. 1 hit.
PS50892. V_SNARE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q7SZZ5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSAPAGAPAP EGGNQAPPNL TSNRRLQQTQ AQVDEVVDIM RVNVDKVLER
60 70 80 90 100
DQKLSELDDR ADALQAGASQ FETSAAKLKN KYWWKNAKMM IILGVICVIV
110
LIIIIVYFST
Length:110
Mass (Da):12,128
Last modified:October 1, 2003 - v1
Checksum:iDF482474CC9816A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL807389 Genomic DNA. No translation available.
BC059626 mRNA. Translation: AAH59626.1.
RefSeqiNP_956299.1. NM_200005.1.
UniGeneiDr.116682.

Genome annotation databases

EnsembliENSDART00000079454; ENSDARP00000073910; ENSDARG00000056877.
GeneIDi336281.
KEGGidre:336281.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiQ7SZZ5_DANRE
AccessioniPrimary (citable) accession number: Q7SZZ5
Entry historyiIntegrated into UniProtKB/TrEMBL: October 1, 2003
Last sequence update: October 1, 2003
Last modified: June 7, 2017
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported